scholarly journals New Models of Care and Innovation in Alzheimer’s Disease and Related Dementias

US Neurology ◽  
2018 ◽  
Vol 14 (1) ◽  
pp. 19
Author(s):  
Anitha Rao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Standard Care ◽  
New Technologies ◽  
Positive Impact ◽  
Models Of Care ◽  
International Conference ◽  
Expert Interview ◽  
New Models

Dr. Anitha Rao delivered several presentations at the Alzheimer’s Association International Conference (AAIC) in London, UK, July 2017.1–3 In an expert interview following AAIC 2017, Dr. Rao discusses the current limitations of standard care for patients with Alzheimer’s disease and related dementias (ADRD), and puts into perspective the potential positive impact of important new technologies such as Neurocern.

scholarly journals Treatment Developments in Alzheimer’s Disease

US Neurology ◽  
2018 ◽  
Vol 14 (1) ◽  
pp. 17
Author(s):  
Martin R Farlow
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Treatment Development ◽  
International Conference ◽  
Expert Interview

The annual Alzheimer’s Association International Conference (AAIC) took place in London, UK in July 2017. In an expert interview, Martin R Farlow reflects on treatment development, one of the key themes of the meeting.

scholarly journals Alzheimer’s Disease—Failure of Drainage of Fluid from the Brain

US Neurology ◽  
2018 ◽  
Vol 14 (1) ◽  
pp. 21
Author(s):  
Roxana Carare
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Basic Science ◽  
Interstitial Fluid ◽  
International Conference ◽  
Expert Interview ◽  
Science Session ◽  
The Brain

The annual Alzheimer’s Association International Conference (AAIC) took place in London, UK in July 2017. In an expert interview, Roxana Carare recaps on the topic of her presentation during the ‘Emerging Concepts in Basic Science’ session, clearance of interstitial fluid of the brain and pathogenesis of dementia.1

The complexity of Alzheimer's disease: an evolving puzzle

2021 ◽  
Author(s):  
Sandro Sorbi ◽  
Camilla Ferrari
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
New Technologies ◽  
Clinical Symptoms ◽  
Real Life ◽  
Pathological Process ◽  
Point Of View ◽  
Biological Entity ◽  
History Of ◽  
Static View

The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end of the century to identify the component of pathological hallmarks, genetic subtypes and to formulate the first pathogenic hypothesis. Thanks to biomarkers and new technologies, the concept of AD then rapidly changed from a static view of an amnestic dementia of the presenium to a biological entity that could be clinically manifested as normal cognition or dementia of different types. What is clearly emerging from studies is that AD is heterogeneous in each aspect, such as amyloid composition, tau distribution, relation between amyloid and tau, clinical symptoms, genetic background, and thus it is probably impossible to explain AD with a single pathological process. The scientific approach to AD suffers from chronological mismatches between clinical, pathological and technological data, causing difficulty in conceiving diagnostic gold standards and in creating models for drug discovery and screening. A recent mathematical computer-based approach offers the opportunity to study AD in real life and to provide a new point of view and the final missing pieces of the AD puzzle.

Impact of Auditory-Visual Bimodality on Lexical Retrieval in Alzheimer's Disease Patients

2015 ◽  
Vol 39 (5-6) ◽  
pp. 348-359
Author(s):  
Isabelle Simoes Loureiro ◽  
Laurent Lefebvre
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positive Impact ◽  
Positive Influence ◽  
Lexical Retrieval ◽  
Visual Modality ◽  
Auditory Modality ◽  
Elderly Persons ◽  
Healthy Elderly ◽  
Stage 1

The aim of this study was to generalize the positive impact of auditory-visual bimodality on lexical retrieval in Alzheimer's disease (AD) patients. In practice, the naming skills of healthy elderly persons improve when additional sensory signals are included. The hypothesis of this study was that the same influence would be observable in AD patients. Sixty elderly patients separated into three groups (healthy subjects, stage 1 AD patients, and stage 2 AD patients) were tested with a battery of naming tasks comprising three different modalities: a visual modality, an auditory modality, and a visual and auditory modality (bimodality). Our results reveal the positive influence of bimodality on the accuracy with which bimodal items are named (when compared with unimodal items) and their latency (when compared with unimodal auditory items). These results suggest that multisensory enrichment can improve lexical retrieval in AD patients.

scholarly journals Zoo Therapy for Alzheimer’s Disease with Real-Time Speech Instruction and Neurofeedback System

2021 ◽  
Author(s):  
Yan Ai ◽  
Hamdi Ben Abdessalem ◽  
Claude Frasson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Virtual Reality ◽  
Real Time ◽  
Positive Impact ◽  
Negative Emotions ◽  
Animal Therapy ◽  
Preliminary Results ◽  
Emotional Value ◽  
The Impact

There is an increasing number of people with Alzheimer’s disease. Negative emotions are not only one of the symptoms of AD, but also the accelerator of the disease. Animal therapy can have a positive impact on the negative emotions of patients, but it has strict requirements for both environments and animals. In this study, we aim to explore the effectiveness of using virtual animals and their impact on the reduction of patients’ negative emotions to improve the user’s cognitive functions. This approach has been implemented in the Zoo Therapy project, which presents an immersive 3D virtual reality animal environment, where the impact on the patient’s emotion is measured in real-time by using electroencephalography (EEG). In addition to creating highly realistic virtual animals, the innovation of Zoo Therapy is also in its communication mechanism as it implements bidirectional human-computer interaction supported by 3 interaction methods: 3D buttons, speech instruction, and Neurofeedback. Patients can actively interact with virtual animals through 3D buttons or speech instructions. The Neurofeedback system will guide the animal to actively interact with the patients according to their real-time emotional changes to reduce their negative emotions. Experiments and preliminary results show that it is possible to interact with virtual animals in Zoo Therapy, and the Neurofeedback system can intervene in Zoo VR environment when the emotional value goes down and might reduce patients’ negative emotions.

Flavonoids with Potential Anti-Amyloidogenic Effects as Therapeutic Drugs for Treating Alzheimer’s Disease

2021 ◽  
pp. 1-29
Author(s):  
Qixin Wang ◽  
Xiaofang Dong ◽  
Ran Zhang ◽  
Changqi Zhao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Aging ◽  
Positive Impact ◽  
Amyloid Β ◽  
The Elderly ◽  
Favorable Effect ◽  
Amyloid Β Protein ◽  
Physical And Mental Health ◽  
Dementia Patients

Alzheimer’s disease (AD) is a central neurodegenerative disease generally among the elderly; it accounts for approximately 50–75%of total cases of dementia patients and poses a serious threat to physical and mental health. Currently available treatments for AD mainly relieves its symptoms, and effective therapy is urgently needed. Deposition of amyloid-β protein in the brain is an early and invariant neuropathological feature of AD. Currently the main efforts in developing anti-AD drugs focus on anti-amyloidogenic therapeutics that prevent amyloid-β production or aggregation and decrease the occurrence of neurotoxic events. The results of an increasing number of studies suggest that natural extracts and phytochemicals have a positive impact on brain aging. Flavonoids belong to the broad group of polyphenols and recent data indicate a favorable effect of flavonoids on brain aging. In this review, we collect relevant discoveries from 1999 to 2021, discuss 75 flavonoids that effectively influence AD pathogenesis, and summarize their functional mechanisms in detail. The data we have reviewed show that, these flavonoids belong to various subclasses, including flavone, flavanone, biflavone, etc. Our results provide a reference for further study of the effects of flavonoids on AD and the progress of anti-AD therapy.

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