scholarly journals Experience in using low-temperature plasma after surgical treatment of breast cancer

Author(s):  
M. Yu. Gerasimenko ◽  
I. S. Evstigneeva ◽  
Ch. T. Salchak ◽  
T. N. Zaitseva ◽  
M. G. Lutoshkina

Background.Plasma medicine is a new direction in science at the intersection of plasma physics and chemistry with biology and medicine low-temperature plasma (LTP) has a number of fundamental advantages, which include high non-specific bactericidal activity, low probability of the appearance of stable forms, the absence of ionizing radiation and highly toxic substances. In addition, LTP stimulates healing of infected wounds at the early stages of exposure, which makes LTP a promising method of treating various pathological conditions. Clinical case description.Low-temperature argon plasma treatment was performed for a patient with a diagnosis of: cancer of the right breast cancer T2N1M0, IIB stage. Condition after non-adjuvant PCT and radical resection of the right breast. Complication: Abscess in the area of the postoperative scar. After the 3rd treatment with plasma flow, the wound was sutured and while continuing treatment with low-temperature argon plasma, the patient began radiation therapy of the right breast and regional lymph flow zones in the mode of classical dose fractionation. During the follow-up period, the patient showed positive dynamics in the area of the postoperative scar, which did not lead to a long period of rehabilitation in the postoperative period and radiation therapy was started in a timely manner. Conclusion.Thus, the use of this technique in clinical practice has proven that the period of rehabilitation in the postoperative period is shortened for continuous comprehensive treatment of severe cancer patients with breast cancer.

2021 ◽  
Vol 21 (9) ◽  
pp. 18662-18675
Author(s):  
Hannah Mugure Kamano ◽  
◽  
Michael Okoth ◽  
Wambui-Kogi Makau ◽  
Patrick Patrick ◽  
...  

Maize (Zea mays var. indentata L.) is the most important food security crop in Kenya and plays an important role in human nutrition. Mycotoxins (MTs) are fungal toxic metabolites which naturally contaminate food and feed. When ingested, inhaled or adsorbed through the skin, even in very small concentrations, are associated with various cancers, retarded growth, suppressed immunity and mutations among other complications. Aflatoxins especially aflatoxin B1, are considered the most lethal in the group of more than three hundred known mycotoxins. In Kenya, aflatoxin contamination in maize leads to huge losses in the country’s breadbasket and also in the grain reserves. One of the possible methods for control of the aflatoxin menace in maize would be through the use of plasma technology. Plasma, an electrically energized matter in form of a gas that is generated at different atmospheric pressures, has several uses. At low temperature, it makes the process of decontamination practical, inexpensive and suitable for products whereby use of heat is not desired. Non thermal plasma, a new discipline in food processing has been shown to destroy micro-organisms including spores to undetectable levels. Over the years, there has been increased concern over the rising cases of aflatoxin poisoning in Kenya due to contaminated maize. The presence of aflatoxins is promoted by various factors, among them poor storage conditions, soil type, insect activity and drought conditions before harvest. Several measures including use of hermetic storage types such as pics (Purdue Improved Cowpea Storage) bags to store maize and proper drying of maize to the right moisture content to discourage mould growth have been suggested and used to tackle the aflatoxin menace. In Mexico and Caribbean countries, nixtamalization is widely practised and has been used to reduce aflatoxin in tortilla. Nixtamilization involves cooking the maize in an alkaline solution resulting in detoxification. The traditional nixtamalization and extrusion cooking processes have been combined in making of the dough (masa) for corn tortillas and have shown better success in elimination of aflatoxin. The main challenge with the use of this method of detoxification is acidification of aflatoxin extracts, which occurs during digestion and can lead to a rebuilding of the aflatoxin molecule leading to poisoning. The application of low temperature plasma technology can bring much needed reprieve in tackling the aflatoxin menace in maize and other foods both in Kenya and even worldwide.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Farhad Nejat ◽  
Khosrow Jadidi ◽  
Hosein Aghamollaei ◽  
Mohammad Amin Nejat ◽  
Nazanin-Sadat Nabavi ◽  
...  

Abstract Background Atmospheric Low-Temperature Plasma (ALTP) can be used as an effective tool in conjunctival cyst ablation, but little is known about how conjunctival ALTP-exposure affects the concentration of inflammatory mediators and also the duration of inflammatory responses. Methods We used 8 female adult Lewis rats that were followed up in 4 groups. The right eye of each rat was selected for the test, whereas the left eye was considered as a control. The ALTP was generated and used to target 3 spots of the conjunctiva. The digital camera examinations were performed to follow-up the clinical outcomes after ALTP exposure. Tear and serum samples were isolated—at 2 days, 1 week, 1 month, and 6 months after treatment—from each rat and the concentration of candidate pro-inflammatory (i.e. IL-1α, IL-2, IL-6, IFN-γ, and TNF-α) and anti-inflammatory cytokines (i.e. IL-4 and IL-10) were measured using flow cytometry. Results The external and digital camera examinations showed no ocular surface complications in all ALTP-exposed rats after 1 week. The analyses revealed that the ALTP transiently increases the concentration of pro-inflammatory cytokines—IL-1α and IL-2 in tear samples in 1 week and 2 days after exposure, respectively; no differences were observed regarding other pro- and anti-inflammatory cytokines in the tear or serum samples. Conclusions ALTP can probably be used as a minimally-invasive therapeutic method that triggers no permanent or continual inflammatory responses. The results of this study might help the patients to shorten the consumption of immunosuppressive drugs, e.g. corticosteroids, that are prescribed to mitigate the inflammation after ALTP-surgery.


2014 ◽  
Vol 13 (1) ◽  
Author(s):  
Ladislav Moravský ◽  
Matej Klas ◽  
Eva Machová ◽  
Katarina Pisklová ◽  
Štefan Matejčík

AbstractA rapid growth of interest in low temperature plasma in medicine in recent years has given a rise to a number of different applications. We report a low cost kHz driven argon plasma jet with flow rate less than 0.15 L min


2019 ◽  
Vol 23 (3) ◽  
pp. 746-754
Author(s):  
Dinar Dilshatovich Fazullin ◽  
Gennady Vitalievich Mavrin ◽  
Vladislav Olegovich Dryakhlov ◽  
Ildar Gilmanovich Shaikhiev ◽  
Irek Rashatovich Nizameyev

Sign in / Sign up

Export Citation Format

Share Document