scholarly journals Prescribing pattern of fixed dose combinations of antibiotics in a post-operative surgical ward of tertiary care teaching hospital

2018 ◽  
Vol 7 (12) ◽  
pp. 2332
Author(s):  
Velvizhy R. ◽  
Johan Pandian J.
Keyword(s):  
Antimicrobial Agents ◽  
Generic Drugs ◽  
Demographic Data ◽  
Tertiary Care ◽  
Drug Combinations ◽  
World Health ◽  
Fixed Dose ◽  
Dose Frequency ◽  
Prescribing Pattern ◽  
Care Teaching

Background: Fixed dose drug combinations (FDCs), are combinations of two or more active drugs. It should be used when the combination has an established advantage over single drug in efficacy, safety and compliance. The World Health Organization (WHO) lists only 19 of such combinations. But Indian market is filled with hundreds of FDCs which were not approved leading to irrational use. This study was focused on finding out the fixed dose combination of antimicrobial agents used in the post-operative general surgery ward of a tertiary care teaching hospital.Methods: After getting approval from institutional human ethics committee the prescriptions of patients admitted during April 2013 to March 2014 were analyzed. Demographic data, FDC prescribed by surgeons, Dose, Frequency, Duration, Route, Formulation, Brand or generic drugs, Adverse events due to use of FDC were collected and SPSS version 17 was used for statistical analysis. Fixed dose combinations were used in 90 Patients. The most commonly used FDC were ampicillin with Cloxacillin (43) followed by amoxicillin with clavulanic acid (22), cefoperazone with sulbactam (19) and piperacillin with tazobactam (6). A common drug used in combination along with FDC was metronidazole and aminoglycoside. The irrational combination seen in this study was ampicillin with Cloxacillin (8.88%) of the total FDC which is not approved by DCGI or FDA.Results: In this study out of 145 drugs used, 41drugs were administered three times a day, 90 drugs were given two times a day and 14 drugs were given once a day dosing. 53 patients received FDCs for prophylaxis and 37 patients for treatment purpose. All FDCs were prescribed in brand names. No adverse drug reaction was observed in this study.Conclusions: Consultants should undergo continuing medical education (CME) on newer drug combinations and their adverse drug reactions which will be evidence-based rather than to rely on representatives.

scholarly journals A prospective observational study on prescribing pattern of antimicrobial agents in the post-operative general surgery ward of a tertiary care teaching hospital

2020 ◽  
Vol 9 (10) ◽  
pp. 1513
Author(s):  
Velvizhy R. ◽  
Johan J. Pandian
Keyword(s):  
Observational Study ◽  
General Surgery ◽  
Prospective Observational Study ◽  
Antimicrobial Agents ◽  
Generic Drugs ◽  
Demographic Data ◽  
Tertiary Care ◽  
Essential Medicine ◽  
Fixed Dose ◽  
Care Teaching

Background: This prospective observational study was done to know the current prescription trend of antimicrobial agents in the post-operative ward. To evaluate the current pattern of antimicrobial agents in the post-operative surgical cases of a tertiary care teaching hospital.Methods: The study was carried out in collaboration with the Department of General Surgery and Department of Pharmacology during April 2013 to March 2014. All parameters like demographic data, antimicrobials agents prescribed by surgeons, dose, frequency, duration, route, formulation, brand or generic drugs, adverse events were collected in the specially structured case proforma. Descriptive statistics was applied using SPSS version 17.0.Results: During the study period, 513 patient case records were analysed in which males are higher than females. A total of 816 drugs were used in 484 patients during the study period. 162 were on a single drug, 190 were on two drugs, 42 were on three drugs and 90 were on fixed dose combination. Brand name of the drugs and parenteral route of administration were preferred in the study. Cephalosporins (52.32%) and metronidazole (34.38%) were the most commonly prescribed group of antimicrobials followed by penicillin (0.9%), aminoglycosides (6.58%), quinolones (5.23%), macrolides (0.45%) and tetracycline (0.14%). Totally 135 (27.89%) patients received drugs which are not included in the essential medicine list of WHO and 112 (23.14%) patients received drugs which are not from national EML.Conclusions: The maximum prescribed antimicrobial agent in the post-operative ward was third generation cephalosporins.

scholarly journals A PROSPECTIVE STUDY ON DRUG UTILIZATION IN OBSTETRIC PROCEDURES WITH EMPHASIS ON ANTIBIOTIC USAGE AT A TERTIARY CARE HOSPITAL

2019 ◽  
Vol 8 (5) ◽  
Author(s):  
Shikha Sachdeva ◽  
Aarti Chaudhary ◽  
Parminder Nain ◽  
Unmesh Santpur
Keyword(s):  
Combination Therapy ◽  
Drug Utilization ◽  
Generic Drugs ◽  
Demographic Data ◽  
Tertiary Care ◽  
World Health ◽  
Antibiotic Administration ◽  
Care Hospital ◽  
Prescribing Pattern ◽  
Antibiotic Combination

Background: Antibiotics are largely prescribed drugs in all major surgical procedures due to high prevalence of infections that has been increase in expenditure and increases antibacterial resistance. Drug utilization studies help to identify and overcome the misuse of antibacterial in prescribing pattern. Hence, the aim of this study was to evaluate the antibiotics utilization patterns in obstetric procedures. Methods:  It is a prospective observational study carried out in department of obstetrics and gynecology, of a multi-specialty teaching hospital (Haryana) after obtaining permission from the IEC. The prescriptions were assessed for patient’s demographic data, antimicrobial preference, dose, duration, and route of administration. Categorization of drugs according to Food and Drug Administration (FDA), and rationality score as per the World Health Organization (WHO). Results: During six month study period 120 patients were included into study. The mean age of women undergoing C-section procedure was 27.79±2.78 years. The maximum (90.83%) length of hospital stay was 2 week by women under C-section procedure. The single antibiotic therapy (ceftriaxone - 53.33%) was the most commonly prescribed antibiotic as prophylaxis but in post- operative prescription orders, triple antibiotic combination therapy (ceftriaxone, metronidazole with gentamycin) was maximum (62.50%) prescribed antibiotic. Parenteral route (96.09% in pre-operative and 59.40% in post-operative) was most common route for antibiotic administration. Out of 2216 drugs, branded drugs were 1893 (85.42%) and generic drugs were 323 (14.58%). Conclusion: The present study facilitates the rational use of ceftriaxone as prophylaxis in C-section and triple antibiotic combination therapy as post-operative by the gynaecologists. These antibiotics are most effective without any adverse effect on mother and fetus when use in recommended dose and frequency during obstetric procedures. Keywords: Antibiotics, Caesarean section delivery, Drug utilization study

scholarly journals A PROSPECTIVE STUDY ON ANTIMICROBIAL UTILIZATION PATTERN IN OUTPATIENT DEPARTMENT AT TERTIARY CARE HOSPITAL, PUNE, INDIA.

2018 ◽  
Vol 11 (5) ◽  
pp. 131
Author(s):  
Sarang A Deshmukh ◽  
Yashasvi Agarwal ◽  
Harshita Hiran ◽  
Uma Bhosale
Keyword(s):  
Antimicrobial Agents ◽  
Demographic Data ◽  
Tertiary Care ◽  
Essential Medicine ◽  
Antibiotic Use ◽  
Oral Dosage ◽  
Fixed Dose ◽  
Care Hospital ◽  
Prescribing Practices ◽  
Cross Sectional

 Objective: The objective of the study was to evaluate antimicrobial prescription pattern in outpatient departments.Method: This was a prospective, cross-sectional and observational study over 12 weeks total 400 prescriptions of either gender and age; containing antimicrobial agents (AMAs) were analyzed for demographic data and the WHO prescribing indicators.Results: Most of prescription were given to men (n=262). The most common group of AMA used was Cephalosporins (n=141, 35.25%); of which Ceftriaxone was most commonly prescribed (n=73, 18.25%). 10 AMAs were from the WHO essential medicine list AMAs. Men outnumbered women in prescribing antibiotics (n=262 vs. 138). Most of AMAs receivers were between 26 and 35 years (n=128, 32%). Amoxicillin+Clavulanic acid fixed-dose combination was most common (n=84, 21%). Most of the prescriptions were containing four drugs per prescriptions (n=130, 32.5%). Only 10% of the prescription was given by generic name and rest 90% were given by brand name. Oral dosage form of AMAs was predominant (n=340, 85%). Vitamins and supplement were most common comedication received by patients.Conclusion: Antibiotic use was found to be reasonable and rational in most of the cases. However, still, prescribers should improve prescribing practices and make it more rational.

scholarly journals Study on rationality of different fixed dose drug combinations in tertiary care hospital: an evaluation study

2020 ◽  
Vol 9 (3) ◽  
pp. 422
Author(s):  
Maddala Rajitha ◽  
Altaf Hussain Shaik ◽  
G. B. Simpson ◽  
A. Vishwa Shanthi
Keyword(s):  
Private Hospital ◽  
Tertiary Care ◽  
Evaluation Study ◽  
Drug Combinations ◽  
Fixed Dose ◽  
Care Hospital ◽  
Medical Sciences ◽  
Care Teaching ◽  
Essential Drug List ◽  
A Prospective Study

Background: The fixed dose drug combinations (FDCs) of drugs is defined as product of two or more active ingredients in a defined composition. There is a need to study the pattern of prescription from time to time to evaluate their rationality. In this context we undertook this study to know the prescription pattern of FDC in our setting. To study the rationality of different prescribed FDCs.Methods: This is a prospective study which is carried out in NIMRA Institute of medical sciences which is a tertiary care teaching private hospital. For this study we have collected one thousand prescriptions of patients for 3 months that is from 10th March 2017 to 25th of June 2017 including both in-patients as well as outpatients. Selection criteria of patients mainly basing on their willingness to give prescriptions. Institutional ethical committee permission was taken for the study. The prescribed FDCs were compared with the essential drug list of FDCs approved by Drugs Controller General of India, July 2018.  we have used descriptive statistics to analyze data. The percentage of FDCs used in each class and their contribution to overall FDCs were calculated.Results: In a total of 2952 drugs were prescribed, of this 747 were FDCs and 2205 were non FDCs. In the prescribed FDCs 89.2% drugs were rational and 10.8% drugs were irrational.Conclusions: From this study, we can conclude that 10.8% of irrational prescription of fixed dose drug combinations are prescribed in Nimra Institute of Medical Sciences which is a tertiary care teaching private hospital.

scholarly journals STUDY OF PRESCRIBING PATTERN OF ANTIMICROBIAL AGENTS IN MEDICINE INTENSIVE CARE UNIT OF A TERTIARY CARE HOSPITAL

2020 ◽  
pp. 136-140
Author(s):  
DUDHE BG ◽  
CHAKRAVORTY ASHISH D ◽  
MANKAR NN ◽  
PISE HN
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Antimicrobial Agents ◽  
Tertiary Care Hospital ◽  
Generic Drugs ◽  
Tertiary Care ◽  
Care Hospital ◽  
Prescribing Pattern ◽  
Case Record ◽  
Treatment Data

Objective: The objective of the study was to assess the current use of antimicrobial agents (AMAs) and to assess prescription writing as per the WHO guidelines in the medicine intensive care unit (MICU). Methods: The present study was conducted on admitted patients in MICU of a tertiary care hospital. The demographic and clinical treatment data of patients were collected in specially designed pro forma from the case record form. Results: Of 400 patients enrolled in the study, 55.50% were male and 44.50% were female. A common indication of AMAs use was infection (61.75%), symptomatic (21.50%), and prophylactic (10.50%) use. In 65% patients, antimicrobial therapy was considered to be rational. The majority of patients have good recovery (61%). Polypharmacy was seen in 89.75% of patients. The average number of drugs prescribed per patient was 8.84±2.55. 1.90±1.20 was average number of AMAs per patient. Commonest AMAs prescribed are ceftriaxone (27.64%), metronidazole, and amoxicillin+clavulanic acid. Conclusion: This study visibly highlights the practice of polypharmacy, low uses of generic drugs, high usage of antibiotic, and injection. Cephalosporins are the most prescribed AMAs in the ICUs. Remedy of this situation requires regulation, education, awareness, compliance with protocol, and guidelines of AMAs use.

Psychotropic drug utilization in psychiatric outpatient department of a tertiary care teaching hospital in India

2017 ◽  
Vol 5 (4) ◽  
pp. 1612
Author(s):  
Mohanraj Rathinavelu Mudhaliar ◽  
Ishrar Shaik Mohammad Ghouse ◽  
Priyanka Sadubugga ◽  
Swaroop Reddy Narala ◽  
Vidyasagar Chinnakotla ◽  
...  
Keyword(s):  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Psychiatric Illness ◽  
Tertiary Care ◽  
Real Life ◽  
Psychotropic Medications ◽  
World Health ◽  
Fixed Dose ◽  
Care Hospital ◽  
Prescribing Pattern

Background: Although psychotropic medications have had a remarkable impact on psychiatric practice that legitimately can be called revolutionary, their utilization and consequences on real life effectiveness and safety in actual clinical practice need continuous study.Methods: The current retrospective study of six months’ duration was designed to assess the utilization of antipsychotics and its prescribing pattern in a tertiary care hospital of south India, which included prescriptions of patients suffering from a psychiatric illness with at least one psychotropic drug of all ages and both sexes.Results: Out of 150 cases reviewed, 46% were of schizophrenia, where male (60.67%) at higher incidence of psychiatric illness, and maximum patients were under the age group of 29-39 years (54.67%). In present study of 355 prescribed drugs 72.67% were psychotropic medications. As per World Health Organization/International Network for Rational Use of Drugs (INRUD) drug use indicators average number of drugs per prescription (2.37%), average number of psychotropic drugs per prescription (1.72%), psychotropic drugs prescribed as Fixed Dose Combinations (FDCs) was 26.36%, and percentage of drugs prescribed by generic name (91.08%). In our study, 48.09% of psychotropic drugs were utilized in the treatment of schizophrenia, diazepam (17.06%) was the only psychotropic medication distributed in the management of all three observed psychiatric disorders and the study showed a higher utilization of psychotropic drugs as FDCs (25.98%) in the management of schizophrenia.Conclusions: The study advocated an overall rational utilization of psychotropic drugs with a fewer deviations due to socio-economic status of patients and prescription practices of healthcare providers. 

scholarly journals A prospective observational study of prescription pattern in a tertiary care teaching hospital of Jharkhand

2019 ◽  
Vol 8 (12) ◽  
pp. 2620
Author(s):  
Abha Kumari ◽  
Keshav Kumar ◽  
Manju Gari ◽  
Kumari Pallavi ◽  
Subhankar Choudhury
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Care Delivery ◽  
Tertiary Care ◽  
Health Care Delivery System ◽  
World Health ◽  
Fixed Dose ◽  
Prescribing Pattern ◽  
Prescribing Practice ◽  
Health Organization

Background: Prescription error and irrational prescribing are the avoidable problems imposed on health care delivery system from prescriber side which must be addressed. Periodic prescription audit helps to curtail the error and irrational prescribing.Methods: A prospective observational study was conducted on patients visiting various Outpatient Department of RIMS, Ranchi, Jharkhand on all working days at 11:00 AM to 12:00 PM from 1 August 2018 to 31 July 2019. Various aspects of collected prescriptions were analyzed by using World Health Organization (WHO) prescribing indicators.Results: In this study, out of 700 prescriptions collected, 76 were excluded. Out of total 624 patients analyzed, 382 (61.28%) were male and 242 (38.72%) were female. 48 (7.69%) patients belonged to ≤18, 464 (74.36%) to 19-64 and 112 (17.95%) to ≥65 years of age group. Tablet (71%) was the most common dosage form. None of prescriptions were having registration number of the doctor. 242 (38.78%) prescriptions did not have a diagnosis duly written. The total no. of drugs prescribed in 624 prescriptions was 2176. Only 32 (5.13%) prescriptions were found to have medicines prescribed in block letters. Antibiotics (29%) were the most common class of drugs prescribed. Average number of drugs per prescription was 3.47. Only 48 (2.20%) drugs were prescribed by their generic name while total of injectables prescribed were 102 (4.68%). Total number of drugs from NLEM was 848 (38.97%). 196 (9.00%) drugs were fixed-dose combination.Conclusions: In our study, we found deficiencies in various parts of prescriptions. Prescribing pattern was not in accordance with WHO recommendation for prescribing practice.

scholarly journals Prescribing pattern of antibiotics in ENT outpatient department in a tertiary care teaching hospital

2020 ◽  
Vol 9 (12) ◽  
pp. 1892
Author(s):  
Jyothsnya Srinivasa ◽  
Vijaya Rajendran ◽  
Pratibha Nadig ◽  
Shubhatara Swamy
Keyword(s):  
Antibiotic Resistance ◽  
Teaching Hospital ◽  
Generic Drugs ◽  
Tertiary Care ◽  
Brand Names ◽  
Outpatient Department ◽  
Antibiotic Prescribing ◽  
Prescribing Pattern ◽  
Tertiary Care Teaching Hospital ◽  
Care Teaching

Background: Antibiotics are the most commonly used and misused of all drugs. Patterns of antibiotic resistance widely follows local patterns of antibiotic prescribing and usage. Periodic data collection and analysis of antibiotic prescriptions at regional level are essential to understand and combat antibiotic resistance. Objective of the study was to study the prescribing pattern of antibiotics in outpatient department of Otorhinolaryngology in a tertiary care teaching hospital. Methods: A prospective observational study of prescribing pattern of antibiotics was conducted in the department of Otorhinolaryngology. Data of antibiotic utilization in outpatient department was collected through duplicate copies of the prescriptions. The data obtained was analyzed and the conclusions were drawn using descriptive analysis.Results: A total of 606 prescriptions were collected and analyzed during the study. Average number of antibiotics prescribed per prescription was 1.24 most of the antibiotics were prescribed for a duration of 1 to 5 days. Commonly prescribed antibiotic class was penicillin (48.1%) followed by quinolone (18.3%). Most of the antibiotics were prescribed by their brand names (98.8%).Conclusions: The present study highlights the wide use of extended spectrum antibiotics, along with brand names for prescribing. Interventions for prescribing of generic drugs from the essential drug list needs to be encouraged among physicians.

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