Evaluation of clinical efficacy of Derinat® in form of spray in practice of district therapist

2019 ◽  
Vol 1 (9) ◽  
pp. 38-46
Author(s):  
A. P. Babkin ◽  
A. A. Zuikova ◽  
O. N. Krasnorutskaya ◽  
Yu. A. Kotova ◽  
D. Yu. Bugrimov ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Respiratory Diseases ◽  
Viral Infections ◽  
Pharmacological Action ◽  
The Body ◽  
Natural Resistance ◽  
Acute Respiratory Diseases ◽  
T Helpers ◽  
T Killers ◽  
Stimulation Of

The widespread worldwide spread of acute respiratory diseases is an urgent problem in health care. Expressed polyetiology of respiratory diseases does not allow to limit the use of specific vaccine preparations and dictates the need to use to combat them a variety of non-specific means that stimulate the natural resistance of the human body. The main pharmacological action of sodium deoxyribonucleate is the stimulation of phagocytic activity of T-helpers and T-killers, increasing the functional activity of neutrophils and monocytes/ macrophages, providing regeneration and repair processes in the epithelial component of antiviral protection of the body. Based on the above, the study of the clinical efficacy of Derinat® in the form of spray in the treatment of acute respiratory viral infections is relevant.

scholarly journals Complex therapy of acute respiratory diseases

2019 ◽  
pp. 91-97 ◽  
Author(s):  
N. V. Orlova
Keyword(s):  
Respiratory Diseases ◽  
Viral Infections ◽  
Bacterial Pathogen ◽  
Symptomatic Therapy ◽  
Time Treatment ◽  
Laboratory Confirmation ◽  
Rational Diagnosis ◽  
Acute Respiratory Diseases ◽  
Antitussive Drugs

Acute respiratory disease (ARD) is a common pathology. Untimely diagnosis and treatment, co-morbidities, old age and children under 1 year of age, pregnancy can increase the severity of the condition and lead to complications and death. According to IDSA recommendations, vaccination is an effective way to prevent complications and fatal influenza cases. Vaccination is primarily for people at risk of serious illness. In cases of suspected influenza, molecular diagnostics is recommended. At the same time, treatment of suspected influenza should be prescribed immediately, without waiting for laboratory confirmation of the diagnosis. Etiotropic treatment aimed at suppressing virus replication should be the first priority in the treatment of acute respiratory viral infections. Bacterial agents may be the primary cause of respiratory diseases or may complicate viral diseases. In the presence of a bacterial pathogen, antibacterial agents are prescribed. ARD symptoms worsen the quality of life of patients. Complex treatment of respiratory diseases includes the prescription of symptomatic therapy: antipyretics, antitussives, vasoconstrictor drugs in rhinorrhea. Cough is the most common respiratory symptom. In various diseases, cough has its own peculiarities, which allows you to carry out differential diagnosis. The American Thoracic Society has proposed schemes of differential search for acute and chronic coughs, which allow rational diagnosis of diseases. The use of antitussive drugs has its own peculiarities: when the cough is non-productive, drugs are prescribed to suppress cough, when the cough is productive - drugs are aimed at facilitating the evacuation of sputum. One of the preparations possessing expectorant, mucolytic and antispasmodic action, is Hedelix syrup on the basis of ivy.

scholarly journals HDFx and Methylated DNA; With Histones Upregulated in Macrophages/ Monocytes Derived From Animal Survivors Subjected to Traumatic, Endotoxin, and Hemorrhagic Shock: Importance of Epigenesis and Potential Reasons for Resistance to Bacterial, Fungal and Viral Infections

2020 ◽  
Vol 5 (4) ◽  
Keyword(s):  
Hemorrhagic Shock ◽  
Host Defense ◽  
Viral Infections ◽  
White Blood Cells ◽  
Nobel Laureate ◽  
Traumatic Shock ◽  
The Body ◽  
Fluid Replacement ◽  
Natural Resistance ◽  
Large Numbers

Each year approximately 60,000 people die from hemorrhagic shock in the U.S.A. with about two million deaths worldwide [1]. Deaths from traumatic shock, worldwide, has been difficult to estimate, due to battles/wars in many countries, but is thought to be more than two million victims/year [1]. Many reasons for these large numbers of deaths are known [for review, see1], for example, inadequate therapeutic measures, unavailability of adequate blood/ plasma/fluid replacement, seeing the patient too late, and unavailability of trained ER personnel, among the major reasons [for recent review, see1]. Another predominant reason for large numbers of hemorrhagic and traumatic shock deaths is the risk of sepsis in many of these victims, resulting in septic shock having mortalities in excess of 40- 75%, depending upon locality, with the lower numbers in the U.S.A. Lastly, and most important is “natural resistance of the body to infectious microorganisms” (i.e, bacteria, funguses, viruses, parasitic organisms, etc.). What is responsible for “natural resistance” has been studied for more than 150 years. We know that the “innate” and “adaptive” immune systems are key elements in defense against infectious microorganisms [2, 3]. But, which elements of these systems make-up major aspects of “resistance” and “host defense” still remains to be worked out. Using starfish, more than 140 years ago, the pioneer/father of immunology, and Nobel Laureate, Elie Metchnikoff, believed that white blood cells and macrophages were key to host-defense [4]. He also believed the body develops molecules/substances, which are key to resistance to infectious microorganisms [4].

scholarly journals THE MANIFESTATON FEATURES OF ACUTE RESPIRATORY DISEASES IN INFANTS

2019 ◽  
Vol 19 (4) ◽  
pp. 38-42 ◽  
Author(s):  
S.M. Tsvirenko ◽  
N.S. Artiomova ◽  
O.I. Ananevych ◽  
I.I. Adruschenko ◽  
O.V. Bеlan
Keyword(s):  
Medical Records ◽  
Inpatient Treatment ◽  
Respiratory Diseases ◽  
Viral Infections ◽  
General Structure ◽  
Underlying Disease ◽  
Community Acquired Pneumonia ◽  
Bronchial Obstruction ◽  
Respiratory Pathology ◽  
Acute Respiratory Diseases

According to WHO, acute respiratory diseases are at the forefront of the incidence rate of infants and are among the most common diseases due to which children are hospitalized. The aim of the research was to analyze the structure of morbidity and features of the course in acute respiratory diseases in infants with the study of the frequency of leading nosological forms that required inpatient treatment. A retrospective analysis of the medical records of inpatients (3845 children), treated during 2016-2018 was conducted. The study found that there is a tendency for an increase in the number of infants who require inpatient treatment, as well as an increased number of nosologies in the treated children. As the underlying disease, the first place in the structure of the morbidity belonged to acute respiratory viral infections. In the dynamics of the studied years, an increase in the frequency of acute obstructive bronchitis was noted. This pathology has the second place in the structure of morbidity among hospitalized children. The permanent third place in the structure of nosologies belongs to acute pneumonia. The premorbid background of most children with bronchial obstruction syndrome and acute community-acquired pneumonia was aggravated. The most commonly determined disorders were I-II degree anemia, overweight, impaired calcium metabolism, aggravated allergic history, transient immune deficiency. Conclusions. Our analysis of the structure of acute respiratory pathology in infants who required inpatient treatment showed that in the dynamics of 2016-2018, there was an increase in cases of acute obstructive bronchitis and acute community-acquired pneumonia. The study of general structure of nosologies in children treated at the inpatient department revealed an increase in their number and a tendency for the formation of comorbid pathology in infants.

scholarly journals Probiotics: Helpful for the prevention of COVID-19?

2020 ◽  
Vol 7 (11) ◽  
pp. 4086-4099
Author(s):  
Nishat Zafar ◽  
Muhammad Aamir Aslam ◽  
Ashiq Ali ◽  
Aisha Khatoon ◽  
Abdul Nazir ◽  
...  
Keyword(s):  
Immune System ◽  
Mass Production ◽  
Viral Infections ◽  
Rapid Development ◽  
The Body ◽  
Alternative Measures ◽  
Alternative Approaches ◽  
Entire World ◽  
And Control ◽  
Stimulation Of

Up to now, no vaccine has been developed for COVID-19 treatment. Although many scientists are working for the rapid development of a vaccine to control this pandemic, nonetheless, it will take time. If the vaccine will be developed soon, it will not be available to the entire world instantly since the mass production of the vaccine will take time. In this scenario, we will have to take alternative measures to control the COVID-19 pandemic. These alternative approaches include the stimulation of the immune system to fight against viral infections. Among the different approaches to strengthen the immune system, the use of probiotics is the best one. Probiotics can help the body to fight against COVID-19 directly and indirectly. In this review, we comprehensively discuss the use of probiotics for the prevention and control of COVID-19.

THE BIOLOGICAL ROLE OF VITAMIN D

Vestnik ◽  
2021 ◽  
pp. 169-172
Author(s):  
Д.Т. Джатдоева ◽  
А.А. Гочияев ◽  
М.Б. Семенов ◽  
З.М. Каппушева
Keyword(s):  
Vitamin D ◽  
Respiratory Diseases ◽  
Postoperative Recovery ◽  
The Body ◽  
Uv Treatment ◽  
Protective Properties ◽  
Acute Respiratory Diseases ◽  
The Moment ◽  
Positive Effect

В статье рассматриваются заболевания, зависящие от уровня витамина D в организме, возможные методы коррекции его уровня и их последствия. Рассматривается зависимость организма -как единого целого от уровня данного витамина в крови. На данный момент во всем мире наблюдается глобальный дефицит витамина D, у всех пациентов, которые сдают данный анализ, которое так же было выявлено на фоне глобальной пандемии “COVID-19”. Влияние витамина D на иммунитет абсолютно точно доказано, и поэтому его дефицитное состояние может ухудшать течение различных заболеваний. Также витамин D выступает в качестве гормона, недостаток которого приводит к патологиям сердечно-сосудистой системы, рахиту, остеопорозу, сахарному диабету, ожирению и другим серьезным заболеваниям. Неоднократно рассматривалось влияние его уровня на постоперационное восстановление. В статье так же приводятся методы коррекции посредством UV в зимнее время, которое как показали данные является опасной. В статье описываются нейродегенеративные расстройства, на которых оказывает огромное влияние уровень данного витамина и его профилактика. Проанализировано влияние его уровня на здоровье пациенток в постменопаузе, приводящее к нежелательным последствиям в том числе и остеопорозу. Приведены примеры влияния на защитные свойства ротовой полости при пародонте и кариесе. Описывается влияние на процесс течения острых респираторных заболеваний у детей, а также влияние на течение болезни при сахарном диабете. The article discusses diseases that depend on the level of vitamin D in the body, possible methods of correcting its level and their consequences. The dependence of the body on the level of this vitamin in the blood is considered. At the moment, there is a global vitamin D deficiency worldwide, which was revealed during the global COVID-19 pandemic. The positive effect of vitamin D on the immune system has been proven, and therefore its deficiency can worsen the course of various diseases. Vitamin D also acts as a hormone, the lack of which leads to pathologies of the cardiovascular system, rickets, osteoporosis, diabetes, obesity, and other serious diseases. The influence of its level on postoperative recovery is also considered. In addition, the article provides methods of correction by means of UV treatment in winter, which, as the data has shown, is dangerous. The article describes neurodegenerative disorders, which are greatly influenced by the level of this vitamin and its prevention. The influence of its level on the health of postmenopausal patients, leading to undesirable consequences, including osteoporosis, is analyzed. Examples of the effect on the protective properties of the oral cavity in periodontal disease and caries are given. The article describes the effect on the course of acute respiratory diseases in children, as well as the effect on the course of the disease in diabetes mellitus.

scholarly journals Role of acute respiratory diseases in pathogenesis of distal limb infections in cattle

2021 ◽  
pp. 190-196
Author(s):  
A. D. Alekseev ◽  
O. G. Petrova ◽  
M. I. Barashkin ◽  
I. M. Milshtein ◽  
V. D. Moskvin
Keyword(s):  
Metabolic Acidosis ◽  
Blood Vessels ◽  
Immune Complexes ◽  
Respiratory Diseases ◽  
Fusobacterium Necrophorum ◽  
The Body ◽  
Circulating Immune Complexes ◽  
Distal Limb ◽  
Bacterial Endotoxins ◽  
Acute Respiratory Diseases

According to current concepts, ruminal and metabolic acidosis occur due to feeding cattle mainly with preserved acidic feeds such as silage and haylage. However, errors in feeding are not the only etiological factor leading to acidosis. In some cases, metabolic acidosis in cattle can develop along with respiratory infection caused by viral and bacterial agents. The main pathological processes resulting from acute respiratory diseases of cattle are bronchitises, tracheites and pneumonias. When the respiratory tract is affected in cattle, hypoxia occurs, causing intoxication and, thus, leading to ruminal acidosis. As a result, vasoactive substances (bacterial endotoxins, histamine, lactate) enter the bloodstream, the vascular endothelium is damaged due to the simultaneous expansion of arterioles and compression of venules, blood fluid is perfused from the vessels into the surrounding tissues, the blood flow in the microcirculatory bed is disrupted. An important role in the disturbance of blood circulation in small blood vessels is played by circulating immune complexes representing the «antigen-antibody» complex. Low molecular weight circulating immune complexes settle in various organs and tissues of the body, lead to inflammation and damage the normal tissue structure. Most frequently, immune complexes affect the endothelium of blood vessels, renal glomeruli and joints. Distal limb vessels are primarily affected in cattle, leading to disturbance of skin trophism of the limbs and hooves, development of laminitis, while the hoof horn is weakly keratinized and cannot resist aggressive mechanical and chemical environmental factors. Damaged hooves are the gateway of infection for the agents of necrobacteriosis (Fusobacterium necrophorum), staphylococcosis (Staphylococcus spp.), streptococcosis (Streptococcus spp.) and other pathogens. In addition, favorable conditions evolve for the development of mixed infection due to reduction in the overall organism resistance, which is observed for both respiratory and distal limb infections.

scholarly journals Significance of complex laboratory diagnostics of ARVI for veterinary practice

2020 ◽  
Vol 196 (5) ◽  
pp. 59-67
Author(s):  
A. PORYVAEVA ◽  
O Petrova ◽  
Elena Pechura ◽  
Natalia Bezborodova ◽  
Ya. LYSOVA
Keyword(s):  
Respiratory Diseases ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Federal District ◽  
Laboratory Diagnostics ◽  
Agricultural Enterprises ◽  
Udmurt Republic ◽  
Acute Respiratory Diseases ◽  
Respiratory Viral Infections ◽  
Diagnostic Technologies

Abstract. This article summarizes the results of laboratory studies of acute respiratory viral infections of cattle in agricultural enterprises of the Ural Federal district and the Udmurt Republic. The purpose of the research was to show the spread of respiratory viral infections in cattle in various regions and the significance of laboratory diagnostics in this pathology. According to research data 815 samples for the period 2018–2020 a variety of combinations of mixed respiratory viruses in animals was detected using biomaterials from different age patients and patients with respiratory diseases of cattle from agricultural enterprises of the Ural Federal district, the Volga Federal District and the Udmurt Republic using polymerase chain reaction, indirect hemagglutination reaction, hemagglutination inhibition reaction, Elisa , and enzyme immunoassay. Scientific novelty. The etiological structure of mixed acute respiratory viral infections in cattle in agricultural enterprises in four regions of the Ural Federal District, the Volga Federal District and the Udmurt Republic in 2018–2020 was studied using modern diagnostic technologies. Results. In the Ural Federal District, the Volga Federal district and the Udmurt Republic, 80 % of cases of acute respiratory diseases were caused by bovine viral infections, mainly representatives of 2 families of viruses whose genome is represented by an RNA molecule (paramixoviruses, togaviruses) and a family of viruses whose genome is represented by a DNA molecule (herpesviruses,). The leading place among acute respiratory infections was occupied by infectious rhinotracheitis of cattle.

scholarly journals Risk factors for respiratory viral infections in newborns

1981 ◽  
Vol 62 (5) ◽  
pp. 24-26
Author(s):  
O. I. Pikuza ◽  
L. A. Kuznetsova ◽  
L. Y. Aleksandrova
Keyword(s):  
Risk Factors ◽  
Respiratory Diseases ◽  
Viral Infections ◽  
Expectant Mother ◽  
Increased Risk ◽  
Negative Effect ◽  
Acute Respiratory Diseases ◽  
The Central Nervous System ◽  
Respiratory Viral Infections ◽  
The Impact

The study of the clinical features of acute respiratory viral infections and pneumonia in 320 newborns made it possible to identify a group of children with an increased risk of an unfavorable course of the disease. A negative effect on the prognosis of acute respiratory diseases in newborns is exerted by toxicosis, acute diseases of women during pregnancy, the impact on the expectant mother of occupational health problems, a burdened obstetric history, prematurity of the newborn, natal trauma of the central nervous system. Specific regimens have been developed to complement the conventional medical history that can facilitate the management of risk conditions and a differentiated approach to the newborn.

Psychological aspects of history e-learning

2021 ◽  
Vol 2021 (03) ◽  
pp. 158-172
Author(s):  
Mikhail Matveev
Keyword(s):  
Chronic Infection ◽  
Respiratory Diseases ◽  
Viral Infections ◽  
Rna Viruses ◽  
Psychological Aspects ◽  
Viral Pathogens ◽  
E Learning ◽  
Acute Respiratory Diseases ◽  
Respiratory Viral Infections

Acute respiratory viral infections (ARVI) cause more than 80% of all acute respiratory diseases. Like most viral pathogens of SARS, coronaviruses are RNA viruses, but they have the largest genome in terms of size - about 29 thousand nucleotides. Live anti-coronavirus vaccines have been developed for dogs and domestic chickens, because their respective varieties cause severe chronic infection and high viral mortality.

scholarly journals PECULIARITIES OF ACUTE RESPIRATORY DISEASES IN PATIENTS WITH ATOPY

2015 ◽  
pp. 57-62
Author(s):  
L. O. Ponezheva ◽  
Zh. B. Ponezheva ◽  
A. N. Kupchenko
Keyword(s):  
Immune Deficiency ◽  
Chronic Inflammation ◽  
Clinical Efficacy ◽  
Transfer Factor ◽  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Respiratory Viruses ◽  
Causative Agents ◽  
Acute Respiratory Diseases

In the work identified clinical and immunological characteristics of the course of ARVI patients with atopy and assessed the clinical efficacy of transfer factor in patients with severe immune deficiency. Emphasized the role of respiratory infections as the most important triggers of exacerbations of atopy and causes more severe and prolonged course. Describes the mechanisms of how respiratory viruses potentiate chronic inflammation and remodeling of the airways. The role of the causative agents of ARVI in patients with atopy deserve more practical attention towards and optimization of therapy.

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