Tamoxifen-induced ER- -SRC3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence

2014 ◽  
Vol 21 (5) ◽  
pp. X1-X3 ◽  
Author(s):  
M. McIlroy ◽  
F. J. Fleming ◽  
Y. Buggy ◽  
A. D. K. Hill ◽  
L. S. Young
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Her2 Positive

scholarly journals Tamoxifen-induced ER-α–SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence

2006 ◽  
Vol 13 (4) ◽  
pp. 1135-1145 ◽  
Author(s):  
Marie Mc Ilroy ◽  
Fergal J Fleming ◽  
Yvonne Buggy ◽  
Arnold D K Hill ◽  
Leonie S Young
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cell Cultures ◽  
Human Breast Cancer ◽  
Molecular Model ◽  
Steroid Receptor ◽  
Model Systems ◽  
Endocrine Treatment ◽  
Human Breast ◽  
Her2 Positive

Differential signalling between the two oestrogen receptor (ER) isoforms in the presence of tamoxifen has been described. We hypothesise that differential recruitment of the steroid receptor co-activator, SRC-3 to ER-α and ER-β may in part explain associations between ER isoforms and response to endocrine treatment. SRC-3 was localised within epithelial cells of breast tumour tissue and was co-localised with ER-α and ER-β, (n = 112). Expression of SRC-3 was found to be positively associated with ER-α (P = 0.0021) and inversely with ER-β (P < 0.0001). Uniquely, this study utilises primary cell cultures derived from patient tumours, thus providing samples not readily available in most molecular model systems. These samples have enabled us to investigate the influence of growth factor pathways on steroid receptor-co-activator interactions. In HER2 (human epidermal growth factor receptor 2) positive primary tumour cell cultures 17β-estradiol induced a decrease in SRC-3, whereas upregulated SRC-3 expression. Furthermore, treatment with tamoxifen-induced SRC-3 recruitment to the ER-oestrogen response element and enhanced interaction between SRC-3 and ER-α, but not ER-β. Knockdown of SRC-3 results in a concomitant loss of expression of the oestrogen target gene pS2. Furthermore, silencing of SRC-3 resensitizes endocrine resistant, HER2 positive cells to the anti-proliferative effects of tamoxifen. The ability of ER-α, but not ER-β to recruit SRC-3 in the presence of tamoxifen may in part explain the differential ER isoform associations with recurrence in human breast cancer.

Multifunctional trastuzumab–chlorin e6 conjugate for the treatment of HER2-positive human breast cancer

2018 ◽  
Vol 6 (5) ◽  
pp. 1217-1226 ◽  
Author(s):  
Kyoung Sub Kim ◽  
Jiyoung Kim ◽  
Da Hye Kim ◽  
Hee Sook Hwang ◽  
Kun Na
Keyword(s):  
Breast Cancer ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Therapeutic Efficacy ◽  
Human Breast Cancer ◽  
Limiting Factors ◽  
Human Breast ◽  
Her2 Positive ◽  
Tumor Tissues ◽  
Effective Penetration

Effective penetration and targeted delivery of anticancer drugs into tumor tissues are limiting factors for achieving enhanced therapeutic efficacy.

Trastuzumab‐monomethyl auristatin E conjugate exhibits potent cytotoxic activity in vitro against HER2‐positive human breast cancer

2018 ◽  
Vol 234 (3) ◽  
pp. 2693-2704 ◽  
Author(s):  
Meghdad Abdollahpour‐Alitappeh ◽  
Majid Lotfinia ◽  
Nader Bagheri ◽  
Koushan Sineh Sepehr ◽  
Mahdi Habibi‐Anbouhi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Her2 Positive

scholarly journals Synergistic antitumor activity by combining trastuzumab with retinoic acid in HER2 positive human breast cancer cells

Oncotarget ◽  
2018 ◽  
Vol 9 (41) ◽  
pp. 26527-26542 ◽  
Author(s):  
Fiorella Vanderhoeven ◽  
Analía Lourdes Redondo ◽  
Ana Laura Martinez ◽  
Laura María Vargas-Roig ◽  
Angel Matias Sanchez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Retinoic Acid ◽  
Antitumor Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Her2 Positive ◽  
Synergistic Antitumor Activity

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

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