scholarly journals Efficacy of alpha-lipoic acid in chronic generalized periodontitis in patients with infiltrative pulmonary tuberculosis

2017 ◽  
Vol 98 (2) ◽  
pp. 194-199
Author(s):  
N A Lunina ◽  
O V Velikaya ◽  
V A Kunin
Keyword(s):  
Pulmonary Tuberculosis ◽  
Lipoic Acid ◽  
Oral Fluid ◽  
Clinical Signs ◽  
Complex Treatment ◽  
Acid Product ◽  
Data Dynamics ◽  
Factor Α ◽  
Gingival Fluid ◽  
Necrosis Factor

Aim. To study clinical efficacy of chronic generalized periodontitis treatment in patients with infiltrative pulmonary tuberculosis with the use of α-lipoic acid. Methods. 50 patients with chronic generalized periodontitis and infiltrative pulmonary tuberculosis randomly divided into 2 groups were examined. The study group included 25 patients who had received α-lipoic acid «Octolipen» in complex treatment for 3 months. The comparison group included 25 patients who were administered complex treatment of tuberculosis and periodontitis without α-lipoic acid. All patients on admission and dynamically after 3 months of treatment had routine clinical studies, cytology analysis of capillary gingival blood and gingival fluid and cytokine status testing of oral fluid. Results. Patients with chronic generalized periodontitis combined with infiltrative pulmonary tuberculosis who received «Octopilen» had statistically significant positive dynamics of clinical signs and decrease of basic dental indices after 3 months of treatment compared to baseline data. Dynamics of IL-1β, tumor necrosis factor α and IL-4 revealed significant decrease of these cytokines concentration in gingival fluid in patients from both groups after 3 months of treatment. Conclusion. Inclusion of α-lipoic acid product to complex treatment of patients with chronic generalized periodontitis combined with infiltrative pulmonary tuberculosis leads to faster clinical remission.

scholarly journals Thalidomide Treatment Reduces Tumor Necrosis Factor α Production and Enhances Weight Gain in Patients with Pulmonary Tuberculosis

1995 ◽  
Vol 1 (4) ◽  
pp. 384-397 ◽  
Author(s):  
Jane M. Tramontana ◽  
Utaiwan Utaipat ◽  
Anthony Molloy ◽  
Pasakorn Akarasewi ◽  
Margaret Burroughs ◽  
...  
Keyword(s):  
Weight Gain ◽  
Tumor Necrosis Factor ◽  
Pulmonary Tuberculosis ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Thalidomide Treatment ◽  
Necrosis Factor

scholarly journals MMP-2 Plays an Important Role During the Early Acute Developmental Phase of Oligofructose-Induced Equine Laminitis

2015 ◽  
Vol 59 (1) ◽  
pp. 149-153 ◽  
Author(s):  
Xinran Li ◽  
Renli Jiang ◽  
Guanying Wang ◽  
Yue Li ◽  
Xiaojing Fan ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Plasma Concentrations ◽  
Clinical Signs ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Developmental Phase ◽  
Tnf Α ◽  
Mitogen Activated Protein ◽  
Factor Α ◽  
Necrosis Factor

Abstract The study was conducted on 24 Mongolian horses, with oligofructose-induced equine laminitis (10 g/kg b.w.). The objective of the study was to investigate the relationships among matrix metalloproteinase 2 (MMP-2), P38 mitogen-activated protein kinases (P38 MAPK), tissue inhibitor of metalloproteinase 2 (TIMP-2), lipopolysaccharides (LPS), and tumour necrosis factor-α (TNF-α) during acute developmental phase of laminitis, and to determine whether there are any characteristic tendencies. Moreover, plasma concentrations of LPS and TNF-α were measured in order to determine the time of leukocytes’ activation. Eleven of the 12 horses showed clinical signs of laminitis. The contents of MMP-2 and P38 MAPK increased significantly from 8 h to 64 h, and the content of TIMP-2 decreased significantly at the same time. Plasma LPS concentrations increased significantly between 8 h and 20 h and reached a peak of 0.024 ± 0.009 EU/mL (equivalent to 3.04 ± 1.19 pg/mL) at 12 h. TNF-α concentration increased between 20 h and 36 h. This data indicates that MMP-2 plays an important role during the early acute developmental phase of oligofructose-induced equine laminitis.

scholarly journals Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis

2003 ◽  
Vol 12 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Levent Kart ◽  
Hakan Buyukoglan ◽  
Ishak O. Tekin ◽  
Remzi Altin ◽  
Zuhal Senturk ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Tumor Necrosis ◽  
Interleukin 2 ◽  
Clinical Manifestations ◽  
Interleukin 4 ◽  
Active Pulmonary Tuberculosis ◽  
Tnf Α ◽  
Soluble Interleukin 2 Receptor ◽  
Factor Α ◽  
Necrosis Factor

The precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-α, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-α, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray (minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-α (20.9±10/15.4±8 pg/ml) and sIL-2R (2569±842/1444±514 pg/ml) were statistically different between patients and controls (p=0.02andp=0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-α and sIL-2R(r=0.34), but there was no correlation between IL-4 and TNF-α, and between IL-4 and sIL-2R(r=−0.23andr=−0.22). The TNF-α level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-α, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity.

Relation of Leptin and Tumor Necrosis Factor α to Body Weight Changes in Patients with Pulmonary Tuberculosis

1999 ◽  
Vol 52 (6) ◽  
pp. 279-283 ◽  
Author(s):  
Bekir Çakır ◽  
Arif Yönem ◽  
Serdar Güler ◽  
Ersin Odabaşı ◽  
Berrin Demirbaş ◽  
...  
Keyword(s):  
Body Weight ◽  
Tumor Necrosis Factor ◽  
Pulmonary Tuberculosis ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Weight Changes ◽  
Body Weight Changes ◽  
Factor Α ◽  
Necrosis Factor
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