In recent years, externally bonded carbon fibre–reinforced polymer has been considered an innovative way to strengthen steel structures attributed to its high strength-to-weight ratio, excellent corrosion resistance and fatigue performance. This article presents an experimental and numerical study on the fatigue behaviour of defected steel beams strengthened with carbon fibre–reinforced polymer laminates, with a special focus on the effect of interfacial debonding. Analytical modelling and numerical simulation confirmed that the interfacial debonding had a pronounced effect on carbon fibre–reinforced polymer strain and stress intensity factor at the crack front. After introducing interfacial debonding from experimental findings into the numerical analysis, the fatigue life and crack propagation versus cycle numbers of the specimens compared well with the test results. Based on the current experimental program, specimens with Sikadur 30 were more prone to debonding failure; therefore, Araldite 420 is suggested for strengthening schemes.