On the question of the therapeutic effect of Konvallene in cardiovascular diseases

1937 ◽  
Vol 33 (3) ◽  
pp. 259-263
Author(s):  
N. N. Kovyazin
Keyword(s):  
Cardiovascular Diseases ◽  
Blood Vessels ◽  
Therapeutic Effect ◽  
Pharmacological Properties ◽  
Clinical Observations

In 1853, Waltz discovered two glucosides in a lily of the valley - convallamarin and convallarin. Subsequent experimental and clinical observations showed that the first glucoside is similar in pharmacological properties to the action of digitalin, but was not used due to the inconstancy of its action; the second glucoside, without acting on the heart and blood vessels, irritates the intestines, causing diarrhea.

scholarly journals Apium Plants: Beyond Simple Food and Phytopharmacological Applications

2019 ◽  
Vol 9 (17) ◽  
pp. 3547 ◽  
Author(s):  
Bahare Salehi ◽  
Alessandro Venditti ◽  
Claudio Frezza ◽  
Aysun Yücetepe ◽  
Ümit Altuntaş ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Breast Milk ◽  
Full Advantage ◽  
Vascular Diseases ◽  
Pharmacological Properties ◽  
Phytochemical Composition ◽  
Medicinal Use ◽  
Medical Benefits ◽  
Phytochemical Constituents ◽  
Future Direction

Apium plants belong to the Apiaceae family and are included among plants that have been in use in traditional medicine for thousands of years worldwide, including in the Mediterranean, as well as the tropical and subtropical regions of Asia and Africa. Some highlighted medical benefits include prevention of coronary and vascular diseases. Their phytochemical constituents consist of bergapten, flavonoids, glycosides, furanocoumarins, furocoumarin, limonene, psoralen, xanthotoxin, and selinene. Some of their pharmacological properties include anticancer, antioxidant, antimicrobial, antifungal, nematocidal, anti-rheumatism, antiasthma, anti-bronchitis, hepatoprotective, appetizer, anticonvulsant, antispasmodic, breast milk inducer, anti-jaundice, antihypertensive, anti-dysmenorrhea, prevention of cardiovascular diseases, and spermatogenesis induction. The present review summarizes data on ecology, botany, cultivation, habitat, medicinal use, phytochemical composition, preclinical and clinical pharmacological efficacy of Apium plants and provides future direction on how to take full advantage of Apium plants for the optimal benefit to mankind.

Clinical Observations on the Blood of the Insane

1885 ◽  
Vol 30 (132) ◽  
pp. 488-508
Author(s):  
S. Rutherford Macphail
Keyword(s):  
Blood Vessels ◽  
The State ◽  
General Paralysis ◽  
Clinical Observations

While the condition of the blood vessels in General Paralysis has been a subject of discussion by many observers, and the state of the pulse, including sphygmographic tracings, has engaged the attention of Thompson and others, I have been unable, in the literature to which I have had access, to find reference to any observations on the state of the blood in this disease.

Current Drug Nano-targeting Strategies for Improvement in the Diagnosis and Treatment of Prevalent Pathologies such as Cardiovascular and Renal Diseases

2019 ◽  
Vol 20 (14) ◽  
pp. 1496-1504 ◽  
Author(s):  
Virna Margarita Martín Giménez ◽  
Lucía Beatriz Fuentes ◽  
Diego Enrique Kassuha ◽  
Walter Manucha
Keyword(s):  
Cardiovascular Diseases ◽  
Side Effects ◽  
Contrast Agent ◽  
Cardiovascular System ◽  
Blood Vessels ◽  
Renal Cancer ◽  
Molecular Targets ◽  
Renal Diseases ◽  
Treatment And Diagnosis ◽  
New Molecular Targets

Background: The kidney and cardiovascular system are closely related to each other during the modulation of the cardiovascular homeostasis. However, the search for new alternatives for the treatment and diagnosis of cardiovascular diseases does not take into account this relationship, so their evaluation results and the advantages offered by their global and integrative analysis are wasted. For example, a variety of receptors that are overexpressed in both pathologies is large enough to allow expansion in the search for new molecular targets and ligands. Nanotechnology offers pharmacological targeting strategies to kidney, heart, and blood vessels for overcoming one of the essential restrictions of traditional cardiovascular therapies the ones related to their unspecific pharmacodynamics distribution in these critical organs. Recent Findings: Drug or contrast agent nano-targeting for treatment or diagnosis of atherosclerosis, thrombosis, renal cancer or fibrosis, glomerulonephritis, among other renal, cardiac and blood vessels pathologies would allow an increase in their efficacy and a reduction of their side effects. Such effects are possible because, through pharmacological targeting, the drug is mainly found at the desired site. Review Purpose: In this mini-review, active, passive, and physical targeting strategies of several nanocarriers that have been assessed and proposed for the treatment and diagnosis of different cardiovascular diseases, are being addressed.

Several observations on the therapeutic effect of arlyl nitrite in retinal pigment degeneration

1935 ◽  
Vol 31 (10) ◽  
pp. 1188-1194
Author(s):  
V. I. Grigoriev ◽  
L. A. Dymschitz
Keyword(s):  
Optic Nerve ◽  
Blood Vessels ◽  
Therapeutic Effect ◽  
Blood Supply ◽  
Retinal Pigment ◽  
Retinal Blood Vessels

Pigmented regeneration of the retina is one of those diseases of the eye's light-receiving apparatus, where the fact of poor blood supply to the retina and the optic nerve is striking. This is manifested by the more or less sharp contraction of retinal blood vessels visible in the ophthalmoscope.

Cardiac and vascular ageing

2017 ◽  
pp. 729-736
Author(s):  
Hidetaka Ota ◽  
Masahiro Akishita
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Chronic Heart Failure ◽  
Left Ventricular Hypertrophy ◽  
Blood Vessels ◽  
Left Ventricular ◽  
Functional Changes ◽  
Healthy Humans ◽  
Vascular Ageing

There is a continuum of expression of cardiac structural and functional alterations that occurs with ageing in healthy humans, and these age-associated cardiac changes seem to be relevant to the increase in left ventricular hypertrophy, chronic heart failure, and arrhythmia that are commonly observed with increasing age. This chapter describes the structural and functional changes in the ageing process of the heart and blood vessels, and provides an overview of representative cardiovascular disease caused by ageing including hypertension, atherosclerosis, and heart failure. In addition, an outline of interventions that have be utilized to prevent and treat ageing related cardiovascular diseases is provided.

scholarly journals Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases

2004 ◽  
Vol 28 (S4) ◽  
pp. S58-S65 ◽  
Author(s):  
J-P Montani ◽  
J F Carroll ◽  
T M Dwyer ◽  
V Antic ◽  
Z Yang ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Blood Vessels ◽  
Ectopic Fat ◽  
Fat Storage ◽  
Heart Blood

scholarly journals Difficulties in management of patients with systemic lupus erythematosus and antiphospholipid syndrome in combination with melanoma and infiltrative tuberculosis (clinical observations)

2021 ◽  
Vol 15 (4) ◽  
pp. 87-93
Author(s):  
A. A. Shumilova ◽  
T. M. Reshetnyak ◽  
F. A. Cheldieva ◽  
A. M. Lila
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Herpes Zoster ◽  
Cardiovascular Diseases ◽  
Antiphospholipid Syndrome ◽  
Lupus Erythematosus ◽  
Clinical Guidelines ◽  
Malignant Neoplasms ◽  
Systemic Lupus ◽  
Clinical Observations

We present two clinical cases: the first patient had combination of antiphospholipid syndrome (APS) and melanoma, and the second – systemic lupus erythematosus (SLE) and APS, melanoma, infiltrative tuberculosis and Herpes zoster. Managing patients with SLE combined with APS is really challenging. Infections and malignant neoplasms, along with kidney damage and cardiovascular diseases, are a significant cause of death in this cohort of patients. The role of antibodies to phospholipids in the onset of malignancy is still under discussion. The combination of rheumatic diseases with oncological or infectious pathology complicates therapy, limiting the use of drugs, recommended by clinical guidelines.

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