Evidence of the relationship of vigour and growth of newborn lambs with thyroid hormone concentration

1997 ◽  
Vol 1997 ◽  
pp. 175-175
Author(s):  
P. Johnston ◽  
J. Roden ◽  
B. Merrell ◽  
W.A. Murray ◽  
W. Haresign
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Rectal Temperature ◽  
Hormone Concentration ◽  
Newborn Lamb ◽  
Uterine Environment ◽  
Thyroid Hormone Concentration ◽  
Relationship Of ◽  
The Relationship

Lambs are born with a well developed hypothalamo-pituitary-thyroid system and are producing tri-iodothyronine (T3) and thyroxine (T4) in significant quantities by birth. Thyroid hormones are high in the newborn lamb and appear to play an important role in adaptation, by the lamb, to the extra-uterine environment. The aims of this study were to look at the effects of the thyroid hormones T3 and T4, on the neonatal lamb's ability to cope with the cold and its activity and vigour. Secondly to obtain preliminary estimates of the heritability of the two hormone concentrations and the lambs rectal temperature to see if they could potentially be useful indicators of the lambs genetic ability to thrive.

scholarly journals Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55–70 years

2009 ◽  
Vol 202 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Clare F Hodkinson ◽  
Ellen E A Simpson ◽  
John H Beattie ◽  
Jacqueline M O'Connor ◽  
David J Campbell ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
T Lymphocytes ◽  
Thyroid Hormones ◽  
Immune Status ◽  
Preliminary Evidence ◽  
Cytotoxic Lymphocytes ◽  
Hormone Concentration ◽  
Healthy Individuals ◽  
Thyroid Hormone Concentration ◽  
Apparently Healthy

A reciprocal relationship between the endocrine and immune system has been demonstrated under pathophysiological conditions. However, few studies have assessed the relationship between thyroid hormones and immune function in apparently healthy individuals. Therefore, to clarify our understanding of normal physiological endocrine–immune interactions this study aimed to examine the interrelationships between thyroid hormones and immunity in healthy individuals. Total triiodothyronine (T3), total thyroxine (T4) and markers of immune status were assessed in 93 free-living and apparently healthy individuals aged 55–70 years. T3 and T4 concentrations were determined by commercially available kits. Immune status was assessed using flow cytometry and biochemical markers. Statistical analysis was performed by partial correlation, controlling for age. Thyroid hormone concentration was positively associated with markers of inflammation (P≤0.05), natural killer-like T cells (P≤0.001), expression of interleukin-6 (IL6) by activated monocytes (P≤0.05); percentage expression of memory T-lymphocytes (P≤0.01), memory T-helper lymphocytes (P≤0.05) and memory T-cytotoxic lymphocytes (P≤0.05), and higher IL2 receptor density on CD3+T-lymphocytes (P≤0.05). Thyroid hormone concentration was inversely associated with early lymphocyte apoptosis (P≤0.05) and the ratio of naïve- to memory T-cytotoxic lymphocytes (P≤0.05). The current study provides preliminary evidence of a role for T3 and T4, within normal physiological ranges, in the maintenance of lymphocyte subpopulations, and in mediating the inflammatory response. In conclusion, these findings highlight the potential implications of altered thyroid function in older individuals and the importance of future research examining thyroid–immune interactions.

The disappearance of l-thyroxine and triiodothyronine from plasma and red and white skeletal muscle after administration of one sc dose of l-thyroxine to hyperthyroid and euthyroid rats

1981 ◽  
Vol 97 (2) ◽  
pp. 226-230 ◽  
Author(s):  
J. W. Janssen ◽  
I. W. L. de Lange-Berkhout ◽  
C. van Hardeveld ◽  
A. A. H. Kassenaar
Keyword(s):  
Skeletal Muscle ◽  
Thyroid Hormone ◽  
Direct Measurement ◽  
Hormone Concentration ◽  
Time Points ◽  
Normal Plasma ◽  
Muscle Types ◽  
Thyroid Hormone Concentration ◽  
The Relationship ◽  
Time Point

Abstract. Rats were made hyperthyroid by repeated sc injections of l-thyroxine (T4) in a two-week period. At several time-points after the last injection, the triiodothyronine (T3) and T4 concentrations in plasma and red and white skeletal muscle were determined by a radioimmunoassay. This was done to investigate the relationship between the change in thyroid-hormone concentration in plasma and muscle and to see whether this change was similar in both muscle types. The results show that: 1. Information about the T3 and T4 concentrations in the muscles of the hyperthyroid rats can only be obtained by direct measurement in the muscles and cannot be gathered from the plasma-T3 concentration at any time-point or from below-normal plasma-T4 concentrations. 2. In hyperthyroid rats T4 and T3 are cleared more rapidly from the plasma than from the skeletal muscle. 3. A proportionally higher T3 concentration is present in the red compared with the white skeletal muscle of hyperthyroid rats.

Can maternal iodine supplementation improve twin- and triplet-born lamb plasma thyroid hormone concentrations and thermoregulation capabilities in the first 24–36 h of life?

2010 ◽  
Vol 148 (4) ◽  
pp. 453-463 ◽  
Author(s):  
J. I. KERSLAKE ◽  
P. R. KENYON ◽  
K. J. STAFFORD ◽  
S. T. MORRIS ◽  
P. C. H. MOREL
Keyword(s):  
Thyroid Hormone ◽  
Rectal Temperature ◽  
Heat Production ◽  
Iodine Concentration ◽  
Maternal Plasma ◽  
Open Circuit ◽  
Hormone Concentration ◽  
Crown Rump Length ◽  
Iodine Supplementation ◽  
Thyroid Hormone Concentration

SUMMARYThe present study investigated the effects of maternal plasma iodine concentration on twin- and triplet-born lamb plasma thyroid hormone concentrations, rectal temperature and maximal heat production. On pregnancy day 68 (P68), 16 twin- and 14 triplet-bearing ewes were randomly chosen from ewes that were injected intramuscularly with 1·5 ml of iodized peanut oil and ewes that were not. Selected ewes were grazed on ad libitum pasture from P68 until parturition. After parturition, lamb blood samples were collected within 5 min of birth and at 3, 12 and 24–36 h after birth. Lamb rectal temperatures were measured within 5 min of birth and at 1, 3 and 12 h after birth. Lamb body weight, crown–rump length and thoracic-girth circumference were recorded at 3 h of age, and the capability of the lamb to produce heat at 24–36 h of age was measured using indirect open-circuit calorimetry. Maternal iodine supplementation successfully increased plasma iodine concentrations of twin- and triplet-bearing ewes throughout pregnancy, but had no effect on the rectal temperature, thyroid hormone concentration and maximal heat production of twin- or triplet-born lambs. Compared with twin-born lambs, triplet-born lambs had lower birth weights, rectal temperatures and plasma T4 and T3 concentrations within 5 min of birth. Overall, under the conditions of the present study, maternal iodine supplementation offered no benefit in improving lamb heat production.

Early change of thyroid hormone concentration after 131I treatment in patients with solitary toxic adenoma

2002 ◽  
Vol 41 (04) ◽  
pp. 178-183 ◽  
Author(s):  
V. Fidler ◽  
K. Zaletel ◽  
S. Gaberšček ◽  
S. Hojker ◽  
E. Pirnat
Keyword(s):  
Thyroid Hormone ◽  
Antithyroid Drugs ◽  
Prospective Clinical Study ◽  
Hormone Concentration ◽  
Toxic Adenoma ◽  
Free Triiodothyronine ◽  
Thyroid Cells ◽  
131I Treatment ◽  
Before And After ◽  
Thyroid Hormone Concentration

Summary Aim: In spite of extensive use of 131I for treatment of hyperthyroidism, the results of early outcome are variable. In our prospective clinical study we tested whether 131I induced necrosis causing clinical aggravation of hyperthyroidism and increasing the free thyroid hormone concentration in the serum of patients with solitary toxic adenoma not pretreated with antithyroid drugs. Patients and methods: 30 consecutive patients were treated with 925 MBq 131I. Serum concentration of thyrotropin (TSH), free thyroxine (fT4), free triiodothyronine (fT3), thyroglobulin (Tg), and interleukin-6 (IL-6) were measured before and after application of 131I. Results: After application of 131I no clinical worsening was observed. FT4 and fT3 concentration did not change significantly within the first five days, whereas both of them significantly decreased after 12 days (p <0.0001). Slight and clinically irrelevant increase in the level of the two thyroid hormones was observed in 9 patients. Furthermore, we observed a prolonged increase in Tg concentration and a transient increase in IL-6 concentration. Conclusion: Neither evidence of any clinical aggravation of hyperthyroidism nor any significant increase in thyroid hormone concentration by 131I induced necrosis of thyroid cells was found. Therefore, the application of 131I may be considered as a safe and effective treatment for patients with hyperthyroidism due to toxic adenoma.

scholarly journals Very rare case of Graves’ disease with resistance to methimazole: a case report and literature review

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199619
Author(s):  
Yusaku Mori ◽  
Munenori Hiromura ◽  
Michishige Terasaki ◽  
Hideki Kushima ◽  
Makoto Ohara ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Rare Case ◽  
Therapeutic Option ◽  
Lithium Carbonate ◽  
Graves Disease ◽  
High Dose ◽  
Hormone Concentration ◽  
Thyroid Hormone Concentration ◽  
Serum Thyroid Hormone ◽  
Inorganic Iodine

Background Methimazole (MMI) is used to treat hyperthyroidism in Graves’ disease. It is rare to encounter patients in whom hyperthyroidism cannot be controlled using high doses of MMI. Case presentation: A 21-year-old woman was referred to our hospital because of MMI-resistant Graves’ disease. Although her MMI dose had been increased to 120 mg/day, her serum thyroid hormone concentration was too high to be measured. Additional therapy with lithium carbonate, and then with dexamethasone and inorganic iodine, was initiated. After 14 days, the patient’s serum thyroid hormone concentration normalized, while she was taking 150 mg/day MMI, 800 mg/day lithium carbonate, 6 mg/day dexamethasone and 306 mg/day inorganic iodine, and total thyroidectomy was then performed. The patient was discharged 8 days after the thyroidectomy and experienced no major complications. Conclusions We have presented a rare case of Graves’ disease that was resistant to high-dose MMI. Combination therapy of MMI with lithium carbonate, dexamethasone and inorganic iodine may represent a therapeutic option for the preoperative preparation of patients with MMI-resistant Graves’ disease.

scholarly journals Effect of thyroid hormone concentration on the transcriptional response underlying induced metamorphosis in the Mexican axolotl (Ambystoma)

BMC Genomics ◽  
2008 ◽  
Vol 9 (1) ◽  
pp. 78 ◽  
Author(s):  
Robert B Page ◽  
Stephen R Voss ◽  
Amy K Samuels ◽  
Jeramiah J Smith ◽  
Srikrishna Putta ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Transcriptional Response ◽  
Hormone Concentration ◽  
Mexican Axolotl ◽  
Thyroid Hormone Concentration

scholarly journals Synergism of Hypothyroidism and Hyperprolactinemia to impact on efficiency of menstrual cycle and ovulatory status

2017 ◽  
Vol 1 (28) ◽  
pp. 661-670
Author(s):  
NASSER NAFAA ABRAHEM ◽  
SAAD HASSAN DREIJ ◽  
Mahdi Saber Al-Deresawi
Keyword(s):  
Thyroid Hormone ◽  
Menstrual Cycle ◽  
Teaching Hospital ◽  
Infertile Women ◽  
Menstrual Disturbance ◽  
Menstrual Irregularities ◽  
Relationship Of ◽  
The Relationship ◽  
Hormonal Assay

This study aimed to determine the relationship of  thyroid hormone disturbance and prolactin over production to impact on the menstrual irregularities anovulation .This  study were carried out in Al-Karama teaching hospital and  included (47) primary infertile women, (30 ) of them were with hypothyroidism , the patients aged between (18-40). This study extended from February to June  2017. The hormonal assay of TSH, FT3, FT4 ,FSH , LH and PRL that revealed  :- There were high  significantly (p < 0.01) increased in TSH concentrations , significantly (p < 0.05) decreased in levels of FT3 and  FT4.Gonadotropins hormones recorded significantly ( p <0.05) decreased in levels of FSH and non significantly increased in levels of LH. Prolactin concentrations that obtained revealed to significantly (p < 0.05) increased in patients with hypothyroidism . This study reported there were (70%) of hypothyroidism patients with menstrual disturbance. We concluded , that hypothyroidism and Hyperprolactinemia commonly related and synergized to menstrual irregularities and ovulatory failure. 

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