scholarly journals Antiphospholipid Syndrome as a Cause of Recurrent Pregnancy Loss: 3 Case Reports and Successful Outcome

2016 ◽  
Vol 29 (2) ◽  
pp. 106-110
Author(s):  
Naima Sharmin Hoque ◽  
Maliha Rashid ◽  
Shafeya Khanam ◽  
Bedoura Sharmin ◽  
Kazi Tawfiq Al Hasan ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Uterine Fibroid ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Case Reports ◽  
Successful Outcome ◽  
Chronic Hypertension ◽  
Healthy Baby ◽  
Causative Factors ◽  
Anti Phospholipid Syndrome

Recurrent pregnancy loss is common problem now a days and is commonly found in our daily practice.There are so many causes that are established as causative factors for recurrent pregnancy loss. Among them systemic causes includes uncontrolled diebetes mellitus, uncontrolled chronic hypertension, hypothyroidism and local causes includes uterine polyp, uterine fibroid, cervical incompetency etc. Anti-phospholipid syndrome has recently been found to be one of the causes for recurrent pregnancy loss and we have not yet enough study in our country regarding this problem that causes recurrent pregnancy loss. Pregnancy with Anti-phospholipid Syndrome (APS) is rare and it is one of the important factor that causes recurrent pregnancy loss at any trimester of pregnancy. Early diagnosis and pre-conceptional precaution for prevention of recurrent pregnancy loss is essential to deliver a healthy fetus in a diagnosed case of APS. Three cases of anti-phospholipid syndrome (APS) are reported here who have successfully deliverd healthy baby. All the cases were presented with the complaints of recurrent pregnancy loss.Bangladesh J Obstet Gynaecol, 2014; Vol. 29(2) : 106-110

scholarly journals Changing trends of causative factors in antenatal mothers with bad obstetric history: a retrospective study

2021 ◽  
Vol 10 (9) ◽  
pp. 3371
Author(s):  
Anu Bhargavi W. B. ◽  
Sailatha R. ◽  
Anuradha C. R.
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Medical Complications ◽  
Changing Trends ◽  
Obstetric History ◽  
Time Period ◽  
Causative Factors ◽  
Underlying Causes ◽  
Work Up ◽  
Male Factors

Background: The death of an infant, in utero or after birth has been a devastating experience for parents and clinicians alike. Various efforts are being made to make an accurate diagnosis of such pregnancy losses at the earliest to prevent the emotional and physical stress that the woman undergoes. This study aims to assess the changing trends in risk factors and outcome of pregnancies in cases of bad obstetric history (BOH) and to identify the newly emerging maternal and fetal factors contributing to incidence of pregnancy loss.Methods: This study is a retrospective analysis of antenatal women with BOH attending the obstetrics and gynecology OPD at Chettinad hospital. The study was conducted during a time period of 1 year (May 2019 to May 2020).Results: The medical complications and underlying causes for BOH were analysed among the study group. Out of 41 women, 6 were diagnosed to have gestational diabetes mellitus (GDM), 8 were found to be hypertensive and 1 APLA positive. Neonatal mortality was encountered in 2 cases, attributing to Inborn error of metabolism. However, the cause for BOH remained unexplained in 3 individuals.Conclusions: A full work-up can be initiated after two consecutive losses to identify and treat the various causes responsible for BOH. Lot of further studies and research are being conducted to unravel the mystery in these cases. Despite these efforts, the male factors contributing to recurrent pregnancy loss have remained largely unexplored.

scholarly journals Study of bad obstetric history cases attending tertiary care centre, Tirupati

2021 ◽  
Vol 8 (4) ◽  
pp. 535-540
Author(s):  
Gowthami B ◽  
Sowjanya Kumari J ◽  
Lakshmi Narayanamma V
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Tertiary Care ◽  
Mode Of Delivery ◽  
Control Group ◽  
Chronic Hypertension ◽  
Age Group ◽  
Obstetric History

To assess the obstetric and medical risk factors in patients with bad obstetric history (BOH) and outcome of pregnancy in case of BOH. A prospective cross-sectional study was conducted in Government maternity hospital, Tirupati for a period of 1 year from December 2017 to November 2018. All pregnant women who were fulfilling inclusion criteria of BOH, as study group and all possible variable were compared with control group, who got selected randomly from the rest of deliveries. And analysed the results in terms of sociodemographic factors, risk factors, pregnancy complications, mode of delivery, maternal and foetal outcome. Of 102 pregnant women in BOH, 76.5% were in age group between 21-30yrs, and 14.7% in age group >30yrs. Primary Recurrent pregnancy loss (RPL) was 51% and that of secondary recurrent pregnancy loss was 49%.History of hypertensive disorders including preeclampsia, eclampsia and chronic hypertension, noted in 11.8% cases, which was higher than previous studies, indicating changing trends in incidence.In foetal complications IUGR (0% vs 9.8%, p=0.026) and IUFD (0% Vs 7.8%, p=0.05) were more in BOH group and statistically significant also. Even though the maternal complications were more in BOH group, there was no statistical significance (P=0.075).Among the various causes of RPL found in the present study, endocrine causes were seen in 12.7%, Anatomical causes were found in 11.8% and in about 63.7% cases no definite cause was found and aetiology was unexplained. Present study, supporting the change in definition of recurrent pregnancy loss from 3 consecutive losses to 2. So early evaluation and with appropriate interventions in most of couples outcomes were fruitful.

Consultative Hematology: The Pregnant Patient Pregnancy Loss

Hematology ◽  
2010 ◽  
Vol 2010 (1) ◽  
pp. 166-172 ◽  
Author(s):  
Shannon M. Bates
Keyword(s):  
Antithrombotic Therapy ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Pregnant Patient ◽  
Quality Data ◽  
Successful Outcome ◽  
Pregnancy Failure ◽  
Increased Risk ◽  
History Of ◽  
Good Quality Data

Abstract The presence of antiphospholipid antibodies has been associated with an increased risk of recurrent pregnancy loss, and there is evidence to suggest that antithrombotic therapy improves the likelihood of a successful outcome in affected women. Recent studies suggest an association between hereditary thrombophilia and pregnancy loss, although a causal role remains controversial. Although the available data are limited and flawed, there is increasing use of antithrombotic therapy in thrombophilic women with a history of pregnancy failure. Given the absence of proven effective therapy in women with unexplained recurrent loss, there is also growing pressure to intervene with antithrombotics in women with no known underlying thrombophilia. This article reviews the evidence for an association between thrombophilia and recurrent pregnancy loss and the data regarding the use of antithrombotic therapy for prevention of loss—an area that remains particularly challenging because of the paucity of good quality data upon which to base clinical decisions.

scholarly journals Successful outcome of pregnancy in bicornuate uterus: a case report

2019 ◽  
Vol 8 (10) ◽  
pp. 4086
Author(s):  
Suman Choudhary ◽  
Prasuna Jelly ◽  
Prakash Mahala
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Transvaginal Ultrasound ◽  
Successful Outcome ◽  
Missed Abortion ◽  
Septate Uterus ◽  
Bicornuate Uterus ◽  
Unicornuate Uterus ◽  
Uterine Growth ◽  
History Of

Bicornuate uterus is a major cause of spontaneous abortion. The recurrent pregnancy loss has been reported to the range of 15% to 27%. There is different type of congenital uterine abnormalities like Bicornuate uterus, septate uterus, arcuate uterus, unicornuate uterus, didelphys uterus. It is important to consider this diagnosis in recurrent miscarriages, malpresentation, intra uterine growth restrictionand preterm deliveries. This report is about self at the age of 25-year-old pregnancy with a history of missed abortion. I was not diagnosing with a bicornuate uterus in my first pregnancy. However, I was diagnosed with a bicornuate uterus based on transvaginal ultrasound and hysterosalpingogram. A successful caesarean section was donein the 38th week of gestation. According to the results, successful outcome could be achieved with bicornuate uterus. The outcome of bicornuate uterus was successful.

scholarly journals Enoxaparin Effect on Pregnancy Outcomes in a Patient with Elevated Plasminogen Activator Inhibitor-1

2020 ◽  
Vol 2020 ◽  
pp. 1-3 ◽  
Author(s):  
Kathleen Minor ◽  
Heidi Leftwich
Keyword(s):  
Plasminogen Activator ◽  
Pregnancy Outcomes ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Plasminogen Activator Inhibitor ◽  
Chronic Hypertension ◽  
Plasminogen Activator Inhibitor 1 ◽  
Adverse Pregnancy ◽  
Activator Inhibitor ◽  
Pai 1

Background. Plasminogen activator inhibitor-1 (PAI-1) inhibits tPA and creates a prothrombotic state. Gene polymorphisms of PAI-1 are associated with elevated levels and adverse pregnancy outcomes. Case. A 36-year-old gravida 6, para 1-1-3-1 with elevated prepregnancy PAI-1 levels, a history of early-onset preeclampsia with severe features superimposed on chronic hypertension, intrauterine growth restriction (IUGR), and recurrent pregnancy loss (RPL), presented with a dichorionic-diamniotic twin gestation. She was managed with aspirin and enoxaparin and delivered appropriately grown twins at 36 weeks and 3 days, due to the development of preeclampsia superimposed on chronic hypertension. She was discharged not on enoxaparin and represented with pulmonary edema on postoperative day 8. Conclusion. It is reasonable to consider testing certain patients with recurrent pregnancy loss and/or early preeclampsia with severe features for PAI-1. If levels are elevated, treatment with prophylactic enoxaparin may be beneficial. Further research is needed to determine the effect of this therapy in patients with exceedingly poor perinatal outcomes to better assess for any impact on improved outcomes.

scholarly journals Term Pregnancy following Myomectomy for Leiomyomatosis

2014 ◽  
Vol 5 (3) ◽  
pp. 107-109
Author(s):  
Suganya Achar ◽  
Arulmozhi Ramarajan
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Endometrial Thickness ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Fertility Treatment ◽  
Term Pregnancy ◽  
Healthy Baby ◽  
Size Number ◽  
One Year

ABSTRACT Uterine fibroids are common during reproductive age. These are found in up to 77% of women. They may be asymptomatic or may present with pain, menorrhagia, infertility or recurrent pregnancy loss. Symptomatic fibroids often mandate surgical management. These situations pose a challenge when encountered in women undergoing fertility treatment. Achieving a pregnancy following myomectomy depends on the size, number and proximity to the endometrium of the fibroids. Here is the case of a 28-year-old lady, with multiple fibroids, who presented with severe dysmenorrhea and menorrhagia for many years and inability to conceive in 3 years after marriage. She underwent extensive myomectomy. The entire endometrial surface was studded with seedling fibroids, which were scooped out along with much of the endometrium. A diagnosis of uterine leiomyomatosis was made. Three months after surgery, an ultrasound scan of the pelvis showed a bulky uterus of normal contour, endometrial thickness of 7 mm, and multiple tiny fibroids. One year later, she presented with a viable pregnancy of 7 to 8 weeks. She delivered a healthy baby at term. How to cite this article Achar S, Ramarajan A. Term Pregnancy following Myomectomy for Leiomyomatosis. Int J Infertil Fetal Med 2014;5(3):107-109.

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