Modern methods of treating rosacea

2019 ◽  
Vol 1 (7) ◽  
pp. 65-71
Author(s):  
O. A. Egorova ◽  
K. A. Novikov
Keyword(s):  
Clinical Manifestations ◽  
Treatment Method ◽  
Current Data ◽  
Trigger Factors ◽  
Laser Technology ◽  
Individual Approach ◽  
Modern Methods ◽  
Methods Of Treatment ◽  
Choice Of Therapy

Presented current data on the etiology of rosacea, the main aspects of pathogenesis, clinical forms of the disease. Reflects trigger factors leading to rosacea, as well as complicating its course. Modern methods of treatment are described, including the use of new safe preparations of ivermectin and brimonidine, providing a good, lasting effect of clinical manifestations of rosacea. The role of laser technology, actively occupying a leading place in the choice of physiotherapeutic treatment method, is noted. The need for an individual approach in the choice of therapy for each patient with rosacea is emphasized.

scholarly journals The role of membrane-destabilizing processes in the pathogenesis and clinical manifestations of perinatal encephalopathy in children

2001 ◽  
Vol 82 (2) ◽  
pp. 137-138
Author(s):  
E. V. Levitina ◽  
G. A. Ivanichev ◽  
M. M. Minnibaev
Keyword(s):  
Nervous System ◽  
Early Diagnosis ◽  
Clinical Manifestations ◽  
Perinatal Period ◽  
Diagnosis And Treatment ◽  
Definition Of ◽  
Methods Of Treatment ◽  
All Diseases ◽  
Made In

2/3 of all diseases of the nervous system in children begin to develop in the perinatal period. In recent decades, great strides have been made in perinatal neurology in the development of criteria for early diagnosis and treatment of diseases. Further study of the biochemical foundations of perinatal lesions of the nervous system with the definition of objective markers of the severity of the lesion will reveal new links in its pathogenesis and develop more effective methods of treatment.

Rhythmic Movement Disorder in Children

CNS Spectrums ◽  
2003 ◽  
Vol 8 (2) ◽  
pp. 135-138 ◽  
Author(s):  
Timothy F. Hoban
Keyword(s):  
Movement Disorder ◽  
Diagnostic Testing ◽  
Clinical Manifestations ◽  
Rhythmic Movement ◽  
Rhythmic Movements ◽  
Repetitive Motion ◽  
Testing Potential ◽  
Methods Of Treatment ◽  
Rhythmic Movement Disorder

AbstractHow should sleep-related rhythmic movements in children be assessed and treated? Rhythmic movement disorder (RMD) represents an unusual variety of childhood parasomnia characterized by repetitive motion of the head, trunk, or extremities, which usually occurs during the transition from wakefulness to sleep or arises during sustained sleep. Although the condition most often affects infants and toddlers in a transient and self-limited fashion, the condition occasionally persists in a problematic fashion, which may nevertheless be amenable to treatment. Since RMD may occasionally cause injury or resemble nocturnal seizure, prompt recognition, and appropriate management on the part of the clinician is essential. This article will examine the spectrum of RMD in children, including their common clinical manifestations; data regarding their epidemiology and natural history; the role of polysomnography, electroencephalography; and other diagnostic testing. Potential causes of the condition and available methods of treatment are also examined.

scholarly journals Congenital epidermolysis bullosa: modern methods of diagnosis and therapy. Prospects for regenerative medicine

2020 ◽  
Vol 96 (1) ◽  
pp. 10-17
Author(s):  
Alexey A. Kubanov ◽  
Arfenya E. Karamova ◽  
Ekaterina S. Monchakovskaya
Keyword(s):  
Quality Of Life ◽  
Epidermolysis Bullosa ◽  
Skin Diseases ◽  
Clinical Manifestations ◽  
Mechanical Effect ◽  
Promising Direction ◽  
Heterogenous Group ◽  
Modern Methods ◽  
Methods Of Treatment

Congenital epidermolysis bullosa is a clinically and genetically heterogenous group of hereditary skin diseases characterized by the formation of bullae and/or erosions in response to insignificant mechanical effect. The variety and severity of clinical manifestations of the disease determine the early disablement of patients and the decrease in the quality of life, which requires the development of pathogenetic and etiological methods of treatment. Methods of gene therapy are the most promising direction to study, since they can affect the cause of congenital epidermolysis bullosa.

Advancements in cancer chemotherapy

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Krzysztof Koper ◽  
Sławomir Wileński ◽  
Agnieszka Koper
Keyword(s):  
Hyperthermic Intraperitoneal Chemotherapy ◽  
Systemic Treatment ◽  
Malignant Tumors ◽  
Treatment Method ◽  
Anticancer Therapy ◽  
Cytostatic Drugs ◽  
Chemotherapy Administration ◽  
Modern Methods ◽  
Worse Prognosis

Abstract Chemotherapy is in most cases a method of systemic treatment of malignant tumors with cytostatic drugs. Although modern methods such as immunotherapy or targeted therapy are used more and more often nowadays, the role of chemotherapy in oncology is still significant. It can be used as an independent treatment method or in combination with other oncological therapies. The action of chemotherapy is closely linked to the cell cycle of the tumor. Advances in technology allow the introduction of different pharmaceutical forms of the same drug. Worse prognosis of metastatic tumors justifies the need to search for new, more effective treatment methods. The main problem of chemotherapy is the occurrence of adverse events. Reducing the frequency and severity of side effects is possible primarily by changing the technique of implementation of chemotherapy administration. These principles are fulfilled by new, increasingly popular therapeutic methods, such as: Perioperative Hyperthermic Intraperitoneal Chemotherapy (HIPEC), Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) or transarterial chemoembolization (TACE). The dynamic development of knowledge concerning cytostatic drugs, including targeting the tumor cell with the form of the drug, allows us to assume that in the future this direction will increase the effectiveness and safety of anticancer therapy.

scholarly journals Associative relationship between atopy, HLA complex genes and other genes

2019 ◽  
Vol 16 (3) ◽  
pp. 5-25
Author(s):  
N G Astafyeva ◽  
B A Shamgunova ◽  
D Yu Kobzev ◽  
I Ae Michailova
Keyword(s):  
Molecular Mechanisms ◽  
Complex Structure ◽  
Clinical Manifestations ◽  
Current Data ◽  
Genetic Determinants ◽  
Genetic Characteristics ◽  
Hla Genes ◽  
Histocompatibility Complex ◽  
History Of

This review presents current data on the associative relationships of genes of the major histocompatibility complex (HLA) and other genes with atopy. Despite the long history of studying the role of HLA class genes in atopy and the introduction of modern technologies and methods, many unresolved issues remain, including the difficulties caused by the heterogeneity of the human population, the complex structure and disequilibrium of linkage between different HLA genes. Although phenotypic heterogeneity is considered as the main limitation in understanding the genetic determinants of atopy, only a few studies have examined the relationships of its typical clinical manifestations induced by aeroallergens with certain HLA genes. The identified molecular mechanisms and genetic characteristics open up the possibility of using new therapeutic targets and modifying existing drugs.

scholarly journals Pruritus and Atopic Dermatitis: from Etiological Features to Management

2020 ◽  
Vol 19 (6) ◽  
pp. 468-476
Author(s):  
Nikolay N. Murashkin ◽  
Leonid A. Opryatin ◽  
Roman V. Epishev ◽  
Alexander I. Materikin ◽  
Eduard T. Ambarchian ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Immune System ◽  
Clinical Studies ◽  
Clinical Manifestations ◽  
Skin Barrier ◽  
Current Data ◽  
Scientific Images

Pruritus is one of the main clinical manifestations of atopic dermatitis, and it significantly reduces the quality of life of patients in childhood. Scientific images on its pathophysiological basis have now undergone significant changes. The histamine exceptional role in pruritus development was confounded, as well as data on immune system involvement in its maintenance was given. This article presents current data on differential approaches to pruritus management depending on its etiopathogenetic characteristics. The role of dermocosmetics in restoration of the skin barrier as the first stage prevention of pruritus in atopic dermatitis was considered. The results of clinical studies showing efficacy of topical agents (innovative component with anti-pruritic action — STIMU-TEX) application are presented.

scholarly journals Porokeratosis: clinical manifestations and treatment options

2020 ◽  
pp. 87-90
Author(s):  
A. B. Yakovlev ◽  
O. A. Golanova
Keyword(s):  
Rare Disease ◽  
Genetic Predisposition ◽  
Autosomal Dominant ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
Trigger Factors ◽  
Dominant Type ◽  
Treatment Approaches ◽  
Autosomal Dominant Type ◽  
Methods Of Treatment

Porokeratosis is a rare disease with an autosomal dominant type of inheritance. It is customary to distinguish classic Mibelli porokeratosis, as well as disseminated and localized variations of the course of dermatosis, which differ in genetic predisposition, trigger factors, and treatment approaches. The article describes the variants of the disease – eruptive itchy papular malformation that occurs on the extremities against the background of microcirculation disorders and giant, developed on the skin of the trunk. The main methods of treatment of porokeratosis are also described.

scholarly journals Cavernous malformations of the brain and modern views on their treatment

2021 ◽  
Vol 2 (2) ◽  
pp. 200-210
Author(s):  
Elena N. Girya ◽  
Valentin V. Sinitsyn ◽  
Alexey S. Tokarev
Keyword(s):  
Radiation Therapy ◽  
Proton Therapy ◽  
Clinical Manifestations ◽  
Alternative Methods ◽  
Cerebral Cavernous Malformations ◽  
Cavernous Malformations ◽  
Modern Methods ◽  
Benign Nature ◽  
The Brain ◽  
Methods Of Treatment

Cavernous malformations of the brain have become an increasingly common pathology in recent years, thanks to the advancement of modern methods of neuroimaging. Despite the benign nature of the course in most cases, these formations can cause convulsions and serious neurological disorders. Typically, clinical manifestations are caused by hemorrhages in the structure of the cavernous and surrounding parenchyma of the brain. The management strategy chosen for patients with cerebral cavernous malformations is determined by the type of malformation, its size, localization, the presence of repeated hemorrhages, and the clinical picture. This literature review focuses on modern methods of treating cerebral cavernous malformations. The main methods of treatment for cavernous malformations of the brain, particularly surgical treatment, have been analyzed. If surgical intervention is not possible, alternative methods of treatment include radiation therapy, such as stereotaxic radiosurgery, and proton therapy, in cases of deep location of foci in functionally significant areas of the brain, which are characterized by the highest risk of complications. Thе possibilities, efficacy, and safety of stereotactic radiosurgical treatment are discussed, as well as the use of proton therapy in the treatment of cavernous malformations. Furthermore, radiation therapy has been shown to be beneficial for cavernous malformations.

UPPER TRACT UROTHELIAL CARCINOMA: MORPHOLOGY, DIAGNOSTICS AND TREATMENT

2018 ◽  
pp. 78-92
Author(s):  
Yu. A. Stepanova ◽  
A. V. Prokofieva ◽  
S. A. Dunaev ◽  
A. V. Glotov ◽  
M. V. Morozovz ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Malignant Tumor ◽  
Urothelial Cancer ◽  
New Technologies ◽  
Clinical Manifestations ◽  
Upper Urinary Tract ◽  
Diagnostic Methods ◽  
Modern Methods ◽  
Methods Of Treatment

Urothelial carcinoma is a malignant tumor that develops from the cells of the urothelium mucosa and can be detected both in the upper parts of the urinary tract (renal and pelvic system and ureter) and in the lower parts (bladder and urethra). Urothelial cancer of the upper urinary tract (UCUUT) is quite rare and accounts for 5–10% of all cases of urothelial cancer. UCUUT remains completely unexplored, having to date two equal theories of origin. Despite the modern radiology and endoscopic equipment, in view of the meager and sufficiently generalized  clinical manifestations (similar to other diseases), especially at the initial stages of the disease, it is necessary to constantly improve diagnostic methods for detecting the disease as early as possible. Already today, thanks to new technologies for diagnosis and treatment, it is possible to identify the disease at different stages and extend life to patients with UCUUT. The article presents data on morphology, clinic, diagnostics and modern methods of treatment of this pathology.

АССОЦИАТИВНЫЕ СВЯЗИ МЕЖДУ АТОПИЕЙ, ГЕНАМИ КОМПЛЕКСА HLA И ДРУГИМИ ГЕНАМИ

2019 ◽  
pp. 5-25
Author(s):  
N.G. Astafyeva ◽  
B.A. Shamgunova ◽  
D.Yu. Kobzev ◽  
I.Ae. Michailova
Keyword(s):  
Molecular Mechanisms ◽  
Complex Structure ◽  
Clinical Manifestations ◽  
Current Data ◽  
Genetic Determinants ◽  
Genetic Characteristics ◽  
Hla Genes ◽  
Histocompatibility Complex ◽  
History Of

В настоящем обзоре представлены современные данные об ассоциативных связях генов главного ком плекса гистосовместимости (HLA) и других генов с атопией. Несмотря на длительную историю изучения роли генов класса HLA при атопии и внедрение современных технологий и методов, остается много не решенных вопросов, в том числе трудности, обусловленные гетерогенностью человеческой популяции, сложной структурой и неравновесностью сцепления между различными генами HLA. Хотя фенотипиче ская гетерогенность рассматривается как основное ограничение в понимании генетических детерминант атопии, лишь в немногих работах изучались связи ее типичных клинических проявлений, индуцированных аэроаллергенами, с определенными генами HLA. Идентифицированные молекулярные механизмы и генетические характеристики открывают возможности использования новых терапевтических мишеней и модификации существующих лекарственных средств.This review presents current data on the associative relationships of genes of the major histocompatibility complex (HLA) and other genes with atopy. Despite the long history of studying the role of HLA class genes in atopy and the introduction of modern technologies and methods, many unresolved issues remain, including the difficulties caused by the heterogeneity of the human population, the complex structure and disequilibrium of linkage between different HLA genes. Although phenotypic heterogeneity is considered as the main limitation in understanding the genetic determinants of atopy, only a few studies have examined the relationships of its typical clinical manifestations induced by aeroallergens with certain HLA genes. The identified molecular mechanisms and genetic characteristics open up the possibility of using new therapeutic targets and modifying existing drugs.

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