scholarly journals Oral Mucosa as a Potential Site for Diagnosis and Treatment of Allergic and Autoimmune Diseases

Foods ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 970
Author(s):  
Cristina Gomez-Casado ◽  
Javier Sanchez-Solares ◽  
Elena Izquierdo ◽  
Araceli Díaz-Perales ◽  
Domingo Barber ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Oral Mucosa ◽  
Food Allergies ◽  
Epithelial Barrier ◽  
Allergic Reactions ◽  
Allergenic Protein ◽  
Inflammatory Signals ◽  
Respiratory Allergies ◽  
Older Subjects

Most prevalent food allergies during early childhood are caused by foods with a high allergenic protein content, such as milk, egg, nuts, or fish. In older subjects, some respiratory allergies progressively lead to food-induced allergic reactions, which can be severe, such as urticaria or asthma. Oral mucosa remodeling has been recently proven to be a feature of severe allergic phenotypes and autoimmune diseases. This remodeling process includes epithelial barrier disruption and the release of inflammatory signals. Although little is known about the immune processes taking place in the oral mucosa, there are a few reports describing the oral mucosa-associated immune system. In this review, we will provide an overview of the recent knowledge about the role of the oral mucosa in food-induced allergic reactions, as well as in severe respiratory allergies or food-induced autoimmune diseases, such as celiac disease.

scholarly journals Porphyromonas gingivalis Impairs Oral Epithelial Barrier through Targeting GRHL2

2019 ◽  
Vol 98 (10) ◽  
pp. 1150-1158 ◽  
Author(s):  
W. Chen ◽  
A. Alshaikh ◽  
S. Kim ◽  
J. Kim ◽  
C. Chun ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Oral Mucosa ◽  
Porphyromonas Gingivalis ◽  
Oral Bacteria ◽  
Conditional Knockout ◽  
Epithelial Barrier ◽  
Wild Type ◽  
Oral Epithelial ◽  
Junction Proteins

Oral mucosa provides the first line of defense against a diverse array of environmental and microbial irritants by forming the barrier of epithelial cells interconnected by multiprotein tight junctions (TJ), adherens junctions, desmosomes, and gap junction complexes. Grainyhead-like 2 (GRHL2), an epithelial-specific transcription factor, may play a role in the formation of the mucosal epithelial barrier, as it regulates the expression of the junction proteins. The current study investigated the role of GRHL2 in the Porphyromonas gingivalis ( Pg)–induced impairment of epithelial barrier functions. Exposure of human oral keratinocytes (HOK-16B and OKF6 cells) to Pg or Pg-derived lipopolysaccharides ( Pg LPSs) led to rapid loss of endogenous GRHL2 and the junction proteins (e.g., zonula occludens, E-cadherin, claudins, and occludin). GRHL2 directly regulated the expression levels of the junction proteins and the epithelial permeability for small molecules (e.g., dextrans and Pg bacteria). To explore the functional role of GRHL2 in oral mucosal barrier, we used a Grhl2 conditional knockout (KO) mouse model, which allows for epithelial tissue-specific Grhl2 KO in an inducible manner. Grhl2 KO impaired the expression of the junction proteins at the junctional epithelium and increased the alveolar bone loss in the ligature-induced periodontitis model. Fluorescence in situ hybridization revealed increased epithelial penetration of oral bacteria in Grhl2 KO mice compared with the wild-type mice. Also, blood loadings of oral bacteria (e.g., Bacteroides, Bacillus, Firmicutes, β- proteobacteria, and Spirochetes) were significantly elevated in Grhl2 KO mice compared to the wild-type littermates. These data indicate that Pg bacteria may enhance paracellular penetration through oral mucosa in part by targeting the expression of GRHL2 in the oral epithelial cells, which then impairs the epithelial barrier by inhibition of junction protein expression, resulting in increased alveolar tissue destruction and systemic bacteremia.

scholarly journals Permeable gut syndrome, gluten, and autoimmune disease: an integrative review

2021 ◽  
Vol 14 (3) ◽  
Author(s):  
Etianne Andrade Araújo ◽  
Alexandre Carli Pinto ◽  
Danilo Everton Cunha Cavalcante ◽  
Francione Moreira Cabral ◽  
Jhonatas Mota Santos ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Intestinal Permeability ◽  
Inflammatory Diseases ◽  
Intestinal Wall ◽  
The Body ◽  
Food Allergies ◽  
Leaky Gut ◽  
Basic Functions ◽  
To Come

Introduction: Leaky Bowel Syndrome or intestinal permeability is a gastrointestinal condition that affects many people. A leaky gut is a trigger for many changes like food allergies and intolerances, autoimmune diseases, colitis, Crohn's and celiac disease, inflammatory diseases, depression, insulin resistance and even cancer have been linked. Objective: To analyze basic information for a better understanding of this topic, from the functioning of the gastrointestinal tract, as the diseases that are associated with it, how the immune system responds to these injuries, the quality, and importance of proteins, and the consequence of this disorder to the body human. Methods: Conducted an integrative literature review. The Pubmed, Google Scholar, and Scielo databases were consulted. Results: The intestine is naturally permeable to many small molecules, so it can absorb vital nutrients. Regulating intestinal permeability is one of the most basic functions of the cells that make up the intestinal wall. But one factor calls our attention, what is the role of gluten in the development of this disease and the worsening of symptoms? Insensitive people, gluten can cause cells to release zonulin, a protein that can break the tight junctions of intestinal tissue. Other factors—such as infections, toxins, stress, and age—can also cause these joints to come apart. Once strong joints break, you have a leaky gut. Gluten, therefore, is the number one cause of this process. A person with a leaky intestine tends to be highly allergic and intolerant to foods and substances, and may or may not manifest intestinal discomfort such as gas and bloating. Conclusion: Based on the literature that supports this theme, it is considered that gluten is a possible villain in the intestinal tract and is related to many autoimmune diseases. Furthermore, as an interventional measure, it is necessary to reduce some carbohydrate-rich foods and the maintenance of the body's balance with specific diets and physical activities.

The role of cytokines and immunoglobulins of the oral fluid in the genesis of autoimmune diseases of the oral mucosa

Stomatologiya ◽  
2019 ◽  
Vol 98 (6) ◽  
pp. 37
Author(s):  
O.F. Rabinovich ◽  
I.M. Rabinovich ◽  
E.S. Abramova
Keyword(s):  
Autoimmune Diseases ◽  
Oral Mucosa ◽  
Oral Fluid

The role of cytokines and immunoglobulins of the oral fluid in the genesis of autoimmune diseases of the oral mucosa

Stomatologiya ◽  
2019 ◽  
Vol 98 (6) ◽  
pp. 42
Author(s):  
O. F. Rabinovich ◽  
I. M. Rabinovich ◽  
E. S. Abramova
Keyword(s):  
Autoimmune Diseases ◽  
Oral Mucosa ◽  
Oral Fluid

scholarly journals Role of the Epidermal Barrier in the Formation of Food Allergies in Children with Genodermatosis

2019 ◽  
Vol 16 (4) ◽  
pp. 234-240 ◽  
Author(s):  
Nikolay N. Murashkin ◽  
Roman A. Ivanov ◽  
A. A. Savelova ◽  
D. V. Fedorov ◽  
L. A. Opryatin ◽  
...  
Keyword(s):  
High Risk ◽  
Food Allergies ◽  
Allergic Reactions ◽  
Epidermal Barrier ◽  
Netherton Syndrome ◽  
Clinical Cases

The article analyzes the most significant genodermatoses associated with a high risk of allergic reactions that may occur in the practice of a dermatologist and pediatrician, such as ichthyosis and ichthyosiform dermatoses, Netherton syndrome and other ichthyosiform erythroderma, peeling skin syndrome, SAM syndrome, as well as congenital bullous epidermolysis. The article also describes in detail the pathogenetic aspects of transcutaneous sensitization, the development of food allergies and the listed above genodermatoses, two illustrative clinical cases are given.

scholarly journals Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2056
Author(s):  
Craig Friesen ◽  
Jennifer Colombo ◽  
Jennifer Schurman
Keyword(s):  
Abdominal Pain ◽  
Current Model ◽  
Mast Cell Activation ◽  
Oral Allergy Syndrome ◽  
Food Allergies ◽  
Allergic Reactions ◽  
Clinical Perspective ◽  
Functional Abdominal Pain ◽  
Food Antigens

Both functional abdominal pain disorders (FAPDs) and food allergies are relatively common in children and adolescents, and most studies report an association between FAPDs and allergic conditions. FAPDs share pathophysiologic processes with allergies, including both immune and psychological processes interacting with the microbiome. No conclusive data are implicating IgE-mediated reactions to foods in FAPDs; however, there may be patients who have IgE reactions localized to the gastrointestinal mucosa without systemic symptoms that are not identified by common tests. In FAPDs, the data appears stronger for aeroallergens than for foods. It also remains possible that food antigens initiate an IgG reaction that promotes mast cell activation. If a food allergen is identified, the management involves eliminating the specific food from the diet. In the absence of systemic allergic symptoms or oral allergy syndrome, it appears unlikely that allergic triggers for FAPDs can be reliably identified by standard testing. Medications used to blunt allergic reactions or symptomatically treat allergic reactions may be useful in FAPDs. The purpose of the current manuscript is to review the current literature regarding the role of allergy in FAPDs from a clinical perspective, including how allergy may fit in the current model of FAPDs.

Allergic Reactions to Food Proteins

2011 ◽  
Vol 81 (23) ◽  
pp. 173-180 ◽  
Author(s):  
Barbara K. Ballmer-Weber
Keyword(s):  
Food Allergies ◽  
Allergic Reactions ◽  
Allergenic Food ◽  
Processed Foods ◽  
Legal Regulations ◽  
Pollen Allergens ◽  
Curative Therapy ◽  
Novel Foods ◽  
Allergenic Proteins ◽  
Adolescents And Adults

Four to eight percent of the population are estimated to be food-allergic. Most food allergies in adolescents and adults are acquired on the basis of cross-reaction to pollen allergens. Theses allergens are ubiquitous in the plant kingdom. Therefore pollen-allergic patients might acquire a multitude of different plant food allergies, and even react to novel foods to which they have never previously been exposed. A curative therapy for food allergy does not yet exist. Food-allergic patients have to rely on strict avoidance diets, The widespread use of industrially processed foods poses a general problem for food-allergic patients. Although the most frequent allergens must be declared openly in the list of ingredients, involuntary contamination with allergy-provoking compounds can occur. The precautionary labelling “may contain” is sometimes applied even if the chance of contamination is very low; on the other hand, foods not declared to contain possible traces of allergenic components may actually contain relevant amounts of allergenic proteins. Switzerland is the only country in Europe with legal regulations on contamination by allergenic food; however, the allowance of 1 g/kg is too high to protect a relevant proportion of food-allergic individuals.

НЕКОТОРЫЕ ОСОБЕННОСТИ РАСПРОСТРАНЕННОСТИ РЕСПИРАТОРНОЙ АЛЛЕРГИИ НА ЮГЕ РОССИИ

2019 ◽  
Author(s):  
D.Sh. Macharadze
Keyword(s):  
Dominant Role ◽  
Pollen Allergy ◽  
Respiratory Allergy ◽  
House Dust Mites ◽  
Dust Mites ◽  
The Past ◽  
Regional Features ◽  
Respiratory Allergies ◽  
Southern Russia

В обзорной статье приведены данные по распространенности респираторной аллергии - аллергического ринита и бронхиальной астмы на юге России, опубликованные за последние десятилетия. Показана доминирующая роль пыльцевой аллергии практически во всем южном регионе России. В Чеченской Республике у больных респираторной аллергией обнаружена сходная частота встречаемости сенсибилизации к клещам домашней пыли и пыльце злаковых трав (51,1 и 52,5 соответственно), тогда как сенсибилизация к пыльце амброзии и полыни встречалась в 3 раза реже (26,6 и 20,7 соответственно) по сравнению с соседними регионами юга России. Эти данные демонстрируют климатогеографические, экологические и другие региональные особенности в распространении респираторной аллергии.The review article presents data on the prevalence of respiratory allergy - allergic rhinitis and bronchial asthma in southern Russia, published over the past decades. The dominant role of pollen allergy is shown in almost the entire southern region of Russia. In the Chechen Republic, sensitization to house dust mites and grass pollen was found in patients with respiratory allergy equally (51.1 and 52.5, respectively), whereas ragweed and mugwort sensitization was 3 times less (26.6 and 20.7, respectively) compared with the neighboring regions of southern Russia. These data demonstrate climate-geographical, environmental and other regional features in the prevalence of respiratory allergies.

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