scholarly journals Comparative study of electroencephalography changes in dementia

2019 ◽  
Vol 7 (8) ◽  
pp. 2970
Author(s):  
Atar Singh ◽  
Abhay Paliwal ◽  
V. S. Pal
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Potential Effect ◽  
Theta Waves ◽  
Eyes Closed ◽  
Dementia Patients ◽  
Health And Social Care ◽  
Intermittent Photic Stimulation ◽  
Severity Of Dementia

Background: Dementia affected about 46 million people in 2015and this number will roughly triple within the next 40 years. In 2011 Alzheimer's Disease International argue that dementia has become one of the most urgent health and social care challenges of the 21st century and its potential effect on economies around the world is attracting global attention. Predicting dementia in the early stages would be essential for better treatment before significant brain damage occurs. Current difficulty is the lack of specific biomarkers. In some previous studies electroencephalography (EEG) have shown the capability to identify dementia early and even classify the degree of its severity at a lower cost for mass screening. The aim and objective of this study was to EEG changes in vascular dementia and Alzheimer's Disease Related Dementias (ADRD) or dementia where no cause is identifiable, to measure severity of dementia by using DSR scale in different subjects and to correlate DSRS with EEG findings.Methods: Study sample was the 40 patients in each three groups- Dementia patients without any known cause of dementia or Alzheimer's Disease Related Dementias (ADRD), Vascular dementia (VaD) patients and Controls (age and sex matched subjects scoring more than the cut of score on dementia Scale). Written informed consent will be taken after explaining the objectives and procedure of study in detail. EEG were recorded in eyes closed, on intermittent photic stimulation and hyperventilation, only eyes closed data was used in study and these data were entered in excel sheet and analyzed using SPSS Software, appropriate statistical test was applied wherever necessary.Results: Participants with VaD have theta waves while ADRD group have delta waves preponderance as compare to control.Conclusions: EEG can have additive value in diagnosing VaD as well as it alone can be helpful in differentiating healthy individuals from dementia patients.

scholarly journals Classifying Non-Dementia and Alzheimer’s Disease/Vascular Dementia Patients Using Kinematic, Time-Based, and Visuospatial Parameters: The Digital Clock Drawing Test

2021 ◽  
Vol 82 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Anis Davoudi ◽  
Catherine Dion ◽  
Shawna Amini ◽  
Patrick J. Tighe ◽  
Catherine C. Price ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Area Under The Curve ◽  
Clock Drawing Test ◽  
Digital Clock ◽  
Clock Drawing ◽  
Drawing Test ◽  
Dementia Patients ◽  
Optimal Area

Background: Advantages of digital clock drawing metrics for dementia subtype classification needs examination. Objective: To assess how well kinematic, time-based, and visuospatial features extracted from the digital Clock Drawing Test (dCDT) can classify a combined group of Alzheimer’s disease/Vascular Dementia patients versus healthy controls (HC), and classify dementia patients with Alzheimer’s disease (AD) versus vascular dementia (VaD). Methods: Healthy, community-dwelling control participants (n = 175), patients diagnosed clinically with Alzheimer’s disease (n = 29), and vascular dementia (n = 27) completed the dCDT to command and copy clock drawing conditions. Thirty-seven dCDT command and 37 copy dCDT features were extracted and used with Random Forest classification models. Results: When HC participants were compared to participants with dementia, optimal area under the curve was achieved using models that combined both command and copy dCDT features (AUC = 91.52%). Similarly, when AD versus VaD participants were compared, optimal area under the curve was, achieved with models that combined both command and copy features (AUC = 76.94%). Subsequent follow-up analyses of a corpus of 10 variables of interest determined using a Gini Index found that groups could be dissociated based on kinematic, time-based, and visuospatial features. Conclusion: The dCDT is able to operationally define graphomotor output that cannot be measured using traditional paper and pencil test administration in older health controls and participants with dementia. These data suggest that kinematic, time-based, and visuospatial behavior obtained using the dCDT may provide additional neurocognitive biomarkers that may be able to identify and tract dementia syndromes.

Neuropsychological Performance in Both Alzheimer’s Disease and Vascular Dementia is Related to Cardiovascular Comorbidity

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
N. Hofrichter ◽  
S. Dick ◽  
E. Tritschler ◽  
A. Knobel ◽  
A. Heinz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Vascular Dementia ◽  
Neuropsychological Testing ◽  
Vascular Pathology ◽  
Neuropsychological Performance ◽  
Neuropsychological Battery ◽  
Cardiovascular Comorbidity ◽  
Dementia Patients

Aims:Vascular pathology has been implicated in the pathogenesis of both Alzheimer's disease and vascular dementia. While performance decrements in vascular dementia are by definition thought to be related to vascular load, performance decrements in Alzheimer's disease have not yet been studied in relationship to cardiovascular comorbidity. The aim of this study was to describe neuropsychological performance in patients with mild Alzheimer's disease and vascular dementia in relationship to cardiovascular comorbidity.Method:39 patients suffering form vascular dementia and 34 patients suffering form Alzheimer's disease underwent neuropsychological testing using an extended neuropsychological battery, including tests of episodic memory, working memory, naming, verbal fluency, executive functions, and language. Cardiovascular comorbidity was assessed form medical history and chart review using the Charlson comorbidity index.Results:Patients suffering form Alzheimer's disease and vascular dementia did not differ in terms of age, education, gender distribution, or dementia severity. Cardiovascular comorbidty was more pronounced in vascular dementia patients. In both Alzheimer's disease and vascular dementia, neuropsychological performance in tests of working memory and executive functioning was related to cardiovascular comorbidity, but the relationship was stronger in vascular dementia.Conclusion:Vascular load affects neuropsychological performance in both Alzheimer's disease and vascular dementia, suggesting that cardiovascular comorbidity affects cognition across both forms of dementia.

P3-128: Communicative and linguistic abilities of Alzheimer's disease and vascular dementia patients: Preliminary results

2008 ◽  
Vol 4 ◽  
pp. T557-T557
Author(s):  
Maria Isabel D. Freitas ◽  
Marcia Radanovic ◽  
Letícia L. Mansur ◽  
Rossana M.R. Funari ◽  
Ricardo Nitrini
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Preliminary Results ◽  
Dementia Patients

scholarly journals NEUROPSI battery subtest profile in subcortical vascular dementia and Alzheimer's disease

2012 ◽  
Vol 6 (3) ◽  
pp. 170-174 ◽  
Author(s):  
Maria Niures P.S. Matioli ◽  
Paulo Caramelli
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Mini Mental State Examination ◽  
Diagnostic Value ◽  
Chi Square ◽  
Significance Level ◽  
Subcortical Vascular Dementia ◽  
Severity Of Dementia ◽  
State Examination

ABSTRACT Objective: To investigate the diagnostic value of subtests of the NEUROPSI battery for differentiating subcortical vascular dementia (SVaD) from Alzheimer's disease (AD). Methods: Thirteen patients with mild SVaD, 15 patients with mild probable AD, and 30 healthy controls, matched for age, education and dementia severity (in the case of patients), were submitted to the Mini-Mental State Examination (MMSE) and NEUROPSI battery. The performance of AD and SVaD groups on NEUROPSI subtests was compared. The statistical analyses were performed using Kruskal-Wallis, Chi-square and Mann-Whitney tests. The results were interpreted at the 5% significance level (p<0.05). Bonferroni's correction was applied to multiple comparisons (a=0.02). Results: SVaD and AD patients showed no statistical difference in MMSE scores (SVaD=20.8 and AD=21.0; p=1.0) or in NEUROPSI total score (SVaD=65.0 and AD=64.3; p=0.56), suggesting a similar severity of dementia. The AD group performed worse on memory recall (<0.01) and SVaD group was worse in verbal fluency subtests (p=0.02). Conclusion: NEUROPSI's memory and language subtests can be an auxiliary tool for differentiating SVaD from AD.

scholarly journals High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study

2019 ◽  
Author(s):  
A.C. van Loenhoud ◽  
C. de Boer ◽  
K. Wols ◽  
Y.A. Pijnenburg ◽  
A.W. Lemstra ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Lewy Body Disease ◽  
Corticobasal Degeneration ◽  
Lower Percentage ◽  
Complexity Level ◽  
Clinical Phenotypes ◽  
Dementia Patients ◽  
Transportation Logistics

AbstractBackgroundGrowing evidence suggests a role of occupation in the emergence and manifestation of dementia. Occupations are often defined by complexity level, although working environments and activities differ in several other important ways. We aimed to capture the multi-faceted nature of occupation through its measurement as a qualitative (instead of a quantitative) variable and explored its relationship with different types of dementia.MethodsWe collected occupational information of 2,121 dementia patients with various suspected etiologies from the Amsterdam Dementia Cohort (age: 67±8, 57% male, MMSE: 21±5). Our final sample included individuals with Alzheimer’s disease (AD) dementia (n=1,467), frontotemporal dementia (n=281), vascular dementia (n=98), Lewy Body disease (n=174) and progressive supranuclear palsy/corticobasal degeneration (n=101). Within the AD group, we used neuropsychological data to further characterize patients by clinical phenotypes. All participants were categorized into one of 11 occupational classes, across which we evaluated the distribution of dementia (sub)types with Chi2 analyses. We gained further insight into occupation-dementia relationships through post-hoc logistic regressions that included various demographic and health characteristics as explanatory variables.ResultsThere were significant differences in the distribution of dementia types across occupation groups (Chi2=85.87, p<.001). Vascular dementia was relatively common in the Transportation/Logistics sector, and higher vascular risk factors partly explained this relationship. Alzheimer’s disease occurred less in Transportation/Logistics and more in Health Care/Welfare occupations, which related to a higher/lower percentage of males. We found no relationships between occupational classes and clinical phenotypes of AD (Chi2=53.65, n.s.).ConclusionsRelationships between occupation and dementia seem to exist beyond complexity level, which offers new opportunities for disease prevention and improvement of occupational health policy.

scholarly journals Etiological Pattern of Dementia in Patients Attending Dementia Clinic in a Referal Hospital

2014 ◽  
Vol 30 (2) ◽  
pp. 77-83
Author(s):  
Md Masud Rana ◽  
Imran Sarker ◽  
Md Shahadat Hossain ◽  
Md Rezaul Karim Khan ◽  
Md Rafiqul Islam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Potential Risk ◽  
Cognitive Abilities ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Dementia Patients ◽  
Potential Risk Factors

Background and objectives: Dementia is characterized by loss of or decline in memory and other cognitive abilities and reduces the lifespan of affected people. The number of people with Alzheimer’s Disease and other dementias is increasing every year because of the steady growth in the older population and stable increment in life expectancy and it is expected to increase two-fold by 2030 and three-fold by 2050.In addition to Alzheimer’s disease there are so many reversible and irreversible causes of dementia. This study was aimed to explore the different etiological factors related to dementia patients. Risk factors for dementia, co-morbid conditions were also included. Methods: This cross sectional study was carried out from 2009 to 2014 at dementia clinic (OPD), department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU). A total number of 166 dementia patients, as diagnosed by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) and confirmed by Mini Mental State Examination(MMSE) score were recruited in this study. Diagnosis of specific type of dementia was made on the basis of established criteria. Results: Alzheimer’s disease(32.5%) and Vascular dementia(31.9%) were the most common etiological factor followed by Mixed dementia(19.9%), PD with dementia(8.4%) and others(7.2%) like hypothyroidism, head injury, epilepsy etc. Increasing age, hypertension, diabetes mellitus, dyslipidemia, IHD, smoking are potential risk factors for dementia. Conclusion: This study concludes Alzheimer’s disease and Vascular dementia are almost equally occurring dementia. There are also some potential risk factors for development of dementia whose modification can bring a great change in dementia treatment and functional outcome of this group of elderly people of Bangladesh. Bangladesh Journal of Neuroscience 2014; Vol. 30 (2): 77-83

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