scholarly journals THE EFFECT OF NUTRITIONAL THERAPY ON QUALITY OF LIFE INDICATORS FOR PATIENTS WITH GASTRIC CANCER AT THE STAGE OF SURGICAL TREATMENT

2019 ◽  
Vol 6 (3) ◽  
pp. 108-114 ◽  
Author(s):  
A. D. Sergienko ◽  
V. E. Khoronenko ◽  
E. V. Gameeva ◽  
A. B. Ryabov ◽  
V. M. Khomyakov
Keyword(s):  
Quality Of Life ◽  
Gastric Cancer ◽  
Surgical Treatment ◽  
Nutritional Therapy ◽  
Main Group ◽  
Control Group ◽  
Quality Of Life Indicators ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Purpose of the study. To determine the effect of nutritional deficiency and nutritional therapy on the quality of life of patients with gastric cancer at the stage of surgical treatment. Patients and methods. In Thoracoabdominal Department of P. Herzen Moscow Oncology Research Institute within 2017– 2019 the quality of life at the stage of surgical treatment of gastric malignant neoplasms was evaluated in 62 patients (36 men and 26 women) aged 34 to 79 years (mean age 61.9 ± 9.55). At the outpatient stage, patients were divided into 2 groups: in the 1st (main) group, patients received nutritive support with specialized mixtures for 10 days before hospitalization, in the 2nd (control) group, patients were asked to follow a high-protein diet without adding specialized mixtures. The quality of life assessment was carried out on the basis of the EORTC-QLQ-C30 Questionnaire, which patients received on the day of hospitalization. Patients repeatedly filled in EORTC-QLQ-C30 Questionnaire before discharge from the hospital, which allowed to assess the dynamics of the quality of life indicators of the studied patients. The study groups were comparable in social and medical indicators. Results. The analysis of the survey results showed that the “general state of health” in the studied groups at the stage of hospitalization is estimated �bove average. Also, in both groups there is a positive dynamics in the values of the above indicator before discharge. Patients of the 1st group who received specialized nutritional mixtures, developed the statistical significance of the differences in the assessment of the quality of life upon admission and before discharge. Thus, it can be argued that nutritional therapy had a significant positive impact on the quality of life in terms of “general health”, in contrast to the control group of patients who did not receive specialized nutritional therapy. There was a general tendency toward an increase in the quality of life indicators at admission and before discharge on all scores of the questionnaire in groups. Thisis a positive assessment by patients of their condition after providing them with medical services. In this case, the discomfort from the symptoms accompanying the disease is reduced, which is confirmed by the scoring results. Statistically significant differences in the assessment of symptoms occur in the study group. Patients having received nutritional therapy noted a decrease in pain, an improvement in the processes of assimilation of food, as well as an improvement in well-being, physical condition, an increase in general tone and energy, a surge of strength and a sense of vitality. In “decreased appetite”score the indices of patients in the main group decreased by more than 3 times, i. e. their appetite improved significantly under treatment. Improving appetite in patients of the main group led to an improvement in the functioning of the gastrointestinal tract as a whole. Patients in this group noted an improvement in digestion and bowel movements. Conclusion The study showed that the quality of life of patients with gastric cancer largely depends on their nutritional deficiency, and nutritional therapy at the stages of surgical treatment, in turn, can significantly improve its results, including in the aspect of their perception by patients. Using the general EORTC QLQ-C30 questionnaire is one of the available methods for assessing the quality of life in patients with gastric cancer.

Dynamics of quality of life of patients as a method of evaluating surgical treatment outcome in oral and oropharyngeal cancer

2021 ◽  
Vol 59 (1) ◽  
pp. 31-35
Author(s):  
N. Trizna ◽  
Z. Kaliadich ◽  
E. Zhaleika ◽  
A. Evmenenko
Keyword(s):  
Quality Of Life ◽  
Treatment Outcome ◽  
Physical Functioning ◽  
Oropharyngeal Cancer ◽  
Individual Therapy ◽  
Quality Of Life Indicators ◽  
Eortc Qlq C30 ◽  
Oral And Oropharyngeal Cancer ◽  
Eortc Qlq

Study of the quality of life indicators is an important part of a comprehensive analysis of new diagnosis, treatment, and prevention methods. It can serve as an additional criterion for selecting individual therapy or rehabilitation, examining the ability to work, and identifying psychological problems. Purpose of the study: The authors took a clinical case to demonstrate the use of внтфьшс monitoring of the quality of life indicators for the assessment of surgical and reconstructive treatment outcome for oral and oropharyngeal cancer. Results: The anticancer treatment effects were reflected in the physical functioning score according to the EORTC QLQ-C30 questionnaire (reduced to 80 points) and some symptomatic scores according to the EORTC QLQ-C30 and EORTC QLQ-H & N35 questionnaires. Medical rehabilitation measures resulted in positive dynamics of physical functioning scores according to the EORTC QLQ-C30 questionnaire (increase to 93.3 points) and symptomatic scores according to the EORTC QLQ-H & N35 questionnaire related to nutrition. At that, the patient has stopped having difficulty eating in public places; his body weight increased. The absence of pain and refusal to take analgesics also testified to successful treatment and improved quality of life. Conclusion: A subjective assessment of the various quality of life aspects in a particular patient provides valuable information about the individual response to the conducted treatment.

Quality of life after Whipple pancreatoduodenectomy and pylorus-preserving pancreatoduodenectomy: a comparative study

2015 ◽  
Vol 6 (3) ◽  
pp. 48-51 ◽  
Author(s):  
Nikolay Yurevich Kokhanenko ◽  
Konstantin Vadimovich Pavelets ◽  
Yuri Vasilevich Radionov ◽  
Yurii Nikolaevich Shiryajev ◽  
Natalya Yurevna Borisova
Keyword(s):  
Quality Of Life ◽  
Comparative Analysis ◽  
Surgical Treatment ◽  
Whipple Procedure ◽  
Periampullary Cancer ◽  
Physical Role ◽  
Time Period ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

The authors performed a comparative analysis of the Quality of life (QOL) in 97 patients after pancreatoduodenectomy, 55 of whom underwent pylorus-preserving surgery (PPDE), and 42 underwent classic Whipple procedure (GPDE). QOL was evaluated using questionnaire EORTC-QLQ-C30, version 3.0, and both analyzed groups were divided into 3 subgroups according to the time period after the surgery (less than 6 mo, 6-12 mo, and more than 12 mo). All the patients were operated on for pancreatic or periampullary cancer. During the first period after surgery (less than 6 mo), the integral QOL index is lower than in patients who were examined after the first 6 mo. After PPDE, parameters of physical, role, emotional, cognitive, and social functioning were higher than after GPDE; however, these differences were not statistically significant (p > 0,05). Indicators of QOL have changed with time, but intergroup (PPDE vs GPDE) differences were not statistically significant in every analyzed time period after surgery. Financial constrains were registered in patients of both groups and at different times after surgical treatment.

scholarly journals Quality of Life Variables Assessment, Before and After Pancreatoduodenectomy (PD): Prospective Study

2015 ◽  
Vol 8 (6) ◽  
pp. 203 ◽  
Author(s):  
Maria Arvaniti ◽  
Nikolaos Danias ◽  
Eleni Theodosopoulou ◽  
Vassilis Smyrniotis ◽  
M. Karaoglou ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pancreatic Cancer ◽  
Surgical Treatment ◽  
Gastrointestinal Symptoms ◽  
The Body ◽  
Full Data ◽  
Before And After ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

<p><strong>INTRODUCTION: </strong>The treatment of pancreatic cancer is a complex problem, due to late diagnosis, the need for specialized surgical treatment, the large number of relapses and poor survival.</p><p><strong>OBJECTIVE: </strong>To evaluate the quality of life of patients with periampulary pancreatic cancer before and after pancreatoduodenectomy (PD).</p><p><strong>MATERIAL &amp; METHOD: </strong>The sample was collected in the "Attikon" University General Hospital (Chaidari)<strong>.</strong> It consists of 20 subjects with a mean age of 65.9 years (SD = 10,2 years). For the quality of life measurement, we used the (EORTC) QLQ-C30 version 3.0., as well as the EORTC QOL-PAN26.</p><p><strong>RESULTS: </strong>From<strong> </strong>the sample of 20 patients who participated, full data were collected for 18 of them during the first month, 17 during the third month and 16 during the sixth month.</p><p>Regarding symptoms, as they were recorded with the QLQ-30 questionnaire, there was a significant increase of fatigue, a significant reduction of pain and constipation, while economic difficulties increased.  As for the mean and median values for the dimensions of the PAN-26 questionnaire during monitoring, there was a significant decrease in pancreatic and liver pain symptoms during follow-up, while the gastrointestinal symptoms increased in frequency. In addition, the body image and sexuality worsened.</p><p><strong>CONCLUSIONS: </strong>The surgical treatment of pancreatic cancer with pancreatoduodenectomy (PD), according to the early survey data using the (EORTC) QLQ-C30 version3.0, and the EORTC QOL-PAN26 questionnaires, seems to have a favorable impact on quality of life, as evidenced by the improvement of most parameters evaluated during the study period.</p>

scholarly journals Current state of antiangiogenic therapy in neuro-oncology and own experience of its use in the radiosurgical treatment of recurrent glioblastoma

2021 ◽  
Vol 27 (1) ◽  
pp. 34-43
Author(s):  
Oleksandr Y. Glavatskyi ◽  
Oksana V. Zemskova ◽  
Hennadii V. Khmelnytskyi ◽  
Konstantin A. Kardash ◽  
Iryna M. Shuba ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Antiangiogenic Therapy ◽  
Intensity Modulated Radiotherapy ◽  
Main Group ◽  
Recurrent Glioblastoma ◽  
Full Blood Count ◽  
Control Group ◽  
Significant Difference ◽  
Eortc Qlq

Objective: to study the effect of antiangiogenic therapy on the quality of life and the level of headache in patients with recurrent glioblastoma who underwent radiosurgical treatment. Materials and methods. A prospective randomized single-center study carried out at the Romodanov Neurosurgery Institute of National Academy of Medical Sciences of Ukraine in 2019-2020 involving 45 patients with GB with clinical and radiological signs of disease progression and local tumor recurrence. In this regard, patients underwent radiosurgical treatment. In the main group (BEV+) 21 patients after stereotactic radiosurgery (SRS) underwent antiangiogenic therapy with Bevacizumab (BEV). In the control group (BEV–), 24 patients did not receive antiangiogenic therapy after SRS. SRS with the use of a linear accelerator «Trilogy» (6 MeV) using intensity-modulated radiotherapy (IMRT). BEV was administered intravenously, once every 3 weeks at a dose of 10 mg / kg body weight. Antiangiogenic therapy was performed under the condition of preserved liver and kidney function, values of full blood count and blood biochemistry within normal range. Global health status and headache levels were calculated according to EORTC QLQ-C30 v. 3.0 and QLQ-BN20 before and six weeks after radiosurgery in the main and control groups. Results. There was no a statistically significant difference between the studied groups of patients’ in quality of life (p = 0.707372) and in headache level (p = 0.846660) before the SRS. Six weeks after SRS, patients in the main group had a statistically significantly higher quality of life (p = 0.000015) and a lower level of headache than patients in the control group (p = 0.000035). During the observation period in patients of both groups there were no adverse events of III-IV degree of toxicity, in particular specific complications of antiangiogenic therapy (hypertension, bleeding, thromboembolism, leukopenia, proteinuria, gastrointestinal disorders, etc.). Conclusions. Antiangiogenic therapy statistically significantly improves the quality of life and reduces the level of headache in patients who underwent radiosurgical treatment for glioblastoma recurrence.

scholarly journals Dynamics of quality of life of patients as a method for evaluating surgical treatment outcome for oral and oropharyngeal cancer

2021 ◽  
Vol 59 (1) ◽  
pp. 31-35
Author(s):  
Natalia Trizna ◽  
Zhanna Kaliadich ◽  
Alena Zhaleiko ◽  
Alesya Evmenenko
Keyword(s):  
Quality Of Life ◽  
Surgical Treatment ◽  
Physical Functioning ◽  
Oropharyngeal Cancer ◽  
Individual Therapy ◽  
Individual Response ◽  
Eortc Qlq C30 ◽  
Oral And Oropharyngeal Cancer ◽  
Eortc Qlq

Relevance: The study of the patients’ quality of life is an important part of a comprehensive analysis of new diagnostic, treatment, and prevention methods. It can serve as an additional criterion for selecting individual therapy or rehabilitation, examining the ability to work, and identifying psychological problems. Purpose: To show the potential of evaluating the outcome of surgical treatment of oral and oropharyngeal cancer with plastic replacement of the post-resection defect by the study of dynamics of patient’s quality of life (on a clinical case) Results: The anticancer treatment effects were reflected in the physical functioning score according to the EORTC QLQ-C30 questionnaire (reduced to 80 points) and some symptomatic scores according to the EORTC QLQ-C30 and EORTC QLQ-H & N35 questionnaires. Medical rehabilitation measures improved physical functioning scores according to the EORTC QLQ-C30 questionnaire (increase to 93.3 points) and symptomatic scores according to the EORTC QLQ-H & N35 questionnaire related to nutrition. At that, the patient has stopped having difficulty eating in public places; his body weight increased. The absence of pain and refusal to take analgesics also testified to successful treatment and improved quality of life. Conclusion: A subjective assessment of the various quality of life aspects in a particular patient provides valuable information about the individual response to the conducted treatment.

Long-term quality of life and nutritional results after laparoscopic sentinel node navigation surgery versus laparoscopic standard gastrectomy for early gastric cancer: Secondary outcomes of a multicenter, randomized phase 3 trial (SENORITA).

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 4054-4054
Author(s):  
Bang Wool Eom ◽  
Hong Man Yoon ◽  
Young-Woo Kim ◽  
Jae Seok Min ◽  
Ji Yeong An ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Phase 3 ◽  
Navigation Surgery ◽  
Sentinel Node Navigation Surgery ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

4054 Background: Laparoscopic sentinel node navigation surgery (LSNNS) has been suggested as an alternative to laparoscopic standard gastrectomy (LSG) in early gastric cancer patients to improve long-term quality of life (QOL) and nutritional outcomes. Here, we present 3-year results of patient-reported quality of life (QOL) and nutrition, secondary endpoints of SENORITA trial. Methods: SENORITA is a prospective multicenter randomized phase 3 trial. Patients diagnosed with early gastric cancer of 3 cm or less were randomly allocated (1:1) to LSNNS for stomach preservation or LSG. The primary endpoint was 3-year disease-free survival. In this study, we analyzed QOL assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and EORTC stomach module (STO22) and nutritional parameters at 3, 12, 24, and 36 months after surgery. Linear mixed model analyses was used to evaluate differences between the two groups. This trial is registered with ClinicalTrials.gov, NCT01804998. Results: From March 2013 to March 2017, a total of 580 patients were randomly assigned and 527 patients were included in the modified intention-to-treat analysis population (258 in LSNNS and 269 in LSG group). QOL questionnaires were available for 99.4% of patients at baseline and then for 92.2%, 83.2%, 72.8%, and 66.9% at 3, 12, 24, and 36 months after surgery, respectively. The LSNNS group had higher physical function score than the LSG group at all time points (p = 0.002). However, there were no significant differences in other scales of EORTC QLQ-C30. Regarding EORTC QLQ-STO22, pain, eating restriction, anxiety, and taste scores were lower (better QOL) at all time points in the LSNNS group than in the LSG group (p = 0.002, < 0.001, < 0.001, and < 0.001, respectively). The summary score of EORTC QLQ-STO22 was also higher in the LSNNS group representing better QOL (p < 0.001). Body mass index, hemoglobin and total protein were significantly higher in the LSNNS group compared with the LSG group. Conclusions: The LSNNS group had better physical function and less symptoms, including pain, eating restriction, anxiety, and taste change compared with the LSG group. Moreover, the nutritional parameters were better maintained in the LSNNS group than in the LSG group. These findings showed benefits of stomach preserving surgery in LSNNS and can be used to help decision making about treatment for patients with early gastric cancer. Clinical trial information: NCT01804998.

Acupuncture for chemotherapy-induced peripheral neuropathy: a randomised controlled pilot study

2019 ◽  
pp. bmjspcare-2018-001542 ◽  
Author(s):  
Eduardo Guilherme D’Alessandro ◽  
Daniela Ribeiro Nebuloni Nagy ◽  
Christina May Moran de Brito ◽  
Elisangela Pinto Marinho Almeida ◽  
Linamara Rizzo Battistella ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Peripheral Neuropathy ◽  
Pilot Study ◽  
Adverse Events ◽  
Control Group ◽  
Life Questionnaire ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Chemotherapy-induced peripheral neuropathy (CIPN) can cause loss of independence and poor quality of life (QoL) due to severe disabilities, but in spite of its importance there is still a lack of data for the management of CIPN. Acupuncture has showed promising results and may be a cost-effective option for the treatment.ObjectivesTo evaluate the effect of acupuncture treatment on neurological symptoms of CIPN and QoL of oncological patients.MethodsWe performed a clinical, single-centre, randomised and controlled pilot study that involved 33 adult patients with cancer and CIPN randomised into two groups (control and acupuncture treated with 10 sessions, two times per week). Both groups were subjected to a complete physical examination and clinical assessment with National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Scale V.2.0, FIM Scale, European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core (EORTC QLQ-C30) Scale and Visual Analogue Scale for pain before and 5 weeks after treatment.ResultsThere were no adverse events, and we found statistical differences in groups in physical (p=0.03) and function (p=0.04) domains of EORTC QLQ-C30 when comparing control and acupuncture groups. About NCI CTCAE Scale and neuropathy sensory symptoms, we found better results in acupuncture group, comparing pretreatment and post-treatment analyses (p=0.01). In control group, we have no differences after 5 weeks (p=0.11).ConclusionAlthough these results suggest an interesting effect of acupuncture on this patient population, the clinical significance has remained unclear. Given the tendency towards benefit and the lack of adverse effects, the authors recommend a follow-up acupuncture trial using higher follow-up time and better sample size.Trial registration numberNCT02309164.

scholarly journals Seasonal Indicators of Blood Pressure, Data of Asthma Control Questionnaires and Quality of Life in Hypertensive Patients with Bronchial Asthma

2020 ◽  
Vol 15 (6) ◽  
pp. 831-839
Author(s):  
G. F. Andreeva ◽  
M. I. Smirnova ◽  
V. M. Gorbunov ◽  
A. S. Kurekhyan ◽  
Ya. N. Koshelyaevskaya
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Bronchial Asthma ◽  
Main Group ◽  
Control Group ◽  
Seasonal Fluctuations ◽  
Hypertensive Patients ◽  
Quality Of Life Indicators ◽  
Different Seasons

Aim. To study the seasonal indicators of quality of life and control of bronchial asthma in hypertensive patients with bronchial asthma, observed by a cardiologist of the state outpatient institution.Material and methods. Data from a prospective cohort study of hypertensive patients, some of which had bronchial asthma without exacerbation, were analyzed. Patients who were observed by a cardiologist at a state outpatient clinic took part in the study. There were other concomitant diseases that occurred in the participants, in addition to hypertension and bronchial asthma. Two groups of patients were formed: the control group (n=85) included patients with hypertension only, the main group (n=40) included hypertension and bronchial asthma. Patients had 3 visits: initial one, and after 6 and 12 months and then data on outcomes (30.1Ѓ}7.6 months of follow-up) were collected. The first and third visits included clinical measurements of blood pressure (BP), 24-hour BP monitoring, spirometry, clinical and biochemical blood tests, a standard survey, survey with questionnaires evaluating the control of bronchial asthma (Asthma Control Questionnaire; ACQ) and the patients quality of life (General Well-Being Questionnaire; GWBQ). The second visit included clinical BP and ACQ and GWBQ questionnaires. A comparison of the average indicators from the total number of observations carried out in winter, spring, summer and autumn periods has been performed.Results. Hypertensive patients with/without bronchial asthma (n=125; 28 men, 97 women, average age 62.6Ѓ}8.8 years, duration of hypertension – 11.6Ѓ}8.6, duration of bronchial asthma – 9.3Ѓ}11.9 years) took part in the study. Outpatient BP levels throughout the study period were maintained at target values in both groups. It was shown that seasonal BP levels do not differ in the compared groups, except for winter indicators: winter daytime systolic BP levels were higher in the main group (p=0.03). Seasonal fluctuations in BP were not detected in the control group, however, they were present in the patients of the main group: winter daytime levels of diastolic BP and average daily levels of diastolic BP and systolic BP were higher than summer ones, and winter daytime systolic BP values (p<0.05) and clinical diastolic BP (p=0.004) – higher than autumn levels. Seasonal quality of life indicators in the main group were worse than in the control group in all seasons. Significant seasonal dynamics of quality of life indicators in patients in two groups was not detected. The ACQ questionnaire showed that asthma control changed in different seasons in accordance with the ACQ total score: in winter and spring – uncontrolled bronchial asthma (total score >1.5), in summer and autumn – partially controlled (total score ≤1.5). During the analysis of various factors associated with the combined primary endpoint (death, transient ischemic attack, angina pectoris, cardiac arrhythmias, arterial revascularization), relationships with quality of life indicators were revealed: negative connections – with indicators characterizing positive psychological health, mood at visit, positive correlations – with psychological abilities.Conclusion: Seasonal fluctuations in ambulatory BP levels were not found in the control group and were found in the main group. The quality of life indicators for patients of the main group were significantly worse than in the control group for all components in all seasons. The control of asthma changed in different seasons in accordance with the ACQ total score: uncontrolled bronchial asthma occurred in winter and spring, partially controlled – in summer and autumn. Correlations of the combined primary endpoint with quality of life indicators were found after analyzing various factors.

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