Association of cord serum albumin with neonatal hyperbilirubinemia among term-neonates

Background: NH affects nearly 60% of term and 80% of preterm neonates during first week of life. 6.1% of well term newborn have a serum bilirubin over 12.9 mg%. Serum bilirubin over 15 mg% is found in 3% of normal term newborns. Neonatal Hyperbilirubinemia (NH) is a cause of concern for the parents as well as for the paediatricians. Aim of study to find out the association between various levels of cord serum albumin (CSA) and significant neonatal hyperbilirubinemia requiring interventions like phototherapy or exchange transfusion and whether it can be used as a risk indicator for subsequent development of significant jaundice.Methods: The present study was conducted on 150 randomly selected eligible term neonates delivered at Department of Pediatrics, Rajkiya Mahila Chikitsalaya, JLN Medical College and Associated Group of Hospitals, Ajmer, India.Results: Authors conducted a prospective study on 150sequentially born term babies. Cord blood was collected at birth and cord serum albumin estimation was done within 4-6 hours of collection of the blood. Cohort was grouped into Group 1, Group 2 and Group 3 based on CSA level ≤ 2.8g/dl, 2.9-3.3g/dl and ≥ 3.4 g/dl respectively. Knowledge of risk factors of NH in neonates could influence decision of early discharge vs. prolonged observation cord serum albumin level of ≤ 2.8g/dl has a correlation with incidence of significant hyperbilirubinemia in term newborns. So this ≤ 2.8g/dl of cord serum albumin level can be used as risk indicator to predict the development of significant hyperbilirubinemia. Whereas cord serum albumin level ≥3.4g/dl is considered safe.Conclusions: Term neonates with hyperbilirubinemia with a total serum bilirubin level ≥17 mg/dl had levels of cord serum albumin of ≤ 2.8 g/dl, and this can be used as a risk indicator to predict the development of NH.

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Cord blood albumin as predictor of neonatal hyperbilirubinemia

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20200118 ◽

2020 ◽

Vol 7 (2) ◽

pp. 405

Author(s):

Chandan M. V. ◽

Praveen B. K.

Keyword(s):

Serum Albumin ◽

Cord Blood ◽

Serum Albumin Level ◽

Albumin Level ◽

Neonatal Hyperbilirubinemia ◽

Total Serum ◽

Risk Indicator ◽

Term Neonates ◽

Cord Serum ◽

Blood Albumin

Background: Measuring the Cord blood Albumin level and predicting neonatal hyperbilirubinemia.Methods: Prospective study was performed on 160 healthy term neonates. Relevant maternal history was collected. Cord blood was collected from the healthy term neonates at birth and cord serum albumin measured. Neonate was assessed for jaundice every day using transcutaneous bilirubinometer. Total Serum Bilirubin (TSB) was assessed if the Transcutaneous Bilirubin (TCB) values were found high and treated according to NICU protocol.Results: Study cohort was grouped as Group A, Group B and Group C based on Cord Serum Albumin (CSA) level ≤3.3 g/dl, 3.3-3.8 g/dl and ≥3.8 g/d respectively. Statistical analysis was done for correlation of CSA with Neonatal Hyperbilirubinemia (NH). It showed that cord serum albumin level ≤3.8 g/dl is critical, as it was seen in 9.1% of neonates who developed neonatal hyperbilirubinemia (p value-0.032).Conclusions: There is a correlation between cord serum albumin level and neonatal hyperbilirubinemia. Cord serum albumin level of ≤3.8 g/dl is a risk indicator in predicting the development of neonatal hyperbilirubinemia.

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A study to determine the level of cord blood albumin in predicting neonatal jaundice

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20201040 ◽

2020 ◽

Vol 7 (4) ◽

pp. 747

Author(s):

Usha Hirevenkanagoudar ◽

Pranam G. M. ◽

Sanjeev Chetty

Keyword(s):

Serum Albumin ◽

Serum Albumin Level ◽

Mode Of Delivery ◽

Antioxidant Property ◽

Albumin Level ◽

Total Serum ◽

Risk Indicator ◽

Maternal Circulation ◽

Cord Serum ◽

Medical College

Background: Most unconjugated bilirubin formed by the fetus is cleared by the placenta into the maternal circulation. Albumin constitutes 70 - 75% of Plasma oncotic pressure. Another important function of albumin is its antioxidant property. Bilirubin binds to albumin in an equimolar ratio. Free bilirubin is anticipated when the molar bilirubin- to- albumin (B: A) ratio is >0.8 Objective of the study was to predict the proportion of newborn requiring intervention for NH (phototherapy or exchange transfusion) based on cord serum albumin level at birth.Methods: The present prospective study was conducted at Navodaya Medical College, Raichur from October 2018 to November 2019. A total of 180 babies which were born during the study period were included in the study. INCLUSION CRITERIA• Term babies both genders• Mode of delivery (normal and C-section)• Birth weight ≥2.5kg.• APGAR ≥7/10 at 1 min. Cord Serum Albumin level was estimated at birth. Total Serum Bilirubin (TSB) estimation was done at 72-96 hours of age. All the babies were followed up daily for first 4 postnatal days and babies were daily assessed for NH and its severity.Results: In our study nearly 54.4% of them had Cord Serum Albumin levels of less than 2.8 gm/dl, 27.3% of them had albumin levels of 2.9 to 3.3 gm/dl, 18.3% of them had Serum Albumin of 3.4 gm/dl. Out of 180 study subjects, 13.9% of them required phototherapy to treat neonatal hyper bilirubinemia and 2.8% of the study subjects required exchange transfusion.Conclusions: From the present study, cord serum albumin level of ≤2.8g/dl has a correlation with incidence of significant hyperbilirubinemia in term newborns. So, this ≤2.8g/dl of cord serum albumin level can be used as risk indicator to predict the development of significant hyperbilirubinemia.

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Comparison of Light Emitting Diode Phototherapy vs Conventional Phototherapy for Neonatal Hyperbilirubinemia: A Quasi-experimental Study

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/49430.15134 ◽

2021 ◽

Author(s):

Charul Mehta ◽

K Gayatri ◽

Dhruvika G Chaudhari ◽

Bhavin Patel ◽

Shashank Bansal ◽

...

Keyword(s):

Experimental Study ◽

Serum Bilirubin ◽

Light Emitting Diode ◽

Neonatal Hyperbilirubinemia ◽

Total Serum ◽

Care Hospital ◽

Term Neonates ◽

Light Emitting ◽

Led Phototherapy ◽

Quasi Experimental

Introduction: Neonatal hyperbilirubinemia is one of the most common problem encountered during the neonatal period. Phototherapy is a widely accepted, cheap, non-invasive relatively safe and effective method of treatment for neonatal hyperbilirubinemia. Aim: To compare the efficacy of Light Emitting Diode (LED) phototherapy vs Conventional Phototherapy for treatment of neonatal hyperbilirubinemia in healthy term neonates. Materials and Methods: A quasi experimental study was conducted in Neonatal Intensive Care Unit and Post-natal wards in a tertiary care hospital affiliated to Medical College and Hospital, Ahmedabad, Gujarat from July 2018 to April 2019 with a sample size of 135 in each group. They were assessed clinically by Kramers method just before initiation of phototherapy, then using Transcutaneous Bilirubinometer (TCB) Total Serum Bilirubin (TSB) level was measured. Bilirubin assessment by these methods were done for every neonate before initiation of phototherapy and then again repeated after 24 and 48 hours of phototherapy. Data was collected and analysed in Microsoft (MS) excel Statistical Package for the Social Sciences (SPSS) 0.26. Chi-square test was used for comparison. Results: In the present study, 158 (58.51%) babies were male and 112 (41.48%) babies were female. Initially, LED was found to be better than Compact Fluorescent (CFL) conventional phototherapy on comparing the average fall in the serum bilirubin level from baseline during the first 24 hours however no such difference in the efficacy between the two light sources was seen after a period of 48 hours. Total 9 (6.66%) patients developed rebound hyperbilirubinemia after completion of conventional phototherapy whereas 14 (10.37%) developed rebound hyperbilirubinemia after completion of 48 hours of LED phototherapy. Conclusion: LED and conventional phototherapy were equally efficacious in managing non haemolytic hyperbilirubinemia in healthy term neonates.

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A COMPARISON STUDY: CORD SERUM ALBUMIN IS COMPARED WITH CORD SERUM BILIRUBIN AS A RISK INDICATOR IN PREDICTING NEONATAL JAUNDICE

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2014/2393 ◽

2014 ◽

Vol 3 (15) ◽

pp. 4017-4022 ◽

Cited By ~ 2

Author(s):

Venkatamurthy M ◽

Murali S M ◽

Mamatha S

Keyword(s):

Serum Albumin ◽

Neonatal Jaundice ◽

Serum Bilirubin ◽

Risk Indicator ◽

Comparison Study ◽

Cord Serum

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To Study the Predictive Value of Umbilical Cord Blood Bilirubin Levels Term Neonates as Marker of Neonatal Hyperbilirubinemia

International Journal of Research and Review ◽

10.52403/ijrr.20210603 ◽

2021 ◽

Vol 8 (6) ◽

pp. 18-23

Author(s):

Jillela Mahesh Reddy ◽

Jonnala Umesh

Keyword(s):

Sensitivity And Specificity ◽

Predictive Value ◽

Neonatal Jaundice ◽

Serum Bilirubin ◽

Hospital Readmissions ◽

Neonatal Morbidity ◽

Neonatal Hyperbilirubinemia ◽

Term Neonates ◽

Cutoff Value ◽

Cord Serum

Background: Infants who are clinically jaundiced in the first few days are more likely to develop hyperbilirubinemia. Hyperbilirubinemia is the most common medical problem in newborn infants. It is the most important cause for hospital readmissions during the early neonatal period and also the cause for neonatal morbidity. Objective: In this prospective study we are going to evaluate the predictive value of cord bilirubin level for identifying term neonates for subsequent hyperbilirubinemia. Materials and Methods: Cord bilirubin levels at birth and subsequently serum bilirubin levels at 72 h were assessed in 291 neonates. The cutoff value was estimated beyond which there was significant hyperbilirubinemia. Statistics employed include quantitative data which is expressed in terms of mean and SD and qualitative in terms of proportions and receiver operator characteristic curve used to find cut-off value and to find sensitivity and specificity. Results: The cutoff value of cord bilirubin >2 mg/dl had sensitivity and specificity of 77.97 and 56.90%, respectively, with positive predictive value of 31.51 and negative predictive value of 91.03% for subsequent hyperbilirubinemia. Conclusion: To decreases the significant burden of untreated severe neonatal jaundice, cord serum bilirubin can be used as a screening tool to identify the neonatal jaundice in term and this prediction of neonatal hyperbilirubinemia has widespread implication especially in our country where there are limited resources. Keywords: Hyperbilirubinemia, Neonatal morbidity, cord serum bilirubin.

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