Prevalence of primary drug resistance to rifampicin and isoniazid in newly diagnosed sputum smear positive pulmonary Tuberculosis

Background: To determine the prevalence of primary drug resistance to either rifampicin or isoniazid alone or both in newly diagnosed sputum smear positive pulmonary tuberculosis patients.Method: A prospective study 100 newly diagnosed sputum smear positive pulmonary TB patients was conducted. The patients with an age of ≥15 years and who had either not taken anti TB treatment or who had taken ATT for less than 1 month were enrolled in this study. Two sputum samples (5ml each), including one early morning sample as per the RNTCP guidelines were collected and subjected to line probe assay (LPA).Results: Out of 100 cases 6 were having resistance to both rifampicin and isoniazid, 9 has resistance to INH alone and 1 had resistance to rifampicin alone.Conclusion: The prevalence of primary drug resistance is high. For early and rapid detection of DR-TB newer modality should be used for the detection of primary drug resistance in sputum smear positive TB patients.

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Study of prevalence Rifampicin and/ or Isoniazid drug resistance among newly diagnosed cases of sputum smear positive pulmonary tuberculosis at tertiary care centre

IP International Journal of Medical Microbiology and Tropical Diseases ◽

10.18231/j.ijmmtd.2020.008 ◽

2020 ◽

Vol 6 (1) ◽

pp. 39-41

Author(s):

Sushant Dilip Muley ◽

◽

Sushant Meshram ◽

Ravi Yadav ◽

Tauseef Naeem ◽

...

Keyword(s):

Drug Resistance ◽

Pulmonary Tuberculosis ◽

Tertiary Care ◽

Sputum Smear ◽

Newly Diagnosed ◽

Care Centre ◽

Tertiary Care Centre ◽

Smear Positive Pulmonary Tuberculosis

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Treatment adherence among sputum smear-positive pulmonary tuberculosis patients in Xinjiang, China: a prospective study

RSC Advances ◽

10.1039/c7ra11820a ◽

2018 ◽

Vol 8 (16) ◽

pp. 8983-8989

Author(s):

Xinji Gong ◽

Yuehua Li ◽

Jing Wang ◽

Gang Wu ◽

Ayinuer Mohemaiti ◽

...

Keyword(s):

Drug Resistance ◽

Drug Therapy ◽

Pulmonary Tuberculosis ◽

Prospective Study ◽

Treatment Adherence ◽

Sputum Smear ◽

Great Effort ◽

Tuberculosis Patients ◽

Smear Positive Pulmonary Tuberculosis ◽

A Prospective Study

Background: Despite great effort to control tuberculosis (TB), low treatment adherence threatens the success of drug therapy, increases the risk of TB transmission, and leads to the development of drug resistance.

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Factors Influencing Sputum Conversion among Smear-Positive Pulmonary Tuberculosis Patients in Morocco

ISRN Pulmonology ◽

10.1155/2013/486507 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 6

Author(s):

Khalid Bouti ◽

Mohammed Aharmim ◽

Karima Marc ◽

Mouna Soualhi ◽

Rachida Zahraoui ◽

...

Keyword(s):

Pulmonary Tuberculosis ◽

Stepwise Regression ◽

Control Measures ◽

Sputum Smear ◽

Tuberculosis Patients ◽

Infection Control Measures ◽

Factors Influencing ◽

Smear Positive Pulmonary Tuberculosis ◽

Sputum Conversion ◽

A Prospective Study

Background. Sputum smear-positive pulmonary tuberculosis patients expel infectious viable bacilli for a period following the commencement of treatment. Objective. To determine the time to sputum smear conversion and study the factors influencing it. Design. A prospective study was undertaken at our hospital in Rabat over a six-month period on a cohort of 119 sputum smear positive patients. Patients were followed up fortnightly. At each followup, specimens were collected and processed for microscopy using standard protocol. Results. 96.6% of our patients completed the study (4 deaths). Sputum conversion rate was 42% after two weeks, 73% after one month, and 95% after two months. Univariate and stepwise regression analysis showed that patients who had high smear grading, miliary, and bilateral radiologic lesions were more likely to undergo delayed sputum conversion (P<0.05). Other factors were thought to influence sputum conversion but were not statistically proven in our study. Conclusion. Since viable bacilli continue to be expelled for up to two months, infection control measures should be maintained for such a time. Patients with high smear grading, miliary, and bilateral radiologic lesions need to be monitored more closely.

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