Access to clean water for drinking and sanitation is an urgent issue that the world is facing. According to the United Nations (UN), approximately one billion people live in extreme poverty, and almost 2.6 billion people live without the basics of adequate sanitation. Over the past two decades, the BioSand Filter has proven to be an effective and efficient point-of-use device to purify water to a potable level in developing countries. The success of this device is due to its simplicity, use of appropriate technology, and sustainability. This chapter discusses a case study of His Hands Mission International’s work installing these filters in the villages of rural Honduras. It focuses on the implementation, adoption, diffusion, and impacts of these filters, providing insight to the system’s factors of success. These factors provide information that can be utilized to improve the chances for success of similar system implementations around the world.