Uric Acid and High-Density Lipoprotein Cholesterol Are Differently Associated with Alzheimer’s Disease and Vascular Dementia

This study was designed to investigate the ameliorative role of sodium selenite and melatonin on acryl amide induced metabolic syndrome in adult male rats. Twenty (20) adult male rats were randomly and equally divided into 4 groups (G1, G2, G3 and G4) and were treated orally for seven weeks G1, (control group) was given distilled water, G2 were given orally 1mg/kg /B.W of Acryl amide, G3 group received 1mg/kg /B.W of Acryl amide followed by 0.5 mg/Kg/ B.W. of sodium selenite orally. G4 group received 1 mg/kg /B.W of acryl amide (orally) followed by 8 mg/Kg/ B.W. melatonin (IP/ injection). Fasting blood samples were collected by cardiac puncture at (0, 7 weeks) of the experiment for measuring serum total cholesterol, triacylglycerol, high density lipoprotein-cholesterol and serum uric acid, in addition to measuring waist circumference .The results showed an occurrence of central obesity, hyper uricemia, dyslipidemia (hyper cholesterolemia, triacyleglycerolemia and lowered high density lipoprotein-cholesterol concentration) in acryl amide treated animals. The results also indicated the alleviation of the changes in the above- mentioned parameters related to metabolic syndrome by sodium selenite and melatonin through lowering central obesity, total cholesterol, triacylglycerol, elevation of serum high density lipoprotein-cholesterol and lowering in serum uric acid.

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The relationship between uric acid to high-density lipoprotein cholesterol ratio and collateral index in patients with chronic total occlusion

Kardiologiia ◽

10.18087/cardio.2021.9.n1750 ◽

2021 ◽

Vol 61 (9) ◽

pp. 61-65

Author(s):

Cihan Aydın ◽

Nadir Emlek

Keyword(s):

Uric Acid ◽

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Collateral Circulation ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Total Occlusion ◽

Group 2 ◽

Group 1

Background High serum uric acid (UA) levels and low high-density lipoprotein cholesterol (HDL–C) levels are accepted as risk factors for cardiovascular mortality. Hyperuricemia and low HDL–C levels were associated with an increased risk of cardiovascular mortality and the development of diabetes and hypertension. However, the association of UA with cardiovascular (CV) mortality,collateral index are undetermined in patients with chronic total occlusion (CTO).Material and methods 124 patients who underwent coronary angiography with the diagnosis of stable or unstable angina pectoris and had chronic total occlusion were included in our study. Blood samples were collected from all patients before the angiography procedure. Coronary collateral circulation (CCC) was graded according to the Rentrop grading system of 0–3. Rentrop grades of 0 and 1 indicated low-grade CCC group, whereas grades 2 and 3 indicated high-grade CCC group. We divided our patients into two groups as low-grade CCC and high-grade CCC and examined these two groups in terms of uric acid / HDL ratios. Group 1: Rentrop classification grade 0–1 (mean age, 63,9±9,9), Group 2: Rentrop classification grade 2–3 (mean age, 62,1±9,4).Results The baseline characteristics were similar in both groups. Uric acid / High density lipoprotein-cholesterol ratios and uric acid levels were higher in group 1 with poor collateral circulation [group 1; 0,21 (0,07–0,39) vs. group 2; 0,16 (0,08–0,31), group 1; 8,2 (3,4–10,4) vs. group 2; 5,85 (3,5–7,7), p<0,001, p<0,001 respectively].Conclusions We found that high Uric acid / High-density lipoprotein-cholesterol ratios and high uric acid levels are associated with poor collateral circulation.

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