scholarly journals Standardised uptake values of 2-deoxy-2-[18F]fluoro-d-glucose using PET/CT in normal cats

2013 ◽  
Vol 58 (No. 2) ◽  
pp. 96-104 ◽  
Author(s):  
YK Cho ◽  
KC Lee
Keyword(s):  
Blood Pool ◽  
Left Ventricular ◽  
Field Of View ◽  
Ct Scanner ◽  
Left Ventricular Free Wall ◽  
Hepatic Parenchyma ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
Normal Humans ◽  
Left And Right

In this study we assessed the normal physiological and dynamic thoracoabdominal distribution of <sup>18</sup>F fluorodeoxyglucose (<sup>18</sup>F-FDG) uptake and the standardized uptake values (SUVs) of the major parenchymal organs in five normal young adult domestic short haired cats. Dynamic PET data were acquired with a transaxial field-of-view (FOV) PET/CT scanner, Regions of interests (ROIs) were manually drawn over the left ventricular free wall, left ventricular blood pool, liver, spleen, and left and right renal cortices. The SUVs of these organs were calculated for 5-min frames over the 90 min acquisition. The uptake of <sup>18</sup>F-FDG within the major organs, showed a tendency to gradually decline, except for the left ventricle and blood pool. The decrease in SUV was rapid after injection with a plateau occurring after 30 minutes. The uptake of <sup>18</sup>F -FDG within the hepatic parenchyma was low compared to that in the kidney at the beginning of study. A steady decline in the hepatic parenchyma SUV was quite similar to that observed for the kidneys .The SUV of <sup>18</sup>F-FDG within the spleen was low. Uptake of <sup>18</sup>F-FDG within the myocardium was minimal. These SUV data from the parenchymal organs of normal cats compares favourably with those of normal humans and dogs and can be used in feline studies using PET/CT for the evaluation of various diseases. Furthermore, PET/CT can provide higher quality images over shorter examination times than conventional PET. &nbsp;

Radiation exposure of patients during 68Ga-DOTATOC PET/CT examinations

2009 ◽  
Vol 48 (05) ◽  
pp. 201-207 ◽  
Author(s):  
K. Zöphel ◽  
R. Freudenberg ◽  
L. Oehme ◽  
M. Andreeff ◽  
G. Wunderlich ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Radiation Exposure ◽  
Somatostatin Receptor ◽  
Blood Pool ◽  
Biological Data ◽  
Whole Body ◽  
Physiological Uptake ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
Routine Clinical Setting

Summary Aim: Investigation of the biodistribution and calculation of dosimetry of Ga-68-DOTATOCfor patients imaged in the routine clinical setting for diagnosis or exclusion of neuroendocrine tumours. Patients, methods: Dynamic PET/CT-imaging (Biograph 16) was performed over 20 min in 14 patients (8 men, 6 women) after injection of (112 ± 22) MBq 68Ga-DOTATOC followed by whole body 3D-acquisition (8 bed positions, 3 or 4 min each) 30 min p.i. and 120 min p.i. Urinary tracer elimination was measured and blood activity was derived non-invasively from the blood pool of the heart. The relevant organs for dosimetry were spleen, kidneys, liver, adrenals, urinary bladder and pituitary gland. Dosimetry was performed using OLINDA/ EXM 1.0 software and specific organ uptake was expressed as standardized uptake values (SUVs). Results: Rapid physiological uptake of the radiotracer could be demonstrated in liver, spleen and kidneys, adrenals and pituitary gland (mean SUVs were 6, 20, 16, 10, and 4, respectively). Radiotracer elimination was exclusively via urine (16% of injected dose within 2h); no redistribution could be observed. The spleen and the kidneys received the highest radiation exposure (0.24 mSv/MBq, 0.22 mSv/MBq resp.), mean effective dose yielded 0.023 mSv/MBq. Conclusion: 68Ga-DOTATOC is used extensively for diagnosis of somatostatin receptor positive tumours because it has several advantages over the 111In-labelled ligand. The derived dosimetric values are lower than first approximations from the biological data of OctreoScan. The use of CT for transmission correction of the PET data delivers radiation exposure up to 1 mSv (low dose).

scholarly journals Field of view alignment on a multimodal PET/CT scanner for small animals

2007 ◽  
Author(s):  
JJ. Vaquero ◽  
J. Pascau ◽  
M. Abella ◽  
A. Sisniega ◽  
E. Lage ◽  
...  
Keyword(s):  
Field Of View ◽  
Small Animals ◽  
Ct Scanner ◽  
Pet Ct

scholarly journals Feasibility of late acquisition [68Ga]Ga-PSMA-11 PET/CT using a long axial field-of-view PET/CT scanner for the diagnosis of recurrent prostate cancer—first clinical experiences

2021 ◽  
Author(s):  
Ian Alberts ◽  
George Prenosil ◽  
Clemens Mingels ◽  
Karl Peter Bohn ◽  
Marco Viscione ◽  
...  
Keyword(s):  
Image Quality ◽  
Case Series ◽  
Likert Scale ◽  
Target Lesion ◽  
Field Of View ◽  
Ct Scanner ◽  
Axial Field ◽  
Retrospective Case ◽  
Imaging Quality ◽  
Pet Ct

Abstract Purpose While acquisition of images in [68 Ga]Ga-PSMA-11 following longer uptake times can improve lesion uptake and contrast, resultant imaging quality and count statistics are limited by the isotope’s half-life (68 min). Here, we present a series of cases demonstrating that when performed using a long axial field-of-view (LAFOV) PET/CT system, late imaging is feasible and can even provide improved image quality compared to regular acquisitions. Methods In this retrospective case series, we report our initial experiences with 10 patients who underwent standard imaging at 1 h p.i. following administration of 192 ± 36 MBq [68 Ga]Ga-PSMA-11 with additional late imaging performed at 4 h p.i. Images were acquired in a single bed position for 6 min at 1 h p.i. and 16 min p.i. at 4 h p.i. using a LAFOV scanner (106 cm axial FOV). Two experienced nuclear medicine physicians reviewed all scans in consensus and evaluated overall image quality (5-point Likert scale), lesion uptake in terms of standardised uptake values (SUV), tumour to background ratio (TBR) and target-lesion signal to background noise (SNR). Results Subjective image quality as rated on a 5-point Likert scale was only modestly lower for late acquisitions (4.2/5 at 4 h p.i.; 5/5 1 h p.i.), TBR was significantly improved (4 h: 3.41 vs 1 h: 1.93, p < 0.001) and SNR was improved with borderline significance (4 h: 33.02 vs 1 h: 24.80, p = 0.062) at later imaging. Images were obtained with total acquisition times comparable to routine examinations on standard axial FOV scanners. Conclusion Late acquisition in tandem with a LAFOV PET/CT resulted in improvements in TBR and SNR and was associated with only modest impairment in subjective visual imaging quality. These data show that later acquisition times for [68 Ga]Ga-PSMA-11 may be preferable when performed on LAFOV systems.

scholarly journals Impact of the Noise Penalty Factor on Quantification in Bayesian Penalized Likelihood (Q.Clear) Reconstructions of 68Ga-PSMA PET/CT Scans

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 847
Author(s):  
Sjoerd Rijnsdorp ◽  
Mark J. Roef ◽  
Albert J. Arends
Keyword(s):  
Penalized Likelihood ◽  
Ct Scans ◽  
Ct Scanner ◽  
Scan Time ◽  
Standardized Uptake Values ◽  
Positron Emission ◽  
Penalty Factor ◽  
Psma Pet ◽  
Pet Ct ◽  
Voxel Grid

Functional imaging with 68Ga prostate-specific membrane antigen (PSMA) and positron emission tomography (PET) can fulfill an important role in treatment selection and adjustment in prostate cancer. This article focusses on quantitative assessment of 68Ga-PSMA-PET. The effect of various parameters on standardized uptake values (SUVs) is explored, and an optimal Bayesian penalized likelihood (BPL) reconstruction is suggested. PET acquisitions of two phantoms consisting of a background compartment and spheres with diameter 4 mm to 37 mm, both filled with solutions of 68Ga in water, were performed with a GE Discovery 710 PET/CT scanner. Recovery coefficients (RCs) in multiple reconstructions with varying noise penalty factors and acquisition times were determined and analyzed. Apparent recovery coefficients of spheres with a diameter smaller than 17 mm were significantly lower than those of spheres with a diameter of 17 mm and bigger (p < 0.001) for a tumor-to-background (T/B) ratio of 10:1 and a scan time of 10 min per bed position. With a T/B ratio of 10:1, the four largest spheres exhibit significantly higher RCs than those with a T/B ratio of 20:1 (p < 0.0001). For spheres with a diameter of 8 mm and less, alignment with the voxel grid potentially affects the RC. Evaluation of PET/CT scans using (semi-)quantitative measures such as SUVs should be performed with great caution, as SUVs are influenced by scanning and reconstruction parameters. Based on the evaluation of multiple reconstructions with different β of phantom scans, an intermediate β (600) is suggested as the optimal value for the reconstruction of clinical 68Ga-PSMA PET/CT scans, considering that both detectability and reproducibility are relevant.

scholarly journals Performance evaluation of the uEXPLORER Total-body PET/CT scanner based on NEMA NU 2-2018 with additional tests to characterize long axial field-of-view PET scanners

2020 ◽  
pp. jnumed.120.250597 ◽  
Author(s):  
Benjamin A. Spencer ◽  
Eric Berg ◽  
Jeffrey P. Schmall ◽  
Negar Omidvari ◽  
Edwin K. Leung ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Field Of View ◽  
Ct Scanner ◽  
Axial Field ◽  
Pet Ct ◽  
Total Body ◽  
Pet Scanners

The effect of activity outside the field of view on image quality for a 3D LSO-based whole body PET/CT scanner

2009 ◽  
Vol 54 (19) ◽  
pp. 5861-5872 ◽  
Author(s):  
R Matheoud ◽  
C Secco ◽  
P Della Monica ◽  
L Leva ◽  
G Sacchetti ◽  
...  
Keyword(s):  
Image Quality ◽  
Field Of View ◽  
Whole Body ◽  
Ct Scanner ◽  
Pet Ct

Performance Characteristics of a New LSO PET/CT Scanner With Extended Axial Field-of-View and PSF Reconstruction

2009 ◽  
Vol 56 (3) ◽  
pp. 633-639 ◽  
Author(s):  
Bjoern W. Jakoby ◽  
Yanic Bercier ◽  
Charles C. Watson ◽  
Bernard Bendriem ◽  
David W. Townsend
Keyword(s):  
Performance Characteristics ◽  
Field Of View ◽  
Ct Scanner ◽  
Axial Field ◽  
Pet Ct

scholarly journals Head-to-Head Comparison of [68Ga]Ga-P16-093 and [68Ga]Ga-PSMA-617 in Dynamic PET/CT Evaluation of the Same Group of Recurrent Prostate Cancer Patients

2021 ◽  
Author(s):  
Guochang Wang ◽  
Haiyan Hong ◽  
Jie Zang ◽  
Qingxing Liu ◽  
Yuanyuan Jiang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Ct Scan ◽  
Cancer Patients ◽  
Blood Pool ◽  
Organ Distribution ◽  
Dynamic Pet ◽  
Recurrent Prostate Cancer ◽  
Detection Ability ◽  
Standardized Uptake Values ◽  
Pet Ct

Abstract Purpose: This study was prospectively designed to evaluate the early dynamic organ distribution and tumor detection ability of [68Ga]Ga-P16-093, which was compared with [68Ga]Ga-PSMA-617 in the same group of recurrent prostate cancer patients.Methods: Twenty patients with recurrent prostate cancer were enrolled. In two consecutive days, each patient underwent a 60-min dynamic PET/CT scan after intravenous administration of 148–185 MBq (4–5 mCi) [68Ga]Ga-P16-093 and [68Ga]Ga-PSMA-617, respectively. Following a low-dose CT scan, serial dynamic PET scans were performed from head to proximate thigh at 9 time points (30 sec/bed at 4, 7, 10, 13 and 16 min, 1 min/bed at 20, 30 and 45 min, and 2 min/bed at 60 min). Standardized uptake values were measured for semi-quantitative comparison.Results: [68Ga]Ga-P16-093 PET/CT revealed a significantly higher tumor uptake at 4 min (SUVmax 7.88 ± 5.26 vs. 6.01 ± 3.88, P < 0.001), less blood pool retention at 4 min (SUVmean 5.12 ± 1.16 vs. 6.14 ± 0.98, P < 0.001) and lower bladder accumulation at 60 min (SUVmean 31.33 ± 27.47 vs. 48.74 ± 34.01, P = 0.042) than [68Ga]Ga-PSMA-617 scan. Significantly higher [68Ga]Ga-P16-093 uptakes were also observed in the parotid gland, liver, spleen and kidney. Besides, [68Ga]Ga-P16-093 exhibited a better detection ability than [68Ga]Ga-PSMA-617 (366 vs. 321, P = 0.009).Conclusions: [68Ga]Ga-P16-093 showed advantages over [68Ga]Ga-PSMA-617 with higher tumor uptakes, tumor-to-blood pool ratio and detection ability, less blood pool and bladder accumulation in recurrent prostate cancer patients.Trial registration [68Ga]Ga-P16-093 and [68Ga]Ga-PSMA-617 PET/CT Imaging in the Same Group of Prostate Cancer Patients (NCT04796467, Registered 12 March 2021, retrospectively registered)URL of registry https://clinicaltrials.gov/ct2/show/NCT04796467

Influence of scan time point and volume of intravenous contrast administration on blood-pool and liver SUVmax and SUVmean in [18F] FDG PET/CT

2018 ◽  
Vol 57 (02) ◽  
pp. 50-55
Author(s):  
Timm Braun ◽  
Panagiota Manava ◽  
Sigrid Ludwigs ◽  
Michael Lell ◽  
Matthias Schoen
Keyword(s):  
Fdg Pet ◽  
Contrast Material ◽  
Blood Pool ◽  
Intravenous Contrast ◽  
Scan Time ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Time Point

Summary Aim: To investigate the influence of scan time point and volume of intravenous contrast material in 18F-FDG PET/CT on maximum and mean standardized uptake values (SUVmax/mean) in bloodpool and liver. Methods: In 120 patients scheduled for routine whole-body 18F-FDG PET/CT the maximum and mean standardized uptake values (SUVmax/SUVmean) in the liver and blood pool were measured after varying scan time-point (delay 0 s-140 s post injectionem) and volume of contrast material (CM; 0 ml, 80 ml, 100 ml of 300 mg/ml of Iodine). Six groups of 20 patients were investigated: (1) without intravenous CM, (2-5) injection of 100 ml CM with a delay of 80 s (2), 100 s (3), 120 s (4), 140 s (5), and 80 ml CM and a delay of 100 s (6). SUVmax, SUVmean, maximum Hounsfield units (HUmax) and average Hounsfield units (HUav) were calculated with the use of manually drawn regions of interests (ROIs) over the aortic arch and healthy liver tissue. Results: SUVmax in bloodpool was significantly higher in group 3, 4 and 6 compared to group 1. Groups 2 and 5 also showed higher mean values of SUVmax, but the difference was not significant. SUVmean in bloodpool was also higher in groups 2, 3, 4, 5 and 6 compared to group 1, but the differences were only statistically significant in group 3. Both SUVmax and SUVmean in healthy liver tissue did not show significant differences when compared to the non contrast-enhanced control group. Conclusion: SUVmax and to a lesser extent SUVmean measured in CM enhanced FDG PET/CT in blood pool could be significantly altered in high contrast CT examinations. This should be kept in mind in PET/CT protocols and evaluation relying on SUVmax and SUVmean, for example when used in the assessment of therapy response, especially in highly vascularized tumor lesions.

Sign in / Sign up

Export Citation Format

Share Document