Dynamics of quality of life of patients as a method for evaluating surgical treatment outcome for oral and oropharyngeal cancer

Relevance: The study of the patients’ quality of life is an important part of a comprehensive analysis of new diagnostic, treatment, and prevention methods. It can serve as an additional criterion for selecting individual therapy or rehabilitation, examining the ability to work, and identifying psychological problems. Purpose: To show the potential of evaluating the outcome of surgical treatment of oral and oropharyngeal cancer with plastic replacement of the post-resection defect by the study of dynamics of patient’s quality of life (on a clinical case) Results: The anticancer treatment effects were reflected in the physical functioning score according to the EORTC QLQ-C30 questionnaire (reduced to 80 points) and some symptomatic scores according to the EORTC QLQ-C30 and EORTC QLQ-H & N35 questionnaires. Medical rehabilitation measures improved physical functioning scores according to the EORTC QLQ-C30 questionnaire (increase to 93.3 points) and symptomatic scores according to the EORTC QLQ-H & N35 questionnaire related to nutrition. At that, the patient has stopped having difficulty eating in public places; his body weight increased. The absence of pain and refusal to take analgesics also testified to successful treatment and improved quality of life. Conclusion: A subjective assessment of the various quality of life aspects in a particular patient provides valuable information about the individual response to the conducted treatment.

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Dynamics of quality of life of patients as a method of evaluating surgical treatment outcome in oral and oropharyngeal cancer

Oncologia i radiologia Kazakhstana ◽

10.52532/2663-4864-2021-1-59-31-35 ◽

2021 ◽

Vol 59 (1) ◽

pp. 31-35

Author(s):

N. Trizna ◽

Z. Kaliadich ◽

E. Zhaleika ◽

A. Evmenenko

Keyword(s):

Quality Of Life ◽

Treatment Outcome ◽

Physical Functioning ◽

Oropharyngeal Cancer ◽

Individual Therapy ◽

Quality Of Life Indicators ◽

Eortc Qlq C30 ◽

Oral And Oropharyngeal Cancer ◽

Eortc Qlq

Study of the quality of life indicators is an important part of a comprehensive analysis of new diagnosis, treatment, and prevention methods. It can serve as an additional criterion for selecting individual therapy or rehabilitation, examining the ability to work, and identifying psychological problems. Purpose of the study: The authors took a clinical case to demonstrate the use of внтфьшс monitoring of the quality of life indicators for the assessment of surgical and reconstructive treatment outcome for oral and oropharyngeal cancer. Results: The anticancer treatment effects were reflected in the physical functioning score according to the EORTC QLQ-C30 questionnaire (reduced to 80 points) and some symptomatic scores according to the EORTC QLQ-C30 and EORTC QLQ-H & N35 questionnaires. Medical rehabilitation measures resulted in positive dynamics of physical functioning scores according to the EORTC QLQ-C30 questionnaire (increase to 93.3 points) and symptomatic scores according to the EORTC QLQ-H & N35 questionnaire related to nutrition. At that, the patient has stopped having difficulty eating in public places; his body weight increased. The absence of pain and refusal to take analgesics also testified to successful treatment and improved quality of life. Conclusion: A subjective assessment of the various quality of life aspects in a particular patient provides valuable information about the individual response to the conducted treatment.

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EORTC Quality of Life Questionnaire With Added Subjective Weighting for Improving Tailored Treatment and Therapy Monitoring in Oncology

10.21203/rs.3.rs-877481/v1 ◽

2021 ◽

Author(s):

Greta Rose ◽

Dirk Rades ◽

Jurgen Dunst ◽

Nikolas von Bubnoff ◽

Andreas Luebbe ◽

...

Keyword(s):

Quality Of Life ◽

Functional Impairment ◽

Physical Functioning ◽

Individual Therapy ◽

Subjective Rating ◽

Individual Treatment ◽

Life Questionnaire ◽

Eortc Qlq C30 ◽

Eortc Qlq

Abstract Background It is good medical practice to use validated questionnaires to compare different treatment options in oncological therapy studies. Over the course of the past few years, it has been suggested that patient-reported outcome measures (PROMs) could also be of value in monitoring individual treatment schemes, especially in the palliative care setting, where quality of life (QoL) is of primary importance. Although the EORTC-QLQ-C30 comprises a set of personal questions, patients are not asked about the subjectively assessed functional impairment associated with the symptom in their individual life situation. Methods We examined whether the results of the EORTC QLQ C-30, one of the most frequently used QoL questionnaires, would be different if the subjective interpretation of symptoms assessed on a function scale, such as physical functioning, are added to the scores. For each of the five functional scales of the EORTC-QLQ C30 the patients were asked to provide a subjective weighting, e.g. "How would you currently rate your physical functioning on a scale from 1 to 5?". A total of 95 answers from 13 patients were evaluated in part at several time points of their therapy. All patients included in this study had various cancers and were receiving only symptomatic but not curative radiation therapy (cerebral or bone). Results By adding the weighting question 86% of answers changed, with 39% of the answers being more positive and 47 % more negative when comparing EORTC QLQ-C30 results and subjective rating. Conclusion The above results show that the addition of the question of functional impairment resulting from a symptom might enable the use of standard questionnaires like the EORTC QLQ-C30 as an instrument for individual therapy management. Further investigation into how the standard questionnaire needs to be adapted is clearly needed und justified.

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THE EFFECT OF NUTRITIONAL THERAPY ON QUALITY OF LIFE INDICATORS FOR PATIENTS WITH GASTRIC CANCER AT THE STAGE OF SURGICAL TREATMENT

Research n Practical Medicine Journal ◽

10.17709/2409-2231-2019-6-3-10 ◽

2019 ◽

Vol 6 (3) ◽

pp. 108-114 ◽

Cited By ~ 1

Author(s):

A. D. Sergienko ◽

V. E. Khoronenko ◽

E. V. Gameeva ◽

A. B. Ryabov ◽

V. M. Khomyakov

Keyword(s):

Quality Of Life ◽

Gastric Cancer ◽

Surgical Treatment ◽

Nutritional Therapy ◽

Main Group ◽

Control Group ◽

Quality Of Life Indicators ◽

Eortc Qlq C30 ◽

Eortc Qlq

Purpose of the study. To determine the effect of nutritional deficiency and nutritional therapy on the quality of life of patients with gastric cancer at the stage of surgical treatment. Patients and methods. In Thoracoabdominal Department of P. Herzen Moscow Oncology Research Institute within 2017– 2019 the quality of life at the stage of surgical treatment of gastric malignant neoplasms was evaluated in 62 patients (36 men and 26 women) aged 34 to 79 years (mean age 61.9 ± 9.55). At the outpatient stage, patients were divided into 2 groups: in the 1st (main) group, patients received nutritive support with specialized mixtures for 10 days before hospitalization, in the 2nd (control) group, patients were asked to follow a high-protein diet without adding specialized mixtures. The quality of life assessment was carried out on the basis of the EORTC-QLQ-C30 Questionnaire, which patients received on the day of hospitalization. Patients repeatedly filled in EORTC-QLQ-C30 Questionnaire before discharge from the hospital, which allowed to assess the dynamics of the quality of life indicators of the studied patients. The study groups were comparable in social and medical indicators. Results. The analysis of the survey results showed that the “general state of health” in the studied groups at the stage of hospitalization is estimated �bove average. Also, in both groups there is a positive dynamics in the values of the above indicator before discharge. Patients of the 1st group who received specialized nutritional mixtures, developed the statistical significance of the differences in the assessment of the quality of life upon admission and before discharge. Thus, it can be argued that nutritional therapy had a significant positive impact on the quality of life in terms of “general health”, in contrast to the control group of patients who did not receive specialized nutritional therapy. There was a general tendency toward an increase in the quality of life indicators at admission and before discharge on all scores of the questionnaire in groups. Thisis a positive assessment by patients of their condition after providing them with medical services. In this case, the discomfort from the symptoms accompanying the disease is reduced, which is confirmed by the scoring results. Statistically significant differences in the assessment of symptoms occur in the study group. Patients having received nutritional therapy noted a decrease in pain, an improvement in the processes of assimilation of food, as well as an improvement in well-being, physical condition, an increase in general tone and energy, a surge of strength and a sense of vitality. In “decreased appetite”score the indices of patients in the main group decreased by more than 3 times, i. e. their appetite improved significantly under treatment. Improving appetite in patients of the main group led to an improvement in the functioning of the gastrointestinal tract as a whole. Patients in this group noted an improvement in digestion and bowel movements. Conclusion The study showed that the quality of life of patients with gastric cancer largely depends on their nutritional deficiency, and nutritional therapy at the stages of surgical treatment, in turn, can significantly improve its results, including in the aspect of their perception by patients. Using the general EORTC QLQ-C30 questionnaire is one of the available methods for assessing the quality of life in patients with gastric cancer.

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Quality of Life of Breast Cancer Women During Chemotherapy with Fluorouracil, Doxorubicin and Cyclophosphamide (FAC) Regimen

Songklanagarind Medical Journal ◽

10.31584/smj.2017.35.4.753 ◽

2017 ◽

Vol 35 (4) ◽

pp. 373

Author(s):

Sophit Korpunsilp ◽

Tipaporn Pongmesa

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Side Effects ◽

Physical Functioning ◽

P Value ◽

Life Questionnaire ◽

Appetite Loss ◽

Eortc Qlq C30 ◽

Eortc Qlq

Objective: To assess quality of life (QoL) of female breast cancer patients undergoing chemotherapy with a fluorouracil, doxorubicin, and cyclophosphamide (FAC) regimen.Material and Method: This prospective analytical study was performed among 40 Thai female patients receiving the FAC regimen at Pranangklao Hospital, Nonthaburi province. Their QoL was assessed using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and Breast Cancer Module (EORTC QLQ-BR23).Results: Most patients were aged 50 years or over (77.5%) and had been diagnosed with stage 2 breast cancer (47.5%). According to the EORTC QLQ-C30, the patients’ QoL significantly decreased compared to the baseline after cycle 3 for global health status (p-value=0.002) and QoL (p-value=0.001), as well as physical functioning (p-value=0.015) and role functioning (p-value=0.001), while symptoms of fatigue, nausea/vomiting, and appetite loss increased (p-value<0.001). After cycle 5, the patients’ QoL was still significantly lower than at baseline, for physical functioning (p-value=0.009) and symptoms of fatigue, nausea/vomiting, appetite loss (p-value<0.001) and dyspnea (p-value=0.005). The EORTC QLQ-BR23 reported significantly worse systemic therapy side effects for both cycles 3 and 5 (p-value<0.001), and distress due to hair loss also appeared after cycle 5 (p-value=0.016). No significant differences were revealed on any scales between cycles 3 and 5.Conclusion: The patients’ QoL significantly decreased after chemotherapy with the FAC regimen, with some side effects from treatment and reduction in some functioning.

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Quality of life after Whipple pancreatoduodenectomy and pylorus-preserving pancreatoduodenectomy: a comparative study

Pediatrician (St Petersburg) ◽

10.17816/ped6348-51 ◽

2015 ◽

Vol 6 (3) ◽

pp. 48-51 ◽

Cited By ~ 1

Author(s):

Nikolay Yurevich Kokhanenko ◽

Konstantin Vadimovich Pavelets ◽

Yuri Vasilevich Radionov ◽

Yurii Nikolaevich Shiryajev ◽

Natalya Yurevna Borisova

Keyword(s):

Quality Of Life ◽

Comparative Analysis ◽

Surgical Treatment ◽

Whipple Procedure ◽

Periampullary Cancer ◽

Physical Role ◽

Time Period ◽

Eortc Qlq C30 ◽

Eortc Qlq

The authors performed a comparative analysis of the Quality of life (QOL) in 97 patients after pancreatoduodenectomy, 55 of whom underwent pylorus-preserving surgery (PPDE), and 42 underwent classic Whipple procedure (GPDE). QOL was evaluated using questionnaire EORTC-QLQ-C30, version 3.0, and both analyzed groups were divided into 3 subgroups according to the time period after the surgery (less than 6 mo, 6-12 mo, and more than 12 mo). All the patients were operated on for pancreatic or periampullary cancer. During the first period after surgery (less than 6 mo), the integral QOL index is lower than in patients who were examined after the first 6 mo. After PPDE, parameters of physical, role, emotional, cognitive, and social functioning were higher than after GPDE; however, these differences were not statistically significant (p > 0,05). Indicators of QOL have changed with time, but intergroup (PPDE vs GPDE) differences were not statistically significant in every analyzed time period after surgery. Financial constrains were registered in patients of both groups and at different times after surgical treatment.

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Quality of Life Variables Assessment, Before and After Pancreatoduodenectomy (PD): Prospective Study

Global Journal of Health Science ◽

10.5539/gjhs.v8n6p203 ◽

2015 ◽

Vol 8 (6) ◽

pp. 203 ◽

Cited By ~ 9

Author(s):

Maria Arvaniti ◽

Nikolaos Danias ◽

Eleni Theodosopoulou ◽

Vassilis Smyrniotis ◽

M. Karaoglou ◽

...

Keyword(s):

Quality Of Life ◽

Pancreatic Cancer ◽

Surgical Treatment ◽

Gastrointestinal Symptoms ◽

The Body ◽

Full Data ◽

Before And After ◽

Eortc Qlq C30 ◽

Eortc Qlq

INTRODUCTION: The treatment of pancreatic cancer is a complex problem, due to late diagnosis, the need for specialized surgical treatment, the large number of relapses and poor survival.OBJECTIVE: To evaluate the quality of life of patients with periampulary pancreatic cancer before and after pancreatoduodenectomy (PD).MATERIAL & METHOD: The sample was collected in the "Attikon" University General Hospital (Chaidari). It consists of 20 subjects with a mean age of 65.9 years (SD = 10,2 years). For the quality of life measurement, we used the (EORTC) QLQ-C30 version 3.0., as well as the EORTC QOL-PAN26.RESULTS: From the sample of 20 patients who participated, full data were collected for 18 of them during the first month, 17 during the third month and 16 during the sixth month.Regarding symptoms, as they were recorded with the QLQ-30 questionnaire, there was a significant increase of fatigue, a significant reduction of pain and constipation, while economic difficulties increased. As for the mean and median values for the dimensions of the PAN-26 questionnaire during monitoring, there was a significant decrease in pancreatic and liver pain symptoms during follow-up, while the gastrointestinal symptoms increased in frequency. In addition, the body image and sexuality worsened.CONCLUSIONS: The surgical treatment of pancreatic cancer with pancreatoduodenectomy (PD), according to the early survey data using the (EORTC) QLQ-C30 version3.0, and the EORTC QOL-PAN26 questionnaires, seems to have a favorable impact on quality of life, as evidenced by the improvement of most parameters evaluated during the study period.

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Quality of life after surgical treatment for oral and oropharyngeal cancer: A prospective longitudinal assessment of patients reconstructed by a microvascular flap

Oral Oncology ◽

10.1016/j.oraloncology.2006.11.017 ◽

2007 ◽

Vol 43 (10) ◽

pp. 1034-1042 ◽

Cited By ~ 55

Author(s):

Pepijn A. Borggreven ◽

Neil K. Aaronson ◽

Irma M. Verdonck-de Leeuw ◽

Martin J. Muller ◽

Milou L.C.H. Heiligers ◽

...

Keyword(s):

Quality Of Life ◽

Surgical Treatment ◽

Oropharyngeal Cancer ◽

Longitudinal Assessment ◽

Microvascular Flap ◽

Oral And Oropharyngeal Cancer ◽

Prospective Longitudinal

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Psychometric validation of the Moroccan version of the EORTC QLQ-C30 in colorectal Cancer patients: cross-sectional study and systematic literature review

BMC Cancer ◽

10.1186/s12885-021-07793-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yacir El Alami ◽

Hajar Essangri ◽

Mohammed Anass Majbar ◽

Saber Boutayeb ◽

Said Benamr ◽

...

Keyword(s):

Quality Of Life ◽

Colorectal Cancer ◽

Discriminant Validity ◽

Cross Sectional Study ◽

Cross Sectional ◽

Related Quality ◽

Eortc Qlq C30 ◽

Eortc Qlq ◽

Colorectal Cancer Patients

Abstract Background Health-related quality of life is mainly impacted by colorectal cancer which justified the major importance addressed to the development and validation of assessment questionnaires. We aimed to assess the validity and reliability of the Moroccan Arabic Dialectal version of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30) in patients with colorectal cancer. Methods We conducted a cross-sectional study using the Moroccan version of the EORTC QLQ-C30 on colorectal cancer patients from the National Oncology Institute of Rabat, in the period from February 2015 to June 2017. The QLQ-C30 was administered to 120 patients. Statistical analysis included reliability, convergent, and discriminant validity as well as known-groups comparisons. Results In total, 120 patients with colorectal cancer were included in the study with 38 (32%) patients diagnosed with colon cancers. Eighty-two patients (68%) had rectal cancer, among which 29 (24%) patients with a stoma. The mean age of diagnosis was 54 years (+/− 13.3). The reliability and validity of the Arabic dialectal Moroccan version of the EORTC QLQ-C30 were satisfactory. [Cronbach’s alpha (α =0.74)]. All items accomplished the criteria for convergent and discriminant validity except for question number 5, which did not complete the minimum required correlation with its own scale (physical functioning). Patients with rectal cancer presented with bad Global health status and quality of life (GHS/QOL), emotional functioning as well as higher fatigue symptoms compared to patients with colon cancer. The difference between patients with and without stoma was significant for diarrhea and financial difficulty. Conclusions The Moroccan Arabic Dialectal version of the QLQ-C30 is a valid and reliable measure of health-related quality of life (HRQOL) in patients with colorectal cancer.

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Impact of individualized management of breakthrough cancer pain on quality of life in advanced cancer patients: CAVIDIOPAL study

Supportive Care in Cancer ◽

10.1007/s00520-021-06006-1 ◽

2021 ◽

Author(s):

Albert Tuca Rodríguez ◽

Miguel Núñez Viejo ◽

Pablo Maradey ◽

Jaume Canal-Sotelo ◽

Plácido Guardia Mancilla ◽

...

Keyword(s):

Quality Of Life ◽

Cancer Pain ◽

Advanced Cancer ◽

Low Doses ◽

Breakthrough Cancer Pain ◽

Eortc Qlq C30 ◽

Eortc Qlq ◽

Individualized Management ◽

The Impact

Abstract Purpose The main aim of the study was to assess the impact of individualized management of breakthrough cancer pain (BTcP) on quality of life (QoL) of patients with advanced cancer in clinical practice. Methods A prospective, observational, multicenter study was conducted in patients with advanced cancer that were assisted by palliative care units. QoL was assessed with the EORTC QLQ-C30 questionnaire at baseline (V0) and after 28 days (V28) of individualized BTcP therapy. Data on background pain, BTcP, comorbidities, and frailty were also recorded. Results Ninety-three patients completed the study. Intensity, duration, and number of BTcP episodes were reduced (p < 0.001) at V28 with individualized therapy. Transmucosal fentanyl was used in 93.8% of patients, mainly by sublingual route. Fentanyl titration was initiated at low doses (78.3% of patients received doses of 67 μg, 100 μg, or 133 μg) according to physician evaluation. At V28, mean perception of global health status had increased from 31.1 to 53.1 (p < 0.001). All scales of EORTC QLQ-C30 significantly improved (p < 0.001) except physical functioning, diarrhea, and financial difficulties. Pain scale improved from 73.6 ± 22.6 to 35.7 ± 22.3 (p < 0.001). Moreover, 85.9% of patients reported pain improvement. Probability of no ≥ 25% improvement in QoL was significantly higher in patients ≥ 65 years old (OR 1.39; 95% CI 1.001–1.079) and patients hospitalized at baseline (OR 4.126; 95% CI 1.227–13.873). Conclusion Individualized BTcP therapy improved QoL of patients with advanced cancer. Transmucosal fentanyl at low doses was the most used drug. Trial registration This study was registered at ClinicalTrials.gov database (NCT02840500) on July 19, 2016.

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United States Utility Algorithm for the EORTC QLU-C10D, a Multiattribute Utility Instrument Based on a Cancer-Specific Quality-of-Life Instrument

Medical Decision Making ◽

10.1177/0272989x211003569 ◽

2021 ◽

pp. 0272989X2110035

Author(s):

Dennis A. Revicki ◽

Madeleine T. King ◽

Rosalie Viney ◽

A. Simon Pickard ◽

Rebecca Mercieca-Bebber ◽

...

Keyword(s):

Quality Of Life ◽

United States ◽

Emotional Functioning ◽

Health State ◽

Life Questionnaire ◽

Multiattribute Utility ◽

Value Set ◽

Eortc Qlq C30 ◽

Eortc Qlq

Background The EORTC QLU-C10D is a multiattribute utility measure derived from the cancer-specific quality-of-life questionnaire, the EORTC QLQ-C30. The QLU-C10D contains 10 dimensions (physical, role, social and emotional functioning, pain, fatigue, sleep, appetite, nausea, bowel problems). The objective of this study was to develop a United States value set for the QLU-C10D. Methods A US online panel was quota recruited to achieve a representative sample for sex, age (≥18 y), race, and ethnicity. Respondents undertook a discrete choice experiment, each completing 16 choice-pairs, randomly assigned from a total of 960 choice-pairs. Each pair included 2 QLU-C10D health states and duration. Data were analyzed using conditional logistic regression, parameterized to fit the quality-adjusted life-year framework. Utility weights were calculated as the ratio of each dimension-level coefficient to the coefficient for life expectancy. Results A total of 2480 panel members opted in, 2333 (94%) completed at least 1 choice-pair, and 2273 (92%) completed all choice-pairs. Within dimensions, weights were generally monotonic. Physical functioning, role functioning, and pain were associated with the largest utility weights. Cancer-specific dimensions, such as nausea and bowel problems, were associated with moderate utility decrements, as were general issues such as problems with emotional functioning and social functioning. Sleep problems and fatigue were associated with smaller utility decrements. The value of the worst health state was 0.032, which was slightly greater than 0 (equivalent to being dead). Conclusions This study provides the US-specific value set for the QLU-C10D. These estimated health state scores, based on responses to the EORTC QLQ-C30 questionnaire, can be used to evaluate the cost-utility of oncology treatments.

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