scholarly journals Interdisciplinary system approach and concept of experimental and analytical method of material selection and design planning in order to improve effectiveness of periodontitis treatment

2021 ◽  
Vol 38 (4) ◽  
pp. 112-120
Author(s):  
N. B. Astashina ◽  
E. P. Rogozhnikova ◽  
A. F. Merzlyakov ◽  
V. N. Nikitin

Objective. One of the most important tasks of dentistry at the present stage is creation of structures, which ensure a unity of dental system form and function and bring it closer to its original natural state. This approach permits to expand significantly the range of orthopedic treatment tasks and implement medical and technical requirements for materials, structures of dentures and splinting devices. Materials and methods. The article reflects the results of an experimental study to determine the Poisson's ratio of the Dental D thermoplastic material used as a structural material for the manufacture of a new therapeutic and preventive dental splint as well as a biomechanical analysis of changes in the displacement amplitude of the teeth included in the splint. Results. As a result, an accurate quantitative assessment of the developed method of tooth immobilization in mild periodontitis is given taking into account the behavior of the bone tissue of the lower jaw, hard tissues of the teeth and periodontium as well as in case when the dentition is affected by the chewing load. Conclusions. The analysis of the obtained data allowed us to form practical recommendations for use of the developed design at the stages of orthopedic treatment of patients with the initial stage of periodontal pathology in order to reduce functional overload of dentition and maintain mobility of teeth at physiological level.

2019 ◽  
Author(s):  
Bradly Alicea ◽  
Richard Gordon ◽  
Thomas Harbich ◽  
Ujjwal Singh ◽  
Asmit Singh ◽  
...  

AbstractRecent years have witnessed a convergence of data and methods that allow us to approximate the shape, size, and functional attributes of biological organisms. This is not only limited to traditional model species: given the ability to culture and visualize a specific organism, we can capture both its structural and functional attributes. We present a quantitative model for the colonial diatom Bacillaria paradoxa, an organism that presents a number of unique attributes in terms of form and function. To acquire a digital model of B. paradoxa, we extract a series of quantitative parameters from microscopy videos from both primary and secondary sources. These data are then analyzed using a variety of techniques, including two rival deep learning approaches. We provide an overview of neural networks for non-specialists as well as present a series of analysis on Bacillaria phenotype data. The application of deep learning networks allows for two analytical purposes. Application of the DeepLabv3 pre-trained model extracts phenotypic parameters describing the shape of cells constituting Bacillaria colonies. Application of a semantic model trained on nematode embryogenesis data (OpenDevoCell) provides a means to analyze masked images of potential intracellular features. We also advance the analysis of Bacillaria colony movement dynamics by using templating techniques and biomechanical analysis to better understand the movement of individual cells relative to an entire colony. The broader implications of these results are presented, with an eye towards future applications to both hypothesis-driven studies and theoretical advancements in understanding the dynamic morphology of Bacillaria.


Author(s):  
Patricia G. Arscott ◽  
Gil Lee ◽  
Victor A. Bloomfield ◽  
D. Fennell Evans

STM is one of the most promising techniques available for visualizing the fine details of biomolecular structure. It has been used to map the surface topography of inorganic materials in atomic dimensions, and thus has the resolving power not only to determine the conformation of small molecules but to distinguish site-specific features within a molecule. That level of detail is of critical importance in understanding the relationship between form and function in biological systems. The size, shape, and accessibility of molecular structures can be determined much more accurately by STM than by electron microscopy since no staining, shadowing or labeling with heavy metals is required, and there is no exposure to damaging radiation by electrons. Crystallography and most other physical techniques do not give information about individual molecules.We have obtained striking images of DNA and RNA, using calf thymus DNA and two synthetic polynucleotides, poly(dG-me5dC)·poly(dG-me5dC) and poly(rA)·poly(rU).


2011 ◽  
Author(s):  
Scott Fluke ◽  
Russell J. Webster ◽  
Donald A. Saucier

2013 ◽  
Author(s):  
Joshua Wilt ◽  
William Revelle

Author(s):  
Barbara Schönig

Going along with the end of the “golden age” of the welfare state, the fordist paradigm of social housing has been considerably transformed. From the 1980s onwards, a new paradigm of social housing has been shaped in Germany in terms of provision, institutional organization and design. This transformation can be interpreted as a result of the interplay between the transformation of national welfare state and housing policies, the implementation of entrepreneurial urban policies and a shift in architectural and urban development models. Using an integrated approach to understand form and function of social housing, the paper characterizes the new paradigm established and nevertheless interprets it within the continuity of the specific German welfare resp. housing regime, the “German social housing market economy”.


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