New Drug Evaluation Using Exercise-Induced Bronchospasm

PEDIATRICS ◽  
1975 ◽  
Vol 56 (5s) ◽  
pp. 937-939
Author(s):  
Arthur C. Sprenkle ◽  
Paul P. VanArsdel ◽  
C. Warren Bierman
Keyword(s):  
Oral Dose ◽  
Drug Evaluation ◽  
Clinical Effectiveness ◽  
Significant Inhibition ◽  
Optimal Dosage ◽  
Significant Activity ◽  
Double Blind ◽  
Post Exercise ◽  
Exercise Induced ◽  
Orally Active

Exercise-induced asthma was used to demonstrate that a xanthone, a new orally active cromolynlike drug, has significant activity in man. The effect of a single oral dose of 8 mg/kg was studied in a double-blind cross-over fashion at two and five hours after administration, with significant inhibition of post-exercise bronchopasm being seen at five hours. Further study seems indicated to determine optimal dosage and clinical effectiveness.

scholarly journals Cyclooxygenase inhibitors and the exercise-induced stress response

2006 ◽  
Vol 18 (1) ◽  
pp. 4 ◽  
Author(s):  
N Claassen ◽  
J Snyman ◽  
A Koorts ◽  
H Nolte ◽  
B Wagenaar ◽  
...  
Keyword(s):  
Single Dose ◽  
Stress Response ◽  
Sports Medicine ◽  
Temperature Response ◽  
Cyclooxygenase Inhibitors ◽  
Double Blind ◽  
Post Exercise ◽  
Induced Stress ◽  
Cyclooxygenase 1 ◽  
Exercise Induced

Objective. This study investigated the effects of single dosages of the non-steroidal anti-inflammatory drug (NSAID) naproxen, and of the coxib, rofecoxib, on the exercise-induced stress response. Design. Eight subjects (age 20.9 ± 1.1 years, weight 70.4 ± 3.9 kg, height 170.9 ± 6.7 cm, body surface area 1.82 ± 0.09 m2, body mass index 24.1 ± 1.3 kg.m-2) took part in a double-blind, drug-placebo, cross-over design study. The experimental procedures were performed on 3 occasions on each volunteer, i.e. once on placebo, once on naproxen (single dose of 1 000 mg) and once on rofecoxib (single dose of 50 mg). Results. Mean post-exercise cortisol values were significantly higher than pre-exercise values with the subjects on placebo (p = 0.0365) and rofecoxib (p = 0.0208), but not on naproxen (p = 0.0732). Post-exercise oral temperatures were significantly higher than pre-exercise temperature values on placebo (p = 0.0153) and rofecoxib (p = 0.0424), but not on naproxen (p = 0.5444). Conclusion. The results of this study suggest a role for cyclooxygenase-1 (COX-1) in the exercise-induced cortisol and temperature response to exercise. South African Journal of Sports Medicine Vol. 18 (1) 2006: pp. 4-8

scholarly journals Cyclooxygenase inhibitors and the exercise-induced stress response

2009 ◽  
Vol 18 (1) ◽  
pp. 4
Author(s):  
N Claassen ◽  
J Snyman ◽  
A Koorts ◽  
H Nolte ◽  
B Wagenaar ◽  
...  
Keyword(s):  
Single Dose ◽  
Stress Response ◽  
Sports Medicine ◽  
Temperature Response ◽  
Cyclooxygenase Inhibitors ◽  
Double Blind ◽  
Post Exercise ◽  
Induced Stress ◽  
Cyclooxygenase 1 ◽  
Exercise Induced

Objective. This study investigated the effects of single dosages of the non-steroidal anti-inflammatory drug (NSAID) naproxen, and of the coxib, rofecoxib, on the exercise-induced stress response. Design. Eight subjects (age 20.9 ± 1.1 years, weight 70.4 ± 3.9 kg, height 170.9 ± 6.7 cm, body surface area 1.82 ± 0.09 m2, body mass index 24.1 ± 1.3 kg.m-2) took part in a double-blind, drug-placebo, cross-over design study. The experimental procedures were performed on 3 occasions on each volunteer, i.e. once on placebo, once on naproxen (single dose of 1 000 mg) and once on rofecoxib (single dose of 50 mg). Results. Mean post-exercise cortisol values were significantly higher than pre-exercise values with the subjects on placebo (p = 0.0365) and rofecoxib (p = 0.0208), but not on naproxen (p = 0.0732). Post-exercise oral temperatures were significantly higher than pre-exercise temperature values on placebo (p = 0.0153) and rofecoxib (p = 0.0424), but not on naproxen (p = 0.5444). Conclusion. The results of this study suggest a role for cyclooxygenase-1 (COX-1) in the exercise-induced cortisol and temperature response to exercise. South African Journal of Sports Medicine Vol. 18 (1) 2006: pp. 4-8

scholarly journals Effects of inhaled salbutamol in exercising non-asthmatic athletes

Thorax ◽  
2001 ◽  
Vol 56 (9) ◽  
pp. 675-679
Author(s):  
C Goubault ◽  
M-C Perault ◽  
E Leleu ◽  
S Bouquet ◽  
P Legros ◽  
...  
Keyword(s):  
Endurance Performance ◽  
Cycle Ergometer ◽  
Metabolic Parameters ◽  
High Dose ◽  
Double Blind ◽  
Endurance Time ◽  
Post Exercise ◽  
Potassium Lactate ◽  
Exercise Induced ◽  
Inhaled Salbutamol

BACKGROUNDBeta-2 agonists such as salbutamol are used, not only by asthmatic athletes to prevent exercise induced asthma, but also by non-asthmatic athletes as a potentially ergogenic agent. We have investigated whether inhaled salbutamol enhances endurance performance in non-asthmatic athletes.METHODSA prospective double blind, randomised, three way crossover design was used to study the effects of 200 μg and 800 μg inhaled salbutamol versus a placebo in 12 trained triathletes. The treatments were compared in three identical cycle ergometer sessions at 85% of the predetermined maximal oxygen uptake. Lung function, endurance time, metabolic parameters (glucose, potassium, lactate, free fatty acid, and glycerol), and psychomotor performance were evaluated.RESULTSNeither endurance time nor post-exercise bronchodilation were significantly different between the treatments. Metabolic parameters were affected by exercise but not by treatment.CONCLUSIONSInhaled salbutamol, even in a high dose, did not have a significant effect on endurance performance in non-asthmatic athletes, although the bronchodilating effect of the drug at the beginning of exercise may have improved respiratory adaptation. Our results do not preclude an ergogenic effect of β2 agonists given by other routes or for a longer period.

scholarly journals Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects

1999 ◽  
Vol 141 (1) ◽  
pp. 22-26 ◽  
Author(s):  
DR Meeking ◽  
JD Wallace ◽  
RC Cuneo ◽  
M Forsling ◽  
DL Russell-Jones
Keyword(s):  
Initial Period ◽  
Area Under The Curve ◽  
Random Order ◽  
Controlled Study ◽  
Double Blind ◽  
Post Exercise ◽  
Gh Secretion ◽  
Exercise Induced ◽  
Male Subjects ◽  
Peak Increase

There is evidence that melatonin may play a role in modulating pituitary secretion, although the mechanisms are unclear. We examined the effects of a single dose of oral melatonin (5mg) on exercise-induced GH secretion. In a randomised, double-blind, placebo-controlled study, seven healthy male subjects undertook an initial period of graded bicycle ergometric exercise to determine maximum workload and oxygen uptake (VO(2max)). Subjects were subsequently studied on two further occasions, receiving either melatonin or placebo in random order at the onset of each study (-60min). At 0 min a period of bicycle exercise was performed for 8 min at a workload corresponding to 70% of that achieved at VO(2max). Serum GH and IGF-binding protein-1 (IGFBP-1) concentration was measured at 15-min intervals from the onset of the study until 120 min post-exercise. Blood was also sampled for the measurement of plasma glucose, insulin, non-esterified fatty acids, IGFBP-3, melatonin and vasopressin concentration. There was an exercise-induced increase in GH concentration following melatonin which was greater compared with placebo as assessed by both area under the curve (P<0.01) and peak increase in GH levels (P<0.01). The peak increase in IGFBP-1 levels post-exercise was also significantly greater following melatonin compared with placebo (P<0. 01) but did not quite reach levels of significance as measured by area under the curve (P=0.07). Since exercise-induced GH secretion is thought to be mediated predominantly through a hypothalamic pathway, it seems likely that melatonin facilitates GH secretion at a hypothalamic level.

scholarly journals No Effect of Tart Cherry Juice or Pomegranate Juice on Recovery from Exercise-Induced Muscle Damage in Non-Resistance Trained Men

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1593 ◽  
Author(s):  
Kirstie L. Lamb ◽  
Mayur K. Ranchordas ◽  
Elizabeth Johnson ◽  
Jessica Denning ◽  
Faye Downing ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
Voluntary Contraction ◽  
Pomegranate Juice ◽  
Elbow Flexors ◽  
Tart Cherry ◽  
Double Blind ◽  
Post Exercise ◽  
Cherry Juice ◽  
Exercise Induced

Tart cherry juice (TC) and pomegranate juice (POM) have been demonstrated to reduce symptoms of exercise-induced muscle damage (EIMD), but their effectiveness has not been compared. This randomized, double-blind, parallel study compared the effects of TC and POM on markers of EIMD. Thirty-six non-resistance trained men (age 24.0 (Interquartile Range (IQR) 22.0, 33.0) years, body mass index (BMI) 25.6 ± 4.0 kg·m−2) were randomly allocated to consume 2 × 250 mL of: TC, POM, or an energy-matched fruit-flavored placebo drink twice daily for nine days. On day 5, participants undertook eccentric exercise of the elbow flexors of their non-dominant arm. Pre-exercise, immediately post-exercise, and at 24 h, 48 h, 72 h and 96 h post-exercise, maximal isometric voluntary contraction (MIVC), delayed onset muscle soreness (DOMS), creatine kinase (CK), and range of motion (ROM) were measured. The exercise protocol induced significant decreases in MIVC (p < 0.001; max decrease of 26.8%, 24 h post-exercise) and ROM (p = 0.001; max decrease of 6.8%, 72 h post-exercise) and significant increases in CK (p = 0.03; max increase 1385 U·L−1, 96 h post-exercise) and DOMS (p < 0.001; max increase of 26.9 mm, 48 h post-exercise). However, there were no statistically significant differences between treatment groups (main effect of group p > 0.05 or group x time interaction p > 0.05). These data suggest that in non-resistance trained men, neither TC nor POM enhance recovery from high-force eccentric exercise of the elbow flexors.

scholarly journals Exercise-Induced Release of Cardiac Troponins in Adolescent vs. Adult Swimmers

2021 ◽  
Vol 18 (3) ◽  
pp. 1285
Author(s):  
Rafel Cirer-Sastre ◽  
Francisco Corbi ◽  
Isaac López-Laval ◽  
Luis Enrique Carranza-García ◽  
Joaquín Reverter-Masià
Keyword(s):  
Cardiac Troponin ◽  
Healthy Subjects ◽  
Troponin T ◽  
Training Experience ◽  
Post Exercise ◽  
Baseline Values ◽  
Exercise Induced ◽  
Cardiac Troponins ◽  
Similar Peak ◽  
Apparently Healthy

To examine the exercise-induced release of cardiac troponin T (cTnT) in adolescent and adult swimmers. Thirty-two trained male (18 adolescents, 14 adults) swam at maximal pace in a 45 min distance trial, and blood samples were drawn before, immediately and 3 h after exercise for subsequent cTnT analysis and comparison. Having comparable training experience and baseline values of cTnT (p = 0.78 and p = 0.13), adults exercised at lower absolute and relative intensity (p < 0.001 and p < 0.001, respectively), but presented higher immediate cTnT after exercise than adolescents (p < 0.001). Despite that, peak concentrations were observed at 3 h post exercise and peak elevations were comparable between groups (p = 0.074). Fourteen (44%) apparently healthy subjects exceeded the cutoff value for myocardial infarction (MI). Adolescents presented a delayed elevation of cTnT compared with adults, but achieved similar peak values.

scholarly journals Relationship of Carbohydrate Intake during a Single-Stage One-Day Ultra-Trail Race with Fatigue Outcomes and Gastrointestinal Problems: A Systematic Review

2021 ◽  
Vol 18 (11) ◽  
pp. 5737
Author(s):  
Soledad Arribalzaga ◽  
Aitor Viribay ◽  
Julio Calleja-González ◽  
Diego Fernández-Lázaro ◽  
Arkaitz Castañeda-Babarro ◽  
...  
Keyword(s):  
Systematic Review ◽  
Single Stage ◽  
Cochrane Library ◽  
Exercise Recovery ◽  
Post Exercise ◽  
Exercise Load ◽  
Gi Symptoms ◽  
Gastrointestinal Problems ◽  
Exercise Induced ◽  
Post Exercise Recovery

Due to the high metabolic and physical demands in single-stage one-day ultra-trail (SOUT) races, athletes should be properly prepared in both physical and nutritional aspects in order to delay fatigue and avoid associated difficulties. However, high carbohydrate (CHO) intake would seem to increase gastrointestinal (GI) problems. The main purpose of this systematic review was to evaluate CHO intake during SOUT events as well as its relationship with fatigue (in terms of internal exercise load, exercise-induced muscle damage (EIMD) and post-exercise recovery) and GI problems. A structured search was carried out in accordance with PRISMA guidelines in the following: Web of Science, Cochrane Library and Scopus databases up to 16 March 2021. After conducting the search and applying the inclusion/exclusion criteria, eight articles in total were included in this systematic review, in all of which CHO intake involved gels, energy bars and sports drinks. Two studies associated higher CHO consumption (120 g/h) with an improvement in internal exercise load. Likewise, these studies observed that SOUT runners whose intake was 120 g/h could benefit by limiting the EIMD observed by CK (creatine kinase), LDH (lactate dehydrogenase) and GOT (aspartate aminotransferase), and also improve recovery of high intensity running capacity 24 h after a trail marathon. In six studies, athletes had GI symptoms between 65–82%. In summary, most of the runners did not meet CHO intake standard recommendations for SOUT events (90 g/h), while athletes who consumed more CHO experienced a reduction in internal exercise load, limited EIMD and improvement in post-exercise recovery. Conversely, the GI symptoms were recurrent in SOUT athletes depending on altitude, environmental conditions and running speed. Therefore, a high CHO intake during SOUT events is important to delay fatigue and avoid GI complications, and to ensure high intake, it is necessary to implement intestinal training protocols.

Inhaled Terbutaline Administered via a Spacer Fully Prevents Exercise-Induced Asthma in Young Asthmatic Subjects: A Double-Blind, Randomized, Placebo-Controlled Study

1989 ◽  
Vol 17 (6) ◽  
pp. 506-513 ◽  
Author(s):  
A.T. Dinh Xuan ◽  
C. Lebeau ◽  
R. Roche ◽  
A. Ferriere ◽  
M. Chaussain
Keyword(s):  
Room Temperature ◽  
Work Load ◽  
Cycle Ergometer ◽  
Forced Expiratory Volume ◽  
Controlled Study ◽  
Adrenergic Agonist ◽  
Double Blind ◽  
Asthmatic Children ◽  
Exercise Induced ◽  
Age Range

The effects of inhaled terbutaline, a β2-adrenergic agonist, administered via a 750-ml spacer device were studied in young asthmatic subjects with exercise-induced asthma. A double-blind, randomized, placebo-controlled study of the effects of inhaled 0.5 mg terbutaline and placebo was conducted in 10 asthmatic children (age range 6–16 years) with documented exercise-induced asthma. Forced expiratory volume in 1 s (FEV1) was measured at baseline, 15 min after inhaling terbutaline or placebo, and at intervals up to 60 min after exercising. Subjects exercised using a cycle ergometer for 5 min at a submaximal, constant work-load while breathing dry air at room temperature. Terbutaline induced bronchodilation at rest in all subject and fully prevented exercise-induced asthma in nine out of the 10 subjects; the exercise-induced fall in FEV1 was markedly reduced in the remaining subject. It is concluded that exercise-induced asthma can be inhibited by pretreatment with inhaled terbutaline, administered via a spacer, in a majority of young asthmatics.

Cardio-respiratory and biochemical responses of military training event at Jungle environment

2021 ◽  
Vol 12 (4) ◽  
pp. 15-23
Author(s):  
Angad Yadav ◽  
Tirthankar Chatterjee ◽  
Debojyoti Bhattacharyya ◽  
Somnath Singh ◽  
Madhusudan Pal
Keyword(s):  
Core Body Temperature ◽  
Statistical Significance ◽  
Military Training ◽  
Venous Blood ◽  
Post Exercise ◽  
Biochemical Responses ◽  
Significant Difference ◽  
Training Event ◽  
Training Activities ◽  
Exercise Induced

Background: In military environment, soldiers regularly practice or undergo different types of extreme training activities. However, globally the literatures available on the physiological and biochemical demand of different extreme military training activities are very scanty and less reported. Aims and Objective: The present study was undertaken to quantify the cardio-respiratory and biochemical responses of military training event in jungle environment. Materials and Methods: Mathew’s Mad Mile (MMM) activity is a type of specialized run of 1.5 mile in jungle environment. This training activity was conducted on rugged jungle terrain comprised of undulated uphill, downhill, muddy surface. Twenty-five SHAPE-1 healthy soldiers were volunteered into training event. Cardiorespiratory data was recorded continuously throughout the event and venous blood sample was drawn before and immediately after completion of the event. Statistical significance was considered at p<0.05. Results: There was no significant difference observed in heart rate and breathing rate while core body temperature was significantly (p = 0.02) higher in slow finisher as compared to fast finisher. In fast finisher, post exercise level of BDNF, BNP, SDH, cortisol and UCP1 increased significantly (p<0.05), whereas, BHB (p<0.01) decreased significantly in comparison to pre-exercise. In slow finishers, post exercise level of cortisol, KYNA and UCP1 increased significantly (p<0.05), whereas, BDNF, BNP and SDH decreased significantly (p<0.05), in comparison to pre-exercise. Conclusion: The outcome of this study indicated that the slow finishers were more susceptible to risk of injury due to higher exercise induced thermogenesis and mental stress in comparison to fast finisher.

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