scholarly journals Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55–70 years

2009 ◽  
Vol 202 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Clare F Hodkinson ◽  
Ellen E A Simpson ◽  
John H Beattie ◽  
Jacqueline M O'Connor ◽  
David J Campbell ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
T Lymphocytes ◽  
Thyroid Hormones ◽  
Immune Status ◽  
Preliminary Evidence ◽  
Cytotoxic Lymphocytes ◽  
Hormone Concentration ◽  
Healthy Individuals ◽  
Thyroid Hormone Concentration ◽  
Apparently Healthy

A reciprocal relationship between the endocrine and immune system has been demonstrated under pathophysiological conditions. However, few studies have assessed the relationship between thyroid hormones and immune function in apparently healthy individuals. Therefore, to clarify our understanding of normal physiological endocrine–immune interactions this study aimed to examine the interrelationships between thyroid hormones and immunity in healthy individuals. Total triiodothyronine (T3), total thyroxine (T4) and markers of immune status were assessed in 93 free-living and apparently healthy individuals aged 55–70 years. T3 and T4 concentrations were determined by commercially available kits. Immune status was assessed using flow cytometry and biochemical markers. Statistical analysis was performed by partial correlation, controlling for age. Thyroid hormone concentration was positively associated with markers of inflammation (P≤0.05), natural killer-like T cells (P≤0.001), expression of interleukin-6 (IL6) by activated monocytes (P≤0.05); percentage expression of memory T-lymphocytes (P≤0.01), memory T-helper lymphocytes (P≤0.05) and memory T-cytotoxic lymphocytes (P≤0.05), and higher IL2 receptor density on CD3+T-lymphocytes (P≤0.05). Thyroid hormone concentration was inversely associated with early lymphocyte apoptosis (P≤0.05) and the ratio of naïve- to memory T-cytotoxic lymphocytes (P≤0.05). The current study provides preliminary evidence of a role for T3 and T4, within normal physiological ranges, in the maintenance of lymphocyte subpopulations, and in mediating the inflammatory response. In conclusion, these findings highlight the potential implications of altered thyroid function in older individuals and the importance of future research examining thyroid–immune interactions.

Evidence of the relationship of vigour and growth of newborn lambs with thyroid hormone concentration

1997 ◽  
Vol 1997 ◽  
pp. 175-175
Author(s):  
P. Johnston ◽  
J. Roden ◽  
B. Merrell ◽  
W.A. Murray ◽  
W. Haresign
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Rectal Temperature ◽  
Hormone Concentration ◽  
Newborn Lamb ◽  
Uterine Environment ◽  
Thyroid Hormone Concentration ◽  
Relationship Of ◽  
The Relationship

Lambs are born with a well developed hypothalamo-pituitary-thyroid system and are producing tri-iodothyronine (T3) and thyroxine (T4) in significant quantities by birth. Thyroid hormones are high in the newborn lamb and appear to play an important role in adaptation, by the lamb, to the extra-uterine environment. The aims of this study were to look at the effects of the thyroid hormones T3 and T4, on the neonatal lamb's ability to cope with the cold and its activity and vigour. Secondly to obtain preliminary estimates of the heritability of the two hormone concentrations and the lambs rectal temperature to see if they could potentially be useful indicators of the lambs genetic ability to thrive.

Early change of thyroid hormone concentration after 131I treatment in patients with solitary toxic adenoma

2002 ◽  
Vol 41 (04) ◽  
pp. 178-183 ◽  
Author(s):  
V. Fidler ◽  
K. Zaletel ◽  
S. Gaberšček ◽  
S. Hojker ◽  
E. Pirnat
Keyword(s):  
Thyroid Hormone ◽  
Antithyroid Drugs ◽  
Prospective Clinical Study ◽  
Hormone Concentration ◽  
Toxic Adenoma ◽  
Free Triiodothyronine ◽  
Thyroid Cells ◽  
131I Treatment ◽  
Before And After ◽  
Thyroid Hormone Concentration

Summary Aim: In spite of extensive use of 131I for treatment of hyperthyroidism, the results of early outcome are variable. In our prospective clinical study we tested whether 131I induced necrosis causing clinical aggravation of hyperthyroidism and increasing the free thyroid hormone concentration in the serum of patients with solitary toxic adenoma not pretreated with antithyroid drugs. Patients and methods: 30 consecutive patients were treated with 925 MBq 131I. Serum concentration of thyrotropin (TSH), free thyroxine (fT4), free triiodothyronine (fT3), thyroglobulin (Tg), and interleukin-6 (IL-6) were measured before and after application of 131I. Results: After application of 131I no clinical worsening was observed. FT4 and fT3 concentration did not change significantly within the first five days, whereas both of them significantly decreased after 12 days (p <0.0001). Slight and clinically irrelevant increase in the level of the two thyroid hormones was observed in 9 patients. Furthermore, we observed a prolonged increase in Tg concentration and a transient increase in IL-6 concentration. Conclusion: Neither evidence of any clinical aggravation of hyperthyroidism nor any significant increase in thyroid hormone concentration by 131I induced necrosis of thyroid cells was found. Therefore, the application of 131I may be considered as a safe and effective treatment for patients with hyperthyroidism due to toxic adenoma.

scholarly journals Very rare case of Graves’ disease with resistance to methimazole: a case report and literature review

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199619
Author(s):  
Yusaku Mori ◽  
Munenori Hiromura ◽  
Michishige Terasaki ◽  
Hideki Kushima ◽  
Makoto Ohara ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Rare Case ◽  
Therapeutic Option ◽  
Lithium Carbonate ◽  
Graves Disease ◽  
High Dose ◽  
Hormone Concentration ◽  
Thyroid Hormone Concentration ◽  
Serum Thyroid Hormone ◽  
Inorganic Iodine

Background Methimazole (MMI) is used to treat hyperthyroidism in Graves’ disease. It is rare to encounter patients in whom hyperthyroidism cannot be controlled using high doses of MMI. Case presentation: A 21-year-old woman was referred to our hospital because of MMI-resistant Graves’ disease. Although her MMI dose had been increased to 120 mg/day, her serum thyroid hormone concentration was too high to be measured. Additional therapy with lithium carbonate, and then with dexamethasone and inorganic iodine, was initiated. After 14 days, the patient’s serum thyroid hormone concentration normalized, while she was taking 150 mg/day MMI, 800 mg/day lithium carbonate, 6 mg/day dexamethasone and 306 mg/day inorganic iodine, and total thyroidectomy was then performed. The patient was discharged 8 days after the thyroidectomy and experienced no major complications. Conclusions We have presented a rare case of Graves’ disease that was resistant to high-dose MMI. Combination therapy of MMI with lithium carbonate, dexamethasone and inorganic iodine may represent a therapeutic option for the preoperative preparation of patients with MMI-resistant Graves’ disease.

scholarly journals Effect of thyroid hormone concentration on the transcriptional response underlying induced metamorphosis in the Mexican axolotl (Ambystoma)

BMC Genomics ◽  
2008 ◽  
Vol 9 (1) ◽  
pp. 78 ◽  
Author(s):  
Robert B Page ◽  
Stephen R Voss ◽  
Amy K Samuels ◽  
Jeramiah J Smith ◽  
Srikrishna Putta ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Transcriptional Response ◽  
Hormone Concentration ◽  
Mexican Axolotl ◽  
Thyroid Hormone Concentration

In vitro TSH and PRL secretion from eutopic and heterotopic rat pituitaries: effects of hypothyroidism

1983 ◽  
Vol 245 (1) ◽  
pp. E32-E37
Author(s):  
H. Ikeda ◽  
M. A. Greer
Keyword(s):  
Thyroid Hormone ◽  
Statistical Significance ◽  
Female Rats ◽  
Pituitary Cells ◽  
Renal Capsule ◽  
Hormone Concentration ◽  
Cell Lysate ◽  
Tsh Secretion ◽  
Thyroid Hormone Concentration

Five adenohypophyses from donors of the same strain, age, and sex were transplanted under the renal capsule of young adult female rats. At least 3 wk later, enzymatically dispersed cells from eutopic or heterotopic adenohypophyses from the same rat were perifused in vitro in a small chamber. Thyrotropin (TSH) and prolactin (PRL) secretion per 10(6) cells were significantly less from heterotopic than from eutopic cells under all conditions. In cells from euthyroid animals, TRH induced TSH secretion only in the eutopic cells but induced PRL secretion in both eutopic and heterotopic cells. Hypothyroidism increased TRH-induced TSH secretion and content in the cell lysate in both eutopic and heterotopic cells but increased TRH-induced PRL secretion only in the eutopic cells. The increase in TSH secretion induced by hypothyroidism in the heterotopic cells was of borderline statistical significance. The inability of TRH to induce TSH secretion in heterotopic pituitary cells from euthyroid rats may be due to a lower set point for thyroid hormone inhibition of TSH secretion in the heterotopic thyrotrophs. Heterotopic pituitary TSH secretion is probably suppressed by the normal plasma thyroid hormone concentration maintained by the eutopic pituitary and may be stimulated by TRH only in the presence of a subnormal plasma thyroid hormone concentration.

Sign in / Sign up

Export Citation Format

Share Document