Study of bone turnover markers, procollagen type 1 N-terminal propeptide and osteocalcin in healthy and type 2 diabetes mellitus postmenopausal women

Background: Individuals with diabetes mellitus are at increased risk of metabolic bone disease due to decrease in bone strength and quality. Several bone turnover markers like serum procollagen type I N propeptide (P1NP) and serum osteocalcin are powerful tools for studying osteoporosis and fracture risk across population to provide diagnostic and prognostic information of bone health. The aim of this study was to recognize possible correlation of levels of serum P1NP and osteocalcin in type-2 diabetic (T2DM) postmenopausal women as compared to healthy postmenopausal women.Methods: The study included 100 proven cases of type-2 diabetic postmenopausal women with age matched healthy postmenopausal women as controls. P1NP, osteocalcin, and other relevant parameters were measured. Differences between diabetics and controls were analyzed.Results: The body mass index was higher in diabetic group as compared to controls. The HbA1c% was (6.94±1.43) in diabetic group and (5.57±1.21) in non-diabetics. Low serum level of 25 (OH) D was observed both in diabetic and non-diabetic groups but significantly lower in T2DM. Procollagen type 1 N propeptide was lower in diabetic group (37.59±17.20 ng/mL) as compared to non-diabetic (52.14±24.82 ng/mL). Osteocalcin was lower (15.64±8.06 ng/ml) as compared to non-diabetic group (21.85±9.12 ng/ml). Lower osteocalcin and P1NP levels found in this study suggests slower bone metabolism with reduced bone formation in postmenopausal diabetics.Conclusions: Serum procollagen type 1 N propeptide and osteocalcin in postmenopausal diabetic women were lower as compared to non-diabetic group.

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Bone turnover marker reference intervals in young females

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/0004563216665123 ◽

2016 ◽

Vol 54 (4) ◽

pp. 438-447 ◽

Cited By ~ 5

Author(s):

Emma T Callegari ◽

Alexandra Gorelik ◽

Suzanne M Garland ◽

Cherie Y Chiang ◽

John D Wark

Keyword(s):

Bone Turnover ◽

Bone Turnover Markers ◽

Bone Turnover Marker ◽

Reference Intervals ◽

Cross Linking ◽

Young Females ◽

Procollagen Type ◽

Turnover Markers ◽

Carboxy Terminal

Background The use of bone turnover markers in clinical practice and research in younger people is limited by the lack of normative data and understanding of common causes of variation in bone turnover marker values in this demographic. To appropriately interpret bone turnover markers, robust reference intervals specific to age, development and sex are necessary. This study aimed to determine reference intervals of bone turnover markers in females aged 16–25 years participating in the Safe-D study. Methods Participants were recruited through social networking site Facebook and were asked to complete an extensive, online questionnaire and attend a site visit. Participants were tested for serum carboxy-terminal cross-linking telopeptide of type 1 collagen and total procollagen type 1 N-propeptide using the Roche Elecsys automated analyser. Reference intervals were determined using the 2.5th to 97.5th percentiles of normalized bone turnover marker values. Results Of 406 participants, 149 were excluded due to medical conditions or medication use (except hormonal contraception) which may affect bone metabolism. In the remaining 257 participants, the reference interval was 230–1000 ng/L for serum carboxy-terminal cross-linking telopeptide of type 1 collagen and 27–131 µg/L for procollagen type 1 N-propeptide. Both marker concentrations were inversely correlated with age and oral contraceptive pill use. Therefore, intervals specific to these variables were calculated. Conclusions We defined robust reference intervals for cross-linking telopeptide of type 1 collagen and procollagen type 1 N-propeptide in young females grouped by age and contraceptive pill use. We examined bone turnover markers’ relationship with several lifestyle, clinical and demographic factors. Our normative intervals should aid interpretation of bone turnover markers in young females particularly in those aged 16 to 19 years where reference intervals are currently provisional.

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Relationship between bone turnover markers and oxidative stress in children with type 1 diabetes mellitus

Pediatric Research ◽

10.1038/s41390-020-01197-5 ◽

2020 ◽

Author(s):

Doaa El Amrousy ◽

Dalia El-Afify ◽

Ahmed Shabana

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Bone Turnover ◽

Type 1 Diabetes Mellitus ◽

Bone Turnover Markers ◽

Turnover Markers ◽

And Oxidative Stress

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Influence of Low Total Triiodothyronine Levels on Bone Turnover Markers in Type 2 Diabetes Mellitus

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s309079 ◽

2021 ◽

Vol Volume 14 ◽

pp. 2727-2733

Author(s):

Zelin Li ◽

Xian Yu ◽

Luping Ren ◽

Zi Wang ◽

Fei Wang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Bone Turnover ◽

Bone Turnover Markers ◽

Total Triiodothyronine ◽

Turnover Markers

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Vitamin D is associated with blood lead exposure through bone turnover in type 2 diabetes patients

Endocrine Connections ◽

10.1530/ec-21-0006 ◽

2021 ◽

Vol 10 (4) ◽

pp. 378-386

Author(s):

Haojie Zhang ◽

Yuke Cui ◽

Ruihua Dong ◽

Wen Zhang ◽

Shihan Chen ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Bone Turnover ◽

Lead Exposure ◽

Bone Turnover Markers ◽

Blood Lead ◽

Mediation Analyses ◽

Turnover Markers ◽

Type 2 Diabetic

Background Bone is thought to be the reservoir of the human lead burden, and vitamin D is associated with bone turnover. We aimed to explore whether exposure to lower 25-hydroxy vitamin D (25(OH)D) levels was associated with higher blood lead levels (BLLs) by increasing the bone turnover rate in individuals with type 2 diabetes. Methods A total of 4103 type 2 diabetic men and postmenopausal women in Shanghai, China, were enrolled in 2018. Their 25(OH)D, β-C-terminal telopeptide (β-CTX), N-MID osteocalcin and procollagen type 1 N-peptide (P1NP) levels were detected. Their BLLs were determined by atomic absorption spectrometry. Mediation analyses were performed to identify the possible role that bone turnover played in the underlying mechanisms. Results In both the men and postmenopausal women, all three bone turnover markers were inversely associated with 25(OH)D and positively associated with the BLL (all P < 0.01) after adjusting for age, current smoking habits, metabolic parameters, duration of diabetes, vitamin D intake, and use of anti-osteoporosis medication. In the mediation analyses, none of the direct associations between 25(OH)D and BLL was significant for the three bone turnover markers, but all three bone turnover markers were found to be significant mediators of the indirect associations between 25(OH)D and BLL. Conclusion The association between vitamin D and BLL was fully mediated by bone turnover markers in type 2 diabetic patients (mediation effect). This finding suggested that vitamin D may protect against blood lead exposure from the bone reservoir by decreasing bone turnover in individuals with type 2 diabetes.

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