PREVENTIVE ROLE OF CACTUS (OPUNTIA FICUS-INDICA) CLADODES ON METHOTREXATE INDUCED BIOCHEMICAL, HEMATOLOGICAL AND OXIDATIVE DAMAGE IN RAT LIVER

AbstractObjective:The objective of the current study is to investigate the protective effect ofMethods:Forty adult male albino rats were divided into four groups as control,Results:The results showed that, administration of EtOH caused a significant decrease (p<0.05) in serum total protein and albumin, whereas ALT and AST and lipid peroxidation (LPO) were increased following EtOH treatment.Conclusion:had a hepatoprotective role against EtOH-induce oxidative stress and inflammation in rat liver.

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Zinc as a micronutrient and its preventive role of oxidative damage in cells

Food & Function ◽

10.1039/c5fo00630a ◽

2015 ◽

Vol 6 (10) ◽

pp. 3195-3204 ◽

Cited By ~ 57

Author(s):

Veronika Kloubert ◽

Lothar Rink

Keyword(s):

Lipid Peroxidation ◽

Oxidative Damage ◽

Inflammatory Cytokines ◽

Zinc Deficiency ◽

Inflammatory Diseases ◽

Ros Production ◽

Chronic Inflammatory Diseases ◽

Preventive Role ◽

Pro Inflammatory Cytokines

Zinc deficiency leads to increased ROS production, thereby causing lipid peroxidation. Subsequently, signallingviathe NF-κB pathway is increased, resulting in the expression of pro-inflammatory cytokines which in turn cause chronic inflammatory diseases.

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The Role of Reactive Oxygen Species in Tumor Treatment and its Impact on Bone Marrow Hematopoiesis

Current Drug Targets ◽

10.2174/1389450120666191021110208 ◽

2020 ◽

Vol 21 (5) ◽

pp. 477-498

Author(s):

Yongfeng Chen ◽

Xingjing Luo ◽

Zhenyou Zou ◽

Yong Liang

Keyword(s):

Reactive Oxygen Species ◽

Bone Marrow ◽

Oxidative Damage ◽

Tumor Cells ◽

Reactive Oxygen ◽

Oxygen Species ◽

Tumor Treatment ◽

Normal Cells ◽

Treatment And Prevention

Reactive oxygen species (ROS), an important molecule inducing oxidative stress in organisms, play a key role in tumorigenesis, tumor progression and recurrence. Recent findings on ROS have shown that ROS can be used to treat cancer as they accelerate the death of tumor cells. At present, pro-oxidant drugs that are intended to increase ROS levels of the tumor cells have been widely used in the clinic. However, ROS are a double-edged sword in the treatment of tumors. High levels of ROS induce not only the death of tumor cells but also oxidative damage to normal cells, especially bone marrow hemopoietic cells, which leads to bone marrow suppression and (or) other side effects, weak efficacy of tumor treatment and even threatening patients’ life. How to enhance the killing effect of ROS on tumor cells while avoiding oxidative damage to the normal cells has become an urgent issue. This study is a review of the latest progress in the role of ROS-mediated programmed death in tumor treatment and prevention and treatment of oxidative damage in bone marrow induced by ROS.

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