scholarly journals Changing trends of causative factors in antenatal mothers with bad obstetric history: a retrospective study

2021 ◽  
Vol 10 (9) ◽  
pp. 3371
Author(s):  
Anu Bhargavi W. B. ◽  
Sailatha R. ◽  
Anuradha C. R.
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Medical Complications ◽  
Changing Trends ◽  
Obstetric History ◽  
Time Period ◽  
Causative Factors ◽  
Underlying Causes ◽  
Work Up ◽  
Male Factors

Background: The death of an infant, in utero or after birth has been a devastating experience for parents and clinicians alike. Various efforts are being made to make an accurate diagnosis of such pregnancy losses at the earliest to prevent the emotional and physical stress that the woman undergoes. This study aims to assess the changing trends in risk factors and outcome of pregnancies in cases of bad obstetric history (BOH) and to identify the newly emerging maternal and fetal factors contributing to incidence of pregnancy loss.Methods: This study is a retrospective analysis of antenatal women with BOH attending the obstetrics and gynecology OPD at Chettinad hospital. The study was conducted during a time period of 1 year (May 2019 to May 2020).Results: The medical complications and underlying causes for BOH were analysed among the study group. Out of 41 women, 6 were diagnosed to have gestational diabetes mellitus (GDM), 8 were found to be hypertensive and 1 APLA positive. Neonatal mortality was encountered in 2 cases, attributing to Inborn error of metabolism. However, the cause for BOH remained unexplained in 3 individuals.Conclusions: A full work-up can be initiated after two consecutive losses to identify and treat the various causes responsible for BOH. Lot of further studies and research are being conducted to unravel the mystery in these cases. Despite these efforts, the male factors contributing to recurrent pregnancy loss have remained largely unexplored.

scholarly journals Study of bad obstetric history cases attending tertiary care centre, Tirupati

2021 ◽  
Vol 8 (4) ◽  
pp. 535-540
Author(s):  
Gowthami B ◽  
Sowjanya Kumari J ◽  
Lakshmi Narayanamma V
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Tertiary Care ◽  
Mode Of Delivery ◽  
Control Group ◽  
Chronic Hypertension ◽  
Age Group ◽  
Obstetric History

To assess the obstetric and medical risk factors in patients with bad obstetric history (BOH) and outcome of pregnancy in case of BOH. A prospective cross-sectional study was conducted in Government maternity hospital, Tirupati for a period of 1 year from December 2017 to November 2018. All pregnant women who were fulfilling inclusion criteria of BOH, as study group and all possible variable were compared with control group, who got selected randomly from the rest of deliveries. And analysed the results in terms of sociodemographic factors, risk factors, pregnancy complications, mode of delivery, maternal and foetal outcome. Of 102 pregnant women in BOH, 76.5% were in age group between 21-30yrs, and 14.7% in age group >30yrs. Primary Recurrent pregnancy loss (RPL) was 51% and that of secondary recurrent pregnancy loss was 49%.History of hypertensive disorders including preeclampsia, eclampsia and chronic hypertension, noted in 11.8% cases, which was higher than previous studies, indicating changing trends in incidence.In foetal complications IUGR (0% vs 9.8%, p=0.026) and IUFD (0% Vs 7.8%, p=0.05) were more in BOH group and statistically significant also. Even though the maternal complications were more in BOH group, there was no statistical significance (P=0.075).Among the various causes of RPL found in the present study, endocrine causes were seen in 12.7%, Anatomical causes were found in 11.8% and in about 63.7% cases no definite cause was found and aetiology was unexplained. Present study, supporting the change in definition of recurrent pregnancy loss from 3 consecutive losses to 2. So early evaluation and with appropriate interventions in most of couples outcomes were fruitful.

Recurrent pregnancy loss

2019 ◽  
Vol 13 (7) ◽  
pp. 402-408
Author(s):  
Priyanka Krishnaswamy ◽  
Rohit Arora
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Recurrent Miscarriage ◽  
Second Trimester ◽  
Successful Pregnancy ◽  
Inherited Thrombophilia ◽  
Epidemiological Factors ◽  
Factors Influencing ◽  
Recurrent Pregnancy Losses ◽  
Male Factors

Miscarriage is defined as the spontaneous loss of a pregnancy before the fetus reaches viability; it includes all pregnancy losses from the time of conception until 24 weeks of gestation. Early miscarriages are common, occurring in 10–20% of all pregnancies, with 2% of second-trimester pregnancies being miscarried before 24 weeks of gestation. Recurrent miscarriage, defined as the loss of three or more consecutive pregnancies, affects 1% of couples trying to conceive with the chance of having two consecutive miscarriages being 5%. Clinical studies show that 3 in 4 women will have a successful pregnancy with supportive care alone. Therefore, couples should be given reassurance about their chances of a successful pregnancy in the future. In this review we look at the epidemiological factors influencing rates of miscarriage, acquired and inherited thrombophilia, genetic, anatomical, endocrine, immune, infective and male factors for recurrent miscarriage. Despite these potential causes, the majority (around 50%) of recurrent pregnancy losses remain unexplained.

scholarly journals Smith–Lemli–Opitz's Syndrome as a Possible Cause of Recurrent Pregnancy Loss: A Case Report

2020 ◽  
Vol 10 (01) ◽  
pp. e118-e120 ◽  
Author(s):  
Anjali Mitra ◽  
Shelley Dolitsky ◽  
Stacy Yadava ◽  
Elena Ashkinadze
Keyword(s):  
Pregnancy Loss ◽  
Dna Analysis ◽  
Recurrent Pregnancy Loss ◽  
First Trimester ◽  
Carrier Screening ◽  
The Third ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy ◽  
Work Up ◽  
Possible Cause

AbstractBased on the known carrier frequency of Smith–Lemli–Opitz's syndrome (SLOS), the prevalence of this disease should be significantly higher than what is observed in the population. This may be due to a higher rate of pregnancy loss in affected embryos. Here, we present the case of a couple who underwent expanded carrier screening (ECS) after experiencing three first trimester pregnancy losses. Both parents were found to be carriers of SLOS mutations, and DNA analysis of the fetal remains of the third loss revealed the aborted fetus had inherited both the maternal and paternal mutations. This suggests SLOS as a reason for this patient's recurrent pregnancy loss (RPL), and therefore, ECS should be considered as part of the RPL work-up.

scholarly journals Antiphospholipid Syndrome as a Cause of Recurrent Pregnancy Loss: 3 Case Reports and Successful Outcome

2016 ◽  
Vol 29 (2) ◽  
pp. 106-110
Author(s):  
Naima Sharmin Hoque ◽  
Maliha Rashid ◽  
Shafeya Khanam ◽  
Bedoura Sharmin ◽  
Kazi Tawfiq Al Hasan ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Uterine Fibroid ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Case Reports ◽  
Successful Outcome ◽  
Chronic Hypertension ◽  
Healthy Baby ◽  
Causative Factors ◽  
Anti Phospholipid Syndrome

Recurrent pregnancy loss is common problem now a days and is commonly found in our daily practice.There are so many causes that are established as causative factors for recurrent pregnancy loss. Among them systemic causes includes uncontrolled diebetes mellitus, uncontrolled chronic hypertension, hypothyroidism and local causes includes uterine polyp, uterine fibroid, cervical incompetency etc. Anti-phospholipid syndrome has recently been found to be one of the causes for recurrent pregnancy loss and we have not yet enough study in our country regarding this problem that causes recurrent pregnancy loss. Pregnancy with Anti-phospholipid Syndrome (APS) is rare and it is one of the important factor that causes recurrent pregnancy loss at any trimester of pregnancy. Early diagnosis and pre-conceptional precaution for prevention of recurrent pregnancy loss is essential to deliver a healthy fetus in a diagnosed case of APS. Three cases of anti-phospholipid syndrome (APS) are reported here who have successfully deliverd healthy baby. All the cases were presented with the complaints of recurrent pregnancy loss.Bangladesh J Obstet Gynaecol, 2014; Vol. 29(2) : 106-110

Male Factors in Recurrent Pregnancy Loss

2016 ◽  
pp. 109-129
Author(s):  
Luna Samanta ◽  
Gayatri Mohanty ◽  
Ashok Agarwal
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Male Factors

scholarly journals Recurrent Pregnancy Loss: A Tragic Reproductive Failure

1970 ◽  
Vol 2 (2) ◽  
pp. 29-35
Author(s):  
Mst Rashida Begum ◽  
Mariya Ehsan ◽  
Mst Sahina Begum ◽  
Hosne Ara Baby ◽  
Maruf Siddiqui ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Genetic Diagnosis ◽  
Life Style Changes ◽  
Consecutive Pregnancy ◽  
Genetic Problem ◽  
Immunological Factors ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Three or more consecutive pregnancy losses are considered as recurrent pregnancy loss (RPL). About 1% of all pregnant women face this distressing problem and o.5% to 5% of spontaneous abortions are recurrent. Genetic, environmental, anatomic, hormonal, infectious and immunological factors are associated with RPL. Sometimes several factors might simultaneously be responsible for RPL. So diagnostic work up is to be extended. Life style changes, hormonal supplementation, anticoagulant and immunotherapy and surgical correction of certain uterine anatomic defects might help the couple to be parent. Genetic problem can be overcome by pre-implantation genetic diagnosis (PGD) and transferring good healthy embryos. Key Words: Recurrent Pregnancy Loss (RPL); Pre Implantation Genetic Diagnosis (PGD) DOI: http://dx.doi.org/10.3329/akmmcj.v2i2.8170 AKMMC J 2011; 2(2): 29-35

Thyroid peroxidase antibodies do not predict outcome in 900 women with recurrent pregnancy loss

2017 ◽  
Author(s):  
Sofie Bliddal ◽  
Nielsen Henriette Svarre ◽  
Aase Krogh-Rasmussen ◽  
Kolte Astrid Marie ◽  
Christiansen Ole Bjarne ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Thyroid Peroxidase ◽  
Thyroid Peroxidase Antibodies
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