scholarly journals Results of the Expert Forum on the application of perampanel in routine clinical practice

2020 ◽  
Vol 12 (2) ◽  
pp. 125-132
Author(s):  
Article Editorial
Keyword(s):  
Clinical Practice ◽  
Safety Profile ◽  
Routine Clinical Practice ◽  
Age And Gender ◽  
Potential Risks ◽  
And Gender ◽  
Gender Groups ◽  
Patients With Epilepsy

In February 2020, in Moscow, Expert Forum was held on the issues of the application of perampanel in routine clinical practice. The main aim of the Forum was to discuss the tolerance and safety profile of perampanel in patients with epilepsy in different age and gender groups in the conditions of routine clinical practice. Leading experts in neurology and epileptology took part in the Forum, wherein the acute data on the efficiency and safety of perampanel and the management of potential risks were presented.

Exceeding the Recommended Energy Limits Due to Age and Gender in Occupational Aerobic Workloads

2022 ◽  
pp. 585-599
Author(s):  
Cesar Omar Balderrama Armendariz ◽  
Jose de Jesus Flores Figueroa ◽  
Judith Lara Reyes ◽  
Ludovico Soto Nogueira
Keyword(s):  
Cardiovascular Diseases ◽  
Musculoskeletal Disorders ◽  
Metabolic Demand ◽  
Heavy Load ◽  
Age And Gender ◽  
Sensitive Factor ◽  
Potential Risks ◽  
Metabolic Expenditure ◽  
And Gender ◽  
Gender Groups

The purpose of this chapter is to analyze the physical aerobic work in terms of the metabolic expenditure and compare it with the recommended boundaries of energy found in literature, proposing an alternative to the potential work overload through a compensatory equation introduced in the standard time of the workstation. To support the study, information considering the estimated metabolic expenditure in workers was applied to a novel procedure to reduce the metabolic demand of the task according to age and gender. Results of the study indicated that women older than 30 years exceeded the energy limits from moderate to very heavy load activities, and men older than 40 years exceeded the energy limits in heavy and very heavy workloads. The proposal of compensatory equation statistically reduced the energy loads below the recommended limits of energy. The aerobic workload is a sensitive factor for age and gender groups and can be potential risks for developing cardiovascular diseases as well as some musculoskeletal disorders.

Exceeding the Recommended Energy Limits Due to Age and Gender in Occupational Aerobic Workloads

2019 ◽  
pp. 128-142
Author(s):  
Cesar Omar Balderrama Armendariz ◽  
Jose de Jesus Flores Figueroa ◽  
Judith Lara Reyes ◽  
Ludovico Soto Nogueira
Keyword(s):  
Cardiovascular Diseases ◽  
Musculoskeletal Disorders ◽  
Metabolic Demand ◽  
Heavy Load ◽  
Age And Gender ◽  
Sensitive Factor ◽  
Potential Risks ◽  
Metabolic Expenditure ◽  
And Gender ◽  
Gender Groups

The purpose of this chapter is to analyze the physical aerobic work in terms of the metabolic expenditure and compare it with the recommended boundaries of energy found in literature, proposing an alternative to the potential work overload through a compensatory equation introduced in the standard time of the workstation. To support the study, information considering the estimated metabolic expenditure in workers was applied to a novel procedure to reduce the metabolic demand of the task according to age and gender. Results of the study indicated that women older than 30 years exceeded the energy limits from moderate to very heavy load activities, and men older than 40 years exceeded the energy limits in heavy and very heavy workloads. The proposal of compensatory equation statistically reduced the energy loads below the recommended limits of energy. The aerobic workload is a sensitive factor for age and gender groups and can be potential risks for developing cardiovascular diseases as well as some musculoskeletal disorders.

EPA-1095 - Impact of pain on the outcomes of depression across age and gender groups in china

2014 ◽  
Vol 29 ◽  
pp. 1
Author(s):  
D. Novick ◽  
W. Montgomery ◽  
V. Moneta ◽  
X. Peng ◽  
R. Brugnoli ◽  
...  
Keyword(s):  
Age And Gender ◽  
And Gender ◽  
Gender Groups

Hair Magnesium content and its relation to Serum Magnesium level in children with Idiopathic Epilepsy

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Hamed Mahmoud Shatla ◽  
Mariam Fathy Abdel Maksoud ◽  
Raghda Mohamed Hesham Zaitoun ◽  
Alaa Rabie Abdel Baset Mahmoud
Keyword(s):  
Serum Magnesium ◽  
Serum Levels ◽  
Magnesium Content ◽  
Magnesium Level ◽  
Idiopathic Epilepsy ◽  
Age And Gender ◽  
Control Subjects ◽  
Significant Difference ◽  
And Gender ◽  
Patients With Epilepsy

Abstract Objective To measure the level of hair Mg, as well as its level in serum, in patients with epilepsy and compare them to the levels found in non-epileptic age and gender matched children, and to explore any potential correlation between either serum or hair level of magnesium and seizure characteristics in children with idiopathic epilepsy. Methods An observational cross-sectional study including 50 children with idiopathic epilepsy and 100 non-epileptic age and gender matched control subjects. Cases were subjected to full history taking, examination and measurements of serum and hair levels of magnesium, control subjects only had their serum and hair level of magnesium measured as for the cases. Results The mean serum magnesium was 29.11 ± 13.42 ug/ml for cases and 27.67 ± 7.24 ug/ml for controls and the median hair level of magnesium was 42.22 ug/g with IQR of 25.9 - 56.82 for cases and 38.6 ug/g with IQR of 25.21 - 61.25 for controls. No statistically significant difference was observed between both groups as regards either serum or hair magnesium levels. No statistically significant correlation was observed between either hair or serum levels of magnesium and seizure characteristics though the correlations were nearing statistical significance for the hair magnesium content. Conclusion Hair magnesium level may be better correlated to seizure characteristics and control than serum levels in patients with epilepsy.

Self and Identity in Personal Blogs

2010 ◽  
pp. 162-184
Author(s):  
Wengao Gong
Keyword(s):  
Developmental Stage ◽  
Cross Cultural ◽  
Cultural Environment ◽  
Cultural Comparison ◽  
Linguistic Practice ◽  
Age And Gender ◽  
Language And Culture ◽  
Cross Cultural Comparison ◽  
And Gender ◽  
Gender Groups

This chapter describes how American bloggers and Chinese bloggers from similar age and gender groups represent themselves and their identities linguistically in their blogs and explores whether and to what extent the differences in terms of the blogging language and culture affect these representations. The author adopts a corpus-based approach and focuses on the description and the comparison of the orthographic features and semantic domain preference as revealed in the blog entries. By conducting a cross-linguistic and cross-cultural comparison between American bloggers and Chinese bloggers, the author finds that bloggers’ linguistic practice is closely related to their developmental stage of life, their gender, and the cultural environment they are immersed in. Meanwhile, bloggers’ linguistic practice is also constrained by the internal system of the language they use for blogging.

Safety of a trastuzumab biosimilar, used under routine clinical practice conditions in adult HER2+ breast cancer patients in Morocco.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13024-e13024
Author(s):  
Hassan Errihani ◽  
Narjiss Berrada ◽  
Mouna Khouchani ◽  
Abdelkader Acharki ◽  
Kamal Lahbabi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Practice ◽  
Adverse Events ◽  
Early Breast Cancer ◽  
Real World ◽  
Safety Profile ◽  
Safety Data ◽  
Routine Clinical Practice ◽  
Her2 Breast Cancer

e13024 Background: Hertraz, the first trastuzumab biosimilar was approved in Morocco in 2017. Real world data on trastuzumab biosimilars are very limited or not available. HERLife is a prospective, non-interventional phase IV study program that investigated the experience of using Hertraz, a biosimilar for trastuzumab (Herceptin), under routine clinical practice conditions in Morocco. The primary aim of this study was to confirm the acceptable safety and tolerability of Hertraz. Methods: Ninety-nine patients with HER2-positive breast cancer treated with Hertraz were enrolled from 8 public and private sector hospitals and followed up for 12 months as part of this non-interventional study. Cardiac events (LVEF) and other unexpected or serious adverse events were monitored. The study arms consisted of patients with early breast cancer (Arm 1, n=70) and metastatic breast cancer (Arm 2, n=29) whose median age was 53 years in both groups. Results: Switching from Herceptin to Hertraz was observed in 45% of 29 MBC patients and 27% of 70 EBC patients. Switching was done at a median of 4th cycle. Pertuzumab was used in combination with Hertraz in 69% and 19% of patients in the metastatic and neoadjuvant settings, respectively. Two patients had a decline in LVEF. One patient treated with Hertraz alone and one patient treated with Hertraz and pertuzumab developed a decrease in LVEF requiring a three-week treatment discontinuation of Hertraz. Treatment of Hertraz was continued after 1 skipped cycle without occurrence of new side effects. No other trastuzumab related adverse events was observed. Four patients in the metastatic group and 2 patients in the early breast cancer arm had a relapse in the 12 months of clinical follow-up. Conclusions: The management of HER2+ breast cancer in Morocco follows the international recommendations. This is the first real world safety data of Hertraz from Morocco. The 12-month follow-up treatment with Hertraz showed an acceptable cardiac safety profile. In cases where there was a switch from Herceptin to Hertraz or Hertraz combined with pertuzumab, the safety profile was similar to that previously reported in other studies.

Sign in / Sign up

Export Citation Format

Share Document