scholarly journals Analysis of postoperative prognostic factors in patients with long bones metastatic lesions

2020 ◽  
Vol 101 (5) ◽  
pp. 685-690
Author(s):  
Jun Wang ◽  
N V Kharchenko ◽  
V Y Karpenko
Keyword(s):  
Quality Of Life ◽  
Surgical Treatment ◽  
Bone Metastases ◽  
Bone Lesions ◽  
Long Bones ◽  
Body Parts ◽  
Limb Pain ◽  
Pathological Fractures ◽  
Metastatic Lesions

Currently, with the development of the concept of cancer treatment, the survival rate of patients has increased significantly, but the percentage of the frequency of various metastatic lesions remains high. The bones of the skeleton are one of the main parts of metastases. In cancer patients, bone metastases usually mean that the disease is at an advanced stage, and the prognosis is not good. These patients often suffer from many complications, including pain, decreased mobility, pathological fractures, etc. The quality of life of patients is seriously deteriorating. Therefore, the main goal of surgical treatment of patients with bone metastases is the earliest possible restoration the function of the affected limb, pain relief, prevention of pathological fractures and the improvement of the quality of life of patients after surgery. This literature review analyzes the incidence of bone metastases in patients, and the dependence of metastatic lesions of long tubular bones on localization incidence of bone metastases in different body parts. The domestic and foreign literature on the surgical treatment of patients with metastatic bone lesions was analyzed. The results of the analysis show that the features of surgical treatment are becoming the main factors influencing the prognosis in patients with metastatic lesions of the long bones.

Bone Diaphysis Metastases, the Ways and Results of Surgical Treatment Saving the Joints

2019 ◽  
Vol 21 (2) ◽  
pp. 99-108 ◽  
Author(s):  
Piotr Szczerba ◽  
Grzegorz Guzik ◽  
Andrzej Bohatyrewicz ◽  
Daniel Kotrych
Keyword(s):  
Quality Of Life ◽  
Surgical Treatment ◽  
Bone Metastases ◽  
Surgical Management ◽  
Surgical Techniques ◽  
Long Bone ◽  
Pathological Fractures ◽  
Oncological Treatment ◽  
Modular Prostheses

Background. A consequence of the progress in oncological treatment is an increasing number of bone complications asso­ciated with metastases. With appropriate choice of oncological treatment and appropriate surgical management, patients may recover their physical function and maintain the previous level of quality of life. Available surgical techniques include intrame­dullary nailing, stabilisation with plates and screws and the use of modular prostheses. Aim of the study: to retrospectively assess the techniques and outcomes of surgical treatment of long bone metastases at the Oncology Orthopaedics Department of the Speciality Hospital in Brzozów, present the possibilities of surgical management and benefits of the chosen method and tentatively choose the most effective approach for restoring function. Material and methods. Between 2013 and 2017, a total of 82 patients were treated for long bone metastases at the Depart­ment of Oncological Orthopaedics. The most common cancers causing bone metastases were breast cancer (37%), myeloma (16%), lung cancer (8%), kidney (15%), prostate (8%), thyroid 4%, colon 1%, uterus 1%, with other sites accounting for 10%. Pathological fractures were diagnosed in 68 patients. Before the surgical treatment, the patients’ quality of life was assessed using the Karnofsky scale, Bollen prognostic scale, severity of pain in a VAS scale, and MSTS performance scale. Metastasis morpho­logy was evaluated with conventional radiographs, CT and PET-CT. Types of surgery comprised intramedullary nailing, the use of plates and screws and the placement of modular prostheses. Patients were divided into three groups with regard to the stabi­li­sation systems used and another three related to tumour location (humerus, femur or tibia). Results. Post-operatively, there was a reduction of pain in the VAS scale. Function (MSTS) was best in patients treated with minimally invasive methods and modular prostheses (p <0.05). An improvement in quality of life in the Karnofsky scale was also noted. The complication rate was 7% and was related to wound healing and thromboembolic complications. Conclusions. 1. Patients with long-bone cancer metastases with pathological fractures or risk of fracture require surgical management. 2. Nailing or modular prosthesis produced the best functional result at 6 weeks post-operatively. 3. All methods of surgical treatment reduced pain and improved the quality of life.

scholarly journals Użyteczność metod radioizotopowych w leczeniu przerzutów nowotworowych do układu kostnego – przegląd metod

2019 ◽  
Vol 15 (4) ◽  
pp. 126-133
Author(s):  
Roksana Zając ◽  
Paulina Radzińska ◽  
Agata Karolina Pietrzak ◽  
Katarzyna Wiecheć ◽  
Jakub Żurawski ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Palliative Therapy ◽  
Clinical Problem ◽  
Bone Lesions ◽  
Neoplastic Disease ◽  
Pathological Fractures ◽  
Oncological Patient ◽  
Important Clinical Problem ◽  
Health Complications

StreszczenieLeczenie dolegliwości bólowych będących konsekwencją przerzutów nowotworowych w układzie kostnym stanowi ważny problem kliniczny z uwagi na istotne obniżenie jakości życia chorego onkologicznego. Towarzyszące zaawansowanej chorobie nowotworowej zmiany przerzutowe oprócz bólu, są także przyczyną złamań patologicznych oraz upośledzenia funkcji ruchowych pacjenta, a nieleczone mogą być przyczyną krytycznych dla życia chorego powikłań. Zastosowanie leczenia radioizotopowego jako jednej z form terapii paliatywnej, jest ważnym i efektywnym sposobem zapobiegania komplikacjom zdrowotnym związanym z rozwojem przerzutów do układu szkieletowego.Abstract  Palliative therapy in patients’ suffering from metastatic bone lesions is an important clinical problem due to a significant reduction in the quality of life of an oncological patient. The metastatic bone lesions regardless pain are also the cause of pathological fractures and impairments of the patient's motor functions and untreated can affect mortality more often than primary neoplastic disease. The palliative therapy using radioisotopes seems to be an important and effective method which might prevent the critical health complications caused by the skeletal tumors.

scholarly journals Capabilities of preoperative targeted therapy in treatment of bone metastases in renal cancer

2019 ◽  
Vol 15 (2) ◽  
pp. 35-41
Author(s):  
Z. A. Yurmazov ◽  
N. A. Lushnikova ◽  
L. V. Spirina ◽  
E. A. Usynin ◽  
E. M. Slonimskaya ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Renal Cell Carcinoma ◽  
Targeted Therapy ◽  
Surgical Treatment ◽  
Bone Metastases ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Study Objective ◽  
Bone Segment

The study objective is to evaluate the effectiveness of preoperative targeted therapy, spectrum and rate of adverse events, as well as quality of life in patients with bone metastases of renal cell carcinoma.Materials and methods. The study was conducted at the Research Institute of Oncology, Tomsk Medical Research Center between 2014 and 2018. The study included 34 patients with bone metastases of renal cell carcinoma who received preoperative targeted therapy with pazopanib for 8 weeks. All patients underwent surgical treatment of both the primary tumor and bone metastases.Results and conclusion. It was shown that preoperative targeted therapy is characterized by a high rate of clinical response and satisfactory tolerability. In some cases, preoperative targeted therapy improves the conditions for surgical treatment of metastatic bone lesions, decreases intraoperative blood loss, decreases the volume and duration of surgical intervention, which, in turn, allows to preserve bigger range of motion in the affected bone segment and improve patients’ quality of life.

scholarly journals Efficiency of Early Activation of Patients after Onco-Orthopedic Operations in the Framework of Stage I of Rehabilitation

2021 ◽  
Vol 3 (2) ◽  
pp. 207-213
Author(s):  
Andrey D. Kaprin ◽  
Mamed D. Aliev ◽  
Elena V. Filonenko ◽  
Alexandra M. Stepanova ◽  
A. V. Bukharov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Surgical Treatment ◽  
Musculoskeletal System ◽  
General Condition ◽  
Axial Skeleton ◽  
Long Bones ◽  
Functional Disorders ◽  
Postoperative Rehabilitation ◽  
Comprehensive Rehabilitation

Patients with tumors of the long bones and axial skeleton are at risk of developing significant functional disorders that not only negatively affect socialization and quality of life, but also the results of therapy. At present, there is no consensus on the choice of tactics for early postoperative rehabilitation after arthroplasty of large joints and decompression and stabilization operations in onco-orthopedics. The article analyzes the influence of early postoperative rehabilitation on the general condition of patients after onco-orthopedic operations. Comprehensive rehabilitation improves the general condition of patients after surgical treatment of patients with tumors of the musculoskeletal system.

Health-related quality of life one year after surgical treatment of the type I chronic aortic dissection

2019 ◽  
Vol 38 (1) ◽  
Author(s):  
Oksana Kamenskaya ◽  
Asya Klinkova ◽  
Irina Loginova ◽  
Alexander Chernyavskiy ◽  
Dmitry Sirota ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Surgical Treatment ◽  
Aortic Dissection ◽  
Type I ◽  
Health Related Quality ◽  
Chronic Aortic Dissection ◽  
Related Quality ◽  
Health Related ◽  
One Year

Psychiatric and psychosocial morbidity 1 year after epilepsy surgery

2020 ◽  
pp. 1-8
Author(s):  
S. Patel ◽  
M. Clancy ◽  
H. Barry ◽  
N. Quigley ◽  
M. Clarke ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Surgical Treatment ◽  
Epilepsy Surgery ◽  
Refractory Epilepsy ◽  
Post Surgery ◽  
Axis I ◽  
Patients With Epilepsy ◽  
The Impact

Abstract Objectives: There is a high rate of psychiatric comorbidity in patients with epilepsy. However, the impact of surgical treatment of refractory epilepsy on psychopathology remains under investigation. We aimed to examine the impact of epilepsy surgery on psychopathology and quality of life at 1-year post-surgery in a population of patients with epilepsy refractory to medication. Methods: This study initially assessed 48 patients with refractory epilepsy using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), the Hospital Anxiety and Depression Scale (HADS) and the Quality of Life in Epilepsy Inventory 89 (QOLIE-89) on admission to an Epilepsy Monitoring Unit (EMU) as part of their pre-surgical assessment. These patients were again assessed using the SCID-I, QOLIE-89 and HADS at 1-year follow-up post-surgery. Results: There was a significant reduction in psychopathology, particularly psychosis, following surgery at 1-year follow-up (p < 0.021). There were no new cases of de novo psychosis and surgery was also associated with a significant improvement in the quality of life scores (p < 0.001). Conclusions: This study demonstrates the impact of epilepsy surgery on psychopathology and quality of life in a patient population with refractory surgery. The presence of a psychiatric illness should not be a barrier to access surgical treatment.

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