THE EFFECT OF EPHEDRINE ON THE EXCRETION OF REDUCING STEROIDS, 17-KETOSTEROIDS AND URIC ACID IN HEALTHY MEN

1952 ◽  
Vol 8 (1) ◽  
pp. 27-31 ◽  
Author(s):  
BARBARA M. BRAY ◽  
W. H. H. MERIVALE ◽  
D. R. C. WILLCOX
Keyword(s):  
Uric Acid ◽  
Urinary Excretion ◽  
Inverse Relationship ◽  
Control Period ◽  
Acid Excretion ◽  
Normal Range ◽  
Healthy Men ◽  
Uric Acid Excretion ◽  
Upper Limit ◽  
Consistent Change

The urinary excretion in five healthy men of 17-ketosteroids, reducing steroids, uric acid and creatinine was studied for a 3-day control period, a period of 2 days during which 6 grains (390 mg.) of ephedrine were given by mouth, and for 1 day immediately thereafter. In all five men the excretion of reducing steroids rose to levels outside the normal range on one of the days on which ephedrine was given. There was an abrupt return to normal, even in the men who showed the increased excretion, on the first day of the administration of ephedrine. In two men 17-ketosteroid excretion rose above the upper limit of normal, but in two others there was no significant alteration, while in one the 17-ketosteroid excretion bore an inverse relationship to that of the reducing steroids. No consistent change occurred in the uric acid excretion.

scholarly journals Studies on Leukemia

Blood ◽  
1956 ◽  
Vol 11 (2) ◽  
pp. 154-166 ◽  
Author(s):  
A. A. SANDBERG ◽  
G. E. CARTWRIGHT ◽  
M. M. WINTROBE
Keyword(s):  
Uric Acid ◽  
Urinary Excretion ◽  
Leukocyte Count ◽  
Normal Subjects ◽  
Lymphocytic Leukemia ◽  
Chronic Myelocytic Leukemia ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Myelocytic Leukemia ◽  
The Mean

Abstract 1. The urinary excretion of uric acid was studied in 17 normal subjects and in 38 patients with leukemia. The mean excretion of uric acid by the normal subjects was 6.5 mg./Kg. of body weight /24 hrs. The mean excretion of uric acid in 14 patients with acute lymphoblastic leukemia was 30.3 mg./Kg. /24 hrs.; in 13 patients with acute myeloblastic leukemia, 13.0 mg.; in 6 patients with chronic lymphocytic leukemia, 5.2 mg.; and in 5 patients with chronic myelocytic leukemia, 13.5 mg. 2. Following therapy with cortisone, 6-mercaptopurine or Amethopterin, the urinary excretion of uric acid increased in the cases of acute leukemia as the leukocyte count declined. As the leukocyte count approached normal levels, the uric acid excretion decreased. The urinary excretion of xanthine and guanine paralleled the excretion of uric acid. 3. In association with the administration of an aromatic nitrogen mustard derivative to one patient with chronic lymphocytic leukemia and Myleran to one patient with chronic myelocytic leukemia, there was only a slight increase in uric acid excretion.

Urinary Purine Excretion in the X-Irradiated Dog

1957 ◽  
Vol 189 (2) ◽  
pp. 315-322 ◽  
Author(s):  
Kenneth Jackson ◽  
Cecil Entenman
Keyword(s):  
Uric Acid ◽  
Radiation Dose ◽  
Ion Exchange ◽  
Urinary Excretion ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Whole Body ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
X Irradiation

Urinary excretion of purine bases by the dog following whole-body x-irradiation was studied. Ion exchange chromatography with Dowex-50 was used to measure uric acid, xanthine, hypoxanthine, guanine, 7-methylguanine and adenine. Changes in the excretion of uric acid and xanthine were noted during the first 24 hours following irradiation. Uric acid excretion was increased following doses between 150 and 500 r. Xanthine excretion increased markedly following superlethal doses but not after midlethal doses. Total purine excretion (allantoin plus uric acid) was increased slightly following irradiation and the degree of the increase was not related to the radiation dose.

Effect of urine flow rate on uric acid excretion in man

1972 ◽  
Vol 15 (4) ◽  
pp. 338-346 ◽  
Author(s):  
Herbert S. Diamond ◽  
Robert Lazarus ◽  
David Kaplan ◽  
David Halberstam
Keyword(s):  
Uric Acid ◽  
Flow Rate ◽  
Urine Flow ◽  
Urine Flow Rate ◽  
Acid Excretion ◽  
Uric Acid Excretion

scholarly journals Effect of pentose ingestion on uric acid excretion

1929 ◽  
Vol 23 (6) ◽  
pp. 1175-1177
Author(s):  
Kate Madders ◽  
Robert Alexander McCance
Keyword(s):  
Uric Acid ◽  
Acid Excretion ◽  
Uric Acid Excretion

scholarly journals POS1144 SERUM URIC ACID TO CREATININE RATIO IS ASSOCIATED WITH URINARY URIC ACID EXCRETION IN PATIENTS WITH GOUT

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 851.2-851
Author(s):  
Z. Zhong ◽  
Y. Huang ◽  
X. Huang ◽  
Q. Huang ◽  
Y. Liu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Output ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Binary Logistic Regression Analysis ◽  
Creatinine Ratio ◽  
Acid Excretion ◽  
Complete Collection ◽  
Uric Acid Excretion

Background:Underexcretion of uric acid is the dominant mechanism leading to hyperuricemia [1] and the 24-hour urinary uric acid excretion is an important measurement. However, it is inconvenient due to accurate timing and complete collection of the specimen.Objectives:The aim of this study was to investigate the relationship between serum uric acid to creatinine ratio (sUACR) and 24-hour urinary uric acid excretion in gout patients.Methods:A total of 110 gout patients fulfilling 2015 ACR/EULAR classification criteria from Guangdong Second Provincial General Hospital from January 2019 to January 2021 were retrospectively enrolled in this study. Patients were divided into underexcretion group (<3600 μmol/24h) and non-underexcretion group (≥3600 μmol/24h). The correlation between sUACR and 24-hour urinary uric acid excretion was analyzed by the Pearson’s correlations analysis. Receiver operation characteristic (ROC) curves were performed to assess the utility of sUACR for discriminating between underexcretion group and non-underexcretion group. Furthermore, the risk factors of uric acid underexcretion were evaluated using binary logistic regression analysis.Results:sUACR in the underexcretion group was significantly lower than the non-underexcretion group (p=0.0001). Besides, sUACR was positively correlated with 24-hour urinary uric acid excretion (r=0.4833, p<0.0001). Furthermore, ROC suggested that the area under the curve (AUC) of sUACR was 0.728, which was higher that of serum uric acid and creatinine. The optimal cutoff point of sUACR was 5.2312, with a sensitivity and specificity of 71.9% and 67.9%. Logistic analysis results revealed that decreased sUACR (<5.2312) was an independent risk factor of underexcretion of uric acid (OR =5.510, 95% CI: 1.952-15.550, P=0.001).Conclusion:sUACR is lower in gout patients with underexcretion of uric acid and may serve as a useful and convenient marker of assessing underexcretion of uric acid in gout patients.References:[1]Perez-Ruiz F, Calabozo M, Erauskin GG, Ruibal A, Herrero-Beites AM. Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthritis Rheum 2002; 47: 610–13.Figure 1.A. Comparison of serum uric acid to creatinine ratio between underexcretion group and non-underexcretion group. B. Correlation between serum uric acid to creatinine ratio and 24h uric acid excretion.Disclosure of Interests:None declared.

Uric acid excretion in normal children

1978 ◽  
Vol 92 (6) ◽  
pp. 911-914 ◽  
Author(s):  
F. Bruder Stapleton ◽  
Michael A. Linshaw ◽  
Khatab Hassanein ◽  
Alan B. Gruskin
Keyword(s):  
Uric Acid ◽  
Acid Excretion ◽  
Normal Children ◽  
Uric Acid Excretion

Uric acid excretion in infants and children

1971 ◽  
Vol 32 (3) ◽  
pp. 377-383 ◽  
Author(s):  
Helen K. Berry ◽  
Mary Granger
Keyword(s):  
Uric Acid ◽  
Infants And Children ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
In Infants And Children

scholarly journals THE EFFECTIVENESS OF RENALOF® COMPARED TO KALKURENAL® AND PLACEBO

2012 ◽  
Vol 19 (2) ◽  
Author(s):  
Benny Kristyantoro ◽  
Sabilal Alif ◽  
Tarmono Djojodimedjo ◽  
Budiono Budiono
Keyword(s):  
Uric Acid ◽  
Surface Area ◽  
Renal Calculi ◽  
Renal Calculus ◽  
Renal Ultrasound ◽  
Acid Excretion ◽  
Stone Surface ◽  
Adjunct Therapy ◽  
Uric Acid Excretion ◽  
Plain Abdominal Film

Objective: To compare the effectiveness after administration of Renalof to Kalkurenal and placebo in patient with renal calculus. Material & Method: We analyzed 30 patient with renal calculi less than or equal to 20 mm (2 cm) between January 2011 and March 2011. Patients were divided into 3 groups. Nine patients were treated with placebo, 8 patients were treated with Kalkurenal and the last 13 patients were treated with Renalof. After 30 days, we analyzed calcium and uric acid excretion for 24 hours and measured the stone with plain abdominal film and renal ultrasound. Results: There were decreased in excretion of calcium and uric acid all of patients but not significant statistically (p > 0,05) and there were significant decreased on stone measurement in patient treated with Renalof. Conclusion: Renalof  can be given as adjunct therapy for patient with renal calculi. Keywords: Calcium and uric acid excretion in urine 24 hours, stone measurement and stone surface area.

scholarly journals Combined Supplementation with Glycine and Tryptophan Reduces Purine-Induced Serum Uric Acid Elevation by Accelerating Urinary Uric Acid Excretion: A Randomized, Single-Blind, Placebo-Controlled, Crossover Study

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2562
Author(s):  
Oshima ◽  
Shiiya ◽  
Nakamura
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Water Solubility ◽  
Elevated Serum ◽  
Acid Excretion ◽  
Japanese Adult ◽  
Urinary Ph ◽  
Uric Acid Excretion ◽  
Combined Supplementation ◽  
Single Blind

The authors previously confirmed the serum uric acid-lowering effects of the combination of glycine and tryptophan in subjects with mild hyperuricemia. This study examined whether combined supplementation with glycine and tryptophan suppressed the elevation in serum uric acid levels caused by purine ingestion and accelerated urinary uric acid excretion in subjects with lower urate excretion using a randomized, single-blind, placebo-controlled, crossover clinical trial design. Healthy Japanese adult males with lower urate excretion ingested water containing purines in addition to dextrin (placebo), tryptophan, glycine, or a glycine and tryptophan mixture. The combined supplementation with glycine and tryptophan significantly reduced the elevated serum uric acid levels after purine ingestion. Glycine alone and in combination with tryptophan significantly increased urinary uric acid excretion and urate clearance compared with the effects of the placebo. Urinary pH increased by the ingestion of the mixture. These results suggested that the improved water solubility of uric acid due to increased urinary pH contributed to the increase of urinary uric acid excretion.

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