An efficient green synthesis of substituted indolin-2-one derivatives using piperidine catalyzed Henry reaction of isatins

2015 ◽  
Vol 2 (7) ◽  
pp. 358-364
Author(s):  
Jagadeesh Kumar
Keyword(s):  
Green Synthesis ◽  
Henry Reaction

Green Synthesis of BaCrO4 Nanoparticles Using Glycyrrhiza Glabra Extract

2014 ◽  
Author(s):  
Faranak Manteghi ◽  
Navid Shahmiri ◽  
Beheshteh Sohrabi ◽  
Sina Golafshan
Keyword(s):  
Green Synthesis ◽  
Glycyrrhiza Glabra

Aiming for a Standardized Protocol for Preparing a Process Green Synthesis Report and for Ranking Multiple Synthesis Plans to a Common Target Product

2019 ◽  
Author(s):  
john andraos
Keyword(s):  
Green Synthesis ◽  
Block Diagram ◽  
Computational Method ◽  
Borda Count ◽  
Target Product ◽  
Material Efficiency ◽  
Synthesis Report ◽  
Common Target ◽  
Greenness Index ◽  
Multiple Synthesis

This paper proposes a standardized format for the preparation of process green synthesis reports that can be applied to chemical syntheses of active pharmaceutical ingredients (APIs) of importance to the pharmaceutical industry. Such a report is comprised of the following eight sections: a synthesis scheme, a synthesis tree, radial pentagons and step E-factor breakdowns for each reaction step, a tabular summary of key material efficiency step and overall metrics for a synthesis plan, a mass process block diagram, an energy consumption audit based on heating and cooling reaction and auxiliary solvents, a summary of environmental and safety-hazard impacts based on organic solvent consumption using the Rowan solvent greenness index, and a cycle time process schedule. Illustrative examples of process green synthesis reports are given for the following pharmaceuticals: 5-HT2B and 5-HT7 receptors antagonist (Astellas Pharma), brivanib (Bristol-Myers Squibb), and orexin receptor agonist (Merck). Methods of ranking synthesis plans to a common target product are also discussed using 6 industrial synthesis plans of apixaban (Bristol-Myers Squibb) as a working example. The Borda count method is suggested as a facile and reliable computational method for ranking multiple synthesis plans to a common target product using the following 4 attributes obtained from a process green synthesis report: process mass intensity, mass of sacrificial reagents used per kg of product, input enthalpic energy for solvents, and Rowan solvent greenness index for organic solvents.<br>

Green synthesis of nanomaterials for early lung cancer detection

2018 ◽  
pp. 1-1
Keyword(s):  
Lung Cancer ◽  
Green Synthesis ◽  
Cancer Detection ◽  
World Wide ◽  
Early Stage ◽  
Age Groups ◽  
Early Lung Cancer ◽  
Lung Cancer Detection ◽  
Synthesis Of Nanomaterials

Lung cancer is the foremost cause of cancer-related deaths world-wide [1]. It affects 100,000 Americans of the smoking population every year of all age groups, particularly those above 50 years of the smoking population [2]. In India, 51,000 lung cancer deaths were reported in 2012, which include 41,000 men and 10,000 women [3]. It is the leading cause of cancer deaths in men; however, in women, it ranked ninth among all cancerous deaths [4]. It is possible to detect the lung cancer at a very early stage, providing a much higher chance of survival for the patients.

Metallic Nanoparticle Synthesis by Green Chemistry

2018 ◽  
Vol 11 (6) ◽  
pp. 4287-4294
Author(s):  
Anikate Sood ◽  
Shweta Agarwal
Keyword(s):  
Green Chemistry ◽  
Green Synthesis ◽  
Biomedical Research ◽  
Metallic Nanoparticles ◽  
Nanoparticle Synthesis ◽  
Synthesis Methods ◽  
Metallic Nanoparticle ◽  
Medical Field ◽  
Advantages And Disadvantages ◽  
Gold Silver

Nanotechnology is the most sought field in biomedical research. Metallic nanoparticles have wide applications in the medical field and have gained the attention of various researchers for advanced research for their application in pharmaceutical field. A variety of metallic nanoparticles like gold, silver, platinum, palladium, copper and zinc have been developed so far. There are different methods to synthesize metallic nanoparticles like chemical, physical, and green synthesis methods. Chemical and physical approaches suffer from certain drawbacks whereas green synthesis is emerging as a nontoxic and eco-friendly approach in production of metallic nanoparticles. Green synthesis is further divided into different approaches like synthesis via bacteria, fungi, algae, and plants. These approaches have their own advantages and disadvantages. In this article, we have described various metallic nanoparticles, different modes of green synthesis and brief description about different metabolites present in plant that act as reducing agents in green synthesis of metallic nanoparticles. 

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