scholarly journals Adaptogenic effect of phlojodicarpus sibiricus extract on cerebral ischemia

2019 ◽  
Vol 17 (2) ◽  
pp. 63-66 ◽  
Author(s):  
Sergey M. Gulyaev ◽  
Vasiliy V. Taraskin ◽  
Ekaterina Z. Urbanova
Keyword(s):  
Nitric Oxide ◽  
Lipid Peroxidation ◽  
Cerebral Ischemia ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Ether Anesthesia ◽  
Effect Of Ph ◽  
Adaptogenic Effect ◽  
The Brain

The aim of the study was to determine the adaptogenic effect of the extract from the roots of Phlojodicarpus sibiricus during ischemic influence on the left hemisphere of the brain. Experiments were conducted on Wistar rats of both sexes weighing 200-220 g. Unilateral cerebral ischemia was induced by permanent occlusion of the left common carotid artery under ether anesthesia. Adaptogenic anti-ischemic effect of Ph. sibiricus was determined by the number of desquamated endotheliocytes, nitrogen oxide metabolites – nitrites in the blood, by the content of lipid peroxidation products – malondialdehyde (MDA) and the activity of the antioxidant defense system in the brain tissue. It is established that Ph. sibiricus has an anti-ischemic effect, reduces the number of endotheliocytes desquamated, increases the level of nitric oxide in the blood (p ≤ 0.05), stimulates SOD and catalase activity, reducing the intensity of lipid peroxidation and the accumulation of MDA in the brain during ischemic exposure (p ≤ 0.05). Preventive administration of Ph. sibiricus extract has an adaptogenic effect in unilateral cerebral ischemia, which consists in reducing desquamated endotheliocytes, increasing the production of nitric oxide by endothelium, increasing the antioxidant defense system and reducing the intensity of oxidative reactions in the brain. Adaptogenic effect of Ph. sibiricus extract is caused by endothelium protective and antioxidant effects.

scholarly journals Neuroprotective Effects of Tea Against Cadmium Toxicity

2019 ◽  
Vol 2 (12) ◽  
pp. 230
Author(s):  
Francis N. Wachira ◽  
G. O. Areba ◽  
R. M. Ngure ◽  
R. Khalid ◽  
F. Maloba ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Brain Tissue ◽  
Antioxidant Defense ◽  
Neuronal Damage ◽  
Cadmium Toxicity ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Neuroprotective Effects ◽  
Histopathological Studies ◽  
The Brain

Background: Cadmium (Cd) is a common pollutant and potential neuro-toxicant to humans. The main treatment for heavy metal toxicity is chelation therapy which is however replete with grave side effects. This study was designed to determine the neuroprotective effects of extracts of the tea beverage on experimentally induced cadmium toxicity in the brain of rats. Cadmiumas CdCl2 was administered subcutaneously while tea was given orally.Methods: Healthy Wister rats were used to study the effects of co-administration of Cd and tea extracts on the brain. Cadmium was injected subcutaneously while tea was administered orally to the rats. Brain tissue from euthanized rats was assayed for Zinc Fingers and Homeoboxes Protein 1 (ZHX1), reduced glutathione (GSH), and lipid peroxidation markers Thiobarbituric Acid Reactive Substances (TBARS). Neurohistochemical and histopathological studies were also carried out on the brain tissues of the rats.Results: Cadmium significantly induced neuronal damage exhibited by a significant (p < 0.05) decrease in ZHX1 in the brain tissue, significant (p <0.05) increase in TBARS, as well as significant (p < 0.05) increase in GSH implying an impaired antioxidant defense system. Co-administration of Cd with black or green tea extracts resulted in a significant decrease in lipid peroxidation as well as maintenance of GSH and ZHX1. The neurohistochemical and histopathological studies in the brain of the rats indicated that the tea extracts significantly reduced CdCl2 toxicity and preserved the normal histological architecture of the brain tissues.Conclusion: This paper reports for the first time the efficacy of tea extracts in protecting rats from cadmium induced toxicity and disturbances of antioxidant defense system in the brain.Key words: Tea; flavonoids; Cadmium; neurotoxicity; Chelating agents.

Influence of ellagic acid on antioxidant defense system and lipid peroxidation in mice

1991 ◽  
Vol 42 (7) ◽  
pp. 1441-1445 ◽  
Author(s):  
Sabhiya Majid ◽  
Krishan L. Khanduja ◽  
Rajinder K. Gandhi ◽  
Sanjay Kapur ◽  
Rati R. Sharma
Keyword(s):  
Lipid Peroxidation ◽  
Ellagic Acid ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System

scholarly journals On the Opportunities of Using the Indices of Lipid Peroxidation – Antioxidant Defense System in the Diagnostics of Varicose Veins of Small Pelvis in Women

2020 ◽  
Vol 5 (1) ◽  
pp. 14-20
Author(s):  
L. I. Kolesnikova ◽  
A. A. Semendyaev ◽  
D. A. Stupin ◽  
M. A. Darenskaya ◽  
L. A. Grebenkina ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Defense ◽  
Varicose Veins ◽  
Antioxidant Defense System ◽  
Pathological Process ◽  
Moderate Degree ◽  
Defense System ◽  
Mild Degree ◽  
Severe Degree ◽  
Degree Of Severity

Background: The prevalence of varicose veins of small pelvic veins in women of reproductive age varies widely – from 5.4 to 80 %, due to the low specificity and low sensitivity of clinical diagnostic techniques, and the absence of biomarkers that can be used to identify the formation and progression of varicose veins of small pelvic veins in women.Aims: To identify changes in the levels of parameters of the system “lipid peroxidation – antioxidant protection” with the development of varicose veins of the pelvis in women, as well as the possibility of their diagnostic use.Materials and methods: We examined 200 women with clinical signs of varicose veins of small pelvis. Control group included 30 women without any pathology of venous system. Treatment group included 137 women with varicose veins of small pelvis: with mild degree of severity – 39 women, with moderate degree of severity – 65 women, with severe degree of severity – 33 women. We performed comparative analysis of lipid peroxidation – antioxidant defense system in women with and without varicose veins of small pelvis taking into account the severity degrees of pathological process.Results: We obtained the most informative indices for lipid peroxidation – antioxidant defense processes in blood of women with varicose veins of small pelvis: concentration of diene conjugate (DC) for the mild degree of severity of pathological process, lipid hydroperoxide (LHP), DC and malonic dialdehyde (MDA) – for the moderate and severe degree of severity, and also changes in the activity of antioxidant enzymes with increase of the severity of the disease. Assessment of the level of catalase (Cat) and glutathione peroxidase (GP) showed their highest informative value at the mild degree of severity. Concentrations of glutathione reductase (GR), glutathione S-transferase (GST) and reduced glutathione (GSH) are more statistically significant markers for severe forms of pathological process.Conclusions: Our research showed the relevance and advisability of the studying the levels of lipid peroxidation – antioxidant defense indices in women with varicose veins of small pelvis. We registered the highest diagnostic value of DC, Cat and GP in the beginning of the disease and of LHP, DC, MDA, GR, GST and GSH – at severe forms of the pathological process. We obtained reference values for DC, MDA, Cat, SOD and GP concentration that can be considered as the predictors of the development of varicose veins of small pelvis.

Evaluation of Lipid Peroxidation—Antioxidant Defense System Depending on the Stage of Stress Reaction in Hypertensive ISIAH Rats

2019 ◽  
Vol 166 (5) ◽  
pp. 610-612
Author(s):  
L. I. Kolesnikova ◽  
L. R. Kolesnikova ◽  
M. A. Darenskaya ◽  
L. V. Natyaganova ◽  
L. A. Grebenkina ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Stress Reaction ◽  
Defense System ◽  
Isiah Rats ◽  
Hypertensive Isiah Rats

Impact of Nutrients on Cellular Lipid Peroxidation and Antioxidant Defense System

1995 ◽  
Vol 26 (1) ◽  
pp. 1-7 ◽  
Author(s):  
DEAN P. JONES ◽  
VALERIAN E. KAGAN ◽  
STEVEN D. AUST ◽  
DONALD J. REED ◽  
STANLEY T. OMAYE
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Cellular Lipid ◽  
Defense System
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