Ovarian papilloma

The incidence rate of thyroid cancer is increasing, especially among young and middle-aged people. In most cases a malignant tumor can be diagnosed at the background of multinodular goiter. Differential diagnosis of malignant and benign tumors of the thyroid presents considerable difficulties. In this situation the decision on the extent of the surgical intervention seems to be important. In the article there are described features of the diagnosis and the choice of the surgical intervention for thyroid cancer associated with multinodular goiter. The morphological examination is the decisive method of diagnosis. The decision on the extent of the operative measure should be both individualized for each particular patient and proceed from the principles of oncological radicalism and functional effect.

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Increased Temperature of Malignant Urinary Bladder Tumors In Vivo: The Application of a New Method Based on a Catheter Technique

Journal of Clinical Oncology ◽

10.1200/jco.2001.19.3.676 ◽

2001 ◽

Vol 19 (3) ◽

pp. 676-681 ◽

Cited By ~ 76

Author(s):

C. Stefanadis ◽

C. Chrysochoou ◽

D. Markou ◽

K Petraki ◽

D. B. Panagiotakos ◽

...

Keyword(s):

Urinary Bladder ◽

Malignant Tumor ◽

Malignant Tumors ◽

New Method ◽

Benign Tumors ◽

Mean Values ◽

Human Urinary Bladder ◽

Catheter Technique ◽

Malignant And Benign Tumors

PURPOSE: The aim of this study was to investigate the existence of any thermal difference between malignant tumors and inflammatory benign lesions of the human urinary bladder and to determine whether it correlates with tumor angiogenesis quantification. PATIENTS AND METHODS: A new method, developed in our institute, is introduced to detect temperature in human urinary bladder, in vivo. This method is based on a thermography catheter. We calculated the differences of the temperature of the solid tumor and of a normal area (ΔT) on 20 subjects (mean age, 72.5 years; 95% confidence interval [CI], 68.5 to 76.4). According to the biopsy histology, Eight (40%) patients had benign tumors, and 12 (60%) had malignant tumors. RESULTS: We found significant differences of ΔT between patients with benign and malignant tumor (P < .001). Also, differences were found for the mean values of angiogenesis level between malignant and benign tumors (P = .0261), and a moderated positive correlation was estimated between the degree of angiogenesis and ΔT (P = .02). Based on logistic regression analysis, we found that a 1-degree increase of ΔT triples the odds of a patient having a malignant tumor (odds ratio = 2.91; 95% CI, 1.97 to 7.78; P < .001), adjusted for the degree of angiogenesis (P = .0236) and the grade of tumor (P < .001). A threshold point of ΔT = 0.7°C was determined, with sensitivity 83% and specificity 75%. CONCLUSION: These findings suggest that the calculated difference of temperature between normal tissue and neoplastic area could be a useful criterion in the diagnosis of malignancy in tumors of the human urinary bladder.

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A new type of phytotherapeutic approach with angiosperms from arid zones of northern Mexico in patients with malignant and benign tumors

Planta Medica ◽

10.1055/s-0029-1234574 ◽

2009 ◽

Vol 75 (09) ◽

Author(s):

CA López-Moreno ◽

LR Quintanilla ◽

GLB Serrano ◽

QE Rosales ◽

FJA Pérez ◽

...

Keyword(s):

Benign Tumors ◽

Arid Zones ◽

Northern Mexico ◽

New Type ◽

Malignant And Benign Tumors

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Dynamics of biochemical and immunological parameters in patients with malignant and benign tumors of the thoracic and lumbar spine

ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS ◽

10.15674/0030-59872017230-34 ◽

2017 ◽

Vol 0 (2) ◽

pp. 30-34

Author(s):

Mykola Korzh ◽

Volodymyr Radchenko ◽

Frieda Leontyeva ◽

Volodymyr Kutsenko ◽

Bogdan Shevtsov ◽

...

Keyword(s):

Lumbar Spine ◽

Benign Tumors ◽

Immunological Parameters ◽

Thoracic And Lumbar Spine ◽

Malignant And Benign Tumors

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“ROLE OF SPECTROSCOPY IN MAGNETIC RESONANCE IMAGING: A CLINICAL REVIEW”

10.36106/ijsr/3129141 ◽

2021 ◽

pp. 20-23

Author(s):

R. Adityan ◽

Sajith Selvaganesan

Keyword(s):

Magnetic Resonance ◽

High Sensitivity ◽

Benign Tumors ◽

Resonance Spectroscopy ◽

Clinical Implementation ◽

Cardiac Muscles ◽

Biochemical Evaluation ◽

Malignant And Benign Tumors ◽

Methylene Group

Magnetic Resonance Spectroscopy (MRS) is used in diagnostic imaging for disease metabolism evaluation. The H MRS is highly used because of the abundance, high sensitivity, etc. The various clinical implementation includes whole-brain MRS is used in measuring metabolites of different brain areas simultaneously. The breast MRS is used in malignant and benign tumors differentiation by the total choline compound. The prostate MRS is used to map the metabolites like citrate, choline, and creatinine. For spinal cord MRS, the myoinositol and N acetyl aspartate were 31 23 1 considered markers for various diseases. The MRS uses nuclei like P, Na, and H for metabolic and biochemical evaluation of cardiac muscles. The liver MRS spectrum has mainly methylene group of lipid, methyl groups of choline, and water. The MRS measures choline, creatinine, lactate, and lipid peaks in uterine leiomyoma and myometrium. Hence there are organ-specic metabolites used as a reference to map the metabolic process by using spectroscopy, making it one of the commonly preferred technique.

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A Comparison of the Changes in Carbohydrate, Fat, and Protein Metabolism Occurring with Malignant and Benign Tumors and the Impact of Nutritional Support

Cancer and Nutrition ◽

10.1007/978-1-4757-9561-5_3 ◽

1991 ◽

pp. 69-95 ◽

Cited By ~ 1

Author(s):

Antonio C. L. Campos ◽

Dan L. Waitzberg ◽

Michael M. Meguid

Keyword(s):

Protein Metabolism ◽

Nutritional Support ◽

Benign Tumors ◽

The Impact ◽

Malignant And Benign Tumors

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Rare presentation of a testicular angiofibroma treated with testis sparing surgery

Archivio Italiano di Urologia e Andrologia ◽

10.4081/aiua.2016.4.330 ◽

2016 ◽

Vol 88 (4) ◽

pp. 330 ◽

Cited By ~ 1

Author(s):

Luca Leone ◽

Paola Fulvi ◽

Giulia Sbrollini ◽

Alessandra Filosa ◽

Enrico Caraceni ◽

...

Keyword(s):

Case Report ◽

Malignant Tumor ◽

Gold Standard ◽

Conservative Surgery ◽

Pathological Examination ◽

Benign Tumors ◽

Frozen Sections ◽

Rare Presentation ◽

Final Histology

Introduction: Testicular benign tumors are very rare (< 5%). Testicular Angiofibroma (AF) is one of those, however the gold standard of treatment and follow-up is still unclear. Case report: A 47 years-old man with only one functioning testis was referred to our clinic for a palpable right testicular mass and atrophic contralateral testis. Patient underwent testis-sparing surgery with inguinal approach and intraoperative frozen sections examination with diagnosis of AF. Final histology confirmed AF. Post-operative follow-up was uneventful. Clinical and ultrasonographic follow-up was negative after 8 months. Conclusion: We report a conservative surgery in a patient with AF of the solitary testis. AF is a benign para-testicular fibrous neoplasm that could be misinterpreted as malignant tumor and treated with orchiectomy. Testis-sparing surgery is recommended in this case with intraoperative pathological examination. The excision of the mass is enough but in front of a possible recurrence a long follow-up is advisable.

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KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimickers

10.21203/rs.3.rs-29911/v1 ◽

2020 ◽

Author(s):

Lucen Jiang ◽

Jianghuan Liu ◽

Qingzhu Wei ◽

Yiyang Wang

Keyword(s):

Bone Tumor ◽

Bone Tumors ◽

Diagnostic Value ◽

Benign Tumors ◽

Malignant Bone Tumor ◽

Malignant Bone Tumors ◽

Potential Marker ◽

Tumors Of Bone ◽

Bone Sarcomas ◽

Malignant And Benign Tumors

Abstract Background Karyopherin α 2 (KPNA2), a member of the Karyopherin α family, has been observed in several cancers but lack substantial investigation in malignant bone tumors. The purpose of the current study was to evaluate KPNA2 expression level and its utility as a novel diagnostic biomarker in osteosarcomas and their malignant bone tumor mimickers, such as chondrosarcomas and Ewing sarcomas.Method We investigated the expression of KPNA2 protein by immunohistochemistry on paraffin embedded surgical specimens from 217 patients with malignant and benign tumors of bone, including 81 osteosarcomas, 42 chondrosarcomas, 9 Ewing sarcomas, 28 osteoid osteoma, 20 osteochondroma and 37 Chondroblastoma. Immunoreactivity was scored semi quantitatively based on stain extent and intensity.Results Seventy one of 81 (87.7%) osteosarcomas, zero of 42 (0%) chondrosarcomas and one of 9 (11.1%) Ewing sarcomas showed immunoreactivity for KPNA2. Negative KPNA2 expression was observed in all of benign bone tumors. Much more positive expression of KPNA2 was found in osteosarcomas as compared with chondrosarcomas and Ewing sarcomas. The sensitivity and specificity of KPNA2 immuno-expression for osteosarcoma was 87.7% and 100%, respectively. In several subtypes of osteosarcomas, immunohistochemical expression of KNA2 was more frequent in osteoblastic (94.5%), with 39 (70.9%) showing strong-intensity staining. KPNA2 positivity was observed in eleven of 13 (84.6%) chondroblastic, three of 6 (50%) fibroblastic, three of 4 (75%) telangiectatic and two of 3 (66.7%) giant cell-rich osteosarcoma. Stronger-intensity staining was observed in osteoblastic osteosarcoma.Conclusion KPNA2 is most frequently expressed in osteosarcomas, particularly in osteoblastic and chondroblastic tumors, but is rarely positive in chondrosarcomas and Ewing sarcomas. This feature may have diagnostic value since it is very useful for distinguishing between osteosarcomas and other bone sarcomas mimickers. This report supports KPNA2 as a novel marker for the diagnosis of osteosarcoma.

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