The role of cytokines and immunoglobulins of the oral fluid in the genesis of autoimmune diseases of the oral mucosa

Most prevalent food allergies during early childhood are caused by foods with a high allergenic protein content, such as milk, egg, nuts, or fish. In older subjects, some respiratory allergies progressively lead to food-induced allergic reactions, which can be severe, such as urticaria or asthma. Oral mucosa remodeling has been recently proven to be a feature of severe allergic phenotypes and autoimmune diseases. This remodeling process includes epithelial barrier disruption and the release of inflammatory signals. Although little is known about the immune processes taking place in the oral mucosa, there are a few reports describing the oral mucosa-associated immune system. In this review, we will provide an overview of the recent knowledge about the role of the oral mucosa in food-induced allergic reactions, as well as in severe respiratory allergies or food-induced autoimmune diseases, such as celiac disease.

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PRINCIPLES OF TREATMENT OF PATIENTS WITH PATHOLOGICAL CHANGES IN THE ORAL MUCOSA, TAKING INTO ACCOUNT THE IMMUNOLOGICAL STATUS

Journal of Volgograd State Medical University ◽

10.19163/1994-9480-2020-4(76)-53-55 ◽

2020 ◽

Vol 76 (4) ◽

pp. 53-55

Author(s):

M.V. Svechnikova ◽

◽

I.A. Selezneva ◽

M.A. Postnikov ◽

◽

...

Keyword(s):

Oral Mucosa ◽

Oral Fluid ◽

Local Treatment ◽

Pathological Changes ◽

Chemotherapy Treatment ◽

Immunological Status ◽

Principles Of Treatment ◽

Relationship Of ◽

The Relationship

The article presents data from our own research on the relationship of local oral fluid immunity in patients with acute leukemia and ulcerative-necrotic lesions of the oral mucosa after chemotherapy treatment. The state of the oral mucosa is described, and the role of the immunoassay method is indicated. The principles of local treatment of this category of patients are proposed.

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Faculty Opinions recommendation of Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of conditioning regimen used.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1091205.544604 ◽

2007 ◽

Author(s):

Harold Atkins

Keyword(s):

Stem Cell ◽

Hematopoietic Stem Cell Transplantation ◽

Stem Cell Transplantation ◽

Autoimmune Diseases ◽

Cell Transplantation ◽

Hematopoietic Stem Cell ◽

Conditioning Regimen ◽

Autoimmune Disorder ◽

Hematopoietic Stem

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Role of Positron Emission Tomography for Central Nervous System Involvement in Systemic Autoimmune Diseases: Status and Perspectives

Current Medicinal Chemistry ◽

10.2174/0929867324666170523144402 ◽

2018 ◽

Vol 25 (26) ◽

pp. 3096-3104 ◽

Cited By ~ 3

Author(s):

Daniele Mauro ◽

Gaetano Barbagallo ◽

Salvatore D`Angelo ◽

Pasqualina Sannino ◽

Saverio Naty ◽

...

Keyword(s):

Positron Emission Tomography ◽

Central Nervous System ◽

Nervous System ◽

Autoimmune Diseases ◽

Pet Imaging ◽

Emission Tomography ◽

Cns Involvement ◽

Systemic Autoimmune Diseases ◽

Positron Emission

In the last years, an increasing interest in molecular imaging has been raised by the extending potential of positron emission tomography [PET]. The role of PET imaging, originally confined to the oncology setting, is continuously extending thanks to the development of novel radiopharmaceutical and to the implementation of hybrid imaging techniques, where PET scans are combined with computed tomography [CT] or magnetic resonance imaging[MRI] in order to improve spatial resolution. Early preclinical studies suggested that 18F–FDG PET can detect neuroinflammation; new developing radiopharmaceuticals targeting more specifically inflammation-related molecules are moving in this direction. Neurological involvement is a distinct feature of various systemic autoimmune diseases, i.e. Systemic Lupus Erythematosus [SLE] or Behcet’s disease [BD]. Although MRI is largely considered the gold-standard imaging technique for the detection of Central Nervous System [CNS] involvement in these disorders. Several patients complain of neuropsychiatric symptoms [headache, epilepsy, anxiety or depression] in the absence of any significant MRI finding; in such patients the diagnosis relies mainly on clinical examination and often the role of the disease process versus iatrogenic or reactive forms is doubtful. The aim of this review is to explore the state-of-the-art for the role of PET imaging in CNS involvement in systemic rheumatic diseases. In addition, we explore the potential role of emerging radiopharmaceutical and their possible application in aiding the diagnosis of CNS involvement in systemic autoimmune diseases.

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Recognize Yourself—Innate Sensing of Non-LTR Retrotransposons

Viruses ◽

10.3390/v13010094 ◽

2021 ◽

Vol 13 (1) ◽

pp. 94

Author(s):

Justine Lagisquet ◽

Kilian Zuber ◽

Thomas Gramberg

Keyword(s):

Pattern Recognition ◽

Nucleic Acid ◽

Autoimmune Diseases ◽

Ltr Retrotransposons ◽

Autoinflammatory Disorders ◽

Protective Measures ◽

Active Elements ◽

Enhanced Expression ◽

Long Interspersed Element

Although mobile genetic elements, or transposons, have played an important role in genome evolution, excess activity of mobile elements can have detrimental consequences. Already, the enhanced expression of transposons-derived nucleic acids can trigger autoimmune reactions that may result in severe autoinflammatory disorders. Thus, cells contain several layers of protective measures to restrict transposons and to sense the enhanced activity of these “intragenomic pathogens”. This review focuses on our current understanding of immunogenic patterns derived from the most active elements in humans, the retrotransposons long interspersed element (LINE)-1 and Alu. We describe the role of known pattern recognition receptors in nucleic acid sensing of LINE-1 and Alu and the possible consequences for autoimmune diseases.

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