scholarly journals A comparative study of serum calcium, magnesium and LDH as the best predictor for severity of pregnancy induced hypertension in the rural population

2017 ◽  
Vol 6 (10) ◽  
pp. 4652
Author(s):  
Mehul Salve ◽  
Aditi Rajgire
Keyword(s):  
Comparative Study ◽  
Serum Calcium ◽  
Magnesium Deficiency ◽  
Serum Magnesium ◽  
Serum Levels ◽  
Normal Pregnancy ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Calcium And Magnesium ◽  
In Pregnancy

Background: Hypertensive disorders of pregnancy are one of the commonly encountered problem by obstetrician of which, pregnancy induced hypertension leads the list. A number of dietary deficiencies or excesses have been blamed as the cause for preeclampsia over centuries. Studies have shown relationship between dietary deficiencies and incidence of preeclampsia. The lowering of serum calcium and the increase of intracellular calcium can cause an elevation of blood pressure in preeclamptic mothers. Recent investigations suggest that magnesium deficiency could play an important role in the pathogenesis of preeclampsia, particularly in regulating the tonus of arterioles and veins. The relationship of serum leptin and lactate dehydrogenase levels were increased in preeclampsia.Methods: A comparative study to evaluate the levels of serum calcium and serum magnesium and LDH in pregnancy induced hypertension and normal pregnancy and to correlate the serum levels of calcium and magnesium and LDH with the pregnancy induced hypertension.Results: The serum calcium and magnesium has significantly decreased in cases as compared to controls. Whereas the levels of LDH was significantly increased in cases compared to controls. Serum calcium decreased in severe PIH cases compared to mild PIH cases but statistically not significant. Serum magnesium in mild PIH is less compared to severe PIH cases. The decrease is not statistically significant. The increase in LDH in mild case is less compared to severe PIH case. The increase is stastically significant.Conclusion: Routine biochemical evaluation of serum concentration of calcium and magnesium early in pregnancy may be helpful in identifying at risk patients for preeclampsia. Hypocalcemia and Hypomagnesemia in patients with pregnancy induced hypertension may have a cause and effect relationship with the disorder. Amongst the biochemical markers studied LDH level was seen as the best predictor of severity of pregnancy induced hypertension.

scholarly journals Comparative analysis of serum calcium and magnesium as a better predictor in cases of mild and severe pre-eclampsia.

2020 ◽  
Vol 27 (08) ◽  
pp. 1722-1727
Author(s):  
Farheen Aslam ◽  
Irum Hayat ◽  
Faizan Ahmad Zakir ◽  
S. Sabahat Haider ◽  
Shams Un Nisa ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Serum Magnesium ◽  
Serum Levels ◽  
Mean Value ◽  
Control Group ◽  
Mortality And Morbidity ◽  
Nulliparous Women ◽  
Gynecology And Obstetrics ◽  
Research Population ◽  
Calcium And Magnesium

Objectives: The hypertensive disorders of pregnancy (HDP), especially severe preeclampsia are most common cause of neonatal and maternal mortality and morbidity. Alteration in metabolism of calcium and magnesium during pregnancy is considered to be one of etiological factor for pre-elampsia. Study Design: Case-control study. Settings: Departments of Pathology and Gynecology and Obstetrics, Bahawal Victoria Hospital. Period: September 2018 to June 2019. Material & Methods: To compare whether serum levels of calcium or magnesium showed significant change in mild and severe preeclamptic patients as compared to control group. Research population consisted of pregnant females that were divided into three groups. The mild and severe preeclamptic groups comprised of 55 and 26 participants respectively and 45 were included in control group. The serum calcium and magnesium levels were measured in these groups. Results: Maximum numbers of preeclamptic cases were presented at 28-32 week of gestation while severe pre-eclamptic group showed most cases in 33-36 weeks. In both groups, most of cases occurred in multiparous women as compared to nulliparous women. The normotensive group showed serum calcium and magnesium levels of 9.08±0.63 and2.12±0.22mg/dl while mild preeclamptic (mPE) had mean value of 7.91±0.64 and 1.58±0.42mg/dl and measurement were 7.67±0.48 and 1.26±0.44 in cases of severe pre eclampsia (sPE). Serum magnesium levels were significantly lower in sPE as compared to mPE (<0.0001) while difference was not statistically significant for serum calcium level (0.14). Conclusion: Both decrease level of serum calcium and magnesium might be risk factor in development of preeclampsia with more emphasis on role of low magnesium as a prognostic marker in severe preeclamptic cases.

scholarly journals Hypo-magnesium and Hyperlipidemia Responsible for Hypertensive Status of Pregnant Women in Pakistani Population

2020 ◽  
pp. 61-66
Author(s):  
Asia Parveen ◽  
Khan Farooq ◽  
Fatima Arshad ◽  
Modasrah Mazhar ◽  
Nureen Zahra ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Serum Magnesium ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Case Group ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Group A

Background/ Aim: Pregnancy induced hypertension (PIH) has been a leading cause of maternal mortality worldwide. It could be responsible for several complications like hemodilution, altered lipid metabolism and deficiencies of different minerals in body. Although the causes of Pregnancy induced hypertension (PIH) remains indistinct. The aim of our present study was to evaluate the changes in magnesium serum levels and lipid profile in hypertensive and normotensive pregnant women. Materials and Methods: An analytical case control study comprising 60 individuals was designed. From which 30 normotensive pregnant women served as control group (A) and 30 pregnancy induced hypertensive women served as case group (B). Patients with pre-existing hypertension were excluded. Results: The independent t-test was used for comparison of various parameters between group A and B. Triacylglycerol (TAG) and low density lipoprotein cholesterol (LDL-C) levels were significantly high in PIH (B) as compare to normotensive group (A). Mean serum values of TG were measured as (195.73 ± 70.28 vs 156.27 ± 55.60 mg dL-1) and LDL-C vs control (87.33 ± 37.74 vs 69.45 ± 28.58 mg dL-1) in PIH and normotensive groups respectively. HDL-C in PIH vs Control (47.40±1.12 vs 54.43 ±1.27 mg dL-1) and Mg+2 PIH vs control (1.36±0.07 vs 1.94±0.35 mg dL-1) were measured respectively. High density lipoprotein cholesterol (HDL-C) and magnesium Mg+2 levels were significantly reduced in PIH. Conclusion: The lower serum magnesium levels and abnormal lipids profile may indicate their possible role as risk factors in the development of PIH in pregnant women. Hence initial diagnosis of hypomagnesemia in PIH cases may help in minimizing the complications and development of new cure strategies.

Soluble Fas and Fas Ligand in Pregnancy

Angiology ◽  
2011 ◽  
Vol 63 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Velore J. Karthikeyan ◽  
Gregory Y. H. Lip ◽  
Sabah Baghdadi ◽  
Deirdre A. Lane ◽  
D. Gareth Beevers ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Fas Ligand ◽  
Normal Pregnancy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pregnancy Induced Hypertension ◽  
Control Groups ◽  
Pregnancy Hypertension ◽  
Soluble Fas ◽  
Induced Hypertension ◽  
In Pregnancy

The pathophysiology of pregnancy-induced hypertension and preeclampsia may involve abnormalities in placentation and the Fas/Fas ligand system. Hypothesizing abnormal plasma Fas and Fas ligand in pregnancy-induced hypertension, we recruited 20 hypertensive pregnant women at mean week 15 and 29 at week 30: 18 were studied at both time points. Control groups were 20 normotensive pregnant women at week 20, 29 women at week 27, and 50 nonpregnant women. sFas and sFas ligand (sFasL) were measured by enzyme-linked immunosorbent assay (ELISA). The hypertensive women had lower sFasL at both stages of their pregnancy ( P < .05). There were no differences in sFas. In 18 hypertensive pregnant women, sFasL fell from week 15 to week 29 ( P < .03). We conclude that sFas and sFasL is unchanged in normal pregnancy. Hypertension in pregnancy is characterized by low sFasL, and levels fall from weeks 15 to 29. This may reflect differences in placentation in the differing physiological and pathological states.

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