scholarly journals Histopathological Analysis of the Pro-Arrhythmogenic Changes in a Suspected Chagas Disease Sudden Death

2020 ◽  
Vol 7 (1) ◽  
pp. 11-16
Author(s):  
Héctor O. Rodríguez ◽  
Keyword(s):  
Sudden Death ◽  
Chagas Disease ◽  
Vital Signs ◽  
Histopathological Analysis ◽  
Ischemic Disease ◽  
Chronic Myocarditis ◽  
Massive Necrosis ◽  
Structural Disease ◽  
Death Cases ◽  
Malignant Arrhythmias

Background Sudden death is the principal cause of fatality in Chagas disease, afflicting to non-symptomatic patients younger than 50-years. For this, sudden death associated with chagasic malignant arrhythmias is underdiagnosed and their pathophysiological basis is poorly understood. Aims In this sense, this work aimed to analyze the histopathological alterations in cardiac structures specialized in the generation/conduction of action potential in an anatomopathological case of non-diagnosed sudden death living in a Chagasic endemic area. Methods The donor was a woman, 62-year-old, which ingressed without vital signs to the emergency room of “Antonio María Pineda” hospital, without any apparent antecedents of cardiac disease. The gross examination was normal, with no external evidence of structural/ischemic disease. Results Microscopic examination revealed nodal like cell depopulation, microvascular disturbances, chronic myocarditis with mononuclear and mast cell infiltrate plus extracellular matrix reaction, and profuse damage of neural structures placed in nodal region. Amastigote nest of Trypanosoma cruzi (T. cruzi) was detected. Conclusion These findings suggest a complex association among parasite persistence, sinus disease, micro-ischemia foci, and neural inflammation in the genesis of malignant arrhythmias of Chagas disease despite the absence of structural disease or massive necrosis. It is important to perform a protocol of examination for no explained sudden death cases in chagasic endemic countries, to avoid misdiagnosed of sudden death associated with Chagas disease.

Anticonvulsant Use Elevated In Sudden Death Cases

2010 ◽  
Vol 40 (2) ◽  
pp. 12
Author(s):  
MITCHEL L. ZOLER
Keyword(s):  
Sudden Death ◽  
Death Cases

scholarly journals Re-evaluation of single nucleotide variants and identification of structural variants in a cohort of 45 sudden unexplained death cases

2021 ◽  
Author(s):  
Jacqueline Neubauer ◽  
Shouyu Wang ◽  
Giancarlo Russo ◽  
Cordula Haas
Keyword(s):  
Sudden Death ◽  
Cardiac Diseases ◽  
Structural Variants ◽  
Single Nucleotide Variants ◽  
Single Nucleotide ◽  
Sudden Unexplained Death ◽  
Unexplained Death ◽  
Pathogenic Variants ◽  
The Impact ◽  
Death Cases

AbstractSudden unexplained death (SUD) takes up a considerable part in overall sudden death cases, especially in adolescents and young adults. During the past decade, many channelopathy- and cardiomyopathy-associated single nucleotide variants (SNVs) have been identified in SUD studies by means of postmortem molecular autopsy, yet the number of cases that remain inconclusive is still high. Recent studies had suggested that structural variants (SVs) might play an important role in SUD, but there is no consensus on the impact of SVs on inherited cardiac diseases. In this study, we searched for potentially pathogenic SVs in 244 genes associated with cardiac diseases. Whole-exome sequencing and appropriate data analysis were performed in 45 SUD cases. Re-analysis of the exome data according to the current ACMG guidelines identified 14 pathogenic or likely pathogenic variants in 10 (22.2%) out of the 45 SUD cases, whereof 2 (4.4%) individuals had variants with likely functional effects in the channelopathy-associated genes SCN5A and TRDN and 1 (2.2%) individual in the cardiomyopathy-associated gene DTNA. In addition, 18 structural variants (SVs) were identified in 15 out of the 45 individuals. Two SVs with likely functional impairment were found in the coding regions of PDSS2 and TRPM4 in 2 SUD cases (4.4%). Both were identified as heterozygous deletions, which were confirmed by multiplex ligation-dependent probe amplification. In conclusion, our findings support that SVs could contribute to the pathology of the sudden death event in some of the cases and therefore should be investigated on a routine basis in suspected SUD cases.

scholarly journals Sudden death of adults in Togo: Autopsy results of a series of 318 cases

2019 ◽  
Author(s):  
Tchin Darre ◽  
Toukilnan Djiwa ◽  
Gado Napo-Koura
Keyword(s):  
Risk Factors ◽  
Pulmonary Embolism ◽  
Sex Ratio ◽  
Sudden Death ◽  
Traffic Accidents ◽  
Cardiac Pathology ◽  
Common Cause ◽  
Cerebral Involvement ◽  
The Mean ◽  
Death Cases

Abstract Objectives: The purpose of the study was to determine the circumstances of occurrence of these sudden deaths, risk factors, to identify the causes of sudden death in adults at autopsy. Results: A total of 318 sudden death cases were recorded. The sex ratio (M/F) was 1.8, and the mean age was 43 ± 0.36 years. Sudden deaths were the second most common reason for autopsies after traffic accidents. The place of death was home in 76.7% of cases and in hospitals in 23.3%. Obesity was noted in 59.4%, with an umbilical adipose panicle varying between 7 and 12 cm thick. Cardiovascular causes excluding cerebral involvement (n=173cases, 54.40%) followed by pulmonary causes (n=100 cases, 31.44%) were the most common cause of sudden death. The predominant cardiac pathology was infarction accounting for 32.07% of all causes of sudden death, and pulmonary embolism with 19.49% was the leading cause at the pulmonary level.

scholarly journals Large pulmonary sclerosing pneumocytoma with massive necrosis and vascular invasion: a case report

2019 ◽  
Vol 2019 (7) ◽  
Author(s):  
Takashi Sakai ◽  
Tomohiro Miyoshi ◽  
Shigeki Umemura ◽  
Jun Suzuki ◽  
Shoko Nakasone ◽  
...  
Keyword(s):  
Lymph Node ◽  
Vascular Invasion ◽  
Advanced Lung Cancer ◽  
Resected Specimen ◽  
Histopathological Analysis ◽  
Node Dissection ◽  
Node Metastasis ◽  
Massive Necrosis ◽  
Left Pneumonectomy ◽  
Malignant Behavior

Abstract Pulmonary sclerosing pneumocytoma (PSP) is pathologically classified as an adenoma and behaves in a benign manner. However, some cases of PSP displayed pathologically malignant behavior, such as lymph node metastasis and necrosis. A 64-year-old woman was referred to our hospital complaining of a cough and breathlessness. Histopathological analysis of the resected specimen by left pneumonectomy and lymph node dissection revealed a large PSP measuring 15 × 14 cm in size, with massive necrosis and vascular invasion. This case was the largest ever reported and suggested that clinico-histological presentation of PSP sometimes showed an aggressive phenotype like advanced lung cancer.

scholarly journals Sudden unexpected death caused by stroke: A nationwide study among children and young adults in Denmark

2017 ◽  
Vol 13 (3) ◽  
pp. 285-291 ◽  
Author(s):  
Frederik Nybye Ågesen ◽  
Bjarke Risgaard ◽  
Sára Zachariasardóttir ◽  
Reza Jabbari ◽  
Thomas Hadberg Lynge ◽  
...  
Keyword(s):  
Young Adults ◽  
Sudden Death ◽  
Cause Of Death ◽  
Neurological Symptoms ◽  
Unexpected Death ◽  
Stroke Subtype ◽  
Nationwide Study ◽  
Male Predominance ◽  
Children And Young Adults ◽  
Death Cases

Background Stroke is the fifth leading cause of death in young individuals globally. Data on the burden of sudden death by stroke are sparse in the young. Aims The aim of this study was to report mortality rates, cause of death, stroke subtype, and symptoms in children and young adults who suffered sudden death by stroke. Methods We conducted a retrospective, nationwide study including all deaths within Danish borders between 2000–2009 and 2007–2009 in persons aged 1–35 years and 36–49 years, respectively. Two physicians identified all sudden death cases through review of all death certificates. All available autopsy reports and records from hospitals and general practitioners were retrieved and a neurologist identified all sudden death by stroke cases. Results Of the 14,567 deaths in the 10-year period, there were 1,698 sudden death cases, of which 52 (3%) were sudden death by stroke. There was a male predominance (56%) and the median age was 33 years. The incidence of sudden death by stroke in individuals aged 1–49 years was 0.19 deaths per 100,000 person-years. Stroke was hemorrhagic in 94% of cases, whereof subarachnoid hemorrhage was the cause of death in 63% of cases. Seventeen (33%) cases contacted the healthcare system because of neurological symptoms, whereof one was suspected of having a stroke (6%). Conclusions Sudden death by stroke in children and young adults occurs primarily due to hemorrhagic stroke. We report a high frequency of neurological symptoms prior to sudden death by stroke. Increased awareness among healthcare professionals towards stroke symptoms in children and young adults may lead to earlier detection of stroke, and thereby potentially lowering the incidence of sudden death by stroke.

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