scholarly journals Synthesis, Spectral Correlations and Antimicrobial Activities of some 2-Hydroxyphenyl-Styrylketone

2013 ◽  
Vol 12 ◽  
pp. 102-119 ◽  
Author(s):  
K. Sathiyamoorthi ◽  
V. Mala ◽  
R. Suresh ◽  
S.P. Sakthinathan ◽  
D. Kamalakkannan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Microwave Irradiation ◽  
Spectral Data ◽  
Spectroscopic Data ◽  
Catalytic Amount ◽  
Antimicrobial Activities ◽  
H Nmr ◽  
Substituent Constants ◽  
Substituted Benzaldehydes ◽  
C Nmr

Some 2’-hydroxyphenylchalcones have been synthesized under microwave irradiation by Claisen-Schmidt condensation between substituted 2-hydroxyacetophenone and substituted benzaldehydes using catalytic amount of SiO2-H3PO4. These chalcones were established by their physical constants and spectroscopic data published earlier. The UV, IR, 1H NMR and 13C NMR spectral data of these chalcone have correlated with Hammett substituent constants, F and R parameters. All the compounds have been subjected to screened for antimicrobial activity.

scholarly journals Solvent-Free Synthesis and Spectral Linearity of Some (E)-2-(substituted benzylideneamino)-N-(3-chloro-4-fluorophenyl)-hexahydro-2H-cyclopenta[b]thiophene-3-carboxamides

2013 ◽  
Vol 13 ◽  
pp. 160-174 ◽  
Author(s):  
Ganesamoorthy Thirunarayanan ◽  
K.G. Sekar
Keyword(s):  
Statistical Analysis ◽  
Microwave Irradiation ◽  
Spectral Data ◽  
Chemical Shifts ◽  
Solvent Free ◽  
Nmr Chemical Shifts ◽  
Substituent Constants ◽  
Substituted Benzaldehydes ◽  
Solvent Free Synthesis ◽  
Spectral Group

Some (E)-2-(substituted benzylideneamino)-N-(3-chloro-4-fluorophenyl)-hexahydro-2H-cyclopenta[b]thiophene-3-carboxamide derivatives have been synthesized by SiO2:H3PO4 catalyzed solvent-free condensation of 2-amino-N-(3-chloro-4-fluorophenyl)-hexahydro-2H-cyclopenta [b]thiophene-3-carboxamide and various substituted benzaldehydes in microwave irradiation. The yield of the imine-carboximido derivatives has been found to be more than 85 %. The purity of all imine-carboximido derivatives has been checked using their physical constants and spectral data. The spectral data of the imine-carboximido derivatives such as infrared ν (cm-1) of CO, NH, C-N, C-Cl, C-F, C=N, and the NMR chemical shifts (δ, ppm) of NH, CH, CO and C=N have been correlated with Hammett substituent constants, F and R parameters. From the results of statistical analysis, the effects of substituent on the above spectral group absorptions have been discussed.

scholarly journals Synthesis and Antibacterial Activity of Some Derivatives of 2-Methylbenzimidazole Containing 1,3,4-Oxadiazole or 1,2,4-Triazole Heterocycle

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Cong Nguyen Tien ◽  
Duc Tran Thi Cam ◽  
Ha Bui Manh ◽  
Dat Nguyen Dang
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Spectral Data ◽  
H Nmr ◽  
Mold And Yeast ◽  
Derivatives Of ◽  
C Nmr

5-[(2-Methyl-1H-benzimidazol-1-yl)methyl]-1,3,4-oxadiazole-2-thiol or 5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-4-(4-methylphenyl)-1,2,4-triazol-3-thiol which were prepared starting from 2-methylbenzimidazole in the reaction with appropriateN-aryl-2-chloroacetamides afforded two series ofN-aryl-2-{5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-1,3,4-oxadiazol-2-yl}sulfanylacetamides andN-aryl-2-{5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-4-(4-methylphenyl)-4H-1,2,4-triazol-3-ylthio}acetamides, respectively. The structures of the compounds were elucidated on the basis of IR, MS,1H-NMR, and13C-NMR spectral data. The compounds containing 1,3,4-oxadiazole or 1,2,4-triazole heterocycle also were tested for their antimicrobial activity against bacteria, mold, and yeast.

Synthesis and antimicrobial activity of 3,4-dihydropyrimidin-2(1H)-one derivatives containing a hydrazone moiety

2018 ◽  
Vol 24 (2) ◽  
pp. 113-117 ◽  
Author(s):  
Hua-Nan Peng ◽  
Li-Min Ye ◽  
Ming Zhang ◽  
Yan-Chun Yang ◽  
Jie Zheng
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Aspergillus Niger ◽  
Antimicrobial Activities ◽  
Bacterial Strains ◽  
Fungal Strains ◽  
H Nmr ◽  
C Nmr

AbstractThe title compounds were synthesized and characterized by IR,1H NMR,13C NMR and HRMS data. Their antimicrobial activities against bacterial strainsEscherichia coliand fungal strainsAspergillus nigerwere evaluated.

Synthesis, Characterization and Antimicrobial Activity of a New Preservative, 6-O-Chitosan Ester of P-Hydroxybenzoic Acid

2011 ◽  
Vol 189-193 ◽  
pp. 1049-1055
Author(s):  
Xi Rong Zhao
Keyword(s):  
Antimicrobial Activity ◽  
Water Solubility ◽  
Antimicrobial Activities ◽  
Amic Acid ◽  
Amino Group ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Escherchia Coli ◽  
Better Than ◽  
C Nmr

A new chitosan ester derivative, chitosan p-hydroxybenzoate is synthesized, which is expected to have antimicrobial activity similar to parabens. The amino group of chitosan reacts well with acyl chloride to prepare a N-amic acid-chitosan. The amino group of chitosan must be protected before synthesizing a 6-O-chitosan ester. Phthalic anhydride is selected to react with chitosan to form N-phthalimide chitosan whose free amino group is protected. By six steps chitosan p-hydroxybenzoate is synthesized. FTIR,1H NMR and13C NMR spectra show that the ester bond is formed between p-hydroxybenzonic acid and chitosan. Water solubility of the ester is slightly better than that of heptyl p-hydroxybenzoate, and its solubility in alcohol is greatly improved. Chitosan p-hydroxybenzoate showes broader spectrum antimicrobial activities. It has strong antimicrobial effects against Gram-negative, Gram-positive bacteria and yeasts. The MICs of chitosan p-hydroxybenzoate for Staphylococcus aureus and Escherchia coli are 0.01% and 0.025%, respectively.

A New Active Compound from Centaurea Species

2006 ◽  
Vol 61 (1-2) ◽  
pp. 44-46 ◽  
Author(s):  
Melek U. Dumlu ◽  
Elcin Gürkan
Keyword(s):  
Active Compound ◽  
Spectroscopic Data ◽  
Chemical Structure ◽  
Sesquiterpene Lactones ◽  
Antimicrobial Activities ◽  
H Nmr ◽  
Steroidal Compound ◽  
Antioxidant And Antimicrobial Activities ◽  
C Nmr

Abstract The extract containing sesquiterpene lactones of Centaurea iberica (Asteraceae) isolated was separated and a steroidal compound, which is stigmast-1,5-dien-3β-ol, was purified. The chemical structure was established based on spectroscopic data (UV, IR, MS, 1H NMR, 13C NMR). Both the extract and the compound showed significant antioxidant and antimicrobial activities

scholarly journals Microwave Assisted Synthesis of New 1-{2, 4-Dihydroxy-5-[5-(aryl)-1-pyridine/pyrimidine-4-carbonyl)-4, 5-dihydro-1H-pyrazol-3-yl]-phenyl}-3-(aryl)-propenones and their Antibacterial Activity

2009 ◽  
Vol 6 (2) ◽  
pp. 323-331
Author(s):  
D. Ashok ◽  
K. Aravind
Keyword(s):  
Antibacterial Activity ◽  
Microwave Irradiation ◽  
Spectral Data ◽  
Acid Hydrazide ◽  
Microwave Assisted Synthesis ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Microwave Assisted ◽  
C Nmr

A series of 1-{2, 4-dihydroxy-5-[5-(aryl)-1-pyridine/pyrimidine-4-carbonyl)-4, 5-dihydro-1H-pyrazol-3-yl]-phenyl}-3-(aryl)-propenones (2a-h) have been synthesized from 1-[2,4-dihydroxy-5-(aryl acryloyl)phenyl]-aryl propenones(1a-h)by Micheal addition with isoniazide/pyrazinic acid hydrazide under microwave irradiation and classical heating. The synthesized compounds were characterized by IR,1H-NMR,13C-NMR and Mass spectral data. All the compounds were screened for their Antibacterial activity.

Synthesis and antimicrobial activity evaluation of new norfloxacine-azole hybrids

2018 ◽  
Vol 24 (6) ◽  
pp. 317-325 ◽  
Author(s):  
Serpil Demirci ◽  
Neslihan Demirbaş ◽  
Meltem Menteşe ◽  
SerapBaşoğlu Özdemir ◽  
Şengül A. Karaoğlu
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Elemental Analysis ◽  
Antimicrobial Activities ◽  
One Pot ◽  
H Nmr ◽  
Microwave Assisted ◽  
Three Component Reaction ◽  
Amino Derivatives ◽  
C Nmr

Abstract Norfloxacin-azole hybrids 3 and 6a,b were synthesized starting from norfloxacin. The treatment of these compounds with amines as a one-pot three-component reaction produced the corresponding amino derivatives 4a,b, 7a–g and 8a,b in good yields. The conventional and microwave-assisted methods were used with the latter method being more efficient. The structures of the synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR and MS. All compounds were screened for their antimicrobial activities. Most of them exhibit excellent antibacterial activity but are not active against selected fungi.

scholarly journals Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines

Pharmacia ◽  
2021 ◽  
Vol 68 (1) ◽  
pp. 175-179
Author(s):  
Yuliia Matiichuk ◽  
Yuri Gorak ◽  
Roman Martyak ◽  
Taras Chaban ◽  
Volodymyr Ogurtsov ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Nmr Spectroscopy ◽  
High Activity ◽  
Carboxylic Acids ◽  
Elemental Analysis ◽  
Spectroscopic Data ◽  
Antimicrobial Activities ◽  
Diazonium Salts ◽  
H Nmr ◽  
New Compounds

By the reaction of furan-2-carboxylic acids and furfural with diazonium salts 1a-j the arylfuran-2-carboxylic acids 4a-e and 5-arylfuran-2-carbaldehydes 5a-f were synthesized. Acids 4a-e were transformed into appropriated acylchlorides 6a-e and were used for preparation of 4-(5-aryl-2-furoyl)morpholines 7a-e. 4-[(5-Aryl-2-furyl)carbonothioyl]morpholines 8a-f were prepared from aldehydes 5a-f by using Willgerodt-Kindler reaction. The structures of the obtained compounds were confirmed by 1H NMR spectroscopy and elemental analysis. All these new compounds gave spectroscopic data in accordance with the proposed structures. The antimicrobial activities of synthesized compounds 7a-e and 8a-f were investigated and the compounds with high activity against C. neoformans ATCC 208821 were identified.

Synthesis of 2-amino-5,7-dimethyl-4-oxopyrido[3,4-e]-1,3-thiazines

1983 ◽  
Vol 48 (12) ◽  
pp. 3426-3432 ◽  
Author(s):  
Dušan Koščík ◽  
Pavol Kristian ◽  
Ondrej Forgáč
Keyword(s):  
Spectral Data ◽  
Chlorine Atom ◽  
Mass Spectra ◽  
High Reactivity ◽  
Secondary Amines ◽  
Dimroth Rearrangement ◽  
H Nmr ◽  
New Synthesis ◽  
C Nmr

New synthesis of pyrido[3,4-e]-1,3-thiazines consisting in reaction of 2,6-dimethyl-4-chloronicotinoyl isothiocyanate with primary or secondary amines, or with benzaldehyde phenylhydrazone, is described. High reactivity of the chlorine atom does not allow isolation of the corresponding thioureas, arising as intermediates, except in the case of the benzylamino derivative. Structure of the products was unequivocally confirmed by their spectral data (IR, UV, 1H NMR, 13C NMR and mass spectra). The synthesized derivatives do not undergo the Dimroth rearrangement.

21,22-Disubstituted 18α,19βH-Ursane Derivatives with Oxabicyclooctane System in Ring E

1993 ◽  
Vol 58 (1) ◽  
pp. 173-190 ◽  
Author(s):  
Eva Klinotová ◽  
Jiří Klinot ◽  
Václav Křeček ◽  
Miloš Buděšínský ◽  
Bohumil Máca
Keyword(s):  
Spectral Data ◽  
Spin Systems ◽  
Coupling Constants ◽  
Complete Analysis ◽  
Nmr Spectrum ◽  
Proton Proton ◽  
H Nmr ◽  
Proton Coupling ◽  
C Nmr

Reaction of 3β-acetoxy-21,22-dioxo-18α,19βH-ursan-28,20β-olide (IIIa) and 20β,28-epoxy-21,22-dioxo-19α,19βH-ursan-3β-yl acetate (IIIb) with diazomethane afforded derivatives XII-XIV with spiroepoxide group in position 21 or 22, which were further converted into hydroxy derivatives XV and XVII. Ethylene ketals VIII-X were also prepared. In connection with the determination of position and configuration of the functional groups at C(21) and C(22), the 1H and 13C NMR spectral data of the prepared compounds are discussed. Complete analysis of two four-spin systems in the 1H NMR spectrum of bisethylenedioxy derivative Xb led to the proton-proton coupling constants from which the structure with two 1,4-dioxane rings condensed with ring E, and their conformation, was derived.

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