scholarly journals Alveolar-Capillary Recruitment: The Relationship of Diffusion Capacity of the Lungs for Carbon Monoxide to Pulmonary Blood Flow in Response to Exercise in PAH Patients

2020 ◽  
Keyword(s):  
Carbon Monoxide ◽  
Blood Flow ◽  
Pulmonary Blood Flow ◽  
Diffusion Capacity ◽  
Capillary Recruitment ◽  
Relationship Of ◽  
Response To Exercise ◽  
The Relationship ◽  
Alveolar Capillary

Effect of furosemide on pulmonary blood flow distribution in resting and exercising horses

1999 ◽  
Vol 86 (6) ◽  
pp. 2034-2043 ◽  
Author(s):  
Howard H. Erickson ◽  
Susan L. Bernard ◽  
Robb W. Glenny ◽  
M. Roger Fedde ◽  
Nayak L. Polissar ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pulmonary Blood Flow ◽  
Flow Distribution ◽  
Thoroughbred Horses ◽  
Dorsal Portion ◽  
Primary Finding ◽  
Pulmonary Arterial ◽  
Relationship Of ◽  
The Relationship ◽  
Rest And Exercise

We determined the spatial distribution of pulmonary blood flow (PBF) with 15-μm fluorescent-labeled microspheres during rest and exercise in five Thoroughbred horses before and 4 h after furosemide administration (0.5 mg/kg iv). The primary finding of this study was that PBF redistribution occurred from rest to exercise, both with and without furosemide. However, there was less blood flow to the dorsal portion of the lung during exercise postfurosemide compared with prefurosemide. Furosemide did alter the resting perfusion distribution by increasing the flow to the ventral regions of the lung; however, that increase in flow was abated with exercise. Other findings included 1) unchanged gas exchange and cardiac output during rest and exercise after vs. before furosemide, 2) a decrease in pulmonary arterial pressure after furosemide, 3) an increase in the slope of the relationship of PBF vs. vertical height up the lung during exercise, both with and without furosemide, and 4) a decrease in blood flow to the dorsal region of the lung at rest after furosemide. Pulmonary perfusion variability within the lung may be a function of the anatomy of the pulmonary vessels that results in a predominantly fixed spatial pattern of flow distribution.

Relation of blood flow to VO2, PO2, and PCO2 in dog gastrocnemius muscle

1988 ◽  
Vol 255 (5) ◽  
pp. H1004-H1010 ◽  
Author(s):  
D. E. Mohrman ◽  
R. R. Regal
Keyword(s):  
Blood Flow ◽  
Steady State ◽  
Gastrocnemius Muscle ◽  
Muscle Blood Flow ◽  
Carbon Dioxide Tension ◽  
Experimental Conditions ◽  
Muscle Oxygen ◽  
Muscle Oxygen Consumption ◽  
Relationship Of ◽  
The Relationship

We pump-perfused gastrocnemius-plantaris muscle preparations at constant pressure to study the relationship of muscle blood flow (Q) to muscle oxygen consumption (VO2), venous oxygen tension (PVO2), and venous carbon dioxide tension (PVCO2) during steady-state exercise at different rates. Tests were performed under four experimental conditions produced by altering the perfusate blood-gas status with a membrane lung. The consistency of the relationship of Q to other variables was evaluated by statistical analysis of fitted curves. Not one of the above listed variables had the same relationship with Q in all four of the experimental conditions we tested. However, we did find that a consistent relationship existed among Q, PVO2, and PVCO2 in our data. That relationship is well described by the equation (Q-23).[PVO2 - (0.5.PVCO2) - 3] = 105 (when Q is expressed in ml.100 g-1.min-1 and PVO2 and PVCO2 in mmHg). One interpretation of this result is that both PO2 and PCO2 are important variables in the control of blood flow in skeletal muscle the combined influence of which could account for nearly all of the hyperemia response to steady-state muscle exercise.

Relationship of pyruvate and lactate during anaerobic metabolism. V: Coronary adequacy

1961 ◽  
Vol 200 (6) ◽  
pp. 1169-1176 ◽  
Author(s):  
William E. Huckabee
Keyword(s):  
Blood Flow ◽  
Coronary Flow ◽  
Cardiac Tissue ◽  
Anaerobic Metabolism ◽  
Constant Ratio ◽  
Blood Concentrations ◽  
Arterial Blood ◽  
Anesthetized Dogs ◽  
Relationship Of ◽  
The Relationship

Veno-arterial differences of pyruvate and lactate across the myocardium in chloralose-anesthetized dogs were very variable; in any one animal they changed continually with time despite constant blood flow and arterial blood concentrations. There was a systematic tendency of v-a lactate to vary with v-a pyruvate, as expressed in the calculated "Δ excess lactate," which remained nearly constant (or, if blood flow changed, bore a constant ratio to (a-v)O2). No change in Δ excess lactate from control values occurred in nonhypoxic experiments despite marked changes in v-a differences, arterial blood composition, and coronary flow. Cardiac Δ excess lactate became positive in most animals breathing 10% O2 in N2; output of excess lactate was also observed in all those in which moderate muscular exercise was induced. This anaerobic metabolism, or change in the relationship between pyruvate and lactate exchanges, was interpreted as an indication that O2 delivery response was not adequate to meet cardiac tissue requirements during such mild stresses when judged by the standards of adequacy of the basal state.

Relation of local skin temperature and local sweating to cutaneous blood flow

1963 ◽  
Vol 18 (4) ◽  
pp. 781-785 ◽  
Author(s):  
Leo C. Senay ◽  
Leon D. Prokop ◽  
Leslie Cronau ◽  
Alrick B. Hertzman
Keyword(s):  
Blood Flow ◽  
Skin Temperature ◽  
Sweat Gland ◽  
Cutaneous Blood Flow ◽  
Local Skin ◽  
Cutaneous Vasodilatation ◽  
Local Skin Temperature ◽  
Relationship Of ◽  
The Relationship ◽  
Cutaneous Blood

The relationship of local skin temperature and the onset of sweating to the local cutaneous blood flow was studied in the forearm and calf. The purpose of the investigation was to appraise the possible relation of sweat gland activity to the cutaneous vasodilatation which has been attributed to bradykinin or to intracranial temperatures. The onset of sweating was not marked by any apparently related increases in the rate of cutaneous blood flow. On the contrary, the onset of sweating was followed often by a stabilization or even a decrease in the level of cutaneous blood flow. The relations of the latter to the local skin temperature were complex, particularly in the forearm. There appeared to be additional unidentified influences, possibly vasomotor, operating on the skin vessels during transitional phases in the relation of skin temperature to blood flow. Submitted on October 15, 1962

scholarly journals Relationship Between Exhaled Na+ and the Diffusion Capacity of the Lungs for Carbon Monoxide (DLCO) and Alveolar‐Capillary Membrane Conductance in Healthy Humans

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Courtney M. Wheatley ◽  
Nicholas A. Cassuto ◽  
William T. Foxx‐Lupo ◽  
Eric C. Wong ◽  
Nicholas A. Delamere ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Membrane Conductance ◽  
Diffusion Capacity ◽  
Healthy Humans ◽  
Capillary Membrane ◽  
Alveolar Capillary

Influence of pulmonary blood flow on management and outcome

2011 ◽  
Keyword(s):  
Blood Flow ◽  
Heart Disease ◽  
Pulmonary Circulation ◽  
Early Life ◽  
Pulmonary Blood Flow ◽  
Venous Blood ◽  
Cyanotic Heart Disease ◽  
Capillary Membrane ◽  
Pulmonary Vascular Development ◽  
Alveolar Capillary

Introduction 50Pulmonary vascular development in early life 50Cyanotic heart disease and pulmonary blood flow 52Delivery of systemic venous blood to the alveolar capillary membrane to allow release of waste CO2 and uptake of O2 depends on the integrity of the pulmonary circulation. Too little blood flow to the lungs and the patient is hypoxic; too much and the lungs become oedematous....

Intrapulmonary blood flow redistribution during hypoxia increases gas exchange surface area

1982 ◽  
Vol 52 (6) ◽  
pp. 1575-1580 ◽  
Author(s):  
R. L. Capen ◽  
W. W. Wagner
Keyword(s):  
Carbon Monoxide ◽  
Blood Flow ◽  
Cardiac Output ◽  
Gas Exchange ◽  
Surface Area ◽  
Vascular Resistance ◽  
Diffusing Capacity ◽  
Capillary Recruitment ◽  
Blood Flow Redistribution ◽  
Exchange Surface

We have previously shown that airway hypoxia causes pulmonary capillary recruitment and raises diffusing capacity for carbon monoxide. This study was designed to determine whether these events were caused by an increase in pulmonary vascular resistance, which redistributed blood flow toward the top of the lung, or by an increase in cardiac output. We measured capillary recruitment at the top of the dog lung by in vivo microscopy, gas exchange surface area of the whole lung by diffusing capacity for carbon monoxide, and blood flow distribution by radioactive microspheres. During airway hypoxia recruitment occurred, diffusing capacity increased, and blood flow was redistributed upward. When a vasodilator was infused while holding hypoxia constant, these effects were reversed; i. e., capillary “derecruitment” occurred, diffusing capacity decreased, and blood flow was redistributed back toward the bottom of the lung. The vasodilator was infused at a rate that left hypoxic cardiac output unchanged. These data show that widespread capillary recruitment during hypoxia is caused by increased vascular resistance and the resulting upward blood flow redistribution.

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