Compared with natural sand, manufactured-sand is of small porosity, poor grain shape and graded, which impacts mixes workability and the properties after hardening. In Concrete, playing the role of retaining moisture water is mainly powder, including cement, powder in the sand and fly ash etc. The amount of powder has a great influence on the properties of concrete, especially on its workability. This paper mainly discusses the influence of amount of cement, cementitious materials, fly ash, water-cement ratio and other factors on the workability, compressive strength and shrinkage of concrete. The experiments show that, in the case of the low amount of cement, workability of the manufactured-sand concrete mixture, compressive strength and shrinkage deformation of test block all meet the actual requirements.