Resistance profile of children and adolescents infected with HIV-1 in urban areas in Togo

2018 ◽  
Vol 28 (4) ◽  
pp. 419-423
Author(s):  
O.E. Takassi ◽  
M. Salou ◽  
K.E. Djadou ◽  
F. Agbéko ◽  
D. Agbèrè ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Urban Areas ◽  
Resistance Profile ◽  
Hiv 1

Virological response and resistance profile in highly treatment‐experienced HIV‐1‐infected patients switching to dolutegravir plus boosted darunavir in clinical practice

HIV Medicine ◽  
2021 ◽  
Author(s):  
Daniele Armenia ◽  
Yagai Bouba ◽  
Roberta Gagliardini ◽  
Lavinia Fabeni ◽  
Vanni Borghi ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Virological Response ◽  
Resistance Profile ◽  
Hiv 1

scholarly journals Prevalence and factors associated with hypertension among school children and adolescents in urban and semi‐urban areas in Cameroon

2021 ◽  
Author(s):  
Chris Nadège Nganou‐Gnindjio ◽  
Doris Bibi Essama ◽  
Jan René Nkeck ◽  
Patrick Yvan Tchebegna ◽  
Kiliane Maeva Tchatchouang ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
School Children ◽  
Urban Areas ◽  
Factors Associated

scholarly journals Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450

1996 ◽  
Vol 3 (4) ◽  
pp. 301-314 ◽  
Author(s):  
C. Nicholas Hodge ◽  
Paul E. Aldrich ◽  
Lee T. Bacheler ◽  
Chong-Hwan Chang ◽  
Charles J. Eyermann ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Human Pharmacokinetics ◽  
Resistance Profile ◽  
X Ray ◽  
Hiv 1

scholarly journals Socioeconomic Differences in Walking Time of Children and Adolescents to Public Green Spaces in Urban Areas—Results of the German Environmental Survey (2014–2017)

2021 ◽  
Vol 18 (5) ◽  
pp. 2326
Author(s):  
Julia Rehling ◽  
Christiane Bunge ◽  
Julia Waldhauer ◽  
André Conrad
Keyword(s):  
Young People ◽  
Children And Adolescents ◽  
Urban Areas ◽  
Green Space ◽  
Positive Impact ◽  
Green Spaces ◽  
Environmental Survey ◽  
Urban Green Spaces ◽  
Public Green Space ◽  
Walking Time

Public green spaces have a high potential for a positive impact on people’s health and wellbeing, especially in urban areas. Studies on environmental justice indicate socially unequal access possibilities to urban green spaces. This article presents results on associations between individual socioeconomic position (SEP) and walking time from home to public green spaces in young people living in urban areas with more than 20,000 inhabitants in Germany. Data were derived from the German Environmental Survey for Children and Adolescents 2014–2017 (GerES V), the environmental module of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS Wave 2). The sample comprises 1149 participants aged 3 to 17 years. A total of 51.5% of the participants reach a public green space on foot within five and 72.8% within ten minutes from home. The lower the participant’s SEP, the longer the walking time. Logistic regression models controlling for age group, sex, migration background, and region of residence show that participants with a low SEP have a significantly higher risk (odds ratio = 1.98; 95% confidence interval: 1.31–2.99) of needing more than ten minutes to walk from home to a public green space than participants with a high SEP. GerES V data indicate that young people living in urban areas in Germany do not equally benefit from the health-promoting potential of green spaces, which is an important aspect of environmental health inequalities.

Prevalence of Transmitted HIV-1 Drug Resistance Mutations in Children and Adolescents in São Paulo, Brazil

2012 ◽  
pp. 1
Author(s):  
Flávia Jacqueline Almeida ◽  
Rosangela Rodrigues ◽  
Mayra Simioni Zaparoli ◽  
Eitan Naaman Berezin ◽  
Marco Aurélio Palazzi Sáfadi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Children And Adolescents ◽  
Sao Paulo ◽  
São Paulo ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv 1

The maturing immune system: implications for development and testing HIV-1 vaccines for children and adolescents

AIDS ◽  
2006 ◽  
Vol 20 (4) ◽  
pp. 483-494 ◽  
Author(s):  
Heather B Jaspan ◽  
Stephen D Lawn ◽  
Jeffrey T Safrit ◽  
Linda-Gail Bekker
Keyword(s):  
Immune System ◽  
Children And Adolescents ◽  
Vaccines For Children ◽  
Hiv 1

scholarly journals In Vitro Antiviral Activity and Cross-Resistance Profile of PL-100, a Novel Protease Inhibitor of Human Immunodeficiency Virus Type 1

2007 ◽  
Vol 51 (11) ◽  
pp. 4036-4043 ◽  
Author(s):  
Serge Dandache ◽  
Guy Sévigny ◽  
Jocelyn Yelle ◽  
Brent R. Stranix ◽  
Neil Parkin ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiviral Activity ◽  
Highly Active Antiretroviral Therapy ◽  
Cross Resistance ◽  
Drug Resistant ◽  
Resistance Profile ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Despite the success of highly active antiretroviral therapy, the current emergence and spread of drug-resistant variants of human immunodeficiency virus (HIV) stress the need for new inhibitors with distinct properties. We designed, produced, and screened a library of compounds based on an original l-lysine scaffold for their potentials as HIV type 1 (HIV-1) protease inhibitors (PI). One candidate compound, PL-100, emerged as a specific and noncytotoxic PI that exhibited potent inhibition of HIV-1 protease and viral replication in vitro (Ki , ∼36 pM, and 50% effective concentration [EC50], ∼16 nM, respectively). To confirm that PL-100 possessed a favorable resistance profile, we performed a cross-resistance study using a panel of 63 viral strains from PI-experienced patients selected for the presence of primary PI mutations known to confer resistance to multiple PIs now in clinical use. The results showed that PL-100 retained excellent antiviral activity against almost all of these PI-resistant viruses and that its performance in this regard was superior to those of atazanavir, amprenavir, indinavir, lopinavir, nelfinavir, and saquinavir. In almost every case, the increase in the EC50 for PL-100 observed with viruses containing multiple mutations in protease was far less than that obtained with the other drugs tested. These data underscore the potential for PL-100 to be used in the treatment of drug-resistant HIV disease and argue for its further development.

scholarly journals Variability of HIV-1 Genomes among Children and Adolescents from São Paulo, Brazil

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62552 ◽  
Author(s):  
Sabri Saeed Sanabani ◽  
Rodrigo Pessôa ◽  
Ana Carolina Soares de Oliveira ◽  
Vanessa Pouza Martinez ◽  
Maria Teresa Maidana Giret ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Sao Paulo ◽  
São Paulo ◽  
Hiv 1
Sign in / Sign up

Export Citation Format

Share Document