Blood serum and follicular fluid relaxin: a pilot study of the hormone effects on ovarian function and fertilization efficiency

Hypothesis/aims of study. To date, one of the most important avenues of research in the field of reproductive medicine is the searching for new biochemical markers of oocyte quality and the prediction of the effectiveness of in vitro fertilization (IVF) protocols. The aim of this study was to assess the effect of relaxin levels in blood serum and follicular fluid on the efficiency of ovulation stimulation, fertilization, and characteristics of the embryos. Study design, materials and methods. This prospective randomized cohort study included 11 patients undergoing infertility treatment in a superovulation stimulation protocol using gonadotropin-releasing hormone antagonists. Age, body mass index, hormonal status, ovarian response, endometrial thickness and structure, the number and quality of oocytes and embryos, as well as fertilization efficiency were assessed. The level of relaxin in blood serum and follicular fluid samples was determined on the day of transvaginal follicle puncture using enzyme immunoassay. Results. A correlation between follicular fluid relaxin levels and body mass index, age, the number of oocytes, and their fertilization efficiency (p 0.05) was established. Changes in follicular fluid relaxin level were revealed depending on the gonadotropin preparations (p 0.05) and triggers of final maturation of oocytes (p 0.05). The tendency of the effect of gonadotropin doses on circulating relaxin levels, and of the hormone itself on endometrial thickness and the quality of oocytes was determined. Conclusion. Determination of the relaxin concentration can be considered as a promising method for predicting the result of ovarian stimulation and the efficiency of fertilization in IVF protocols.

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Impact of body mass index on levels of soluble interleukin-6 receptor in follicular fluid of women undergoing in-vitro fertilization

Fertility and Sterility ◽

10.1016/j.fertnstert.2017.02.013 ◽

2017 ◽

Vol 107 (3) ◽

pp. e7 ◽

Cited By ~ 1

Author(s):

Laurice Bou Nemer ◽

R. Ann Word ◽

Bruce R. Carr ◽

Orhan Bukulmez

Keyword(s):

Body Mass Index ◽

In Vitro Fertilization ◽

Body Mass ◽

Follicular Fluid ◽

Interleukin 6 ◽

Vitro Fertilization ◽

Interleukin 6 Receptor

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The Effect of Maternal Body Mass Index on In Vitro Fertilization-Intracytoplasmic Sperm Injection Treatment: A Prospective Comparative Study

10.21203/rs.3.rs-298772/v1 ◽

2021 ◽

Author(s):

Zeynep Ozturk Inal ◽

Hasan Ali Inal

Keyword(s):

Body Mass Index ◽

In Vitro Fertilization ◽

Body Mass ◽

Intracytoplasmic Sperm Injection ◽

Endometrial Thickness ◽

Maternal Body Mass Index ◽

Maternal Body ◽

Vitro Fertilization ◽

Stimulating Hormone

Abstract Purpose: To evaluate whether or not maternal body mass index (BMI) has an effect on pregnancy rates following in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) treatment.Methods: A total of 869 patients who had undergone IVF-ICSI treatment between 2012 and 2017 were included in this study. The participants were stratified according to maternal BMI as Group 1 (BMI<25 kg/m2; n=394), Group 2 (25 kg/m2<BMI <30 kg/m2; n=303), and Group 3 (BMI>25 kg/m2; n=172). Basal parameters and IVF-ICSI outcomes were compared between the groups.Results: While there were no differences between the groups in terms of age, smoking status, etiology of infertility, thyroid-stimulating hormone, prolactin levels, antral follicle count, and stimulation protocol (p>0.05), there was significant statistical difference (p<0.05) in terms of BMI, duration of infertility, baseline follicle-stimulating hormone, luteinizing hormone, estradiol (E2), duration of stimulation, total gonadotropin dose required, peak E2 levels, progesterone levels, endometrial thickness on hCG administration, and cycle cancellation rate. In addition, the numbers of MII and 2PN oocytes retrieved and the rates of clinical pregnancy, live births, and miscarriages were also different between the groups (p<0.05).Conclusion: Our data suggest that there is an inverse impact of increased BMI on laboratory and reproductive outcome parameters of IVF-ICSI treatment. Taking cost-effectiveness into consideration, weight loss should be suggested before ovulation is induced.

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Comprehensive analysis of body mass index effects on in vitro fertilization outcomes

10.26226/morressier.573c1512d462b80296c98821 ◽

2016 ◽

Author(s):

Laura Privitera

Keyword(s):

Body Mass Index ◽

In Vitro Fertilization ◽

Body Mass ◽

Comprehensive Analysis ◽

Vitro Fertilization

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Body Mass Index, Follicle-Stimulating Hormone and their Predictive Value in vitro Fertilization

Revista de Chimie ◽

10.37358/rc.18.7.6428 ◽

2018 ◽

Vol 69 (7) ◽

pp. 1842-1845

Author(s):

Lavinia Stelea ◽

Izabella Petre ◽

Marius Craina ◽

Brigitha Vlaicu ◽

Alina Sisu ◽

...

Keyword(s):

Body Mass Index ◽

Risk Factor ◽

In Vitro Fertilization ◽

Body Mass ◽

Predictive Value ◽

Follicle Stimulating Hormone ◽

Vitro Fertilization ◽

Weight Problems ◽

Fertility Disorder

The aim of this study was to determine if body mass can be considered a risk factor for infertility, and if we can find any correlations between the age values and the FSH and estradiol values, and between the BMI values and the FSH and estradiol values. Our whole sample contains 100 patients splinted in two groups (pregnant patients N1=57 subjects, 57%, and not � pregnant patients N1=43 subjects,43%). In the first part we conducted our analysis on the whole group and after that we focused the analysis on the two groups and we made some comparisons between the groups. We obtained a medium, extremely significant correlation in all scenarios between the age and the FSH values. This is the best association from all the cases which we tested. In all twelve cases we have a positive correlation (r ] 0). As well, we obtained that a BMI value higher than 25can be considered a risk factor for obtaining a pregnancy (p[0.05, RR ] 1, OR]1) . Our study shows that women who have weight problems have much less chances of conceiving a baby, even if they ovulate normally. The risk of infertility increases proportionally to the extra pounds. Irregular ovulation in women is the most common fertility disorder due to obesity disease.

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