scholarly journals Cyclooxygenase inhibitors and the exercise-induced stress response

2006 ◽  
Vol 18 (1) ◽  
pp. 4 ◽  
Author(s):  
N Claassen ◽  
J Snyman ◽  
A Koorts ◽  
H Nolte ◽  
B Wagenaar ◽  
...  
Keyword(s):  
Single Dose ◽  
Stress Response ◽  
Sports Medicine ◽  
Temperature Response ◽  
Cyclooxygenase Inhibitors ◽  
Double Blind ◽  
Post Exercise ◽  
Induced Stress ◽  
Cyclooxygenase 1 ◽  
Exercise Induced

Objective. This study investigated the effects of single dosages of the non-steroidal anti-inflammatory drug (NSAID) naproxen, and of the coxib, rofecoxib, on the exercise-induced stress response. Design. Eight subjects (age 20.9 ± 1.1 years, weight 70.4 ± 3.9 kg, height 170.9 ± 6.7 cm, body surface area 1.82 ± 0.09 m2, body mass index 24.1 ± 1.3 kg.m-2) took part in a double-blind, drug-placebo, cross-over design study. The experimental procedures were performed on 3 occasions on each volunteer, i.e. once on placebo, once on naproxen (single dose of 1 000 mg) and once on rofecoxib (single dose of 50 mg). Results. Mean post-exercise cortisol values were significantly higher than pre-exercise values with the subjects on placebo (p = 0.0365) and rofecoxib (p = 0.0208), but not on naproxen (p = 0.0732). Post-exercise oral temperatures were significantly higher than pre-exercise temperature values on placebo (p = 0.0153) and rofecoxib (p = 0.0424), but not on naproxen (p = 0.5444). Conclusion. The results of this study suggest a role for cyclooxygenase-1 (COX-1) in the exercise-induced cortisol and temperature response to exercise. South African Journal of Sports Medicine Vol. 18 (1) 2006: pp. 4-8

scholarly journals Cyclooxygenase inhibitors and the exercise-induced stress response

2009 ◽  
Vol 18 (1) ◽  
pp. 4
Author(s):  
N Claassen ◽  
J Snyman ◽  
A Koorts ◽  
H Nolte ◽  
B Wagenaar ◽  
...  
Keyword(s):  
Single Dose ◽  
Stress Response ◽  
Sports Medicine ◽  
Temperature Response ◽  
Cyclooxygenase Inhibitors ◽  
Double Blind ◽  
Post Exercise ◽  
Induced Stress ◽  
Cyclooxygenase 1 ◽  
Exercise Induced

Objective. This study investigated the effects of single dosages of the non-steroidal anti-inflammatory drug (NSAID) naproxen, and of the coxib, rofecoxib, on the exercise-induced stress response. Design. Eight subjects (age 20.9 ± 1.1 years, weight 70.4 ± 3.9 kg, height 170.9 ± 6.7 cm, body surface area 1.82 ± 0.09 m2, body mass index 24.1 ± 1.3 kg.m-2) took part in a double-blind, drug-placebo, cross-over design study. The experimental procedures were performed on 3 occasions on each volunteer, i.e. once on placebo, once on naproxen (single dose of 1 000 mg) and once on rofecoxib (single dose of 50 mg). Results. Mean post-exercise cortisol values were significantly higher than pre-exercise values with the subjects on placebo (p = 0.0365) and rofecoxib (p = 0.0208), but not on naproxen (p = 0.0732). Post-exercise oral temperatures were significantly higher than pre-exercise temperature values on placebo (p = 0.0153) and rofecoxib (p = 0.0424), but not on naproxen (p = 0.5444). Conclusion. The results of this study suggest a role for cyclooxygenase-1 (COX-1) in the exercise-induced cortisol and temperature response to exercise. South African Journal of Sports Medicine Vol. 18 (1) 2006: pp. 4-8

Effect of SunGold TM Kiwifruit and Vitamin C Consumption on Ameliorating Exercise‐Induced Stress Response in Women

2021 ◽  
pp. 2001219
Author(s):  
Ajmol Ali ◽  
Sunali Mehta ◽  
Carlene Starck ◽  
Marie Wong ◽  
Wendy J. O'Brien ◽  
...  
Keyword(s):  
Stress Response ◽  
Vitamin C ◽  
Induced Stress ◽  
Exercise Induced

New Drug Evaluation Using Exercise-Induced Bronchospasm

PEDIATRICS ◽  
1975 ◽  
Vol 56 (5s) ◽  
pp. 937-939
Author(s):  
Arthur C. Sprenkle ◽  
Paul P. VanArsdel ◽  
C. Warren Bierman
Keyword(s):  
Oral Dose ◽  
Drug Evaluation ◽  
Clinical Effectiveness ◽  
Significant Inhibition ◽  
Optimal Dosage ◽  
Significant Activity ◽  
Double Blind ◽  
Post Exercise ◽  
Exercise Induced ◽  
Orally Active

Exercise-induced asthma was used to demonstrate that a xanthone, a new orally active cromolynlike drug, has significant activity in man. The effect of a single oral dose of 8 mg/kg was studied in a double-blind cross-over fashion at two and five hours after administration, with significant inhibition of post-exercise bronchopasm being seen at five hours. Further study seems indicated to determine optimal dosage and clinical effectiveness.

scholarly journals Efficacy of Nx4 to Reduce Plasma Cortisol and Gastrin Levels in Norwegian Sled Dogs During an Exercise Induced Stress Response: A Prospective, Randomized, Double Blinded, Placebo-Controlled Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Alexandra Keller ◽  
Jana Conradi ◽  
Corinna Weber ◽  
Klaus Failing ◽  
Melanie Wergin
Keyword(s):  
Placebo Group ◽  
Stress Response ◽  
Plasma Cortisol ◽  
High Performance ◽  
Main Study ◽  
Plasma Gastrin ◽  
Induced Stress ◽  
Sled Dogs ◽  
Exercise Induced ◽  
Double Blinded

Introduction: An exercise induced stress response is commonly seen in high performance sled dogs, resulting in increased plasma cortisol. A stress induced rise of cortisol might result in increased prevalence of gastritis and gastric ulcers mediated by an increase of gastrin. Neurexan® (Nx4) is a medicinal product used for stress relief by reduction of cortisol. The aim of the study was to show that Nx4 reduces plasma cortisol and plasma gastrin in high performance sled dogs and to show tolerability of Nx4 in dogs.Material and Methods: First, a pilot study was done to validate the increase of cortisol by performance. The data from the pilot study was used for sample size estimation via an adapted power analysis as well as the identification of important variables. These were then used in the randomization procedure of the main study. Second, a prospective randomized, double blinded, placebo-controlled cohort study was conducted. The main study included 45 sled dogs, assigning 23 dogs to the Nx4 group, and 22 dogs to the placebo group, to analyze plasma cortisol and plasma gastrin at four time points: before, directly after and 30 and 120 min after performance.Results: For the main target variable, area under the curve (AUC) of plasma cortisol, a significantly lower adjusted mean value in the Nx4 group compared to the placebo group (p = 0.031) was found. Plasma gastrin was also significantly reduced in the Nx4 group 30 min after performance (p = 0.023), resulting in a significantly reduced plasma gastrin AUC in the Nx4 group compared to the placebo group (p = 0.049).Discussion: Within the limitation of the study, the results carry implications for the usefulness of Nx4 to reduce exercise induced plasma cortisol and gastrin levels. The reduction of the exercise induced stress response could help to improve the welfare of high-performance sled dogs. Since activation of the hypothalamic-pituitary-adrenal axis resulting in increased cortisol is similar for exercise induced stress and psychologic stress, the same might be true independent of the stressor, making Nx4 potentially useful in any stressful situation for dogs.

scholarly journals Mountain bike racing - the influence of prior glycogen-inducing exercise and glutamine supplementation on selected stress and immune parameters

2006 ◽  
Vol 18 (4) ◽  
pp. 122
Author(s):  
C Smith ◽  
KH Myburgh
Keyword(s):  
Sports Medicine ◽  
Suppressive Effect ◽  
Relative Increase ◽  
Exercise Stress ◽  
Glutamine Supplementation ◽  
Monocyte Count ◽  
Mountain Bike ◽  
Double Blind ◽  
Post Exercise ◽  
Immune Parameters

Objective. To investigate the effect of pre-exercise glutamine supplementation and the influence of a prior acute bout of glycogen-reducing exercise on the general stress and immune response to acute high-intensity cycling. Design. Randomised, double-blind, cross-over supplementation study. Setting and intervention. Subjects performed a series of 4 simulated mountain-bike races lasting ≈60 minutes each on separate days 1 week apart, with/ without prior glycogen- reducing exercise on a known outdoor course with/ without pre-exercise glutamine supplementation. Blood samples were collected pre- and immediately post-exercise after each race. Main outcome measures. Circulating concentrations of cortisol (COR) and dehydroepiandrosterone-sulphate (DHEAS) were assessed at all time points, as well as changes in white blood cell (WBC) subpopulation distribution. Results. COR was elevated in all groups post-exercise (p < 0.0001), but neither glycogen reduction, nor glutamine supplementation had any effect. DHEAs increased post-exercise (p < 0.05), with a greater relative increase in glutamine-supplemented subjects (p = 0.07). Total WBC and neutrophil counts in all groups were elevated after exercise (both p < 0.0005). Glutamine supplementation had no effect on differential WBC counts or distribution, but total WBC (p = 0.06) and monocyte (p < 0.05) counts showed greater increases after glycogen reduction. Gluta- mine supplementation was associated with greater postexercise decreases in CD4+ count (p = 0.07) and CD4+: CD8+ ratio (p = 0.01) after glycogen-reducing exercise. Conclusions. We conclude that pre-exercise glutamine supplementation may have an anticortisol effect by enhancing the DHEAS response to exercise stress. The suppressive effect of glutamine supplementation on CD4+: CD8+ ratio and its positive effect on monocyte count after repeated bouts of exercise warrants further investigation. South African Journal of Sports Medicine Vol. 18 (4) 2006: pp. 122-128

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