EFFECTS OF ANDROGENS AND PROLACTIN ON THE RATE OF PRODUCTION AND COMPOSITION OF SEBUM IN HYPOPHYS-ECTOMIZED FEMALE RATS

SUMMARY The effect of five androgens on the activity of the sebaceous glands of female rats hypophysectomized at 3–4 weeks of age was studied by determining the rate of production and palmitate: stearate ratio of the skin surface lipids. Both of these values reflected the stimulation of the sebaceous glands by androgens, but the palmitate: stearate ratio appeared to be a more sensitive index of low androgenic activity than the production rate. The response of the sebaceous glands to the androgens tested increased in the order (the relative potencies were calculated from the palmitate: stearate ratios): androstenedione, 17; dehydroepiandrosterone, 33; androstanolone, 48; androstanediol, 91; and testosterone propionate, 100. Prolactin did not enhance the stimulation of the sebaceous glands induced by testosterone propionate.

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Trichobilharzia ocellata: chemical stimuli of duck skin for cercarial attachment

Parasitology ◽

10.1017/s0031182000080148 ◽

1988 ◽

Vol 96 (3) ◽

pp. 507-517 ◽

Cited By ~ 15

Author(s):

W. Feiler ◽

W. Haas

Keyword(s):

Close Contact ◽

Skin Surface ◽

Preen Gland ◽

Surface Lipids ◽

Skin Surface Lipids ◽

Chemical Stimuli ◽

Host Identification ◽

Host Signals ◽

Trichobilharzia Ocellata ◽

Stimulation Of

SUMMARYTrichobilharzia ocellatacercariae attach readily to the foot skin of their duck host, but poorly to preen-gland contents. The attachment to duck foot disappears when the skin surface lipids are extracted, and can be restored by reapplication of the lipids to the skin. Hydrophilic skin extracts are without any effect. Thin-layer chromatographic fractionation of duck-foot skin surface lipids reveals cholesterol and ceramides as attachment stimuli. A stimulation of cercarial attachment by these hydrophobic host signals is supported by the host identification pattern of the cercariae, which secures a close contact with encountered substrates.

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ROLE OF THE GONADS IN THE REGULATION OF SEBACEOUS GLANDS IN RATS: COMPARISON OF THE EFFECTS OF CASTRATION AT AND AFTER BIRTH

Journal of Endocrinology ◽

10.1677/joe.0.0850261 ◽

1980 ◽

Vol 85 (2) ◽

pp. 261-265 ◽

Cited By ~ 3

Author(s):

YEE CHU TOH

Keyword(s):

Skin Surface ◽

Female Rats ◽

Sprague Dawley ◽

Sebaceous Glands ◽

Male And Female Rats ◽

Sprague Dawley Rats ◽

Sequential Event ◽

Sebum Production ◽

Skin Surface Lipids

Sprague–Dawley rats were castrated either within 24 h of birth or at 4 weeks of age. Control animals were sham operated. Intact female rats were also included for comparison. Sebum production was assessed at 80 days of age by measuring the amount of skin-surface lipids that could be extracted with acetone and which had been produced during 2 days. The removal of the testes at birth reduced the activity of the sebaceous glands to a level more nearly approaching that seen in the female rats whereas castration at 4 weeks of age only partially decreased the rate of sebum secretion so that it was intermediate between the male and female rats. The weights of the pituitary gland, thyroid and adrenal glands increased after castration but there were no differences between rats castrated at birth and those castrated at 4 weeks of age except in the weight of the thyroid gland. It would appear that the role of the testes in the control of the activity of the sebaceous glands is a sequential event which has already started at birth.

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Human Sebaceous Glands: How Studies of Skin Surface Lipids Have Provided Knowledge of Their Function and Control

Dermatology ◽

10.1159/000095053 ◽

2006 ◽

Vol 213 (3) ◽

pp. 261-261

Author(s):

John S. Strauss

Keyword(s):

Skin Surface ◽

Sebaceous Glands ◽

Surface Lipids ◽

Skin Surface Lipids ◽

And Control

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Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids

10.1101/2021.04.04.438351 ◽

2021 ◽

Author(s):

Takayoshi Inoue ◽

Tetsuya Kuwano ◽

Yuya Uehara ◽

Michiko Yano ◽

Naoki Oya ◽

...

Keyword(s):

Atopic Dermatitis ◽

Transcriptome Analysis ◽

Skin Diseases ◽

Skin Surface ◽

Hair Follicles ◽

Sebaceous Glands ◽

Non Invasive ◽

Skin Physiology ◽

Surface Lipids ◽

Skin Surface Lipids

Non-invasive acquisition of mRNA data from the skin would be extremely useful for understanding skin physiology and diseases. Inspired by the holocrine process, in which the sebaceous glands secrete cell contents into the sebum, we focused on the possible presence of mRNAs in skin surface lipids (SSLs). We found that measurable human mRNAs exist in SSLs, where sebum protects them from degradation by RNases. The AmpliSeq transcriptome analysis was modified to measure SSL-RNAs, and our results revealed that SSL-RNAs predominantly contained mRNAs derived from sebaceous glands, epidermis, and hair follicles. Analysis of SSL-RNAs non-invasively collected from patients with atopic dermatitis revealed significantly increased expression of inflammation-related genes and decreased expression of terminal differentiation-related genes, consistent with the results of previous reports. Further, we found that lipid synthesis-related genes were downregulated in the sebaceous glands of patients with atopic dermatitis. These results indicate that the analysis of SSL-RNAs is promising to understand the pathophysiology of skin diseases.

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THE PRODUCTION OF SEBUM IN YOUNG RATS: EFFECTS OF AGE, SEX, HYPOPHYSECTOMY AND TREATMENT WITH SOMATOTROPHIC HORMONE AND SEX HORMONES

Journal of Endocrinology ◽

10.1677/joe.0.0430113 ◽

1969 ◽

Vol 43 (1) ◽

pp. 113-118 ◽

Cited By ~ 22

Author(s):

T. NIKKARI ◽

M. VALAVAARA

Keyword(s):

Growth Hormone ◽

Body Weight ◽

Skin Surface ◽

Secretion Rate ◽

Female Rats ◽

Male Rats ◽

Surface Lipids ◽

Somatotrophic Hormone ◽

Sebum Production ◽

Skin Surface Lipids

SUMMARY The secretion rate of sebum in rats aged 3–14 weeks was determined by measuring the amount of acetone-extractable skin surface lipids produced during 2 days. The results were expressed as mg. sebum/100 g. body weight/2 days. The secretion rate of male rats was found to increase with age (from 16 mg./100 g. at 3 weeks to 35 mg./100 g. at 14 weeks), while that of female rats (16 mg./100 g.) remained unchanged. Hypophysectomy of 3-week-old female rats resulted in lowering of the secretion rate to 13 mg./100 g. at 10 weeks. No change in the secretion rate of the hypophysectomized animals occurred during either growth hormone or oestradiol treatment, but testosterone in doses of 1 mg. and 0·2 mg./day increased sebum production (to 37 mg./100 g. and 24 mg./100 g., respectively). The increase obtained with testosterone (0·2 mg./day) was smaller (20 mg./100 g.), when oestradiol (3 μg./day) was given simultaneously.

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