scholarly journals Spontaneous dietary protein intake during progression of chronic renal failure.

1995 ◽  
Vol 6 (5) ◽  
pp. 1386-1391
Author(s):  
T A Ikizler ◽  
J H Greene ◽  
R L Wingard ◽  
R A Parker ◽  
R M Hakim
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Dietary Protein ◽  
Protein Intake ◽  
Mixed Model ◽  
Dietary Protein Intake ◽  
Nutritional Indices ◽  
Igf I ◽  
Progression Of Renal Failure ◽  
The Mean

Malnutrition at the initiation of dialysis is a strong predictor of subsequent increased mortality on dialysis. Few studies have documented the relationship between the progression of renal failure and spontaneous dietary protein intake (DPI) and other indices of malnutrition. In this prospective study, renal function was sequentially measured by creatinine clearance (CrCl) and DPI by 24-h urine collection; simultaneously, multiple sequential biochemical nutritional indices, including serum albumin, transferrin, prealbumin, and insulin-like growth factor-I (IGF-I) concentrations, were measured. The study involved 90 patients (46 men and 44 women) with chronic renal failure (CRF) of various causes monitored in an outpatient clinic. Dietary interventions were minimal. The mean duration of follow-up was 16.5 +/- 11.8 months. The results show that the mean (+/- SD) DPI was 1.01 +/- 0.21 g/kg per day for patients with CrCl over 50 mL/min and decreased to 0.85 +/- 0.23 g/kg per day for patients with CrCl between 25 and 50 mL/min. The DPI further decreased to a level of 0.70 +/- 0.17 g/kg per day for patients with CrCl between 10 and 25 mL/min and was 0.54 +/- 0.16 g/kg per day for patients with CrCl below 10 mL/min. This trend was statistically significant (P < 0.001). A similar statistically significant trend was observed for serum cholesterol, transferrin, and total creatinine excretion (all P < 0.01). A mixed model analysis indicated that for each 10 mL/min decrease in CrCl, DPI decreased by 0.064 +/- 0.007 g/kg per day, transferrin decreased by 16.7 +/- 4.1 mg/dL, weight decreased by 0.38 +/- 0.13% of initial weight, and IGF-I decreased by 6.2 +/- 1.9 ng/mL. It was concluded that the progression of renal failure is associated with a spontaneous decrease in DPI, especially below a CrCl of 25 mL/min, and that most nutritional indices in CRF patients worsen as CrCl and DPI decrease. Dietary protein restriction should be used cautiously in CRF patients when CrCl falls below 25 mL/min.

The Estimation of Dietary Protein Intake in Chronic Renal Failure

1989 ◽  
Vol 4 (10) ◽  
pp. 877-882 ◽  
Author(s):  
G. A. Coles ◽  
J. H. Meadows ◽  
C. Bright ◽  
K. Tomlinson
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake

Increased protein level of PEPT1 intestinal H+-peptide cotransporter upregulates absorption of glycylsarcosine and ceftibuten in 5/6 nephrectomized rats

2005 ◽  
Vol 288 (4) ◽  
pp. G664-G670 ◽  
Author(s):  
Yuriko Shimizu ◽  
Satohiro Masuda ◽  
Kumiko Nishihara ◽  
Lin Ji ◽  
Masahiro Okuda ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Dietary Protein ◽  
Peptide Transporter ◽  
Protein Digestion ◽  
Small Peptides ◽  
Progression Of Renal Failure ◽  
Progression Of Renal Disease ◽  
Drug Pharmacokinetics ◽  
Pept1 Mrna

In chronic renal failure (CRF), dietary protein is one of the factors that deteriorates residual renal functions. Numerous studies have indicated that the products of protein digestion are mainly absorbed as small peptides. However, how small peptides are absorbed in CRF remains poorly understood. H+-coupled peptide transporter (PEPT1/ SLC15A1) plays an important role in the absorption of small peptides and peptide-like drugs in the small intestine. Because dietary protein intake is one of the risk factors for renal failure, the alteration of intestinal PEPT1 might have implications in the progression of renal disease as well as the pharmacokinetics of peptide-like drugs. In this study, we examined the alteration of intestinal PEPT1 in 5/6 nephrectomized (5/6 NR) rats, extensively used as a model of chronic renal failure. Absorption of [14C]glycylsarcosine and ceftibuten was significantly increased in 5/6 NR rats compared with sham-operated rats, without a change in intestinal protease activity. Western blot analysis indicated that the amount of intestinal PEPT1 protein in 5/6 NR rats was increased mainly at the upper region. On the other hand, the amount of intestinal PEPT1 mRNA was not significantly different from that of sham-operated rats. These findings indicate that the increase in absorption of small peptides and peptide-like drugs, caused by the upregulation of intestinal PEPT1 protein, might contribute to the progression of renal failure as well as the alteration of drug pharmacokinetics.

scholarly journals Effects of dietary protein on renal function and lipid metabolism in five-sixths nephrectomized rats

2003 ◽  
Vol 89 (4) ◽  
pp. 491-497 ◽  
Author(s):  
Shu-Tzu Chen ◽  
Sheng-Jeng Peng ◽  
Jiun-Rong Chen
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Lipid Metabolism ◽  
Chronic Renal Failure ◽  
Renal Disease ◽  
Dietary Protein ◽  
Casein Diet ◽  
Experimental Animals ◽  
Rate Of Progression ◽  
Progression Of Renal Failure

The objective of the present experiment was to examine the effect of substituting different quantities of soyabean protein for casein on renal function and lipid metabolism in rats with chronic renal failure induced by a five-sixths nephrectomy. Experimental animals were subjected to a nephrectomy and fed either casein or soyabean protein (200 or 100 g/kg diet). The diets were isoenergetic with identical fat, Na, K and P contents. Rats ingesting 200 g casein/kg diet showed a significantly (P<0·05) accelerated course of chronic renal failure, while the soyabean-protein groups showed retarded progression of the experimentally induced renal disease and hypercholesterolaemic effects. Rats in the low-soyabean-protein diet (100 g/kg) also demonstrated increased serum albumin and decreased serum triacylglycerol, total cholesterol concentrations and blood urea-N; however, the low-casein diet significantly (P<0·05) increased serum triacylglycerol. Results of the present study show that the replacement of casein by soyabean protein was related to the rate of progression of renal failure and improvement in lipid profiles in serum of five-sixths nephrectomized rats.

Effect of dietary protein intake and intravenous glucose infusion on plasma concentrations of insulin-like growth factor-I in lambs

1992 ◽  
Vol 132 (2) ◽  
pp. 195-199 ◽  
Author(s):  
G. V. Kriel ◽  
M. J. Bryant ◽  
M. A. Lomax
Keyword(s):  
Growth Factor ◽  
Dietary Protein ◽  
Protein Intake ◽  
Jugular Vein ◽  
Glucose Infusion ◽  
Insulin Like Growth Factor ◽  
Dietary Protein Intake ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

ABSTRACT Two separate experiments were carried out to examine the effect of dietary protein intake on basal and GHstimulated plasma insulin-like growth factor-I (IGF-I) concentrations during either saline or glucose infusion into the jugular vein. In experiment 1, six castrated male lambs (27·1 ± 1·2 kg live weight (LW)) were fed a diet restricted in both metabolizable energy (ME; 0·18 MJ/kg LW per day) and nitrogen (2·0 g/kg LW per day) intakes, while in experiment 2 a further six lambs were fed a similar restricted ME intake but an increased nitrogen intake (3·0 g/kg LW per day). In both experiments glucose (experiment 1, 0·009 mmol/kg LW per min; experiment 2, 0·015 mmol/kg LW per min) or saline (0·25 ml/min) was infused for 6 days and plasma samples were obtained from the jugular vein at hourly intervals on day 4 (basal) or on days 5 and 6 after an i.v. GH challenge. In experiment 1 there was no increase in plasma IGF-I concentrations in response to the GH challenge during saline infusion, but during glucose infusion the plasma concentration of IGF-I increased to a peak after 24 h and declined over the next 20 h. Basal concentrations of IGF-I, insulin and glucose were significantly higher during glucose infusion. In experiment 2 the area under the IGF-I peak in response to the GH challenge was the same for the infusions of saline and glucose but the peak value for IGF-I was significantly higher during glucose infusion due to higher concentrations in the basal period. It is concluded that feeding a dietary intake of metabolisable energy and nitrogen which is only just sufficient to meet the requirements for maintenance of body tissues completely abolishes the increase in plasma IGF-I in response to GH challenge. Increasing the nitrogen supply in the diet or i.v. infusion of glucose re-establishes the IGF-I response to GH challenge as well as increasing basal IGF-I concentrations. The potential involvement of circulating concentrations of insulin, glucose and amino acids in the control of plasma IGF-I levels are discussed. Journal of Endocrinology (1992) 132, 195–199

scholarly journals Clinical and Dietary Determinants of Muscle Mass in Patients with Type 2 Diabetes: Data from the Diabetes and Lifestyle Cohort Twente

2021 ◽  
Vol 10 (22) ◽  
pp. 5227
Author(s):  
Annis C. Jalving ◽  
Milou M. Oosterwijk ◽  
Ilse J. M. Hagedoorn ◽  
Gerjan Navis ◽  
Stephan J. L. Bakker ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Muscle Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Modifiable Risk Factors ◽  
Dietary Protein Intake ◽  
Cross Sectional ◽  
The Mean

Low muscle mass in patients with type 2 diabetes is associated with a progressively higher risk of morbidity and mortality. The aim of this study was to identify modifiable targets for intervention of muscle mass in type 2 diabetes. Cross-sectional analyses were performed in 375 patients of the Diabetes and Lifestyle Cohort Twente-1 study. Muscle mass was estimated by 24 h urinary creatinine excretion rate (CER, mmol/24 h). Patients were divided in sex-stratified tertiles of CER. To study determinants of CER, multivariable linear regression analyses were performed. Protein intake was determined by Maroni formula and by a semi-quantitative Food Frequency Questionnaire. The mean CER was 16.1 ± 4.8 mmol/24 h and 10.9 ± 2.9 mmol/24 h in men and women, respectively. Lower CER was significantly associated with older age (p < 0.001) as a non-modifiable risk factor, whereas higher BMI (p = 0.015) and lower dietary protein intake (both methods p < 0.001) were identified as modifiable risk factors for lower CER. Overall body mass index (BMI) was high, even in the lowest CER tertile the mean BMI was 30.9 kg/m2, mainly driven by someone’s body weight (p = 0.004) instead of someone’s height (p = 0.58). In the total population, 28% did not achieve adequate protein intake of >0.8 g/kg/day, with the highest percentage in the lowest CER tertile (52%, p < 0.001). Among patients with type 2 diabetes treated in secondary care, higher BMI and low dietary protein intake are modifiable risk factors for lower muscle mass. Considering the risk associated with low muscle mass, intervention may be useful. To that purpose, dietary protein intake and BMI are potential targets for intervention.

scholarly journals The mean dietary protein intake at different stages of chronic kidney disease is higher than current guidelines

2013 ◽  
Vol 83 (4) ◽  
pp. 724-732 ◽  
Author(s):  
Linda W. Moore ◽  
Laura D. Byham-Gray ◽  
J. Scott Parrott ◽  
Diane Rigassio-Radler ◽  
Sreedhar Mandayam ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
The Mean ◽  
Current Guidelines

scholarly journals Stimulation of erythropoietin secretion by continuous subcutaneous infusion of recombinant human GH in anemic patients with chronic renal failure

1998 ◽  
pp. 302-306 ◽  
Author(s):  
M Sohmiya ◽  
K Ishikawa ◽  
Y Kato
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Infusion Pump ◽  
Experimental Period ◽  
Gh Treatment ◽  
Subcutaneous Infusion ◽  
Igf I ◽  
Basal Plasma ◽  
The Mean ◽  
Plasma Gh

We have investigated the effect of human GH on erythropoietin (EPO) secretion in eight anemic patients with chronic renal failure (CRF) (three males and five females, aged from 46 to 83 years). Recombinant human GH was infused subcutaneously at a flow rate of 2 microg/kg body weight per 0.1 ml/h for 72 h using a portable infusion pump. Blood samples were obtained immediately before and 2, 4, 6, 12, 24, 36, 48, 60, 72, 84, 96, 108, 120 and 168 h after the start of GH infusion. Storage urine samples were obtained before and 24, 48 and 72 h after the start of the infusion. The mean (+/- S.E.M.) basal plasma GH levels increased from 1.9 +/- 0.3 to 18.8 +/- 0.7 microg/l during the GH infusion. Plasma IGF-I levels increased 12 h after the start of GH treatment and the mean peak values of 403.6 +/- 38.5 microg/l were obtained at 72 h. Plasma EPO levels increased 6 h after the start of GH infusion, and the peak values of 38.4 +/- 11.6 IU/l were obtained at 96 h (P < 0.05 vs basal values 24.5 +/- 7.2 IU/l). Reticulocyte counts increased from 28.7 +/- 5.2 x 10(3)/microl to 40.3 +/- 8.0 x 10(3)/l at 108 h, 43.6 +/- 9.2 x 10(3)/microl at 120 h and 41.7 +/- 7.7 x 10(3)/microl at 160 h (P < 0.05). Serum urea nitrogen decreased at 72 h (P < 0.05), whereas there was no significant change in urinary excretion of nitrogen. Hemoglobin levels were not significantly changed throughout the experimental period. These findings indicate that human GH has a stimulating effect on EPO secretion in anemic patients with CRF.

Association between lean mass and dietary protein intake in postmenopausal women

2016 ◽  
Author(s):  
Vladyslav Povoroznyuk ◽  
Nataliia Dzerovych ◽  
Roksolana Povorooznyuk
Keyword(s):  
Postmenopausal Women ◽  
Lean Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake

RELATIONSHIP BETWEEN CARDIOVASCULAR DISEASES AND ANATOMOSIS OF ARTERIOVENOUS FISTULAR IN PATIENTS WITH REGULARLY HEMODIALYSIS

2017 ◽  
pp. 88-92
Author(s):  
Van Hien Pham ◽  
Huu Vu Quang Nguyen ◽  
Tam Vo
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Cardiovascular Diseases ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Negative Correlation ◽  
Mean Value ◽  
The Mean

Background: Cardiovascular diseases are the leading cause of death in patients with chronic renal failure. When a patient undergoes dialysis, making AVF or AVG causes cardiovascular events. Understanding the relationship between complications: hypertension, heart failure, AVF or AVG (formation time, position, diameter) helps us monitor, detect, prevent and treatment of complications to limit the risk of death in patients with dialysis. Objective: Relationship between cardiovascular diseases and anatomosis of arteriovenous fistular in patients with regularly hemodialysis at Cho Ray Hospital. Methods: A cross-sectional study was conducted at Cho Ray Hospital from 2015 to 2016. The survey some cardiovascular diseases are done by clinical examination, tests for diagnostic imaging such as X-ray, electrocardiogram and echocardiogram: heart and diameter of anastomosis AVF, AVG. Results: The study population included 303 patients with chronic renal failure who were dialysis. Of which, patients aged 25-45 accounted for the highest proportion (43.9%). The proportion of male and female patients was similar (48.5% and 51.5% respectively). The mean value of systolic blood pressure on patients made AVF, AVG less than 12 months is higher than patients made AVF, AVG over 12 months, and there is negative correlation (r = -0.43) between AVF, AVG and systolic blood pressure (p <0.05). The mean value of diastolic blood pressure on patients made AVF, AVG less than 12 months is lower than patients made AVF, AVG over 12 months, and and there is positive correlation (r = -0.43) between AVF, AVG and diastolic blood pressure (p <0.05) (p <0.05). The prevalence of patients with heart failure made AVF, AVG over 12 months is higher than that of the under 12 months group, there is a negative correlation (r = - 0.43) between AVF, AVG diameter and EF index (p <0.05). Conclusion: It is important to note the diameter of anastomosis AVF, AVG in patients with chronic renal failure dialysis to limit cardiovascular complications, especially heart failure. Key words: Chronic kidney disease, hemodialysis.

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