Early-Delayed, Radiation-Induced Cognitive Deficits in Adult Rats are Heterogeneous and Age-Dependent

Disruptions of endoplasmic reticulum (ER) Ca2+ homeostasis are heavily linked to neuronal pathology. Depletion of ER Ca2+ stores can result in cellular dysfunction and potentially cell death, although adaptive processes exist to aid in survival. We examined the age and region dependence of one postulated, adaptive response to ER store-depletion (SD), hyperpolarization-activated cation-nonspecific ( h)-channel plasticity in neurons of the dorsal and ventral hippocampus (DHC and VHC, respectively) from adolescent and adult rats. With the use of whole-cell patch-clamp recordings from the soma and dendrites of CA1 pyramidal neurons, we observed a change in h-sensitive measurements in response to SD, induced by treatment with cyclopiazonic acid, a sarcoplasmic reticulum/ER Ca2+-ATPase blocker. We found that whereas DHC and VHC neurons in adolescent animals respond to SD with a perisomatic expression of SD h plasticity, adult animals express SD h plasticity with a dendritic and somatodendritic locus of plasticity in DHC and VHC neurons, respectively. Furthermore, SD h plasticity in adults was dependent on membrane potential and on the activation of L-type voltage-gated Ca2+ channels. These results suggest that cellular responses to the impairment of ER function, or ER stress, are dependent on brain region and age and that the differential expression of SD h plasticity could provide a neural basis for region- and age-dependent disease vulnerabilities.

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Short-Term Exposure to Enriched Environment in Adult Rats Restores MK-801-Induced Cognitive Deficits and GABAergic Interneuron Immunoreactivity Loss

Molecular Neurobiology ◽

10.1007/s12035-017-0715-z ◽

2017 ◽

Vol 55 (1) ◽

pp. 26-41 ◽

Cited By ~ 9

Author(s):

Ane Murueta-Goyena ◽

Naiara Ortuzar ◽

Pascual Ángel Gargiulo ◽

José Vicente Lafuente ◽

Harkaitz Bengoetxea

Keyword(s):

Cognitive Deficits ◽

Enriched Environment ◽

Gabaergic Interneuron ◽

Short Term ◽

Adult Rats ◽

Mk 801 ◽

Short Term Exposure

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Age-Dependent Rat Lung Deposition Patterns of Inhaled 20 Nanometer Gold Nanoparticles and their Quantitative Biokinetics in Adult Rats

ACS Nano ◽

10.1021/acsnano.8b01826 ◽

2018 ◽

Vol 12 (8) ◽

pp. 7771-7790 ◽

Cited By ~ 23

Author(s):

Wolfgang G. Kreyling ◽

Winfried Möller ◽

Uwe Holzwarth ◽

Stephanie Hirn ◽

Alexander Wenk ◽

...

Keyword(s):

Gold Nanoparticles ◽

Lung Deposition ◽

Rat Lung ◽

Adult Rats ◽

Deposition Patterns ◽

Age Dependent

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Neuronal Replacement After Traumatic or Age-Dependent Brain Damage

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462300003755 ◽

1985 ◽

Vol 1 (1) ◽

pp. 93-107

Author(s):

Anders Björklund ◽

Fred H. Gage

Keyword(s):

Research Work ◽

Adult Rats ◽

Functional Potential ◽

Neural Grafts ◽

Age Dependent ◽

Long Time ◽

Tissue Grafts ◽

And Behavior ◽

The Brain ◽

Host Brain

During the last few years evidence has accumulated that fetal neurons, implanted into the depth of the brain in adult rats, can reestablish damaged connections in the host brain and substitute functionally for elements lost or damaged as a result of a preceding lesion. This research work has led to the realization that, contrary to traditional views, the adult mammalian CNS has a potential to incorporate new neuronal elements into already established neuronal circuitry and that such implanted neurons can modify the function and behavior of the recipient. For a long time it was thought that the remarkable regenerative and functional potential of CNS tissue grafts that had been demonstrated in cold-blooded vertebrates reflected a fundamental difference in the regenerative properties of central nervous tissue between cold-blooded vertebrates and mammals. During the last few years it has become evident however, that at least certain types of intracerebral neural grafts can perfoum just as well in developing and mammals as in developing or adult submammalian vertebrates.

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Age-dependent neurobehavioral responses by young and mature adult rats to systemic kainic acid

Restorative Neurology and Neuroscience ◽

10.3233/rnn-1996-10206 ◽

1996 ◽

Vol 10 (2) ◽

pp. 103-108

Author(s):

Cesario V. Borlongan ◽

Kimberly B. Bjugstad ◽

Christine E. Stahl ◽

Shajmil D. Ross ◽

Gary W. Arendash ◽

...

Keyword(s):

Kainic Acid ◽

Adult Rats ◽

Mature Adult ◽

Age Dependent

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Age-Dependent Cognitive Deficits and Neuronal Apoptosis in Cyclooxygenase-2 Transgenic Mice

Journal of Neuroscience ◽

10.1523/jneurosci.21-20-08198.2001 ◽

2001 ◽

Vol 21 (20) ◽

pp. 8198-8209 ◽

Cited By ~ 154

Author(s):

Katrin I. Andreasson ◽

Alena Savonenko ◽

Sveta Vidensky ◽

Joseph J. Goellner ◽

Yan Zhang ◽

...

Keyword(s):

Transgenic Mice ◽

Cognitive Deficits ◽

Neuronal Apoptosis ◽

Cyclooxygenase 2 ◽

Age Dependent

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Age-Dependent Regulation of Lipogenesis in Human and Rat Adipocytes

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2003-030994 ◽

2004 ◽

Vol 89 (9) ◽

pp. 4601-4606 ◽

Cited By ~ 9

Author(s):

Ashraf F. Kamel ◽

Svante Norgren ◽

Karin Strigård ◽

Anders Thörne ◽

Hossein Fakhrai-Rad ◽

...

Keyword(s):

Adipose Tissue ◽

Glucose Transport ◽

Glucose Transporter ◽

Age Groups ◽

Tissue Growth ◽

Adult Rats ◽

Male Adult ◽

Rat Adipocytes ◽

Transporter Protein ◽

Age Dependent

The regulation of adipocyte metabolism is of importance for adipose tissue growth and therefore also for the development of obesity. This study was designed to investigate the regulation of basal and insulin-induced lipogenesis, glucose transport, and glucose transporter protein expression in human and rat adipocytes from different age groups. The study included 21 infants, 21 children, nine adults, and 80 male weaned and 20 male adult Fischer rats. The lipogenesis experiments were performed under conditions at which glucose transport is rate limiting. Basal lipogenesis was approximately three times higher in infants and children than in adults, whereas insulin-induced lipogenesis was two times higher in infants than in children and adults. In rats, basal lipogenesis, insulin-induced lipogenesis, and insulin sensitivity were two times higher in weaned than in adult animals. Moreover, basal and insulin-induced glucose transport were two times higher in weaned than in adult rats. No differences were detected in GLUT1 or GLUT4 content between any of the age groups in human or in rat adipocytes. In conclusion, basal and insulin-stimulated lipogenesis are increased in adipocytes early in life. This may promote adipose tissue growth in early age. The data indicate that age-dependent variation in basal and insulin-stimulated lipogenesis is differently regulated.

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