scholarly journals SCLEROATROPHIC LICHEN - CURRENT DATA ON THE ETIOLOGY, PATHOGENESIS, CLINICAL FEATURES AND TREATMENT

2019 ◽  
Vol 22 (3-4) ◽  
pp. 73-85
Author(s):  
Yulia Aleksandrovna Semenchak
Keyword(s):  
Differential Diagnosis ◽  
Sexual Dysfunction ◽  
Connective Tissue ◽  
Metabolic Disorders ◽  
Current Data ◽  
Mucous Membranes ◽  
Clinical Variants ◽  
Limited Scleroderma ◽  
Immunological Changes ◽  
Methods Of Treatment

Scleroatrophic lichen (SL) - chronic autoimmune dermatosis, is one of the clinical variants of limited scleroderma, characterized by multifactorial genesis of development against the background of immunological changes, vascular and metabolic disorders in the connective tissue, which is characterized by severe focal atrophy of the skin and mucous membranes of the external genitals. SL is a debilitating disease causing itching, pain, dysuria and impaired urination, dyspareunia and significant sexual dysfunction in women and men. This article presents a review of current literature data on the etiology and pathogenesis, clinical picture, classification, differential diagnosis of the disease, as well as methods of treatment of patients. This review is based on the analysis of 64 articles, which were obtained from eLibrary, PubMed, NCBI, Embase.

Modern ideas about lichen planus of vulva

2021 ◽  
pp. 63-66
Author(s):  
S. I. Surkichin ◽  
I. A. Apolikhina ◽  
R. Yu. Mayorov ◽  
M. Avin
Keyword(s):  
Differential Diagnosis ◽  
Lichen Planus ◽  
Patient Management ◽  
Local Treatment ◽  
Treatment Regimens ◽  
Inflammatory Dermatosis ◽  
Mucous Membranes ◽  
Alternative Approaches ◽  
Unclear Etiology ◽  
Methods Of Treatment

Lichen planus (LP) is a T-cell-mediated inflammatory dermatosis with an unclear etiology that affects the skin, nails and mucous membranes. The article outlines modern ideas about lichen planus, affecting the vulva. The issues of etiopathogenesis, clinical picture, differential diagnosis of various forms of this dermatosis are considered. The histopathological picture of vulvar LPL is described in detail. Possible complications, including anatomical abnormalities of the vulvar architectonics and the risk of malignant transformation, are considered. Various methods of treatment for this disease, local treatment regimens are presented, an overview of systemic drugs is given, as well as alternative approaches to patient management.

scholarly journals Diaphragmatic hernia: formation mechanisms, clinical picture, treatment tactics

2019 ◽  
Vol 44 (3) ◽  
pp. 84-92
Author(s):  
N. B. Gubergrits ◽  
N. V. Byelyayeva ◽  
A. Ye. Klochkov ◽  
G. M. Lukashevich ◽  
P. G. Fomenko ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Connective Tissue ◽  
Motor Activity ◽  
Diaphragmatic Hernia ◽  
Clinical Manifestations ◽  
Current Data ◽  
Abdominal Pressure ◽  
Formation Mechanisms ◽  
Hernia Formation ◽  
Suppressive Action

The article presents current data on etiology, pathogenesis of diaphragmatic hernia. Types of diaphragmatic hernia are described in detail, namely: axial, paraesophageal, mixed; transient and fixed. Pathogenesis of the formation of hiatal hernia includes: failure of the connective tissue structures involved in the formation of the esophago-gastric junction; significant increase in intra-abdominal pressure; increase in motor activity of the esophagus (hypermotor dyskinesia). Clinical manifestations and peculiarities of pain, including pseudo-coronary pain, differential diagnosis, are described. Recommendations for non-drug treatment, including lifestyle and nutritional changes, are presented. Particular attention is paid to pantoprazole as a means of choice for therapy of patients. Advantages of pantoprazole as compared with other proton pump inhibitors are presented: selectivity of action depending on pH, absence of “decussation” with the metabolism of other drugs, efficacy, duration of acid suppressive action, safety, favorable pharmacoeconomic characteristics.

scholarly journals Self-induced dermatosis: a diagnostic problem at the intersection of two specialties

2021 ◽  
Vol 24 (1) ◽  
pp. 61-70
Author(s):  
Olga Yu. Olisova ◽  
Natalia P. Teplyuk ◽  
Lyailya N. Kayumova ◽  
Lyudmila M. Smirnova ◽  
Ekaterina M. Anpilogova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Clinical Picture ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Current Data ◽  
Drug Reactions ◽  
Diagnostic Problem ◽  
Significant Similarity ◽  
Sudden Appearance ◽  
Methods Of Treatment

Self-induced dermatoses is a group of artificial skin injuries and its appendages caused by self-injuring by the patient in order to get rid of negative emotions and painful sensations or to simulate a well-known dermatitis because of the pathological desire to be hospitalized to meet emotional or financial needs. A significant similarity of clinical manifestations of self-induced dermatoses and oorganic dermatoses (vasculitis, cystic medicine, gangrenous pyoderma, drug reactions, etc.), the inefficiency of dermatological treatment with the sudden appearance of new lesions, as well as the deliberate concealment by the patient the real causes of skin lesions and giving false anamnesis lead to difficulties in diagnosis of self-induced dermatoses. The article presents current data on the main diagnostic criteria and effective methods of treatment of this disease based on several foreign and russian publications; own clinical cases descriptions are also provided. Self-induced dermatoses must be considered as a possible differential diagnosis in cases when no well-known dermatoses can explain the clinical picture and anamnesis does not match it; new destructive lesions appear spontaneously, despite the ongoing treatment.

Modern methods of treating rosacea

2019 ◽  
Vol 1 (7) ◽  
pp. 65-71
Author(s):  
O. A. Egorova ◽  
K. A. Novikov
Keyword(s):  
Clinical Manifestations ◽  
Treatment Method ◽  
Current Data ◽  
Trigger Factors ◽  
Laser Technology ◽  
Individual Approach ◽  
Modern Methods ◽  
Methods Of Treatment ◽  
Choice Of Therapy

Presented current data on the etiology of rosacea, the main aspects of pathogenesis, clinical forms of the disease. Reflects trigger factors leading to rosacea, as well as complicating its course. Modern methods of treatment are described, including the use of new safe preparations of ivermectin and brimonidine, providing a good, lasting effect of clinical manifestations of rosacea. The role of laser technology, actively occupying a leading place in the choice of physiotherapeutic treatment method, is noted. The need for an individual approach in the choice of therapy for each patient with rosacea is emphasized.

Dermal fibrosarcoma in a Cashmere goat

2019 ◽  
Vol 47 (03) ◽  
pp. 192-195
Author(s):  
Julia Schoiswohl ◽  
Bianca Lambacher ◽  
Andrea Klang ◽  
Reinhild Krametter-Frötscher
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Connective Tissue ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Low Grade ◽  
Cashmere Goat ◽  
Short Lifespan ◽  
Production Processes

AbstractFibrosarcomas are malignant tumors of the connective tissue, which are characterized by proliferation of fibroblasts. Most of these tumors are localized subcutaneously and cause different symptoms depending on their location. The case report describes a dermal tumor on the outside of the pinna in a 7-year-old female Cashmere goat. The tumor was surgically removed and histopathological examination revealed a low grade fibrosarcoma. Although tumors are rare in ruminants because of the animals’ short lifespan (age of slaughtering in most cases < 24 months) in modern production processes, they should be considered as a differential diagnosis.

Cheilitis Granulomatosa Miescher: Treatment with Clofazimine and Review of the Literature

2001 ◽  
Vol 110 (10) ◽  
pp. 964-967 ◽  
Author(s):  
Gerd Jürgen Ridder ◽  
Milo Fradis ◽  
Erwin Löhle
Keyword(s):  
Differential Diagnosis ◽  
Young Woman ◽  
Alternative Treatment ◽  
Rare Condition ◽  
Review Of The Literature ◽  
Cheilitis Granulomatosa ◽  
Methods Of Treatment

Cheilitis granulomatosa Miescher is a rare condition of unknown cause characterized by intermittent lip swelling that gradually persists and causes cosmetic deformity. We report the case of a young woman with cheilitis granulomatosa as a monosymptomatic manifestation of Melkersson-Rosenthal syndrome successfully treated by the antileprosy agent clofazimine, and propose clofazimine as an alternative treatment in cases refractory to corticosteroids. The differential diagnosis and current methods of treatment are summarized, and the literature is reviewed and discussed.

scholarly journals Hereditary Connective Tissue Diseases in Young Adult Stroke: A Comprehensive Synthesis

2011 ◽  
Vol 2011 ◽  
pp. 1-18 ◽  
Author(s):  
Olivier M. Vanakker ◽  
Dimitri Hemelsoet ◽  
Anne De Paepe
Keyword(s):  
Connective Tissue ◽  
Metabolic Disorders ◽  
Type Iv Collagen ◽  
Connective Tissue Diseases ◽  
Haemorrhagic Stroke ◽  
Monogenic Disease ◽  
Connective Tissue Disorders ◽  
Ehlers Danlos Syndrome ◽  
Type Iv ◽  
Danlos Syndrome

Though the genetic background of ischaemic and haemorrhagic stroke is often polygenetic or multifactorial, it can in some cases result from a monogenic disease, particularly in young adults. Besides arteriopathies and metabolic disorders, several connective tissue diseases can present with stroke. While some of these diseases have been recognized for decades as causes of stroke, such as the vascular Ehlers-Danlos syndrome, others only recently came to attention as being involved in stroke pathogenesis, such as those related to Type IV collagen. This paper discusses each of these connective tissue disorders and their relation with stroke briefly, emphasizing the main clinical features which can lead to their diagnosis.

Epithelium-connective tissue interface of oral mucous membranes

1978 ◽  
Vol 45 (3) ◽  
pp. 416-423 ◽  
Author(s):  
George P. Wysocki ◽  
John Wallitschek ◽  
John Hardie
Keyword(s):  
Connective Tissue ◽  
Mucous Membranes ◽  
Tissue Interface

scholarly journals CERVICAL INSUFFICIENCY: CLASSIFICATION, ETIOPATHOGENESIS, DIAGNOSIS, METHODS OF PROPHYLAXIS AND CORRECTIONS (CLINICAL LECTURE)

2020 ◽  
pp. 35-47
Author(s):  
I.A. Zhabchenko ◽  
S.N. Zanko
Keyword(s):  
Differential Diagnosis ◽  
Connective Tissue ◽  
Cervical Insufficiency ◽  
Short Cervix ◽  
Historical Aspect ◽  
Etiological Agents ◽  
Clinical Lecture

Тhe clinical lecture presents modern views on the problem of cervical insufficiency and its role in the miscarriage. Etiological agents of the cervical insufficiency development, its classification, diagnostic and differential diagnosis with short cervix have been reviewed. Particular attention has been drawn to the role of progesterone, microelements and connective tissue for development and progress of the mentioned pathology. The historical aspect was applied both for methods of possible treatments and prophylaxis of the cervical insufficiency and for advanced surgical and conservative correction. The algorithm of the obstetric actions for the cervical insufficiency is proposed.

scholarly journals Gender, clinical and topographic features of the localized scleroderma lesions in anogenital area

2020 ◽  
Vol 23 (3) ◽  
pp. 165-173
Author(s):  
Elena S. Snarskaya ◽  
Yulia A. Semenchak
Keyword(s):  
Clinical Symptoms ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Steady Increase ◽  
Family Doctors ◽  
Topographic Features ◽  
Anogenital Area ◽  
Clinical Variants ◽  
Limited Scleroderma ◽  
And Gender

Background: Currently, there is an increase in the number of skin lesions of anogenital localization, which is a silent epidemic, both due to the steady increase in the incidence of this pathology, and the interdisciplinary aspect of this problem. Materials and methods: In the article, the authors first analyzed and presented the data of clinical and morphological analysis of 104 patients with various clinical variants of limited scleroderma, on the basis of which the main phenotypic and gender-specific clinical and topographical features of anogenital zone lesions in this group of patients are presented. Results: Scleroatrophic lichen is one of the clinical variants of limited scleroderma, which is characterized by damage to the mucous membranes of the external genitals in both women and men. Lesions of such localization are late and often mistakenly diagnosed by specialists of related disciplines (obstetricians, gynecologists, urologists, family doctors, allergists, cosmetologists), which leads to high risks of developing genitourenal syndrome. Conclusions: The development of scleroatrophic lesions in the anogenital zone is accompanied by pronounced clinical symptoms, including: itching, pain of varying intensity, dysuria, dyspareunia and significant sexual dysfunction.

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