Outcome of HIV-positive children and adolescents treated with second-line antiretroviral agents in Congo

2018 ◽  
Vol 28 (4) ◽  
pp. 413-418
Author(s):  
J.R. Mabiala Babela ◽  
M. Kibangou Lenvo ◽  
E.R. Nika ◽  
L.C. Ollandzobo Ikobo ◽  
S.V. Missambou Mandilou ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Hiv Positive ◽  
Second Line ◽  
Antiretroviral Agents

Disclosure Experiences and Challenges Among Children and Adolescents Living with HIV/AIDS in Nigeria-A Review of the Literature

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Nzube Pauline Okolo-Francis ◽  
Uyinonijesu Diamond Victor-Ogie ◽  
Abdulmumin Ibrahim ◽  
Amos Abimbola Oladunni ◽  
Goodness Ogeyi Odey ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Healthcare Workers ◽  
Negative Impact ◽  
Hiv Positive ◽  
Review Of The Literature ◽  
Hiv Status ◽  
Clinical Context ◽  
The Mean ◽  
Living With Hiv ◽  
Status Disclosure

Context: Disclosure of HIV positive infection status in children and Adolescents is multifaceted and should take into consideration their age, psychosocial maturity, cultural and clinical context. This study was conducted to examine disclosure experiences and challenges among children and ALWHA in Nigeria. Evidence Acquisition: We conducted narrative review of relevant literatures by searching PubMed, Google scholar and Medscape using predetermined keywords. Results: Findings are presented under themes of process of disclosure and age of disclosure, reasons and challenges of disclosure, reactions and responses to disclosure, consistent with various authors. This study shows that the mean age and reasons for HIV positive status disclosure are variable. Disclosure was mostly executed at home and mostly carried out by parents or caregivers of HIV-infected children. Reactions of children and ALWHA upon disclosure was mainly negative and ranged from feeling of anger to expression of shock to feeling of sadness and to crying. Barriers to HIV-positive status disclosure among caregivers were perceived sense immaturity and age of the child, fear of stigma, fear of child’s inability to cope, fear of blaming the parents and refusal to take antiretroviral (ARV) drugs. While caregivers highlighted several factors that affect disclosure of HIV status to children and adolescents, this study reveals both positive and negative impact on their emotions. Conclusions: It is of note that approach to disclosure is critical, therefore caregivers and healthcare workers should be properly trained and supported with resources required to effectively carry out disclosure. There is need for continuous research to understand and develop age and culture specific approaches to disclosure in children and adolescents in Nigeria.

scholarly journals Comorbidity of HIV, hypertension, and diabetes and associated factors among people receiving antiretroviral therapy in Bahir Dar city, Ethiopia

2020 ◽  
Vol 10 ◽  
pp. 2235042X1989931
Author(s):  
Zenebework Getahun ◽  
Muluken Azage ◽  
Taye Abuhay ◽  
Fantu Abebe
Keyword(s):  
Antiretroviral Therapy ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Noncommunicable Diseases ◽  
Hiv Positive ◽  
Bahir Dar ◽  
Second Line ◽  
Double Burden ◽  
Cross Sectional ◽  
Hiv Positive Adults

Background: People living with human immunodeficiency virus (HIV) are facing an increased burden of noncommunicable diseases (NCDs) comorbidity. There is, however, paucity of information on the magnitude of HIV-NCDs comorbidity, its associated factors, and how the health system is responding to the double burden in Ethiopia. Objective: To determine the magnitude of comorbidity between HIV and hypertension or diabetes and associated factors among HIV-positive adults receiving antiretroviral therapy (ART) in Bahir Dar city, Ethiopia. Methods: A facility-based cross-sectional study was conducted among 560 randomly selected HIV-positive adults taking ART. Data were collected using a structured questionnaire and analyzed using SPSS version 23. Descriptive statistics were used to describe the data. A logistic regression model was fit to identify associated factors with comorbidity of HIV and NCDs. Results: The magnitude of comorbidity was 19.6% (95% confidence interval (CI): 16.0–23.0). Being older (55 and above years) adjusted odds ratio (AOR: 8.5; 95% CI: 3.2–15.1), taking second-line ART regimen containing tenofovir (AOR: 2.7; 95% CI: 1.3–5.6), and increased body mass index (BMI) ≥25 (AOR: 2.7; 95% CI: 1.2–6.5) were the factors associated with comorbidity. Participants reported that they were not managed in an integrated and coordinated manner. Conclusions: The magnitude of comorbidity among adults was high in the study area. Being older, second-line ART regimen and high BMI ≥25 increased the odds of having NCDs among HIV-positive adults. Targeted screening for the incidences of NCDs, addressing modifiable risk factors, and providing integrated care would help to improve the quality of life comorbid patients.

Staphylococcus aureus Infections in HIV-positive Children and Adolescents

2012 ◽  
Vol 31 (3) ◽  
pp. 284-286 ◽  
Author(s):  
J. Chase McNeil ◽  
Kristina G. Hulten ◽  
Sheldon L. Kaplan ◽  
Heidi L. Schwarzwald ◽  
Edward O. Mason
Keyword(s):  
Staphylococcus Aureus ◽  
Children And Adolescents ◽  
Hiv Positive

scholarly journals A Phenomenological Account of HIV Disclosure Experiences of Children and Adolescents from Northern and Southern Ghana

2019 ◽  
Vol 16 (4) ◽  
pp. 595 ◽  
Author(s):  
Seth Appiah ◽  
Inge Kroidl ◽  
Michael Hoelscher ◽  
Olena Ivanova ◽  
Jonathan Dapaah
Keyword(s):  
Children And Adolescents ◽  
Social Protection ◽  
Hiv Transmission ◽  
Hiv And Aids ◽  
Hiv Disclosure ◽  
Hiv Positive ◽  
Hiv Status ◽  
Nations Programme ◽  
United Nations Programme ◽  
Southern Ghana

Disclosure of HIV status to infected children, though challenged by caregiver dilemma, remains central in achieving the United Nations Programme on HIV and AIDS (UNAIDS) global goal of 90/90/90. This study explores children’s HIV disclosure experiences across Northern and Southern Ghana. A qualitative interpretative phenomenological design facilitated the recruitment of 30 HIV positive disclosed children and adolescents aged 9–19 years in 12 antiretroviral treatment (ART) centers in Northern and Southern Ghana between January 2017 and June 2018. Data was collected via in-depth interviews. We used phenomenological analysis applying concepts and categories identification, patterns and interconnections searching, mapping, theme building and constant comparative technique to draw conclusions. Disclosure of HIV status to children occurred with little or no preparation. Caregivers intentionally or out of dilemma often prolonged or postponed disclosure to when children aged older. Illness severity and disease progression principally defined the need for disclosure. Children preference for early status disclosure averaged at age 10 was demonstrated despite the initial disclosure experience of shock and disappointment. There was improved medication adherence despite the challenge of limited knowledge about HIV transmission, financial difficulty and food insecurity. Context and culturally adapted pre- and post- disclosure guideline laced with social protection package is needed to support HIV positive children.

scholarly journals Nutritional status and lipid profile of HIV-positive children and adolescents using antiretroviral therapy

Clinics ◽  
2011 ◽  
Vol 66 (6) ◽  
pp. 997-1002 ◽  
Author(s):  
Patricia Viganó Contri ◽  
Érica Miranda Berchielli ◽  
Marina Hjertquist Tremeschin ◽  
Bento Vidal de Moura Negrini ◽  
Roberta Garcia Salomão ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Nutritional Status ◽  
Lipid Profile ◽  
Children And Adolescents ◽  
Hiv Positive

Pharmacology of second-line antituberculosis drugs and potential for interactions with antiretroviral agents

AIDS ◽  
2009 ◽  
Vol 23 (4) ◽  
pp. 437-446 ◽  
Author(s):  
Katherine M Coyne ◽  
Anton L Pozniak ◽  
Mohammed Lamorde ◽  
Marta Boffito
Keyword(s):  
Second Line ◽  
Antituberculosis Drugs ◽  
Antiretroviral Agents

Craniofacial morphology of HIV-positive children and adolescents undergoing antiretroviral therapy: A pilot study

2018 ◽  
Vol 153 (1) ◽  
pp. 26-35
Author(s):  
Maria Luiza Veloso de Almeida Watanabe ◽  
Adriana Oliveira Lira Ortega ◽  
Catalina Riera Costa ◽  
Emiko Saito Arita ◽  
Karem L. Ortega
Keyword(s):  
Antiretroviral Therapy ◽  
Pilot Study ◽  
Children And Adolescents ◽  
Craniofacial Morphology ◽  
Hiv Positive

scholarly journals Treatment durability and virological response in treatment-experienced HIV-positive patients on an integrase inhibitor-based regimen: an Australian cohort study

Sexual Health ◽  
2016 ◽  
Vol 13 (4) ◽  
pp. 335 ◽  
Author(s):  
Nicole L. De La Mata ◽  
David A. Cooper ◽  
Darren Russell ◽  
Don Smith ◽  
Ian Woolley ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Viral Suppression ◽  
Treatment Time ◽  
Treatment Options ◽  
Additional Treatment ◽  
Baseline Viral Load ◽  
Patient Treatment ◽  
Hiv Positive ◽  
Second Line ◽  
Treatment Experience

Background: Integrase inhibitors (INSTI) are a newer class of antiretroviral (ARV) drugs that offer additional treatment options for experienced patients. Our aim is to describe treatment durability and virological outcomes in treatment-experienced HIV-positive patients using INSTI-based regimens. Methods: All patients in the Australian HIV Observational Database who had received an INSTI-based regimen ≥ 14 days as well as previous therapy were included in the study. We defined two groups of treatment-experienced patients: (1) those starting a second-line regimen with INSTI; and (2) highly experienced patients, defined as having prior exposure to all three main ARV classes, nucleoside reverse transcriptase inhibitor, nonnucleoside reverse transcriptase inhibitors and protease inhibitors, before commencing INSTI. Survival methods were used to determine time to viral suppression and treatment switch, stratified by patient treatment experience. Covariates of interest included age, gender, hepatitis B and C co-infection, previous antiretroviral treatment time, patient treatment experience and baseline viral load. Results: Time to viral suppression and regimen switching from INSTI initiation was similar for second-line and highly experienced patients. The probability of achieving viral suppression at 6 months was 77.7% for second-line patients and 68.4% for highly experienced patients. There were 60 occurrences of regimen switching away from INSTI observed over 1274.0 person-years, a crude rate of 4.71 (95% CI: 3.66–6.07) per 100 person-years. Patient treatment experience was not a significant factor for regimen switch according to multivariate analysis, adjusting for relevant covariates. Conclusions: We found that INSTI-based regimens were potent and durable in experienced HIV-positive patients receiving treatment outside clinical trials. These results confirm that INSTI-based regimens are a robust treatment option.

scholarly journals Treatment Outcomes and Resistance Patterns of Children and Adolescents on Second-Line Antiretroviral Therapy in Asia

2016 ◽  
Vol 72 (4) ◽  
pp. 380-386 ◽  
Author(s):  
Wasana Prasitsuebsai ◽  
Sirinya Teeraananchai ◽  
Thida Singtoroj ◽  
Khanh Huu Truong ◽  
Jintanat Ananworanich ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Children And Adolescents ◽  
Treatment Outcomes ◽  
Second Line ◽  
Resistance Patterns ◽  
Second Line Antiretroviral Therapy
Sign in / Sign up

Export Citation Format

Share Document