scholarly journals Synthesis, Characterization and Study of the Biological activity of Some Aldimines Derivatives

2006 ◽  
Vol 3 (4) ◽  
pp. 257-261 ◽  
Author(s):  
Mohamed N. Ibrahim ◽  
Hazem K. Al - Deeb
Keyword(s):  
Biological Activity ◽  
Schiff Bases ◽  
Aromatic Aldehyde ◽  
Aromatic Amine ◽  
Elemental Analysis ◽  
Primary Aromatic Amine ◽  
H Nmr

A number of imines derivatives have been synthesized, they were obtained by condensation of aromatic aldehyde derivatives with primary aromatic amine derivatives. Their structures have been characterised by IR,1H NMR in addition to the elemental analysis. The biological activity of these imines (which are also known as Schiff bases) were examined against different type of microorganisms and they found to have considerable activity in comparison with the most commonly used antibiotics.

scholarly journals Studies on Synthesis of Aldimines: Part-I. Synthesis, Characterization and Biological Activity of Aldimines from Benzaldehyde with variedly substituted anilines

2018 ◽  
Author(s):  
C. J. Patil ◽  
Manisha C. Patil ◽  
Mrunmayee C. Patil
Keyword(s):  
Biological Activity ◽  
Aromatic Aldehyde ◽  
Elemental Analysis ◽  
High Purity ◽  
Aromatic Amines ◽  
Condensation Reaction ◽  
Physical Constant ◽  
High Yield ◽  
Substituted Anilines

A conventional condensation reaction of an aromatic aldehyde, Benzaldehyde with seven different aromatic amines viz. Aniline, 2-Choro-aniline, 3-Choro-aniline, 4-Choro-aniline, 2-Nitro-aniline, 3-Nitro-aniline and 4-Nitro-aniline and reacted efficiently to synthesize a series of Aldmines, I to VII, in moderate to high yield and high purity. The reaction was monitored and the products were analyzed by employing the TLC technique. All the products obtained were characterized by their colour, physical constant, TLC, elemental analysis and spectral (UV-Vis and FTIR) method. The synthesized Aldimines were subjected to in vitro biological activity.

scholarly journals PEG Mediated Eco-Friendly One Pot Sunthesis of Benzylamine Coumarin Derivatives Using Multicomponent Reactant

2014 ◽  
Vol 30 ◽  
pp. 177-184
Author(s):  
Denish J. Viradiya ◽  
Vipul C. Kotadiya ◽  
Mita D. Khunt ◽  
Bharat H. Baria ◽  
Umed C. Bhoya
Keyword(s):  
Functional Groups ◽  
Aromatic Aldehyde ◽  
Elemental Analysis ◽  
Room Temperature ◽  
Coumarin Derivatives ◽  
One Pot ◽  
H Nmr ◽  
Wide Range ◽  
Hydroxy Coumarin ◽  
Target Molecules

A green resourceful, eco-friendly and facile protocol was developed for the synthesis of benzylamine coumarin derivatives by the reaction of 4-hydroxy coumarin, secondary amine and aromatic aldehyde in the presence of PEG400 as a solvent as well as catalyst at room temperature. A wide range of functional groups were tolerated in the developed protocol. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis. The target molecules were obtained in good to excellent yield applying this method.

scholarly journals Synthesis of Thiophenyl Thiazole Based Novel Quinoxaline Derivatives

2015 ◽  
Vol 51 ◽  
pp. 115-124
Author(s):  
Haresh G. Kathrotiya ◽  
Yogesh T. Naliapara
Keyword(s):  
Aromatic Amine ◽  
Elemental Analysis ◽  
Condensation Reaction ◽  
High Yield ◽  
Experimental Procedure ◽  
H Nmr ◽  
Quinoxaline Derivatives ◽  
Ft Ir ◽  
C Nmr

A new series of thiophenyl thiazole based novel quinoxaline derivatives 4a-4t have been synthesized by base catalysed condensation reaction. In which 6-substituted 2,3-dichloroquinoxaline 1a and 4-(thiophen-2-yl) thiazol-2-amine 2b reacted in basic condition to afford intermediate 3c which reacts with various aromatic amine to form final compounds. Easy experimental procedure, high yield, and selectivity are the imperative features of this method. The identity of all the compounds has been established by 1H NMR, 13C NMR, FT-IR, and elemental analysis.

scholarly journals Synthesis and Biological Activity of Some Novel 4-(5-Mercapto-1,3,4-thiadiazol-2-yl)-2-phenyl-5-[2-phenylvinyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

2010 ◽  
Vol 7 (2) ◽  
pp. 545-550
Author(s):  
Kumar Sanjeev S. Lamani ◽  
Oblennavar Kortesh
Keyword(s):  
Antibacterial Activity ◽  
Biological Activity ◽  
Antifungal Activity ◽  
Elemental Analysis ◽  
Mass Spectra ◽  
Antimicrobial Properties ◽  
H Nmr ◽  
Efficient Route ◽  
C Nmr

A novel and efficient route have been designed for the synthesis of 4-(5-mercapto-1,3,4-thiadiazol-2-yl)-2-phenyl-5-[2-phenylvinyl]-2,4-dihydro-3H-1,2,4-triazol-3-one. All the synthesized compound were characterized by elemental analysis, IR,1H NMR,13C NMR and mass spectra. All the synthesized products were evaluated for their antibacterial activity againstB. SubtilisandE.Coliand antifungal activity againstA. nigerandC.Albicanrespectively. The results indicate that the present compounds may serve as better fungicides when compared to bactericides. The synthesized compounds have turned to be wonder by possessing antimicrobial properties.

scholarly journals Synthesis, Characterization, and Biological Activity of 5-Phenyl-1,3,4-thiadiazole-2-amine Incorporated Azo Dye Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Chinnagiri T. Keerthi Kumar ◽  
Jathi Keshavayya ◽  
Tantry N. Rajesh ◽  
Sanehalli K. Peethambar ◽  
Angadi R. Shoukat Ali
Keyword(s):  
Biological Activity ◽  
Sulphuric Acid ◽  
Elemental Analysis ◽  
Azo Dye ◽  
Single Step ◽  
H Nmr ◽  
Single Step Reaction ◽  
C Nmr

5-Phenyl-1,3,4-thiadiazole-2-amine has been synthesized by single step reaction. A series of heterocyclic azodyes were synthesized by diazotisation of 5-phenyl-1,3,4-thiadiazole-2-amine by nitrosyl sulphuric acid followed by coupling with different coupling compounds such as 8-hydroxyquinoline, 2,6-diaminopyridine, 2-naphthol, N,N-dimethyl aniline, resorcinol, and 4,6-dihydroxypyrimidine. The dyes were characterized by UV-Vis, IR, 1H-NMR, 13C NMR, and elemental analysis. The synthesized compounds were also screened for biological activity.

scholarly journals Methylbis(2,6-dichIorthiophenoIato)bismut(III) — Synthese, fungizide und bakterizide Aktivität/ Methylbis(2,6-dichlorothiophenolato)bism uth(III) — Synthesis, Fungicidal and Bactericidal Activity

1987 ◽  
Vol 42 (8) ◽  
pp. 940-942 ◽  
Author(s):  
Thomas Klapötke ◽  
Petra Gowik
Keyword(s):  
Biological Activity ◽  
Mass Spectroscopy ◽  
Elemental Analysis ◽  
Bactericidal Activity ◽  
H Nmr

AbstractThe methylbis(thiophenolato)bismuth(III) derivative CH3Bi(SCAH3Cl2-2.6)2 was prepared by reaction of CH3BiBr2 with equivalent amounts of the appropriate lithium thiolate. The new Bi organyl was characterized by elemental analysis, 1H NMR. IR . and mass spectroscopy. The biological activity against bacteria, yeasts, and moulds was investigated.

scholarly journals Synthesis and Antimicrobial Activity of (1-Acetyl/1-Phenyl)-3-{4'-[(4'''-Chlorophenyl) (Phenyl) Methyl Amino] Phenyl}-5-Aryl-Pyrazoline

2015 ◽  
Vol 49 ◽  
pp. 104-108
Author(s):  
J.V. Guna ◽  
V.N. Bhadani ◽  
H.D. Purohit ◽  
Dipak M. Purohit
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Thin Layer ◽  
Elemental Analysis ◽  
Moderate Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Bacteria And Fungi ◽  
Layer Chromatography

1-Acetyl-3-{4'-[(4'''-chlorophenyl) (phenyl) methyl amino] phenyl}-5-aryl-pyrazolines (3a-3l) and 1-Phenyl-3-{4'-[(4'''-chlorophenyl) (phenyl) methyl amino] phenyl}-5-aryl-pyrazolines (4a-4l) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram -ve bacteria and fungi. Some of the compounds showed moderate activity in concentration 50 μg/ml. The structure of the products have been elucidated by IR, 1H-NMR, mass spectral data elemental analysis and Thin layer chromatography.

scholarly journals Synthesis, Characterization and Antibacterial Activity of Schiff Bases and their Metal Complexes Derived from 4-Acyl-1-phenyl-3-methyl-2-pyrazolin-5-ones and 2-Amino-4(4'-methylphenyl)-thiazole

2010 ◽  
Vol 7 (4) ◽  
pp. 1396-1406 ◽  
Author(s):  
A. S. Thakar ◽  
K. K. Singh ◽  
K. T. Joshi ◽  
A. M. Pancholi ◽  
K. S. Pandya
Keyword(s):  
Antibacterial Activity ◽  
Schiff Bases ◽  
Elemental Analysis ◽  
Mass Spectra ◽  
Nmr Spectra ◽  
Electrical Conductance ◽  
H Nmr ◽  
Infrared Spectral ◽  
Ft Ir ◽  
C Nmr

4-Acyl-1-phenyl-3-methyl-2-pyrazolin-5-ones condensed with 2-amino-4(4'-methylphenyl)-thiazole to form Schiff base. These Schiff bases from complexes of type ML22H2O (M=Mn, Fe, Co, Ni and Cu). Elemental analysis, magnetic susceptibility, electrical conductance, electronic and Infrared spectral data suggested octahedral structure for the complexes. All the compounds were tested for their antibacterial activity. The result indicates that the growth of the tested organism was inhibited by most of the compounds. These Schiff bases are characterized by elemental analysis, mass spectra,1H-NMR spectra,13C NMR spectra and FT IR spectra.

scholarly journals Synthesis and Antimicrobial Activity of Some Novel Schiff Bases Containing 1,2,4-Triazole-3-thione

2010 ◽  
Vol 7 (s1) ◽  
pp. S458-S464 ◽  
Author(s):  
M. M. Çalisir ◽  
B. Koçyigit-kaymakçioglu ◽  
B. Özbek ◽  
G. ÖtÜk
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
Schiff Bases ◽  
Elemental Analysis ◽  
Aromatic Aldehydes ◽  
H Nmr ◽  
Chemical Structures

A series of Schiff bases(4a-j)were prepared by reacting 4-amino-5-(1-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione and substituted aromatic aldehydes. The chemical structures were confirmed by means of UV,1H NMR, IR, MS(API-ES) spectral data and elemental analysis. All the synthesized compounds were screened for their antimicrobial activity. Among the tested compounds, Schiff bases with 4-OH and 4-NO2substituent exhibited remarkable antimicrobial activity against all the tested microorganism.

Schiff Bases of Methanesulfonylhydrazine. Synthesis, Spectroscopic Characterization, Conformational Analysis, and Biological Activity

1999 ◽  
Vol 54 (12) ◽  
pp. 1553-1562 ◽  
Author(s):  
Nicolay I. Dodoff ◽  
Ümmühan Özdemir ◽  
Nurcan Karacan ◽  
Milka Ch. Georgieva ◽  
Spiro M. Konstantinov ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Biological Activity ◽  
Conformational Analysis ◽  
Schiff Bases ◽  
Spectroscopic Characterization ◽  
Hydroxyl Group ◽  
Conformational Isomerism ◽  
Cytotoxic Effects ◽  
H Nmr ◽  
Intramolecular Hydrogen

Three novel Schiff bases: salicylaldehyde methanesulfonylhydrazone (1), 2-hydroxyacetophenone methanesulfonylhydrazone (2) and 2-hydroxy-1-naphthaldehyde methanesulfonylhydrazone (3) have been synthesized. Compounds 1-3, as well as acetone methanesulfonylhydrazone (4) have been characterized by TLC, 1H NMR and IR spectra. The spectroscopic results for 1-3 have revealed the presence of an intramolecular hydrogen bond between the hydroxyl group and the imine N atom. The conformational isomerism of 1-4 with respect to the rotations around the SN and NN bonds have been studied by the method of molecular mechanics. Compounds 1-4 and methanesulfonylhydrazine exhibit antibacterial and cytotoxic effects.

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