scholarly journals Agonist-bound nuclear receptors: not just targets of coactivators

2003 ◽  
Vol 31 (1) ◽  
pp. 1-7 ◽  
Author(s):  
I Fernandes ◽  
JH White
Keyword(s):  
Nuclear Receptors ◽  
Target Gene ◽  
Molecular Genetic ◽  
Agonist Binding ◽  
Full Understanding ◽  
Genetic Studies ◽  
Nuclear Receptor Superfamily ◽  
Wide Range ◽  
Target Promoters ◽  
Target Gene Transcription

Members of the nuclear receptor superfamily of ligand-regulated transcription factors are targets of a wide range of lipophilic signaling molecules as well as several drugs and xenobiotics that modulate many aspects of physiology and metabolism. Agonist binding to receptors is associated with recruitment of coactivators, which are essential for activation of target gene transcription. However, several biochemical and molecular genetic studies have shown that a full understanding of the function of agonist-bound receptors must also accommodate the recruitment of corepressors. These factors may attenuate agonist-induced transactivation, act more transiently as part of a cycle of cofactors recruited to target promoters by ligand-bound receptors, or function in hormone-dependent repression of target gene expression.

scholarly journals Microsatellites Cross-Species Amplification across Some African Cichlids

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Etienne Bezault ◽  
Xavier Rognon ◽  
Karim Gharbi ◽  
Jean-Francois Baroiller ◽  
Bernard Chevassus
Keyword(s):  
Microsatellite Markers ◽  
Oreochromis Niloticus ◽  
Molecular Genetic ◽  
Point Of View ◽  
Genetic Studies ◽  
African Cichlid ◽  
Wide Range ◽  
The Mean ◽  
High Level ◽  
African Cichlids

The transfer of the genomic resources developed in the Nile tilapia, Oreochromis niloticus, to other Tilapiines sensu lato and African cichlid would provide new possibilities to study this amazing group from genetics, ecology, evolution, aquaculture, and conservation point of view. We tested the cross-species amplification of 32 O. niloticus microsatellite markers in a panel of 15 species from 5 different African cichlid tribes: Oreochromines (Oreochromis, Sarotherodon), Boreotilapiines (Tilapia), Chromidotilapines, Hemichromines, and Haplochromines. Amplification was successfully observed for 29 markers (91%), with a frequency of polymorphic (P95) loci per species around 70%. The mean number of alleles per locus and species was 3.2 but varied from 3.7 within Oreochromis species to 1.6 within the nontilapia species. The high level of cross-species amplification and polymorphism of the microsatellite markers tested in this study provides powerful tools for a wide range of molecular genetic studies within tilapia species as well as for other African cichlids.

Assessment of changes in biochemical parameters and their role as markers of pathological processes

2020 ◽  
pp. 57-63
Author(s):  
Olga Alekseevna Petrischeva
Keyword(s):  
Biochemical Parameters ◽  
Laboratory Tests ◽  
Correct Diagnosis ◽  
Molecular Genetic ◽  
Clinical Situation ◽  
Test Results ◽  
Genetic Studies ◽  
Maximum Information ◽  
Wide Range ◽  
The One

The data of laboratory tests can often provide up to 70% of information about the disease, and the test results can help the doctor not only in the correct diagnosis and competent prescription of treatment, but also should be aimed at conducting a subsequent assessment of its effectiveness. At the present stage, laboratory tests are represented by a wide range of clinical, immunological, biochemical, microbiological, histological and molecular genetic studies. Evaluation of some parameters (for example, a clinical blood test and a general urinalysis) is carried out practically at each patient's request for medical help, while others are evaluated only if there are indications. For example, if a patient complains of severe dysuric disorders, determining the level of amylase in this case will be uninformative, but urinalysis according to Nechiporenko will contribute to the correct diagnosis. A doctor of a clinical specialty, on the one hand, must clearly understand which tests can help in making a diagnosis and will carry the maximum information content, and, on the other hand, try to avoid unnecessary prescription of tests that have low evidence in a particular clinical situation. One of the most frequently prescribed tests is the conduct of biochemical studies, therefore, in today's article we will try to figure out how biochemical parameters change in various pathological processes, and what information they can bring.

Molecular genetic research on IQ: can it be done? Should it be done?

1996 ◽  
Vol 28 (4) ◽  
pp. 490-507 ◽  
Author(s):  
Jo Daniels ◽  
Peter McGuffin ◽  
Mike Owen
Keyword(s):  
Single Gene ◽  
Molecular Genetic ◽  
Genetic Research ◽  
Cultural Factors ◽  
Shared Environment ◽  
Religious Denomination ◽  
Genetic Investigation ◽  
Genetic Studies ◽  
Single Gene Disorders ◽  
Wide Range

An obvious requirement before embarking on molecular genetic investigation of a trait is prior evidence from ‘classic’ genetic studies that there is indeed a genetic component. Many behavioural traits are familial and these range from comparatively uncommon single gene disorders such as Huntington's disease which has a typical mendelian dominant pattern of transmission, to much commoner characteristics such as career choice or religious denomination which, it might be assumed, are heavily influenced by cultural factors. In between, there is a wide range of attributes including personality type, cognitive ability and liability to common disorders such as depression, that show a tendency to run in families, and which could conceivably be explained by shared genes, shared environment or a combination of the two.

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