The Study of Lipid Proton Composition Change in a Rat Model of High Fat Diet Induced Fatty Liver by Magnetic Resonance Spectroscopy Analysis

2021 ◽  
Vol 44 (4) ◽  
pp. 315-325
Author(s):  
Sang-Hyeok Kim ◽  
Seung-Man Yu
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Fatty Liver ◽  
Rat Model ◽  
High Fat Diet ◽  
Resonance Spectroscopy ◽  
Composition Change ◽  
High Fat ◽  
Spectroscopy Analysis

scholarly journals A high fat diet alters metabolic and bioenergetic function in the brain: A magnetic resonance spectroscopy study

2016 ◽  
Vol 97 ◽  
pp. 172-180 ◽  
Author(s):  
Kayla Raider ◽  
Delin Ma ◽  
Janna L. Harris ◽  
Isabella Fuentes ◽  
Robert S. Rogers ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
High Fat Diet ◽  
Resonance Spectroscopy ◽  
Spectroscopy Study ◽  
High Fat ◽  
Magnetic Resonance Spectroscopy Study ◽  
The Brain

Hyperpolarized 129Xe Magnetic Resonance Spectroscopy in a Rat Model of Bronchopulmonary Dysplasia

2021 ◽  
Author(s):  
Jordan David Fliss ◽  
Brandon Zanette ◽  
Yonni Friedlander ◽  
Siddharth Sadanand ◽  
Andras A Lindenmaier ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Gas Exchange ◽  
Magnetic Resonance Spectroscopy ◽  
Bronchopulmonary Dysplasia ◽  
Rat Model ◽  
Resonance Spectroscopy ◽  
Gas Exchange Parameters ◽  
Functional Changes ◽  
Non Invasive

Premature infants often require mechanical ventilation and oxygen therapy which can result in bronchopulmonary dysplasia (BPD), characterized by developmental arrest and impaired lung function. Conventional clinical methods for assessing the prenatal lung are not adequate for the detection and assessment of long-term health risks in infants with BPD, highlighting the need for a non-invasive tool for the characterization of lung microstructure and function. Theoretical diffusion models, like the Model of Xenon Exchange (MOXE), interrogate alveolar gas exchange by predicting the uptake of inert Hyperpolarized (HP) 129Xe gas measured with HP 129Xe magnetic resonance spectroscopy (MRS). To investigate HP 129Xe MRS as a tool for non-invasive characterization of pulmonary microstructural and functional changes in vivo, HP 129Xe gas exchange data were acquired in an oxygen exposure rat model of BPD that recapitulates the fewer and larger distal airways and pulmonary vascular stunting characteristics of BPD. Gas exchange parameters from MOXE, including airspace mean chord length (L­m), apparent hematocrit in the pulmonary capillaries (HCT), and pulmonary capillary transit time (tx), were compared with airspace mean axis length and area density (MAL and ρ­A) and percentage area of tissue and air (PTA and PAA) from histology. L­m was significantly larger in the exposed rats (p=0.003) and correlated with MAL, ρ­A, PTA, and PAA (0.59<|ρ|<0.66 and p<0.05). Observed increase in HCT (p=0.012) and changes in tx are also discussed. These findings support the use of HP 129Xe MRS for detecting fewer, enlarged distal airways in this rat model of BPD, and potentially in humans.

scholarly journals Evaluation of nonalcoholic fatty liver model in rats using 1H magnetic resonance spectroscopy

2008 ◽  
Vol 16 (15) ◽  
pp. 1612 ◽  
Author(s):  
Zai-Yi Liu ◽  
Chang-Hong Liang ◽  
Qiu-Shi Wang ◽  
Yu-Bao Liu ◽  
Li Xu ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Fatty Liver ◽  
Resonance Spectroscopy ◽  
1H Magnetic Resonance Spectroscopy ◽  
Nonalcoholic Fatty Liver ◽  
Liver Model
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