scholarly journals Study of prevalence Rifampicin and/ or Isoniazid drug resistance among newly diagnosed cases of sputum smear positive pulmonary tuberculosis at tertiary care centre

2020 ◽  
Vol 6 (1) ◽  
pp. 39-41
Author(s):  
Sushant Dilip Muley ◽  
◽  
Sushant Meshram ◽  
Ravi Yadav ◽  
Tauseef Naeem ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Tertiary Care ◽  
Sputum Smear ◽  
Newly Diagnosed ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Smear Positive Pulmonary Tuberculosis

scholarly journals Assessment of tuberculosis spatial hotspot areas among smear positive pulmonary tuberculosis patients attending JSS: a tertiary health care centre from Mysore district, South India

2019 ◽  
Vol 6 (10) ◽  
pp. 4322
Author(s):  
Krishna Karthik Manthravadi ◽  
Tejashree Anantharaj ◽  
Satya Sai Badveti
Keyword(s):  
Spatial Distribution ◽  
Pulmonary Tuberculosis ◽  
Hot Spot ◽  
Demographic Data ◽  
Tertiary Care ◽  
Health Concern ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Tuberculosis Patients ◽  
Smear Positive Pulmonary Tuberculosis

Background: Tuberculosis (TB) is a disease of public health concern, with a varying distribution across settings depending on socio-economic status, HIV burden, availability and performance of the health system. In 2017, TB caused an estimated 1.3 million deaths (range, 1.2–1.4 million) among HIV-negative people, and there were an additional 300 000 deaths from TB (range, 266 000–335 000) among HIV-positive people. The current TB program reports are often compiled and reported at higher administrative units and there is limited information about the spatial distribution of the disease. Hence, we aimed to assess the spatial distribution and hot spot areas of the disease among the patients attending a tertiary care centre in Mysore over a period of 3 years.Methods: This is a taluk based study, the spatial analysis and hot spot area identification was done by collecting the demographic data from the smear positive pulmonary tuberculosis patients attending JSS a tertiary care centre from Mysore district. Hot spot areas and areas with TB transmission are identified and estimated using GIS software tool. Distribution of TB incidence was mapped with the population density from 2016-2018.Results: Spatial mapping of smear positive tuberculosis revealed that majority of cases were recorded from Mysore city followed by T. N. Pura and Hunsur taluk regions.Conclusions: This study emphasized on finding hot spot areas and local clusters involved in TB transmission.

scholarly journals Prevalence of primary drug resistance to rifampicin and isoniazid in newly diagnosed sputum smear positive pulmonary Tuberculosis

2019 ◽  
Vol 7 (9) ◽  
pp. 3532
Author(s):  
Ashok Kumar ◽  
Jawahar Lal Joshi ◽  
Abdurazack Umathoor ◽  
Vishal Chopra ◽  
Komaldeep Kaur ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Early Morning ◽  
Sputum Smear ◽  
Newly Diagnosed ◽  
Primary Drug Resistance ◽  
Smear Positive Pulmonary Tuberculosis ◽  
Probe Assay ◽  
A Prospective Study ◽  
Primary Drug

Background: To determine the prevalence of primary drug resistance to either rifampicin or isoniazid alone or both in newly diagnosed sputum smear positive pulmonary tuberculosis patients.Method: A prospective study 100 newly diagnosed sputum smear positive pulmonary TB patients was conducted. The patients with an age of ≥15 years and who had either not taken anti TB treatment or who had taken ATT for less than 1 month were enrolled in this study. Two sputum samples (5ml each), including one early morning sample as per the RNTCP guidelines were collected and subjected to line probe assay (LPA).Results: Out of 100 cases 6 were having resistance to both rifampicin and isoniazid, 9 has resistance to INH alone and 1 had resistance to rifampicin alone.Conclusion: The prevalence of primary drug resistance is high. For early and rapid detection of DR-TB newer modality should be used  for the detection of primary drug resistance in sputum smear positive TB patients.

scholarly journals Current pattern of drug resistance in new cases of pulmonary tuberculosis at a tertiary care centre in India

2015 ◽  
pp. 192-195
Author(s):  
Abhishek Agarwal ◽  
Shiv Gupta ◽  
Rajendra Prasad ◽  
Sudhanshu Kathuria ◽  
Jaswant Chauhan ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Current Pattern

scholarly journals Response of leuprolide on gonadal functions of women with overt hypothyroidism: a tertiary care centre study from Uttar Pradesh - India

2019 ◽  
Vol 8 (1) ◽  
pp. 277
Author(s):  
Manish Srivastav ◽  
Alankar Tiwari ◽  
Nihit Kharkwal ◽  
Keshav Kumar Gupta
Keyword(s):  
Human Subject ◽  
Tertiary Care ◽  
Uttar Pradesh ◽  
Ovarian Response ◽  
P Value ◽  
Overt Hypothyroidism ◽  
Newly Diagnosed ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Healthy Females

Background: Hypothyroidism can cause menstrual disturbances mainly oligoanovualtory cycles and sometimes menorrhagia. It has also been seen to cause subfertility and pregnancy related complications. Various studies have been done to evaluate gonadal dysfunctions in overt hypothyroidism but very few studies are there which have done using a gonadotrophin response in that subset of patients. Present study evaluates the response of leuprolide on gonadal functions of women with overt hypothyroidism in a tertiary care centre at Meerut.Methods: In this study 50 females of age 20 to 40 years with newly diagnosed overt hypothyroidism were taken as cases and age and Body Mass Index (BMI) matched healthy females were taken as controls. Both in cases and controls, basal FSH, LH, estradiol was measured on 2nd day to 5th day of menstrual cycle. Thereafter Leuprolide 20 mcg/kg was given subcutaneously on the same day. Post leuprolide test, stimulated LH, FSH and estradiol were measured. Basal and stimulated values were compared between both groups.Results: Basal LH was significantly higher in controls (8.2±3.2 mIU/L) when compared to cases (6.45±2.75 mIU/L) with a p value 0.03(<0.05). Basal estradiol and FSH levels were found to be nearly similar and non-significant in cases and controls. No significant differences were found between stimulated mean LH and estradiol in both the groups. Leuprolide response after stimulation test was found to be sluggish in patients with overt hypothyroidism compared to normal euthyroid controls. This study is the rare one done on human subject in tertiary care centre of India, however large sample and multicentric trials are necessary before establishing the biochemical results.Conclusions: Pituitary and gonadal (ovarian) response to leuprolide was found to have impaired (decreased) in overt hypothyroidism cases. This is the first study to be done in overt hypothyroid subjects to asses both basal and stimulated gonadotropin levels.

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